Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy

Project Information

ChiCC

Grant agreement ID: 863799

DOI 10.3030/863799

EC signature date 3 March 2020

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 890,00

EU contribution € 1 999 890,00

Coordinated by

THE UNIVERSITY OF LIVERPOOL
United Kingdom

Deliverables

Open Research Data Pilot (1)

Data Management Plan

ORDP Deliverable

Publications

Peer reviewed articles (5)

A directed enolization strategy enables by-product-free construction of contiguous stereocentres en route to complex amino acids

Author(s): Fenglin Hong, Timothy P. Aldhous, Paul D. Kemmitt, John F. Bower
Published in: Nature Chemistry, Issue 16, 2024, Page(s) 1125-1132, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-024-01473-5

Iridium-Catalyzed Enantioselective Alkene Hydroalkylation via a Heteroaryl-Directed Enolization–Decarboxylation Sequence

Author(s): Changcheng Jing, Wenbin Mao, and John F. Bower*
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c10163

Enantioselective Intermolecular Murai-Type Alkene Hydroarylation Reactions

Author(s): Timothy P. Aldhous , Raymond W. M. Chung , Andrew G. Dalling , John F. Bower
Published in: Synthesis, 2021, ISSN 0039-7881
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0040-1720406

Atom and step economical synthesis of acyclic quaternary centers <i>via</i> iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes

Author(s): Phillippa Cooper; Andrew G. Dalling; Elliot H. E. Farrar; Timothy P. Aldhous; Simon Grélaud; Eleanor Lester; Lyman J. Feron; Paul D. Kemmitt; Matthew N. Grayson; John F. Bower
Published in: Cooper , P , Dalling , A G , Farrar , E H E , Aldhous , T P , Grélaud , S , Lester , E , Feron , L J , Kemmitt , P D , Grayson , M N & Bower , J F 2022 , ' Atom and step economical synthesis of acyclic quaternary centers via iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes ' , Chemical Science , vol. 13 , no. 37 , pp. 11183-11189 . https://doi.org/10.1039/D2SC02790A, Issue 1, 2022, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc02790a

An Aza-Enolate Strategy Enables Iridium-Catalyzed Enantioselective Hydroalkenylations of Minimally Polarized Alkenes en Route to Complex N-Aryl β²-Amino Acids

Author(s): Fenglin Hong, Craig M. Robertson, John F. Bower
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 22923-22929, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c07519