Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy

Project Information

ChiCC

Grant agreement ID: 863799

DOI

10.3030/863799

Project closed

EC signature date 3 March 2020

Start date 1 September 2020

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 890,00

EU contribution

€ 1 999 890,00

Coordinated by

THE UNIVERSITY OF LIVERPOOL
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

ORDP Deliverable

Publications

Peer reviewed articles (12)

Heteroaryl-Directed Iridium-Catalyzed Enantioselective C–H Alkenylations of Secondary Alcohols

Author(s): Wenbin Mao, Craig M. Robertson, John F. Bower
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 118-124, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c16414

A directed enolization strategy enables by-product-free construction of contiguous stereocentres en route to complex amino acids

Author(s): Fenglin Hong, Timothy P. Aldhous, Paul D. Kemmitt, John F. Bower
Published in: Nature Chemistry, Issue 16, 2024, Page(s) 1125-1132, ISSN 1755-4330
Publisher: Nature Publishing Group
DOI: 10.1038/s41557-024-01473-5

Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters

Author(s): Timothy P. Aldhous, Raymond Chung, Abbas Hassan, Andrew G. Dalling, Phillippa Cooper, Simon Grélaud, Richard J. Mudd, Lyman J. Feron, Paul D. Kemmitt, John F. Bower
Published in: Angewandte Chemie International Edition, Issue 64, 2026, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202502569

The Discovery and Development of an Iridium‐Catalyzed N→C Alkyl Transfer Reaction

Author(s): Erin C. Boddie, Phillippa Cooper, L. Anders Hammarback, Richard J. Mudd, Lyman J. Feron, John F. Bower
Published in: Angewandte Chemie, Issue 137, 2025, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202509193

Iridium-Catalyzed Enantioselective Alkene Hydroalkylation via a Heteroaryl-Directed Enolization–Decarboxylation Sequence

Author(s): Changcheng Jing, Wenbin Mao, and John F. Bower*
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c10163

Enantioselective Intermolecular Murai-Type Alkene Hydroarylation Reactions

Author(s): Timothy P. Aldhous , Raymond W. M. Chung , Andrew G. Dalling , John F. Bower
Published in: Synthesis, 2021, ISSN 0039-7881
Publisher: Georg Thieme Verlag
DOI: 10.1055/s-0040-1720406

Atom and step economical synthesis of acyclic quaternary centers <i>via</i> iridium-catalyzed hydroarylative cross-coupling of 1,1-disubstituted alkenes

Author(s): Phillippa Cooper; Andrew G. Dalling; Elliot H. E. Farrar; Timothy P. Aldhous; Simon Grélaud; Eleanor Lester; Lyman J. Feron; Paul D. Kemmitt; Matthew N. Grayson; John F. Bower
Published in: Chemical Science, Issue 1, 2022, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sc02790a

A Strategy for the Formal C−N Cross‐Coupling of Tertiary Amines

Author(s): Peter R. Ledwith, Madelene L. Cooney, Karim A. Bahou, Javier García‐Cárceles, Joshua Thomson, John F. Bower
Published in: Angewandte Chemie, Issue 136, 2025, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202411555

Iridium-Catalyzed Stereoselective α-Alkylation of α-Hydroxy Ketones with Minimally Polarized Alkenes

Author(s): Yihong Wang, Fenglin Hong, Craig M. Robertson, Richard J. Mudd, John F. Bower
Published in: Journal of the American Chemical Society, Issue 148, 2026, Page(s) 3911-3917, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c19724

An Iridium‐Catalyzed Conia‐ene Reaction for the Diastereo‐ and Enantioselective Synthesis of Complex Ring Systems

Author(s): Romi S. Aggarwal, Wenbin Mao, Craig M. Robertson, John F. Bower
Published in: Angewandte Chemie, Issue 138, 2026, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.6718169

β-Substituted Styrenes in Heteroaryl-Directed Hydroalkylative Cross-Couplings: Regio-, Diastereo-, and Enantioselective Formation of β-Stereogenic Tertiary Alcohols

Author(s): Wenbin Mao, Craig M. Robertson, John F. Bower
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 43261-43266, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.5c17840

An Aza-Enolate Strategy Enables Iridium-Catalyzed Enantioselective Hydroalkenylations of Minimally Polarized Alkenes en Route to Complex N-Aryl β²-Amino Acids

Author(s): Fenglin Hong, Craig M. Robertson, John F. Bower
Published in: Journal of the American Chemical Society, Issue 146, 2024, Page(s) 22923-22929, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c07519