Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy

Project Information

GlycoSpec

Grant agreement ID: 863934

DOI

10.3030/863934

EC signature date 2 March 2020

Start date 1 August 2020

End date 31 January 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 642 850,00

EU contribution

€ 2 642 850,00

Coordinated by

FREIE UNIVERSITAET BERLIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Predicting Structural Motifs of Glycosaminoglycans using Cryogenic Infrared Spectroscopy and Random Forest

Author(s): Riedel, J; Lettow, M.; Grabarics, M.; Götze, M.; Miller, R. L.; Boons, G.-J.; Meijer, G.; von Helden, G; Szekeres, G. P.; Pagel, K.
Published in: Journal of the American Chemical Society, 2023, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c12762

Untersuchung des reaktiven Intermediats der RNA Autohydrolyse mittels kryogener Infrarotspektroskopie in der Gasphase

Author(s): Kim Greis, Carla Kirschbaum, Dr. Martín I. Taccone, Dr. Michael Götze, Sandy Gewinner, Dr. Wieland Schöllkopf, Prof. Gerard Meijer, Prof. Gert von Helden, Prof. Kevin Pagel
Published in: Angewandte Chemie, Issue 134, 2022, ISSN 0044-8249
Publisher: Wiley
DOI: 10.1002/ange.202115481

A 3D-Printed Offline Nano-ESI Source for Bruker MS Instruments

Author(s): Michael Götze, Lukasz Polewski, Leïla Bechtella, Kevin Pagel
Published in: Journal of the American Society for Mass Spectrometry, Issue 34, 2023, Page(s) 2403-2406, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.3c00214

Establishing Fatty Acid Double Bond Position and Configuration by Gas-Phase Infrared Spectroscopy

Author(s): Kirschbaum, C.; Young, R. S. E.; Greis, K.; Menzel, J. P.; Gewinner, S.; Schöllkopf, W.; Meijer, G.; von Helden, G.; Causon, T.; Narreddula, V. R.; Poad, B. L. J.; Blanksby, S. J.; Pagel, K.,
Published in: Chemical Science, Issue 14, 2023, Page(s) 2518-2527, ISSN 2041-6539
Publisher: RSC
DOI: 10.1039/d2sc06487a

Lipid Analysis by Mass Spectrometry coupled with Laser Light, Analysis and Sensing

Author(s): Kirschbaum, C.; Pagel, K.
Published in: Analysis and Sensing, 2023, Page(s) e202200103, ISSN 2629-2742
Publisher: Wiley
DOI: 10.1002/anse.202200103

Decoding the Fucose Migration Product during Mass-Spectrometric Analysis of Blood Group Epitopes

Author(s): Lettow, M.; Mucha, E.; Greis, K.; Yaman, M.; Manz, C.; Hoffmann, W.; Lambeth, T.R.; Meijer, G.; Julian, R.R.; von Helden, G.; Marianski, M.; Pagel, K.
Published in: Angewandte Chemie International Edition, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202302883

Cryogenic infrared spectroscopy provides mechanistic insight into the fragmentation of phospholipid silver adducts

Author(s): Kirschbaum, C.; Greis, K.; Gewinner, S.; Schöllkopf, W.; Meijer, G.; Helden, G.; Pagel, K.
Published in: Analytical and Bioanalytical Chemistry, 2022, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-022-03927-6

The Effect of Electron Density in Acyl Protecting Groups on the Selectivity of Galactosylations

Author(s): Greis, K.; Leichnitz, S.; Kirschbaum, C.; Chang, C.-W.; Meijer, G.; von Helden, G.; Seeberger, P. H.; Pagel, K.
Published in: Journal of the American Chemical Society, Issue 144, 2022, Page(s) 20258–20266, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c05859

Neighboring Group Participation of Benzoyl Protecting Groups in C3- and C6-Fluorinated Glucose

Author(s): Kim Greis, Carla Kirschbaum, Giulio Fittolani, Eike Mucha, Rayoon Chang, Gert von Helden, Gerard Meijer, Martina Delbianco, Peter H. Seeberger, Kevin Pagel
Published in: European Journal of Organic Chemistry, 2022, ISSN 1434-193X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ejoc.202200255

State-of-the-art Glycosaminoglycan Characterization

Author(s): Zappe, A.; Miller, R.L.; Struwe, W.B.; Pagel, K.
Published in: Mass Spectrometry Reviews, Issue 41, 2022, Page(s) 194-202, ISSN 1098-2787
Publisher: Wiley
DOI: 10.1002/mas.21737

The Impact of Leaving Group Anomericity on the Structure of Glycosyl Cations

Author(s): Greis, K.; Mucha, E.; Lettow, M.; Thomas, D. A.; Kirschbaum, C.; Moon, S.; Pardo, A.; von Helden, G.; Meijer, G.; Gilmore, K.; Seeberger, P. H.; Pagel, K.
Published in: ChemPhysChem, Issue 21, 2020, Page(s) 1905-1907, ISSN 1439-4235
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202000473

Studying the Key Intermediate of RNA Autohydrolysis by Cryogenic Gas-Phase Infrared Spectroscopy

Author(s): Kim Greis, Carla Kirschbaum, Dr. Martín I. Taccone, Dr. Michael Götze, Sandy Gewinner, Dr. Wieland Schöllkopf, Prof. Gerard Meijer, Prof. Gert von Helden, Prof. Kevin Pagel
Published in: Angewandte Chemie International Edition, 2022, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202115481

Characterization and Fate of a Septanosyl Ferrier Cation in the Gas and Solution Phases

Author(s): Kim Greis; Caleb E. Griesbach; Carla Kirschbaum; Gerard Meijer; Gert von Helden; Kevin Pagel; Mark W. Peczuh
Published in: The Journal of Organic Chemistry, Issue 88, 2023, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.3c00079

Elucidating reactive sugar-intermediates by mass spectrometry

Author(s): Chun-Wei Chang, Dana Wehner, Gurpur Rakesh D. Prabhu, Eunjin Moon, Marc Safferthal, Leïla Bechtella, Nicklas Österlund, Gaël M. Vos, Kevin Pagel
Published in: Communications Chemistry, Issue 8, 2025, ISSN 2399-3669
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42004-025-01467-5

Mechanistic insight into benzylidene-directed glycosylation reactions using cryogenic infrared spectroscopy

Author(s): Chun-Wei Chang, Kim Greis, Gurpur Rakesh D. Prabhu, Dana Wehner, Carla Kirschbaum, Katja Ober, América Y. Torres-Boy, Sabrina Leichnitz, Gerard Meijer, Gert von Helden, Peter H. Seeberger, Kevin Pagel
Published in: Nature Synthesis, Issue 3, 2024, Page(s) 1377-1384, ISSN 2731-0582
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44160-024-00619-0

Direct Experimental Characterization of a Sialyl Cation

Author(s): Franziska Dahlmann, Caleb E. Griesbach, América Y. Torres‐Boy, Gert von Helden, Mark W. Peczuh, Kevin Pagel, Kim Greis
Published in: Chemistry – A European Journal, Issue 31, 2025, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202403724

Direct Experimental Characterization of the Ferrier Glycosyl Cation in the Gas Phase.

Author(s): Kim Greis; Kim Greis; Carla Kirschbaum; Carla Kirschbaum; Sabrina Leichnitz; Sabrina Leichnitz; Sandy Gewinner; Wieland Schöllkopf; Gert von Helden; Gerard Meijer; Peter H. Seeberger; Peter H. Seeberger; Kevin Pagel; Kevin Pagel
Published in: Organic Letters, 2020, Page(s) 8916-8919, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.0c03301

Studying the Intrinsic Reactivity of Chromanes by Gas-Phase Infrared Spectroscopy

Author(s): Carla Kirschbaum, Kim Greis, América Y. Torres-Boy, Jerome Riedel, Sandy Gewinner, Wieland Schöllkopf, Gerard Meijer, Gert von Helden, Kevin Pagel
Published in: Journal of the American Society for Mass Spectrometry, Issue 35, 2024, Page(s) 1950-1958, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.4c00216

Multiply charged ion profiles in the UHPLC-HRMS analysis of palytoxin analogues from <i>Ostreopsis</i> cf. <i>ovata</i> blooms

Author(s): Noemí Inmaculada Medina-Pérez, Francisco Javier Santos, Elisa Berdalet, Encarnación Moyano
Published in: Analytical Methods, Issue 15, 2024, Page(s) 1355-1364, ISSN 1759-9660
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ay02019j

Mass Spectrometry-Based Techniques to Elucidate the Sugar Code.

Author(s): Márkó Grabarics; Márkó Grabarics; Maike Lettow; Maike Lettow; Carla Kirschbaum; Carla Kirschbaum; Kim Greis; Kim Greis; Christian Manz; Christian Manz; Kevin Pagel; Kevin Pagel
Published in: Chemical Reviews, 2021, ISSN 0009-2665
Publisher: American Chemical Society
DOI: 10.1021/acs.chemrev.1c00380

Reinvestigation of the internal glycan rearrangement of Lewis a and blood group type H1 epitopes

Author(s): Vasilis Kontodimas, Murat Yaman, Kim Greis, Maike Lettow, Kevin Pagel, Mateusz Marianski
Published in: Physical Chemistry Chemical Physics, Issue 26, 2024, Page(s) 14160-14170, ISSN 1463-9076
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cp04491b

Glycosaminoglycans: What Remains To Be Deciphered?

Author(s): Serge Perez; Olga Makshakova; Jesus Angulo; Emiliano Bedini; Antonella Bisio; Jose Luis de Paz; Elisa Fadda; Marco Guerrini; Michal Hricovini; Milos Hricovini; Frederique Lisacek; Pedro M. Nieto; Kevin Pagel; Giulia Paiardi; Ralf Richter; Sergey A. Samsonov; Romain R. Vivès; Dragana Nikitovic; Sylvie Ricard Blum
Published in: JACS Au, Issue 4, 2023, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.2c00569