Mechanical Biomarkers for Prediction of Cancer Immunotherapy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Autores: Christiana M. Neophytou, Myrofora Panagi, Triantafyllos Stylianopoulos, Panagiotis Papageorgis
Publicado en: Cancers, Edición 13/9, 2021, Página(s) 2053, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092053

Dynamic heterogeneity in COVID-19: Insights from a mathematical model

Autores: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Lance L. Munn, Rakesh K. Jain, Triantafyllos Stylianopoulos
Publicado en: PLOS ONE, Edición 19, 2024, Página(s) e0301780, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0301780

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

Autores: Constantinos Harkos, Triantafyllos Stylianopoulos, Rakesh K. Jain
Publicado en: PLOS Computational Biology, Edición 19, 2024, Página(s) e1011740, ISSN 1553-7358
Editor: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1011740

Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy

Autores: Chrysovalantis Voutouri, Fotios Mpekris, Myrofora Panagi, Connor Krolak, Christina Michael, John D. Martin, Michalakis A. Averkiou, Triantafyllos Stylianopoulos
Publicado en: Acta Biomaterialia, Edición 167, 2024, Página(s) 121-134, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2023.06.007

Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models

Autores: Fotios Mpekris, Petri Ch. Papaphilippou, Myrofora Panagi, Chrysovalantis Voutouri, Christina Michael, Antonia Charalambous, Mariyan Marinov Dinev, Anna Katsioloudi, Marianna Prokopi-Demetriades, Andreas Anayiotos, Horacio Cabral, Theodora Krasia-Christoforou, Triantafyllos Stylianopoulos
Publicado en: ACS Nano, Edición 17, 2023, Página(s) 24654-24667, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.3c03305

Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition

Autores: Maria Kalli, Fotios Mpekris, Antonia Charalambous, Christina Michael, Chrystalla Stylianou, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Antonia Papoui, John D. Martin, Triantafyllos Stylianopoulos
Publicado en: Communications Biology, Edición 7, 2024, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07268-1

Nanomechanical properties of solid tumors as treatment monitoring biomarkers

Autores: Andreas Stylianou, Fotios Mpekris, Chrysovalantis Voutouri, Antonia Papoui, Anastasia Constantinidou, Evros Kitiris, Michalis Kailides, Triantafyllos Stylianopoulos
Publicado en: Acta Biomaterialia, Edición 17427061, 2022, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.021

Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

Autores: Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Publicado en: Cell Reports Medicine, Edición 5, 2024, Página(s) 101626, ISSN 2666-3791
Editor: Cell
DOI: 10.1016/j.xcrm.2024.101626

Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy

Autores: Mpekris F., C. Voutouri, M. Panagi, J.W Baish, R.K Jain, T. Stylianopoulos
Publicado en: Journal of Controlled Release, Edición 01683659, 2022, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2022.03.008

Endothelin Inhibition Potentiates Cancer Immunotherapy Revealing Mechanical Biomarkers Predictive of Response

Autores: Chrysovalantis Voutouri, Myrofora Panagi, Fotios Mpekris, Andreas Stylianou, Christina Michael, Michalakis A. Averkiou, John D. Martin, Triantafyllos Stylianopoulos
Publicado en: Advanced Therapeutics, Edición 2000289, 2021, Página(s) 2000289, ISSN 2366-3987
Editor: Wiley-VCH
DOI: 10.1002/adtp.202000289

Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano‐immunotherapy in Breast Cancer Lung Metastasis

Autores: Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Publicado en: Advanced Science, Edición 8/3, 2021, Página(s) 2001917, ISSN 2198-3844
Editor: Wiley-VCH
DOI: 10.1002/advs.202001917

Convection-Enhanced Delivery in silico study for personalized brain cancer treatment

Autores: Chryso Lambride, Vasileios Vavourakis, Triantafyllos Stylianopoulos
Publicado en: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editor: Frontiers
DOI: 10.21203/rs.3.rs-998895/v1

Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy

Autores: Demetris Englezos, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Publicado en: Translational Oncology, Edición 44, 2024, Página(s) 101944, ISSN 1936-5233
Editor: Neoplasia Press
DOI: 10.1016/j.tranon.2024.101944

Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy

Autores: Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Publicado en: npj Biological Physics and Mechanics, Edición 1, 2024, ISSN 3004-863X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44341-024-00002-2

Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models

Autores: Myrofora Panagi, Fotios Mpekris, Pengwen Chen, Chrysovalantis Voutouri, Yasuhiro Nakagawa, John D. Martin, Tetsuro Hiroi, Hiroko Hashimoto, Philippos Demetriou, Chryso Pierides, Rekha Samuel, Andreas Stylianou, Christina Michael, Shigeto Fukushima, Paraskevi Georgiou, Panagiotis Papageorgis, Petri Ch. Papaphilippou, Laura Koumas, Paul Costeas, Genichiro Ishii, Motohiro Kojima, Kazunori Kataoka, Ho
Publicado en: Nature Communications, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34744-1

Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition

Autores: Myrofora Panagi, Fotios Mpekris, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Chloe Symeonidou, Eleni Porfyriou, Christina Michael, Andreas Stylianou, John D. Martin, Horacio Cabral, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Publicado en: Clinical Cancer Research, Edición 30, 2024, Página(s) 2582-2597, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0246

Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

Autores: Constantinos Harkos, Triantafyllos Stylianopoulos
Publicado en: Journal of Theoretical Biology, Edición 583, 2024, Página(s) 111768, ISSN 0022-5193
Editor: Academic Press
DOI: 10.1016/j.jtbi.2024.111768

Exploring the landscape of immunotherapy approaches in sarcomas

Autores: Pampina Pilavaki, Myrofora Panagi, Samia Arifi, Robin L. Jones, Triantafyllos Stylianopoulos, Anastasia Constantinidou
Publicado en: Frontiers in Oncology, 2023, ISSN 2234-943X
Editor: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1069963

Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II

Autores: Kalli M., R. Li, G.B. Mills, T. Stylianopoulos, I.K. Zervantonakis
Publicado en: Molecular Cancer Research, Edición 15417786, 2022, ISSN 1541-7786
Editor: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-21-0266

Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics

Autores: Harkos, C.; Svensson, S.F., Emblem, K.E., and Stylianopoulos, T.
Publicado en: Cancers, Edición 20726694, 2022, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040884

In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer

Autores: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Publicado en: Cell Reports Medicine, Edición 5, 2024, Página(s) 101436, ISSN 2666-3791
Editor: Elsevier BV
DOI: 10.1016/j.xcrm.2024.101436

Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer

Autores: Lance L. Munn, Triantafyllos Stylianopoulos, Natalie K. Jain, C. Corey Hardin, Melin J. Khandekar, Rakesh K. Jain
Publicado en: Clinical Cancer Research, Edición 27, 2022, Página(s) 2706-2711, ISSN 1078-0432
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-4750

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2

Autores: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Publicado en: Proceedings of the National Academy of Sciences, Edición 120, 2023, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2211132120

Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness

Autores: Panagi M., P. Pilavaki, A. Constantinidou, T. Stylianopoulos
Publicado en: Theranostics, Edición 18387640, 2022, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.72800

A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas

Autores: Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Christina Michael, Antonia Papoui, Triantafyllos Stylianopoulos
Publicado en: Neoplasia, Edición 51, 2024, Página(s) 100990, ISSN 1476-5586
Editor: Elsevier
DOI: 10.1016/j.neo.2024.100990

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

Autores: Chrysovalantis Voutouri, Mohammad Reza Nikmaneshi, C. Corey Hardin, Ankit B. Patel, Ashish Verma, Melin J. Khandekar, Sayon Dutta, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Publicado en: Proceedings of the National Academy of Sciences, Edición 118, 2022, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2021642118

Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

Autores: Maria Kalli, Triantafyllos Stylianopoulos
Publicado en: APL Bioengineering, Edición 8, 2025, ISSN 2473-2877
Editor: AIP Publishing
DOI: 10.1063/5.0183302

Pancreatic Cancer Presents Distinct Nanomechanical Properties During Progression

Autores: Andreas Stylianou; Chrysovalantis Voutouri; Fotios Mpekris; Triantafyllos Stylianopoulos
Publicado en: Annals of Biomedical Engineering, Edición 1, 2023, ISSN 1573-9686
Editor: Springer
DOI: 10.1007/s10439-023-03168-3

Beyond matrix stiffness: targeting force-induced cancer drug resistance

Autores: Maria Kalli, Matthew D. Poskus, Triantafyllos Stylianopoulos, Ioannis K. Zervantonakis
Publicado en: Trends in Cancer, Edición 9, 2024, Página(s) 937-954, ISSN 2405-8033
Editor: Elsevier BV
DOI: 10.1016/j.trecan.2023.07.006

Evaluation of growth-induced, mechanical stress in solid tumors and spatial association with extracellular matrix content

Autores: Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Publicado en: Biomechanics and Modeling in Mechanobiology, Edición 22, 2023, Página(s) 1625-1643, ISSN 1617-7959
Editor: Springer Verlag
DOI: 10.1007/s10237-023-01716-3

Dissecting the Impact of the Gut Microbiome on Cancer Immunotherapy

Autores: Rakesh Jain, Andreas Hadjigeorgiou, Constantinos Harkos, Aditya Mishra, Golnaz Morad, Sarah Johnson, Nadim Ajami, Jennifer Wargo, Lance Munn, Triantafyllos Stylianopoulos
Publicado en: 2024
Editor: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-3647386/v1

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