Mechanical Biomarkers for Prediction of Cancer Immunotherapy

Informazioni relative al progetto

Immuno-Predictor

ID dell’accordo di sovvenzione: 863955

DOI

10.3030/863955

Progetto chiuso

Data della firma CE 16 Marzo 2020

Data di avvio 1 Aprile 2020

Data di completamento 31 Marzo 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

UNIVERSITY OF CYPRUS
Cyprus

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (30)

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Autori: Christiana M. Neophytou, Myrofora Panagi, Triantafyllos Stylianopoulos, Panagiotis Papageorgis
Pubblicato in: Cancers, Numero 13/9, 2021, Pagina/e 2053, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092053

Dynamic heterogeneity in COVID-19: Insights from a mathematical model

Autori: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Lance L. Munn, Rakesh K. Jain, Triantafyllos Stylianopoulos
Pubblicato in: PLOS ONE, Numero 19, 2024, Pagina/e e0301780, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0301780

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

Autori: Constantinos Harkos, Triantafyllos Stylianopoulos, Rakesh K. Jain
Pubblicato in: PLOS Computational Biology, Numero 19, 2024, Pagina/e e1011740, ISSN 1553-7358
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1011740

Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy

Autori: Chrysovalantis Voutouri, Fotios Mpekris, Myrofora Panagi, Connor Krolak, Christina Michael, John D. Martin, Michalakis A. Averkiou, Triantafyllos Stylianopoulos
Pubblicato in: Acta Biomaterialia, Numero 167, 2024, Pagina/e 121-134, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2023.06.007

Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models

Autori: Fotios Mpekris, Petri Ch. Papaphilippou, Myrofora Panagi, Chrysovalantis Voutouri, Christina Michael, Antonia Charalambous, Mariyan Marinov Dinev, Anna Katsioloudi, Marianna Prokopi-Demetriades, Andreas Anayiotos, Horacio Cabral, Theodora Krasia-Christoforou, Triantafyllos Stylianopoulos
Pubblicato in: ACS Nano, Numero 17, 2023, Pagina/e 24654-24667, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.3c03305

Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition

Autori: Maria Kalli, Fotios Mpekris, Antonia Charalambous, Christina Michael, Chrystalla Stylianou, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Antonia Papoui, John D. Martin, Triantafyllos Stylianopoulos
Pubblicato in: Communications Biology, Numero 7, 2024, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07268-1

Nanomechanical properties of solid tumors as treatment monitoring biomarkers

Autori: Andreas Stylianou, Fotios Mpekris, Chrysovalantis Voutouri, Antonia Papoui, Anastasia Constantinidou, Evros Kitiris, Michalis Kailides, Triantafyllos Stylianopoulos
Pubblicato in: Acta Biomaterialia, Numero 17427061, 2022, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.021

Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

Autori: Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Pubblicato in: Cell Reports Medicine, Numero 5, 2024, Pagina/e 101626, ISSN 2666-3791
Editore: Cell
DOI: 10.1016/j.xcrm.2024.101626

Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy

Autori: Mpekris F., C. Voutouri, M. Panagi, J.W Baish, R.K Jain, T. Stylianopoulos
Pubblicato in: Journal of Controlled Release, Numero 01683659, 2022, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2022.03.008

Endothelin Inhibition Potentiates Cancer Immunotherapy Revealing Mechanical Biomarkers Predictive of Response

Autori: Chrysovalantis Voutouri, Myrofora Panagi, Fotios Mpekris, Andreas Stylianou, Christina Michael, Michalakis A. Averkiou, John D. Martin, Triantafyllos Stylianopoulos
Pubblicato in: Advanced Therapeutics, Numero 2000289, 2021, Pagina/e 2000289, ISSN 2366-3987
Editore: Wiley-VCH
DOI: 10.1002/adtp.202000289

Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano‐immunotherapy in Breast Cancer Lung Metastasis

Autori: Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Pubblicato in: Advanced Science, Numero 8/3, 2021, Pagina/e 2001917, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202001917

Convection-Enhanced Delivery in silico study for personalized brain cancer treatment

Autori: Chryso Lambride, Vasileios Vavourakis, Triantafyllos Stylianopoulos
Pubblicato in: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editore: Frontiers
DOI: 10.21203/rs.3.rs-998895/v1

Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy

Autori: Demetris Englezos, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Pubblicato in: Translational Oncology, Numero 44, 2024, Pagina/e 101944, ISSN 1936-5233
Editore: Neoplasia Press
DOI: 10.1016/j.tranon.2024.101944

Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy

Autori: Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Pubblicato in: npj Biological Physics and Mechanics, Numero 1, 2024, ISSN 3004-863X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44341-024-00002-2

Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models

Autori: Myrofora Panagi, Fotios Mpekris, Pengwen Chen, Chrysovalantis Voutouri, Yasuhiro Nakagawa, John D. Martin, Tetsuro Hiroi, Hiroko Hashimoto, Philippos Demetriou, Chryso Pierides, Rekha Samuel, Andreas Stylianou, Christina Michael, Shigeto Fukushima, Paraskevi Georgiou, Panagiotis Papageorgis, Petri Ch. Papaphilippou, Laura Koumas, Paul Costeas, Genichiro Ishii, Motohiro Kojima, Kazunori Kataoka, Ho
Pubblicato in: Nature Communications, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34744-1

Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition

Autori: Myrofora Panagi, Fotios Mpekris, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Chloe Symeonidou, Eleni Porfyriou, Christina Michael, Andreas Stylianou, John D. Martin, Horacio Cabral, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Pubblicato in: Clinical Cancer Research, Numero 30, 2024, Pagina/e 2582-2597, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0246

Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

Autori: Constantinos Harkos, Triantafyllos Stylianopoulos
Pubblicato in: Journal of Theoretical Biology, Numero 583, 2024, Pagina/e 111768, ISSN 0022-5193
Editore: Academic Press
DOI: 10.1016/j.jtbi.2024.111768

Exploring the landscape of immunotherapy approaches in sarcomas

Autori: Pampina Pilavaki, Myrofora Panagi, Samia Arifi, Robin L. Jones, Triantafyllos Stylianopoulos, Anastasia Constantinidou
Pubblicato in: Frontiers in Oncology, 2023, ISSN 2234-943X
Editore: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1069963

Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II

Autori: Kalli M., R. Li, G.B. Mills, T. Stylianopoulos, I.K. Zervantonakis
Pubblicato in: Molecular Cancer Research, Numero 15417786, 2022, ISSN 1541-7786
Editore: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-21-0266

Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics

Autori: Harkos, C.; Svensson, S.F., Emblem, K.E., and Stylianopoulos, T.
Pubblicato in: Cancers, Numero 20726694, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040884

In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer

Autori: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Pubblicato in: Cell Reports Medicine, Numero 5, 2024, Pagina/e 101436, ISSN 2666-3791
Editore: Elsevier BV
DOI: 10.1016/j.xcrm.2024.101436

Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer

Autori: Lance L. Munn, Triantafyllos Stylianopoulos, Natalie K. Jain, C. Corey Hardin, Melin J. Khandekar, Rakesh K. Jain
Pubblicato in: Clinical Cancer Research, Numero 27, 2022, Pagina/e 2706-2711, ISSN 1078-0432
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-4750

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2

Autori: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 120, 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2211132120

Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness

Autori: Panagi M., P. Pilavaki, A. Constantinidou, T. Stylianopoulos
Pubblicato in: Theranostics, Numero 18387640, 2022, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.72800

A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas

Autori: Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Christina Michael, Antonia Papoui, Triantafyllos Stylianopoulos
Pubblicato in: Neoplasia, Numero 51, 2024, Pagina/e 100990, ISSN 1476-5586
Editore: Elsevier
DOI: 10.1016/j.neo.2024.100990

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

Autori: Chrysovalantis Voutouri, Mohammad Reza Nikmaneshi, C. Corey Hardin, Ankit B. Patel, Ashish Verma, Melin J. Khandekar, Sayon Dutta, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2021642118

Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

Autori: Maria Kalli, Triantafyllos Stylianopoulos
Pubblicato in: APL Bioengineering, Numero 8, 2025, ISSN 2473-2877
Editore: AIP Publishing
DOI: 10.1063/5.0183302

Pancreatic Cancer Presents Distinct Nanomechanical Properties During Progression

Autori: Andreas Stylianou; Chrysovalantis Voutouri; Fotios Mpekris; Triantafyllos Stylianopoulos
Pubblicato in: Annals of Biomedical Engineering, Numero 1, 2023, ISSN 1573-9686
Editore: Springer
DOI: 10.1007/s10439-023-03168-3

Beyond matrix stiffness: targeting force-induced cancer drug resistance

Autori: Maria Kalli, Matthew D. Poskus, Triantafyllos Stylianopoulos, Ioannis K. Zervantonakis
Pubblicato in: Trends in Cancer, Numero 9, 2024, Pagina/e 937-954, ISSN 2405-8033
Editore: Elsevier BV
DOI: 10.1016/j.trecan.2023.07.006

Evaluation of growth-induced, mechanical stress in solid tumors and spatial association with extracellular matrix content

Autori: Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Pubblicato in: Biomechanics and Modeling in Mechanobiology, Numero 22, 2023, Pagina/e 1625-1643, ISSN 1617-7959
Editore: Springer Verlag
DOI: 10.1007/s10237-023-01716-3

Other (1)

Dissecting the Impact of the Gut Microbiome on Cancer Immunotherapy

Autori: Rakesh Jain, Andreas Hadjigeorgiou, Constantinos Harkos, Aditya Mishra, Golnaz Morad, Sarah Johnson, Nadim Ajami, Jennifer Wargo, Lance Munn, Triantafyllos Stylianopoulos
Pubblicato in: 2024
Editore: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-3647386/v1