Mechanical Biomarkers for Prediction of Cancer Immunotherapy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Publications

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Auteurs: Christiana M. Neophytou, Myrofora Panagi, Triantafyllos Stylianopoulos, Panagiotis Papageorgis
Publié dans: Cancers, Numéro 13/9, 2021, Page(s) 2053, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13092053

Dynamic heterogeneity in COVID-19: Insights from a mathematical model

Auteurs: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Lance L. Munn, Rakesh K. Jain, Triantafyllos Stylianopoulos
Publié dans: PLOS ONE, Numéro 19, 2024, Page(s) e0301780, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0301780

Mathematical modeling of intratumoral immunotherapy yields strategies to improve the treatment outcomes

Auteurs: Constantinos Harkos, Triantafyllos Stylianopoulos, Rakesh K. Jain
Publié dans: PLOS Computational Biology, Numéro 19, 2024, Page(s) e1011740, ISSN 1553-7358
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/journal.pcbi.1011740

Ultrasound stiffness and perfusion markers correlate with tumor volume responses to immunotherapy

Auteurs: Chrysovalantis Voutouri, Fotios Mpekris, Myrofora Panagi, Connor Krolak, Christina Michael, John D. Martin, Michalakis A. Averkiou, Triantafyllos Stylianopoulos
Publié dans: Acta Biomaterialia, Numéro 167, 2024, Page(s) 121-134, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2023.06.007

Pirfenidone-Loaded Polymeric Micelles as an Effective Mechanotherapeutic to Potentiate Immunotherapy in Mouse Tumor Models

Auteurs: Fotios Mpekris, Petri Ch. Papaphilippou, Myrofora Panagi, Chrysovalantis Voutouri, Christina Michael, Antonia Charalambous, Mariyan Marinov Dinev, Anna Katsioloudi, Marianna Prokopi-Demetriades, Andreas Anayiotos, Horacio Cabral, Theodora Krasia-Christoforou, Triantafyllos Stylianopoulos
Publié dans: ACS Nano, Numéro 17, 2023, Page(s) 24654-24667, ISSN 1936-0851
Éditeur: American Chemical Society
DOI: 10.1021/acsnano.3c03305

Mechanical forces inducing oxaliplatin resistance in pancreatic cancer can be targeted by autophagy inhibition

Auteurs: Maria Kalli, Fotios Mpekris, Antonia Charalambous, Christina Michael, Chrystalla Stylianou, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Antonia Papoui, John D. Martin, Triantafyllos Stylianopoulos
Publié dans: Communications Biology, Numéro 7, 2024, ISSN 2399-3642
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-07268-1

Nanomechanical properties of solid tumors as treatment monitoring biomarkers

Auteurs: Andreas Stylianou, Fotios Mpekris, Chrysovalantis Voutouri, Antonia Papoui, Anastasia Constantinidou, Evros Kitiris, Michalis Kailides, Triantafyllos Stylianopoulos
Publié dans: Acta Biomaterialia, Numéro 17427061, 2022, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2022.10.021

Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy

Auteurs: Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Publié dans: Cell Reports Medicine, Numéro 5, 2024, Page(s) 101626, ISSN 2666-3791
Éditeur: Cell
DOI: 10.1016/j.xcrm.2024.101626

Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy

Auteurs: Mpekris F., C. Voutouri, M. Panagi, J.W Baish, R.K Jain, T. Stylianopoulos
Publié dans: Journal of Controlled Release, Numéro 01683659, 2022, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2022.03.008

Endothelin Inhibition Potentiates Cancer Immunotherapy Revealing Mechanical Biomarkers Predictive of Response

Auteurs: Chrysovalantis Voutouri, Myrofora Panagi, Fotios Mpekris, Andreas Stylianou, Christina Michael, Michalakis A. Averkiou, John D. Martin, Triantafyllos Stylianopoulos
Publié dans: Advanced Therapeutics, Numéro 2000289, 2021, Page(s) 2000289, ISSN 2366-3987
Éditeur: Wiley-VCH
DOI: 10.1002/adtp.202000289

Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano‐immunotherapy in Breast Cancer Lung Metastasis

Auteurs: Fotios Mpekris, Myrofora Panagi, Chrysovalantis Voutouri, John D. Martin, Rekha Samuel, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Panagiotis Papageorgis, Philippos Demetriou, Chryso Pierides, Laura Koumas, Paul Costeas, Motohiro Kojima, Genichiro Ishii, Anastasia Constantinidou, Kazunori Kataoka, Horacio Cabral, Triantafyllos Stylianopoulos
Publié dans: Advanced Science, Numéro 8/3, 2021, Page(s) 2001917, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202001917

Convection-Enhanced Delivery in silico study for personalized brain cancer treatment

Auteurs: Chryso Lambride, Vasileios Vavourakis, Triantafyllos Stylianopoulos
Publié dans: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.21203/rs.3.rs-998895/v1

Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy

Auteurs: Demetris Englezos, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
Publié dans: Translational Oncology, Numéro 44, 2024, Page(s) 101944, ISSN 1936-5233
Éditeur: Neoplasia Press
DOI: 10.1016/j.tranon.2024.101944

Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy

Auteurs: Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Publié dans: npj Biological Physics and Mechanics, Numéro 1, 2024, ISSN 3004-863X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s44341-024-00002-2

Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models

Auteurs: Myrofora Panagi, Fotios Mpekris, Pengwen Chen, Chrysovalantis Voutouri, Yasuhiro Nakagawa, John D. Martin, Tetsuro Hiroi, Hiroko Hashimoto, Philippos Demetriou, Chryso Pierides, Rekha Samuel, Andreas Stylianou, Christina Michael, Shigeto Fukushima, Paraskevi Georgiou, Panagiotis Papageorgis, Petri Ch. Papaphilippou, Laura Koumas, Paul Costeas, Genichiro Ishii, Motohiro Kojima, Kazunori Kataoka, Ho
Publié dans: Nature Communications, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34744-1

Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition

Auteurs: Myrofora Panagi, Fotios Mpekris, Chrysovalantis Voutouri, Andreas G. Hadjigeorgiou, Chloe Symeonidou, Eleni Porfyriou, Christina Michael, Andreas Stylianou, John D. Martin, Horacio Cabral, Anastasia Constantinidou, Triantafyllos Stylianopoulos
Publié dans: Clinical Cancer Research, Numéro 30, 2024, Page(s) 2582-2597, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-24-0246

Investigating the synergistic effects of immunotherapy and normalization treatment in modulating tumor microenvironment and enhancing treatment efficacy

Auteurs: Constantinos Harkos, Triantafyllos Stylianopoulos
Publié dans: Journal of Theoretical Biology, Numéro 583, 2024, Page(s) 111768, ISSN 0022-5193
Éditeur: Academic Press
DOI: 10.1016/j.jtbi.2024.111768

Exploring the landscape of immunotherapy approaches in sarcomas

Auteurs: Pampina Pilavaki, Myrofora Panagi, Samia Arifi, Robin L. Jones, Triantafyllos Stylianopoulos, Anastasia Constantinidou
Publié dans: Frontiers in Oncology, 2023, ISSN 2234-943X
Éditeur: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.1069963

Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II

Auteurs: Kalli M., R. Li, G.B. Mills, T. Stylianopoulos, I.K. Zervantonakis
Publié dans: Molecular Cancer Research, Numéro 15417786, 2022, ISSN 1541-7786
Éditeur: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-21-0266

Inducing Biomechanical Heterogeneity in Brain Tumor Modeling by MR Elastography: Effects on Tumor Growth, Vascular Density and Delivery of Therapeutics

Auteurs: Harkos, C.; Svensson, S.F., Emblem, K.E., and Stylianopoulos, T.
Publié dans: Cancers, Numéro 20726694, 2022, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14040884

In silico clinical studies for optimal COVID-19 vaccination schedules in patients with cancer

Auteurs: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Publié dans: Cell Reports Medicine, Numéro 5, 2024, Page(s) 101436, ISSN 2666-3791
Éditeur: Elsevier BV
DOI: 10.1016/j.xcrm.2024.101436

Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer

Auteurs: Lance L. Munn, Triantafyllos Stylianopoulos, Natalie K. Jain, C. Corey Hardin, Melin J. Khandekar, Rakesh K. Jain
Publié dans: Clinical Cancer Research, Numéro 27, 2022, Page(s) 2706-2711, ISSN 1078-0432
Éditeur: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-20-4750

Mechanistic model for booster doses effectiveness in healthy, cancer, and immunosuppressed patients infected with SARS-CoV-2

Auteurs: Chrysovalantis Voutouri, C. Corey Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Publié dans: Proceedings of the National Academy of Sciences, Numéro 120, 2023, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2211132120

Immunotherapy in soft tissue and bone sarcoma: unraveling the barriers to effectiveness

Auteurs: Panagi M., P. Pilavaki, A. Constantinidou, T. Stylianopoulos
Publié dans: Theranostics, Numéro 18387640, 2022, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.72800

A synergistic approach for modulating the tumor microenvironment to enhance nano-immunotherapy in sarcomas

Auteurs: Fotios Mpekris, Myrofora Panagi, Antonia Charalambous, Chrysovalantis Voutouri, Christina Michael, Antonia Papoui, Triantafyllos Stylianopoulos
Publié dans: Neoplasia, Numéro 51, 2024, Page(s) 100990, ISSN 1476-5586
Éditeur: Elsevier
DOI: 10.1016/j.neo.2024.100990

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

Auteurs: Chrysovalantis Voutouri, Mohammad Reza Nikmaneshi, C. Corey Hardin, Ankit B. Patel, Ashish Verma, Melin J. Khandekar, Sayon Dutta, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain
Publié dans: Proceedings of the National Academy of Sciences, Numéro 118, 2022, ISSN 0027-8424
Éditeur: National Academy of Sciences
DOI: 10.1073/pnas.2021642118

Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

Auteurs: Maria Kalli, Triantafyllos Stylianopoulos
Publié dans: APL Bioengineering, Numéro 8, 2025, ISSN 2473-2877
Éditeur: AIP Publishing
DOI: 10.1063/5.0183302

Pancreatic Cancer Presents Distinct Nanomechanical Properties During Progression

Auteurs: Andreas Stylianou; Chrysovalantis Voutouri; Fotios Mpekris; Triantafyllos Stylianopoulos
Publié dans: Annals of Biomedical Engineering, Numéro 1, 2023, ISSN 1573-9686
Éditeur: Springer
DOI: 10.1007/s10439-023-03168-3

Beyond matrix stiffness: targeting force-induced cancer drug resistance

Auteurs: Maria Kalli, Matthew D. Poskus, Triantafyllos Stylianopoulos, Ioannis K. Zervantonakis
Publié dans: Trends in Cancer, Numéro 9, 2024, Page(s) 937-954, ISSN 2405-8033
Éditeur: Elsevier BV
DOI: 10.1016/j.trecan.2023.07.006

Evaluation of growth-induced, mechanical stress in solid tumors and spatial association with extracellular matrix content

Auteurs: Andreas G. Hadjigeorgiou, Triantafyllos Stylianopoulos
Publié dans: Biomechanics and Modeling in Mechanobiology, Numéro 22, 2023, Page(s) 1625-1643, ISSN 1617-7959
Éditeur: Springer Verlag
DOI: 10.1007/s10237-023-01716-3

Dissecting the Impact of the Gut Microbiome on Cancer Immunotherapy

Auteurs: Rakesh Jain, Andreas Hadjigeorgiou, Constantinos Harkos, Aditya Mishra, Golnaz Morad, Sarah Johnson, Nadim Ajami, Jennifer Wargo, Lance Munn, Triantafyllos Stylianopoulos
Publié dans: 2024
Éditeur: Research Square Platform LLC
DOI: 10.21203/rs.3.rs-3647386/v1

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