From parental risk to child mental illness: a genetically informed investigation of intergenerational risk pathways

Project Information

I-RISK

Grant agreement ID: 863981

DOI

10.3030/863981

Project closed

EC signature date 24 April 2020

Start date 1 June 2020

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 183 293,00

EU contribution

€ 2 183 293,00

Coordinated by

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

Author(s): Laurence J Howe, Humaira Rasheed, Paul R Jones, Dorret I Boomsma, David M Evans, Alexandros Giannelis, Caroline Hayward, John L Hopper, Amanda Hughes, Hannu Lahtinen, Shuai Li, Penelope A Lind, Nicholas G Martin, Pekka Martikainen, Sarah E Medland, Tim T Morris, Michel G Nivard, Jean-Baptiste Pingault, Karri Silventoinen, Jennifer A Smith, Emily A Willoughby, James F Wilson, null null, Rafael Ahls
Published in: International Journal of Epidemiology, Issue 52, 2023, Page(s) 1579-1591, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyad079

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study

Author(s): Leonard Frach, Wikus Barkhuizen, Andrea G. Allegrini, Helga Ask, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Frank Dudbridge, Eivind Ystrom, Alexandra Havdahl, Jean-Baptiste Pingault
Published in: Molecular Psychiatry, Issue 29, 2024, Page(s) 951-961, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02383-7

Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits

Author(s): Samuel Ghatan, Jard de Vries, Jean-Baptiste Pingault, Vincent W Jaddoe, Charlotte Cecil, Janine F Felix, Fernando Rivadeneira, Carolina Medina-Gomez
Published in: Human Molecular Genetics, Issue 34, 2025, Page(s) 1744-1752, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaf117

Mother's and children's <scp>ADHD</scp> genetic risk, household chaos and children's <scp>ADHD</scp> symptoms: A gene–environment correlation study

Author(s): Jessica C. Agnew‐Blais; Jasmin Wertz; Louise Arseneault; Daniel W. Belsky; Andrea Danese; Jean‐Baptiste Pingault; Guilherme V. Polanczyk; Karen Sugden; Benjamin Williams; Terrie E. Moffitt
Published in: Agnew‐Blais , J C , Wertz , J , Arseneault , L , Belsky , D W , Danese , A , Pingault , J , Polanczyk , G V , Sugden , K , Williams , B & Moffitt , T E 2022 , ' Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms : A gene–environment correlation study ' , Journal of Child Psychology and Psychiatry , vol. 63 , no. 10 , pp. 1153-1163 . https://doi.org/10.1111/, Issue 1, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1111/jcpp.13659

Subjective and objective experiences of childhood adversity: a meta‐analysis of their agreement and relationships with psychopathology

Author(s): Emma R. Francis; Anna Tsaligopoulou; Sarah E. Stock; Jean‐Baptiste Pingault; Jessie R. Baldwin
Published in: Crossref, Issue 1, 2023, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1111/jcpp.13803

Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems

Author(s): Yasmin I. Ahmadzadeh, Tabea Schoeler, Meredith Han, Jean-Baptiste Pingault, Cathy Creswell, Tom A. McAdams
Published in: Journal of the American Academy of Child &amp; Adolescent Psychiatry, Issue 60, 2024, Page(s) 823-840, ISSN 0890-8567
Publisher: Elsevier BV
DOI: 10.1016/j.jaac.2020.12.037

Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies

Author(s): Jessie R. Baldwin, Biyao Wang, Lucy Karwatowska, Tabea Schoeler, Anna Tsaligopoulou, Marcus R. Munafò, Jean-Baptiste Pingault
Published in: American Journal of Psychiatry, Issue 180, 2024, Page(s) 117-126, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220174

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study

Author(s): Pingault, J.-B., Barkhuizen, W., Wang, B., Hannigan, L. J., Eilertsen, E. M., Corfield, E., Andreassen, O. A., Ask, H., Tesli, M., Askeland, R. B., Davey Smith, G., Stoltenberg, C., Davies, N. M., Reichborn-Kjennerud, T., Ystrom, E., & Havdahl, A.6
Published in: Molecular Psychiatry, 2022, ISSN 1476-5578
Publisher: Wiley
DOI: 10.1038/s41380-022-01863-6

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Author(s): Laurence J. Howe, Michel G. Nivard, Tim T. Morris, Ailin F. Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Rafael Ahlskog, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M. Ratliff, Lawrence F. Bielak, Marianne Nygaard, Alexandros Giannelis, Emily A. Willoughby, Chandra A. Reynolds, Jared V. Balbona,
Published in: Nature Genetics, Issue 54, 2025, Page(s) 581-592, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-022-01062-7

Causal inference methods for intergenerational research using observational data.

Author(s): Leonard Frach, Eshim S. Jami, Tom A. McAdams, Frank Dudbridge, Jean-Baptiste Pingault
Published in: Psychological Review, Issue 130, 2025, Page(s) 1688-1703, ISSN 0033-295X
Publisher: American Psychological Association
DOI: 10.1037/rev0000419

Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Author(s): Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pål R. Njølstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafò, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Published in: Translational Psychiatry, Issue 13, 2023, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-023-02348-y

Research Review: A guide to computing and implementing polygenic scores in developmental research

Author(s): Andrea G. Allegrini; Jessie R. Baldwin; Wikus Barkhuizen; Jean‐Baptiste Pingault
Published in: Journal of Child Psychology and Psychiatry, Issue 1, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1111/jcpp.13611

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

Author(s): Tabea Schoeler; Doug Speed; Eleonora Porcu; Nicola Pirastu; Jean-Baptiste Pingault; Zoltán Kutalik
Published in: Schoeler , T , Speed , D , Porcu , E , Pirastu , N , Pingault , J B & Kutalik , Z 2023 , ' Participation bias in the UK Biobank distorts genetic associations and downstream analyses ' , Nature Human Behaviour . https://doi.org/10.1038/s41562-023-01579-9, Issue 2, 2023, ISSN 2397-3374
Publisher: Nature
DOI: 10.1038/s41562-023-01579-9

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline

Author(s): Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-59383-0

Positive and negative parenting practices and offspring disruptive behavior: A meta-analytic review of quasi-experimental evidence.

Author(s): Lucy Karwatowska, Francesca Solmi, Jessie R. Baldwin, Sara R. Jaffee, Essi Viding, Jean-Baptiste Pingault, Bianca Lucia De Stavola
Published in: Psychological Bulletin, Issue 151, 2026, Page(s) 1363-1381, ISSN 0033-2909
Publisher: American Psychological Association
DOI: 10.1037/bul0000495

On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families

Author(s): Espen M. Eilertsen; Rosa Cheesman; Ziada Ayorech; Espen Røysamb; Jean‐Baptiste Pingault; Pål R. Njølstad; Ole A. Andreassen; Alexandra Havdahl; Tom A. McAdams; Fartein A. Torvik; Eivind Ystrøm
Published in: 0021-9630, Issue 1, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1111/jcpp.13654

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

Author(s): A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-025-57694-w

A genetically informed Registered Report on adverse childhood experiences and mental health

Author(s): Jessie R. Baldwin, Hannah M. Sallis, Tabea Schoeler, Mark J. Taylor, Alex S. F. Kwong, Jorim J. Tielbeek, Wikus Barkhuizen, Varun Warrier, Laura D. Howe, Andrea Danese, Eamon McCrory, Fruhling Rijsdijk, Henrik Larsson, Sebastian Lundström, Robert Karlsson, Paul Lichtenstein, Marcus Munafò, Jean-Baptiste Pingault
Published in: Nature Human Behaviour, Issue 7, 2024, Page(s) 269-290, ISSN 2397-3374
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41562-022-01482-9

The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation

Author(s): Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Published in: Nature Human Behaviour, Issue 9, 2025, Page(s) 584-594, ISSN 2397-3374
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-02061-w

Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations

Author(s): Jean-Baptiste Pingault; Frühling Rijsdijk; Tabea Schoeler; Shing Wan Choi; Saskia Selzam; Eva Krapohl; Paul F. O’Reilly; Frank Dudbridge
Published in: PLoS Genetics, Issue 1, 2021, ISSN 1553-7390
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1009590

Genetic associations between non-cognitive skills and academic achievement over development

Author(s): Margherita Malanchini, Andrea G. Allegrini, Michel G. Nivard, Pietro Biroli, Kaili Rimfeld, Rosa Cheesman, Sophie von Stumm, Perline A. Demange, Elsje van Bergen, Andrew D. Grotzinger, Laurel Raffington, Javier De la Fuente, Jean-Baptiste Pingault, Elliot M. Tucker-Drob, K. Paige Harden, Robert Plomin
Published in: Nature Human Behaviour, Issue 8, 2024, Page(s) 2034-2046, ISSN 2397-3374
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-01967-9

Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

Author(s): Jean‐Baptiste Pingault; Andrea G. Allegrini; Tracy Odigie; Leonard Frach; Jessie R. Baldwin; Frühling Rijsdijk; Frank Dudbridge
Published in: Journal of Child Psychology and Psychiatry, Issue 2, 2022, ISSN 1469-7610
Publisher: Wiley
DOI: 10.1111/jcpp.13607