From parental risk to child mental illness: a genetically informed investigation of intergenerational risk pathways

Información del proyecto

I-RISK

Identificador del acuerdo de subvención: 863981

DOI

10.3030/863981

Proyecto cerrado

Fecha de la firma de la CE 24 Abril 2020

Fecha de inicio 1 Junio 2020

Fecha de finalización 30 Noviembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 2 183 293,00

Aportación de la UE

€ 2 183 293,00

Coordinado por

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (22)

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

Autores: Laurence J Howe, Humaira Rasheed, Paul R Jones, Dorret I Boomsma, David M Evans, Alexandros Giannelis, Caroline Hayward, John L Hopper, Amanda Hughes, Hannu Lahtinen, Shuai Li, Penelope A Lind, Nicholas G Martin, Pekka Martikainen, Sarah E Medland, Tim T Morris, Michel G Nivard, Jean-Baptiste Pingault, Karri Silventoinen, Jennifer A Smith, Emily A Willoughby, James F Wilson, null null, Rafael Ahls
Publicado en: International Journal of Epidemiology, Edición 52, 2023, Página(s) 1579-1591, ISSN 0300-5771
Editor: Oxford University Press
DOI: 10.1093/ije/dyad079

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study

Autores: Leonard Frach, Wikus Barkhuizen, Andrea G. Allegrini, Helga Ask, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Frank Dudbridge, Eivind Ystrom, Alexandra Havdahl, Jean-Baptiste Pingault
Publicado en: Molecular Psychiatry, Edición 29, 2024, Página(s) 951-961, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-023-02383-7

Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits

Autores: Samuel Ghatan, Jard de Vries, Jean-Baptiste Pingault, Vincent W Jaddoe, Charlotte Cecil, Janine F Felix, Fernando Rivadeneira, Carolina Medina-Gomez
Publicado en: Human Molecular Genetics, Edición 34, 2025, Página(s) 1744-1752, ISSN 0964-6906
Editor: Oxford University Press
DOI: 10.1093/hmg/ddaf117

Mother's and children's <scp>ADHD</scp> genetic risk, household chaos and children's <scp>ADHD</scp> symptoms: A gene–environment correlation study

Autores: Jessica C. Agnew‐Blais; Jasmin Wertz; Louise Arseneault; Daniel W. Belsky; Andrea Danese; Jean‐Baptiste Pingault; Guilherme V. Polanczyk; Karen Sugden; Benjamin Williams; Terrie E. Moffitt
Publicado en: Agnew‐Blais , J C , Wertz , J , Arseneault , L , Belsky , D W , Danese , A , Pingault , J , Polanczyk , G V , Sugden , K , Williams , B & Moffitt , T E 2022 , ' Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms : A gene–environment correlation study ' , Journal of Child Psychology and Psychiatry , vol. 63 , no. 10 , pp. 1153-1163 . https://doi.org/10.1111/, Edición 1, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1111/jcpp.13659

Subjective and objective experiences of childhood adversity: a meta‐analysis of their agreement and relationships with psychopathology

Autores: Emma R. Francis; Anna Tsaligopoulou; Sarah E. Stock; Jean‐Baptiste Pingault; Jessie R. Baldwin
Publicado en: Crossref, Edición 1, 2023, ISSN 1469-7610
Editor: Wiley
DOI: 10.1111/jcpp.13803

Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems

Autores: Yasmin I. Ahmadzadeh, Tabea Schoeler, Meredith Han, Jean-Baptiste Pingault, Cathy Creswell, Tom A. McAdams
Publicado en: Journal of the American Academy of Child &amp; Adolescent Psychiatry, Edición 60, 2024, Página(s) 823-840, ISSN 0890-8567
Editor: Elsevier BV
DOI: 10.1016/j.jaac.2020.12.037

Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies

Autores: Jessie R. Baldwin, Biyao Wang, Lucy Karwatowska, Tabea Schoeler, Anna Tsaligopoulou, Marcus R. Munafò, Jean-Baptiste Pingault
Publicado en: American Journal of Psychiatry, Edición 180, 2024, Página(s) 117-126, ISSN 0002-953X
Editor: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220174

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study

Autores: Pingault, J.-B., Barkhuizen, W., Wang, B., Hannigan, L. J., Eilertsen, E. M., Corfield, E., Andreassen, O. A., Ask, H., Tesli, M., Askeland, R. B., Davey Smith, G., Stoltenberg, C., Davies, N. M., Reichborn-Kjennerud, T., Ystrom, E., & Havdahl, A.6
Publicado en: Molecular Psychiatry, 2022, ISSN 1476-5578
Editor: Wiley
DOI: 10.1038/s41380-022-01863-6

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Autores: Laurence J. Howe, Michel G. Nivard, Tim T. Morris, Ailin F. Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Rafael Ahlskog, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M. Ratliff, Lawrence F. Bielak, Marianne Nygaard, Alexandros Giannelis, Emily A. Willoughby, Chandra A. Reynolds, Jared V. Balbona,
Publicado en: Nature Genetics, Edición 54, 2025, Página(s) 581-592, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-022-01062-7

Causal inference methods for intergenerational research using observational data.

Autores: Leonard Frach, Eshim S. Jami, Tom A. McAdams, Frank Dudbridge, Jean-Baptiste Pingault
Publicado en: Psychological Review, Edición 130, 2025, Página(s) 1688-1703, ISSN 0033-295X
Editor: American Psychological Association
DOI: 10.1037/rev0000419

Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Autores: Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pål R. Njølstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafò, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Publicado en: Translational Psychiatry, Edición 13, 2023, ISSN 2158-3188
Editor: Nature Publishing Group
DOI: 10.1038/s41398-023-02348-y

Research Review: A guide to computing and implementing polygenic scores in developmental research

Autores: Andrea G. Allegrini; Jessie R. Baldwin; Wikus Barkhuizen; Jean‐Baptiste Pingault
Publicado en: Journal of Child Psychology and Psychiatry, Edición 1, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1111/jcpp.13611

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

Autores: Tabea Schoeler; Doug Speed; Eleonora Porcu; Nicola Pirastu; Jean-Baptiste Pingault; Zoltán Kutalik
Publicado en: Schoeler , T , Speed , D , Porcu , E , Pirastu , N , Pingault , J B & Kutalik , Z 2023 , ' Participation bias in the UK Biobank distorts genetic associations and downstream analyses ' , Nature Human Behaviour . https://doi.org/10.1038/s41562-023-01579-9, Edición 2, 2023, ISSN 2397-3374
Editor: Nature
DOI: 10.1038/s41562-023-01579-9

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline

Autores: Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-59383-0

Positive and negative parenting practices and offspring disruptive behavior: A meta-analytic review of quasi-experimental evidence.

Autores: Lucy Karwatowska, Francesca Solmi, Jessie R. Baldwin, Sara R. Jaffee, Essi Viding, Jean-Baptiste Pingault, Bianca Lucia De Stavola
Publicado en: Psychological Bulletin, Edición 151, 2026, Página(s) 1363-1381, ISSN 0033-2909
Editor: American Psychological Association
DOI: 10.1037/bul0000495

On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families

Autores: Espen M. Eilertsen; Rosa Cheesman; Ziada Ayorech; Espen Røysamb; Jean‐Baptiste Pingault; Pål R. Njølstad; Ole A. Andreassen; Alexandra Havdahl; Tom A. McAdams; Fartein A. Torvik; Eivind Ystrøm
Publicado en: 0021-9630, Edición 1, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1111/jcpp.13654

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

Autores: A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-57694-w

A genetically informed Registered Report on adverse childhood experiences and mental health

Autores: Jessie R. Baldwin, Hannah M. Sallis, Tabea Schoeler, Mark J. Taylor, Alex S. F. Kwong, Jorim J. Tielbeek, Wikus Barkhuizen, Varun Warrier, Laura D. Howe, Andrea Danese, Eamon McCrory, Fruhling Rijsdijk, Henrik Larsson, Sebastian Lundström, Robert Karlsson, Paul Lichtenstein, Marcus Munafò, Jean-Baptiste Pingault
Publicado en: Nature Human Behaviour, Edición 7, 2024, Página(s) 269-290, ISSN 2397-3374
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41562-022-01482-9

The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation

Autores: Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Publicado en: Nature Human Behaviour, Edición 9, 2025, Página(s) 584-594, ISSN 2397-3374
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-02061-w

Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations

Autores: Jean-Baptiste Pingault; Frühling Rijsdijk; Tabea Schoeler; Shing Wan Choi; Saskia Selzam; Eva Krapohl; Paul F. O’Reilly; Frank Dudbridge
Publicado en: PLoS Genetics, Edición 1, 2021, ISSN 1553-7390
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1009590

Genetic associations between non-cognitive skills and academic achievement over development

Autores: Margherita Malanchini, Andrea G. Allegrini, Michel G. Nivard, Pietro Biroli, Kaili Rimfeld, Rosa Cheesman, Sophie von Stumm, Perline A. Demange, Elsje van Bergen, Andrew D. Grotzinger, Laurel Raffington, Javier De la Fuente, Jean-Baptiste Pingault, Elliot M. Tucker-Drob, K. Paige Harden, Robert Plomin
Publicado en: Nature Human Behaviour, Edición 8, 2024, Página(s) 2034-2046, ISSN 2397-3374
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-01967-9

Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

Autores: Jean‐Baptiste Pingault; Andrea G. Allegrini; Tracy Odigie; Leonard Frach; Jessie R. Baldwin; Frühling Rijsdijk; Frank Dudbridge
Publicado en: Journal of Child Psychology and Psychiatry, Edición 2, 2022, ISSN 1469-7610
Editor: Wiley
DOI: 10.1111/jcpp.13607