From parental risk to child mental illness: a genetically informed investigation of intergenerational risk pathways

Informacje na temat projektu

I-RISK

Identyfikator umowy o grant: 863981

DOI

10.3030/863981

Projekt został zamknięty

Data podpisania przez KE 24 Kwietnia 2020

Data rozpoczęcia 1 Czerwca 2020

Data zakończenia 30 Listopada 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 2 183 293,00

Wkład UE

€ 2 183 293,00

Koordynowany przez

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (22)

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

Autorzy: Laurence J Howe, Humaira Rasheed, Paul R Jones, Dorret I Boomsma, David M Evans, Alexandros Giannelis, Caroline Hayward, John L Hopper, Amanda Hughes, Hannu Lahtinen, Shuai Li, Penelope A Lind, Nicholas G Martin, Pekka Martikainen, Sarah E Medland, Tim T Morris, Michel G Nivard, Jean-Baptiste Pingault, Karri Silventoinen, Jennifer A Smith, Emily A Willoughby, James F Wilson, null null, Rafael Ahls
Opublikowane w: International Journal of Epidemiology, Numer 52, 2023, Strona(/y) 1579-1591, ISSN 0300-5771
Wydawca: Oxford University Press
DOI: 10.1093/ije/dyad079

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study

Autorzy: Leonard Frach, Wikus Barkhuizen, Andrea G. Allegrini, Helga Ask, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Frank Dudbridge, Eivind Ystrom, Alexandra Havdahl, Jean-Baptiste Pingault
Opublikowane w: Molecular Psychiatry, Numer 29, 2024, Strona(/y) 951-961, ISSN 1359-4184
Wydawca: Nature Publishing Group
DOI: 10.1038/s41380-023-02383-7

Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits

Autorzy: Samuel Ghatan, Jard de Vries, Jean-Baptiste Pingault, Vincent W Jaddoe, Charlotte Cecil, Janine F Felix, Fernando Rivadeneira, Carolina Medina-Gomez
Opublikowane w: Human Molecular Genetics, Numer 34, 2025, Strona(/y) 1744-1752, ISSN 0964-6906
Wydawca: Oxford University Press
DOI: 10.1093/hmg/ddaf117

Mother's and children's <scp>ADHD</scp> genetic risk, household chaos and children's <scp>ADHD</scp> symptoms: A gene–environment correlation study

Autorzy: Jessica C. Agnew‐Blais; Jasmin Wertz; Louise Arseneault; Daniel W. Belsky; Andrea Danese; Jean‐Baptiste Pingault; Guilherme V. Polanczyk; Karen Sugden; Benjamin Williams; Terrie E. Moffitt
Opublikowane w: Agnew‐Blais , J C , Wertz , J , Arseneault , L , Belsky , D W , Danese , A , Pingault , J , Polanczyk , G V , Sugden , K , Williams , B & Moffitt , T E 2022 , ' Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms : A gene–environment correlation study ' , Journal of Child Psychology and Psychiatry , vol. 63 , no. 10 , pp. 1153-1163 . https://doi.org/10.1111/, Numer 1, 2022, ISSN 1469-7610
Wydawca: Wiley
DOI: 10.1111/jcpp.13659

Subjective and objective experiences of childhood adversity: a meta‐analysis of their agreement and relationships with psychopathology

Autorzy: Emma R. Francis; Anna Tsaligopoulou; Sarah E. Stock; Jean‐Baptiste Pingault; Jessie R. Baldwin
Opublikowane w: Crossref, Numer 1, 2023, ISSN 1469-7610
Wydawca: Wiley
DOI: 10.1111/jcpp.13803

Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems

Autorzy: Yasmin I. Ahmadzadeh, Tabea Schoeler, Meredith Han, Jean-Baptiste Pingault, Cathy Creswell, Tom A. McAdams
Opublikowane w: Journal of the American Academy of Child &amp; Adolescent Psychiatry, Numer 60, 2024, Strona(/y) 823-840, ISSN 0890-8567
Wydawca: Elsevier BV
DOI: 10.1016/j.jaac.2020.12.037

Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies

Autorzy: Jessie R. Baldwin, Biyao Wang, Lucy Karwatowska, Tabea Schoeler, Anna Tsaligopoulou, Marcus R. Munafò, Jean-Baptiste Pingault
Opublikowane w: American Journal of Psychiatry, Numer 180, 2024, Strona(/y) 117-126, ISSN 0002-953X
Wydawca: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220174

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study

Autorzy: Pingault, J.-B., Barkhuizen, W., Wang, B., Hannigan, L. J., Eilertsen, E. M., Corfield, E., Andreassen, O. A., Ask, H., Tesli, M., Askeland, R. B., Davey Smith, G., Stoltenberg, C., Davies, N. M., Reichborn-Kjennerud, T., Ystrom, E., & Havdahl, A.6
Opublikowane w: Molecular Psychiatry, 2022, ISSN 1476-5578
Wydawca: Wiley
DOI: 10.1038/s41380-022-01863-6

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Autorzy: Laurence J. Howe, Michel G. Nivard, Tim T. Morris, Ailin F. Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Rafael Ahlskog, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M. Ratliff, Lawrence F. Bielak, Marianne Nygaard, Alexandros Giannelis, Emily A. Willoughby, Chandra A. Reynolds, Jared V. Balbona,
Opublikowane w: Nature Genetics, Numer 54, 2025, Strona(/y) 581-592, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-022-01062-7

Causal inference methods for intergenerational research using observational data.

Autorzy: Leonard Frach, Eshim S. Jami, Tom A. McAdams, Frank Dudbridge, Jean-Baptiste Pingault
Opublikowane w: Psychological Review, Numer 130, 2025, Strona(/y) 1688-1703, ISSN 0033-295X
Wydawca: American Psychological Association
DOI: 10.1037/rev0000419

Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Autorzy: Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pål R. Njølstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafò, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Opublikowane w: Translational Psychiatry, Numer 13, 2023, ISSN 2158-3188
Wydawca: Nature Publishing Group
DOI: 10.1038/s41398-023-02348-y

Research Review: A guide to computing and implementing polygenic scores in developmental research

Autorzy: Andrea G. Allegrini; Jessie R. Baldwin; Wikus Barkhuizen; Jean‐Baptiste Pingault
Opublikowane w: Journal of Child Psychology and Psychiatry, Numer 1, 2022, ISSN 1469-7610
Wydawca: Wiley
DOI: 10.1111/jcpp.13611

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

Autorzy: Tabea Schoeler; Doug Speed; Eleonora Porcu; Nicola Pirastu; Jean-Baptiste Pingault; Zoltán Kutalik
Opublikowane w: Schoeler , T , Speed , D , Porcu , E , Pirastu , N , Pingault , J B & Kutalik , Z 2023 , ' Participation bias in the UK Biobank distorts genetic associations and downstream analyses ' , Nature Human Behaviour . https://doi.org/10.1038/s41562-023-01579-9, Numer 2, 2023, ISSN 2397-3374
Wydawca: Nature
DOI: 10.1038/s41562-023-01579-9

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline

Autorzy: Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-59383-0

Positive and negative parenting practices and offspring disruptive behavior: A meta-analytic review of quasi-experimental evidence.

Autorzy: Lucy Karwatowska, Francesca Solmi, Jessie R. Baldwin, Sara R. Jaffee, Essi Viding, Jean-Baptiste Pingault, Bianca Lucia De Stavola
Opublikowane w: Psychological Bulletin, Numer 151, 2026, Strona(/y) 1363-1381, ISSN 0033-2909
Wydawca: American Psychological Association
DOI: 10.1037/bul0000495

On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families

Autorzy: Espen M. Eilertsen; Rosa Cheesman; Ziada Ayorech; Espen Røysamb; Jean‐Baptiste Pingault; Pål R. Njølstad; Ole A. Andreassen; Alexandra Havdahl; Tom A. McAdams; Fartein A. Torvik; Eivind Ystrøm
Opublikowane w: 0021-9630, Numer 1, 2022, ISSN 1469-7610
Wydawca: Wiley
DOI: 10.1111/jcpp.13654

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

Autorzy: A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-57694-w

A genetically informed Registered Report on adverse childhood experiences and mental health

Autorzy: Jessie R. Baldwin, Hannah M. Sallis, Tabea Schoeler, Mark J. Taylor, Alex S. F. Kwong, Jorim J. Tielbeek, Wikus Barkhuizen, Varun Warrier, Laura D. Howe, Andrea Danese, Eamon McCrory, Fruhling Rijsdijk, Henrik Larsson, Sebastian Lundström, Robert Karlsson, Paul Lichtenstein, Marcus Munafò, Jean-Baptiste Pingault
Opublikowane w: Nature Human Behaviour, Numer 7, 2024, Strona(/y) 269-290, ISSN 2397-3374
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41562-022-01482-9

The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation

Autorzy: Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Opublikowane w: Nature Human Behaviour, Numer 9, 2025, Strona(/y) 584-594, ISSN 2397-3374
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-02061-w

Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations

Autorzy: Jean-Baptiste Pingault; Frühling Rijsdijk; Tabea Schoeler; Shing Wan Choi; Saskia Selzam; Eva Krapohl; Paul F. O’Reilly; Frank Dudbridge
Opublikowane w: PLoS Genetics, Numer 1, 2021, ISSN 1553-7390
Wydawca: Public Library of Science
DOI: 10.1371/journal.pgen.1009590

Genetic associations between non-cognitive skills and academic achievement over development

Autorzy: Margherita Malanchini, Andrea G. Allegrini, Michel G. Nivard, Pietro Biroli, Kaili Rimfeld, Rosa Cheesman, Sophie von Stumm, Perline A. Demange, Elsje van Bergen, Andrew D. Grotzinger, Laurel Raffington, Javier De la Fuente, Jean-Baptiste Pingault, Elliot M. Tucker-Drob, K. Paige Harden, Robert Plomin
Opublikowane w: Nature Human Behaviour, Numer 8, 2024, Strona(/y) 2034-2046, ISSN 2397-3374
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-01967-9

Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

Autorzy: Jean‐Baptiste Pingault; Andrea G. Allegrini; Tracy Odigie; Leonard Frach; Jessie R. Baldwin; Frühling Rijsdijk; Frank Dudbridge
Opublikowane w: Journal of Child Psychology and Psychiatry, Numer 2, 2022, ISSN 1469-7610
Wydawca: Wiley
DOI: 10.1111/jcpp.13607