From parental risk to child mental illness: a genetically informed investigation of intergenerational risk pathways

Informazioni relative al progetto

I-RISK

ID dell’accordo di sovvenzione: 863981

DOI

10.3030/863981

Progetto chiuso

Data della firma CE 24 Aprile 2020

Data di avvio 1 Giugno 2020

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 183 293,00

Contributo UE

€ 2 183 293,00

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (22)

Educational attainment, health outcomes and mortality: a within-sibship Mendelian randomization study

Autori: Laurence J Howe, Humaira Rasheed, Paul R Jones, Dorret I Boomsma, David M Evans, Alexandros Giannelis, Caroline Hayward, John L Hopper, Amanda Hughes, Hannu Lahtinen, Shuai Li, Penelope A Lind, Nicholas G Martin, Pekka Martikainen, Sarah E Medland, Tim T Morris, Michel G Nivard, Jean-Baptiste Pingault, Karri Silventoinen, Jennifer A Smith, Emily A Willoughby, James F Wilson, null null, Rafael Ahls
Pubblicato in: International Journal of Epidemiology, Numero 52, 2023, Pagina/e 1579-1591, ISSN 0300-5771
Editore: Oxford University Press
DOI: 10.1093/ije/dyad079

Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study

Autori: Leonard Frach, Wikus Barkhuizen, Andrea G. Allegrini, Helga Ask, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Frank Dudbridge, Eivind Ystrom, Alexandra Havdahl, Jean-Baptiste Pingault
Pubblicato in: Molecular Psychiatry, Numero 29, 2024, Pagina/e 951-961, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-023-02383-7

Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits

Autori: Samuel Ghatan, Jard de Vries, Jean-Baptiste Pingault, Vincent W Jaddoe, Charlotte Cecil, Janine F Felix, Fernando Rivadeneira, Carolina Medina-Gomez
Pubblicato in: Human Molecular Genetics, Numero 34, 2025, Pagina/e 1744-1752, ISSN 0964-6906
Editore: Oxford University Press
DOI: 10.1093/hmg/ddaf117

Mother's and children's <scp>ADHD</scp> genetic risk, household chaos and children's <scp>ADHD</scp> symptoms: A gene–environment correlation study

Autori: Jessica C. Agnew‐Blais; Jasmin Wertz; Louise Arseneault; Daniel W. Belsky; Andrea Danese; Jean‐Baptiste Pingault; Guilherme V. Polanczyk; Karen Sugden; Benjamin Williams; Terrie E. Moffitt
Pubblicato in: Agnew‐Blais , J C , Wertz , J , Arseneault , L , Belsky , D W , Danese , A , Pingault , J , Polanczyk , G V , Sugden , K , Williams , B & Moffitt , T E 2022 , ' Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms : A gene–environment correlation study ' , Journal of Child Psychology and Psychiatry , vol. 63 , no. 10 , pp. 1153-1163 . https://doi.org/10.1111/, Numero 1, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1111/jcpp.13659

Subjective and objective experiences of childhood adversity: a meta‐analysis of their agreement and relationships with psychopathology

Autori: Emma R. Francis; Anna Tsaligopoulou; Sarah E. Stock; Jean‐Baptiste Pingault; Jessie R. Baldwin
Pubblicato in: Crossref, Numero 1, 2023, ISSN 1469-7610
Editore: Wiley
DOI: 10.1111/jcpp.13803

Systematic Review and Meta-analysis of Genetically Informed Research: Associations Between Parent Anxiety and Offspring Internalizing Problems

Autori: Yasmin I. Ahmadzadeh, Tabea Schoeler, Meredith Han, Jean-Baptiste Pingault, Cathy Creswell, Tom A. McAdams
Pubblicato in: Journal of the American Academy of Child &amp; Adolescent Psychiatry, Numero 60, 2024, Pagina/e 823-840, ISSN 0890-8567
Editore: Elsevier BV
DOI: 10.1016/j.jaac.2020.12.037

Childhood Maltreatment and Mental Health Problems: A Systematic Review and Meta-Analysis of Quasi-Experimental Studies

Autori: Jessie R. Baldwin, Biyao Wang, Lucy Karwatowska, Tabea Schoeler, Anna Tsaligopoulou, Marcus R. Munafò, Jean-Baptiste Pingault
Pubblicato in: American Journal of Psychiatry, Numero 180, 2024, Pagina/e 117-126, ISSN 0002-953X
Editore: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220174

Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study

Autori: Pingault, J.-B., Barkhuizen, W., Wang, B., Hannigan, L. J., Eilertsen, E. M., Corfield, E., Andreassen, O. A., Ask, H., Tesli, M., Askeland, R. B., Davey Smith, G., Stoltenberg, C., Davies, N. M., Reichborn-Kjennerud, T., Ystrom, E., & Havdahl, A.6
Pubblicato in: Molecular Psychiatry, 2022, ISSN 1476-5578
Editore: Wiley
DOI: 10.1038/s41380-022-01863-6

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Autori: Laurence J. Howe, Michel G. Nivard, Tim T. Morris, Ailin F. Hansen, Humaira Rasheed, Yoonsu Cho, Geetha Chittoor, Rafael Ahlskog, Penelope A. Lind, Teemu Palviainen, Matthijs D. van der Zee, Rosa Cheesman, Massimo Mangino, Yunzhang Wang, Shuai Li, Lucija Klaric, Scott M. Ratliff, Lawrence F. Bielak, Marianne Nygaard, Alexandros Giannelis, Emily A. Willoughby, Chandra A. Reynolds, Jared V. Balbona,
Pubblicato in: Nature Genetics, Numero 54, 2025, Pagina/e 581-592, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-022-01062-7

Causal inference methods for intergenerational research using observational data.

Autori: Leonard Frach, Eshim S. Jami, Tom A. McAdams, Frank Dudbridge, Jean-Baptiste Pingault
Pubblicato in: Psychological Review, Numero 130, 2025, Pagina/e 1688-1703, ISSN 0033-295X
Editore: American Psychological Association
DOI: 10.1037/rev0000419

Do environmental effects indexed by parental genetic variation influence common psychiatric symptoms in childhood?

Autori: Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pål R. Njølstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafò, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Pubblicato in: Translational Psychiatry, Numero 13, 2023, ISSN 2158-3188
Editore: Nature Publishing Group
DOI: 10.1038/s41398-023-02348-y

Research Review: A guide to computing and implementing polygenic scores in developmental research

Autori: Andrea G. Allegrini; Jessie R. Baldwin; Wikus Barkhuizen; Jean‐Baptiste Pingault
Pubblicato in: Journal of Child Psychology and Psychiatry, Numero 1, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1111/jcpp.13611

Participation bias in the UK Biobank distorts genetic associations and downstream analyses

Autori: Tabea Schoeler; Doug Speed; Eleonora Porcu; Nicola Pirastu; Jean-Baptiste Pingault; Zoltán Kutalik
Pubblicato in: Schoeler , T , Speed , D , Porcu , E , Pirastu , N , Pingault , J B & Kutalik , Z 2023 , ' Participation bias in the UK Biobank distorts genetic associations and downstream analyses ' , Nature Human Behaviour . https://doi.org/10.1038/s41562-023-01579-9, Numero 2, 2023, ISSN 2397-3374
Editore: Nature
DOI: 10.1038/s41562-023-01579-9

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline

Autori: Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-59383-0

Positive and negative parenting practices and offspring disruptive behavior: A meta-analytic review of quasi-experimental evidence.

Autori: Lucy Karwatowska, Francesca Solmi, Jessie R. Baldwin, Sara R. Jaffee, Essi Viding, Jean-Baptiste Pingault, Bianca Lucia De Stavola
Pubblicato in: Psychological Bulletin, Numero 151, 2026, Pagina/e 1363-1381, ISSN 0033-2909
Editore: American Psychological Association
DOI: 10.1037/bul0000495

On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families

Autori: Espen M. Eilertsen; Rosa Cheesman; Ziada Ayorech; Espen Røysamb; Jean‐Baptiste Pingault; Pål R. Njølstad; Ole A. Andreassen; Alexandra Havdahl; Tom A. McAdams; Fartein A. Torvik; Eivind Ystrøm
Pubblicato in: 0021-9630, Numero 1, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1111/jcpp.13654

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

Autori: A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-57694-w

A genetically informed Registered Report on adverse childhood experiences and mental health

Autori: Jessie R. Baldwin, Hannah M. Sallis, Tabea Schoeler, Mark J. Taylor, Alex S. F. Kwong, Jorim J. Tielbeek, Wikus Barkhuizen, Varun Warrier, Laura D. Howe, Andrea Danese, Eamon McCrory, Fruhling Rijsdijk, Henrik Larsson, Sebastian Lundström, Robert Karlsson, Paul Lichtenstein, Marcus Munafò, Jean-Baptiste Pingault
Pubblicato in: Nature Human Behaviour, Numero 7, 2024, Pagina/e 269-290, ISSN 2397-3374
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41562-022-01482-9

The impact of self-report inaccuracy in the UK Biobank and its interplay with selective participation

Autori: Tabea Schoeler, Jean-Baptiste Pingault, Zoltán Kutalik
Pubblicato in: Nature Human Behaviour, Numero 9, 2025, Pagina/e 584-594, ISSN 2397-3374
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-02061-w

Genetic sensitivity analysis: Adjusting for genetic confounding in epidemiological associations

Autori: Jean-Baptiste Pingault; Frühling Rijsdijk; Tabea Schoeler; Shing Wan Choi; Saskia Selzam; Eva Krapohl; Paul F. O’Reilly; Frank Dudbridge
Pubblicato in: PLoS Genetics, Numero 1, 2021, ISSN 1553-7390
Editore: Public Library of Science
DOI: 10.1371/journal.pgen.1009590

Genetic associations between non-cognitive skills and academic achievement over development

Autori: Margherita Malanchini, Andrea G. Allegrini, Michel G. Nivard, Pietro Biroli, Kaili Rimfeld, Rosa Cheesman, Sophie von Stumm, Perline A. Demange, Elsje van Bergen, Andrew D. Grotzinger, Laurel Raffington, Javier De la Fuente, Jean-Baptiste Pingault, Elliot M. Tucker-Drob, K. Paige Harden, Robert Plomin
Pubblicato in: Nature Human Behaviour, Numero 8, 2024, Pagina/e 2034-2046, ISSN 2397-3374
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41562-024-01967-9

Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes

Autori: Jean‐Baptiste Pingault; Andrea G. Allegrini; Tracy Odigie; Leonard Frach; Jessie R. Baldwin; Frühling Rijsdijk; Frank Dudbridge
Pubblicato in: Journal of Child Psychology and Psychiatry, Numero 2, 2022, ISSN 1469-7610
Editore: Wiley
DOI: 10.1111/jcpp.13607