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Creating a comprehensive functional map of the viral and host factors in HCMV infection

Project description

Viral and host factors in HCMV infection

The herpesvirus human cytomegalovirus (HCMV), a type of herpesvirus, is a ubiquitous pathogen infecting much of the world's population. Albeit asymptomatic in most healthy individuals, HCMV can lead to severe congenital disease, morbidity and mortality in immunocompromised adults and during pregnancy. Many fundamental questions about this virus remain poorly understood, including which host and viral factors affect HCMV infection in different cell types. The EU-funded DissectCMV project aims to develop unique tool sets to discover which of these factors regulate the HCMV life cycle. Using high-throughput technologies, researchers will comprehensively characterise the viral elements regulating HCMV progression and the factors determining lytic or latent infection outcome. The resulting screening platform will facilitate dissection and characterisation of HCMV-essential components in any cell type. This work will serve as a paradigm for the study of other herpesviruses and complex host-pathogen interactions.

Host institution

WEIZMANN INSTITUTE OF SCIENCE
Net EU contribution
€ 2 000 000,00
Address
Herzl Street 234
7610001 Rehovot
Israel

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 2 000 000,00
Address
Herzl Street 234
7610001 Rehovot

See on map

Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00