Viral and host factors in HCMV infection
The herpesvirus human cytomegalovirus (HCMV), a type of herpesvirus, is a ubiquitous pathogen infecting much of the world's population. Albeit asymptomatic in most healthy individuals, HCMV can lead to severe congenital disease, morbidity and mortality in immunocompromised adults and during pregnancy. Many fundamental questions about this virus remain poorly understood, including which host and viral factors affect HCMV infection in different cell types. The EU-funded DissectCMV project aims to develop unique tool sets to discover which of these factors regulate the HCMV life cycle. Using high-throughput technologies, researchers will comprehensively characterise the viral elements regulating HCMV progression and the factors determining lytic or latent infection outcome. The resulting screening platform will facilitate dissection and characterisation of HCMV-essential components in any cell type. This work will serve as a paradigm for the study of other herpesviruses and complex host-pathogen interactions.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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