Macro-Nanomedicine to Treat Metastatic Cancer

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Nanoparticle Diagnostics and Theranostics in the Clinic

Author(s): Roger M. Pallares, Felix M. Mottaghy, Volkmar Schulz, Fabian Kiessling, Twan Lammers
Published in: Journal of Nuclear Medicine, Issue 63, 2023, Page(s) 1802-1808, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.263895

CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy

Author(s): Diana Möckel, Matthias Bartneck, Patricia Niemietz, Maike Wagner, Josef Ehling, Elena Rama, Marek Weiler, Felix Gremse, Dirk Eulberg, Robert Pola, Michal Pechar, Tomas Etrych, Gert Storm, Fabian Kiessling, Frank Tacke, Twan Lammers
Published in: Journal of Controlled Release, Issue 365, 2024, Page(s) 358-368, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.11.044

Hybrid ultrasound and photoacoustic contrast agent designs combining metal phthalocyanines and PBCA microbubbles

Author(s): Roman A. Barmin, MirJavad Moosavifar, Rui Zhang, Stephan Rütten, Sven Thoröe-Boveleth, Elena Rama, Tarun Ojha, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Published in: Journal of Materials Chemistry B, Issue 12, 2024, Page(s) 2511-2522, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3tb02950f

Nonspherical ultrasound microbubbles

Author(s): Anshuman Dasgupta, Tao Sun, Roberto Palomba, Elena Rama, Yong-Zhi Zhang, Chanikarn Power, Diana Moeckel, Mengjiao Liu, Apoorva Sarode, Marek Weiler, Alessandro Motta, Céline Porte, Zuzanna Magnuska, Asmaa Said ElShafei, Roman Barmin, Adam Graham, Arthur McClelland, Dirk Rommel, Elmar Stickeler, Fabian Kiessling, Roger M. Pallares, Laura De Laporte, Paolo Decuzzi, Nathan McDannold, Samir Mitrago
Published in: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2218847120

Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles

Author(s): Federica De Lorenzi, Larissa Yokota Rizzo, Rasika Daware, Alessandro Motta, Maike Baues, Matthias Bartneck, Michael Vogt, Marc van Zandvoort, Leonard Kaps, Qizhi Hu, Marielle Thewissen, Luca Casettari, Cristianne J. F. Rijcken, Fabian Kiessling, Alexandros Marios Sofias, Twan Lammers
Published in: Drug Delivery and Translational Research, Issue 13, 2023, Page(s) 1195-1211, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01204-8

A randomized controlled clinical trial

Author(s): Metselaar, Josbert M.; Middelink, Leonie M.; Wortel, Cornelis H.; Bos, Reinhard; van Laar, Jacob M.; Vonkeman, Harald E.; Westhovens, Rene; Lammers, Twan; Yao, Siu Long; Kothekar, Mudgal; Raut, Atul; Bijlsma, Johannes W.J.
Published in: VOLUME=341;STARTPAGE=548;ENDPAGE=554;ISSN=0168-3659;TITLE=Journal of controlled release, Issue 1, 2023, ISSN 0168-3659
Publisher: Elsevier BV

Nanoparticle delivery to tumours: from EPR and ATR mechanisms to clinical impact

Author(s): Anshuman Dasgupta, Alexandros Marios Sofias, Fabian Kiessling, Twan Lammers
Published in: Nature Reviews Bioengineering, Issue 2, 2024, Page(s) 714-716, ISSN 2731-6092
Publisher: Springer-Nature
DOI: 10.1038/s44222-024-00203-3

Iron metabolism: pathophysiology and pharmacology

Author(s): Karolin Roemhild, Finn von Maltzahn, Ralf Weiskirchen, Ruth Knüchel, Saskia von Stillfried, Twan Lammers
Published in: Trends in Pharmacological Sciences, Issue 42/8, 2021, Page(s) 640-656, ISSN 0165-6147
Publisher: Elsevier BV
DOI: 10.1016/j.tips.2021.05.001

Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges

Author(s): Tarun Ojha, Qizhi Hu, Claudio Colombo, Jan Wit, Michiel Geijn, Mies J. Steenbergen, Mahsa Bagheri, Hiltrud Königs‐Werner, Eva Miriam Buhl, Ruchi Bansal, Yang Shi, Wim E. Hennink, Gert Storm, Cristianne J. F. Rijcken, Twan Lammers
Published in: Biotechnology Journal, Issue 16/6, 2021, Page(s) 2000212, ISSN 1860-6768
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.202000212

Effect of Radical Polymerization Method on Pharmaceutical Properties of Π Electron-Stabilized HPMA-Based Polymeric Micelles

Author(s): Armin Azadkhah Shalmani; Zaheer Ahmed; Maryam Sheybanifard; Alec Wang; Marek Weiler; Eva Miriam Buhl; Geir Klinkenberg; Ruth Schmid; Wim Hennink; Fabian Kiessling; Josbert M. Metselaar; Twan Lammers; Quim Peña; Yang Shi
Published in: Biomacromolecules, Issue 1, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01261

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions

Author(s): Thomas Anchordoquy, Natalie Artzi, Irina V. Balyasnikova, Yechezkel Barenholz, Ninh M. La-Beck, Jacob S. Brenner, Warren C. W. Chan, Paolo Decuzzi, Agata A. Exner, Alberto Gabizon, Biana Godin, Samuel K. Lai, Twan Lammers, Michael J. Mitchell, S. Moein Moghimi, Vladimir R. Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J. Serkova, Ravi Singh, Avi Schroeder, Anna A.
Published in: ACS Nano, Issue 18, 2024, Page(s) 13983-13999, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c00182

Liposome manufacturing under continuous flow conditions: towards a fully integrated set-up with in-line control of critical quality attributes

Author(s): Maryam Sheybanifard; Luis P. B. Guerzoni; Abdolrahman Omidinia-Anarkoli; Laura De Laporte; Johannes Buyel; Rut Besseling; Michiel Damen; Ad Gerich; Twan Lammers; Josbert M. Metselaar
Published in: Lab on a Chip, Issue 1, 2022, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2lc00463a

Polymeric materials for ultrasound imaging and therapy

Author(s): Roman A. Barmin, MirJavad Moosavifar, Anshuman Dasgupta, Andreas Herrmann, Fabian Kiessling, Roger M. Pallares, Twan Lammers
Published in: Chemical Science, Issue 14, 2024, Page(s) 11941-11954, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3sc04339h

Transferrin Receptor‐Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation

Author(s): Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia‐Marie Fletcher, Mirjavad Moosavifar, Roman Barmin, Céline Porte, Eva Miriam Buhl, Céline Bastard, Roger M. Pallares, Fabian Kiessling, Nathan McDannold, Samir Mitragotri, Twan Lammers
Published in: Advanced Materials, Issue 35, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308150

A randomized controlled clinical trial

Author(s): Metselaar, Josbert M.; Middelink, Leonie M.; Wortel, Cornelis H.; Bos, Reinhard; van Laar, Jacob M.; Vonkeman, Harald E.; Westhovens, Rene; Lammers, Twan; Yao, Siu Long; Kothekar, Mudgal; Raut, Atul; Bijlsma, Johannes W.J.
Published in: Journal of Controlled Release, Issue 1, 2022, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.12.007

Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes

Author(s): Jeffrey Momoh; Dimitrios Kapsokalyvas; Michael Vogt; Sjoerd Hak; Fabian Kiessling; Marc van Zandvoort; Twan Lammers; Alexandros Marios Sofias
Published in: Advanced Drug Delivery Reviews, Issue 1, 2022, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114528

Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles

Author(s): Mengjiao Liu; Anshuman Dasgupta; Na Qu; Elena Rama; Fabian Kiessling; Twan Lammers
Published in: ACS Biomaterials Science Engineering, Issue 2, 2022, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.1c01203

Nanomedicine Tumor Targeting

Author(s): Twan Lammers
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202312169

Towards bypassing EPR

Author(s): Mohamadreza Amin; Twan Lammers; Timo L.M. ten Hagen
Published in: Advanced Drug Delivery Reviews, Issue 1, 2022, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114503

Dexamethasone nanomedicines for COVID-19

Author(s): Twan Lammers, Alexandros Marios Sofias, Roy van der Meel, Raymond Schiffelers, Gert Storm, Frank Tacke, Steffen Koschmieder, Tim H. Brümmendorf, Fabian Kiessling, Josbert M. Metselaar
Published in: Nature Nanotechnology, Issue 15, 2021, Page(s) 622-624, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-020-0752-z

Nanoscale engineering of gold nanostars for enhanced photoacoustic imaging

Author(s): Rui Zhang, Sven Thoröe-Boveleth, Dmitry N. Chigrin, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Published in: Journal of Nanobiotechnology, Issue 22, 2024, ISSN 1477-3155
Publisher: BioMed Central
DOI: 10.1186/s12951-024-02379-7

Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles

Author(s): Ilaria Biancacci, Qingxue Sun, Diana Möckel, Felix Gremse, Stefanie Rosenhain, Fabian Kiessling, Matthias Bartneck, Qizhi Hu, Marielle Thewissen, Gert Storm, Wim E. Hennink, Yang Shi, Cristianne J.F. Rijcken, Twan Lammers, Alexandros Marios Sofias
Published in: Journal of Controlled Release, Issue 328, 2020, Page(s) 805-816, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2020.09.046

Clinical translation and landscape of silver nanoparticles

Author(s): Manuel Dias, Rui Zhang, Twan Lammers, Roger M. Pallares
Published in: Drug Delivery and Translational Research, Issue 15, 2025, Page(s) 789-797, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01716-5

Enhanced Stable Cavitation and Nonlinear Acoustic Properties of Poly(butyl cyanoacrylate) Polymeric Microbubbles after Bioconjugation

Author(s): Roman A. Barmin; Anshuman Dasgupta; Anne Rix; Marek Weiler; Lia Appold; Stephan Rütten; Frederic Padilla; Alexander J. C. Kuehne; Andrij Pich; Laura De Laporte; Fabian Kiessling; Roger M. Pallares; Twan Lammers
Published in: ACS Biomaterials Science Engineering, Issue 1, 2023, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.2c01021

Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

Author(s): Chenghua Liang, Xiangyang Bai, Cuiling Qi, Qingxue Sun, Xiaoyan Han, Tianyun Lan, Haibo Zhang, Xiaoming Zheng, Rongpu Liang, Ju Jiao, Zongheng Zheng, Jiafeng Fang, Purun Lei, Yan Wang, Diana Möckel, Josbert M. Metselaar, Gert Storm, Wim E. Hennink, Fabian Kiessling, Hongbo Wei, Twan Lammers, Yang Shi, Bo Wei
Published in: Biomaterials, Issue 266, 2021, Page(s) 120432, ISSN 0142-9612
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120432

Cancer nanomedicine meets immunotherapy: opportunities and challenges

Author(s): Qingxue Sun, Xiangyang Bai, Alexandros Marios Sofias, Roy van der Meel, Eduardo Ruiz-Hernandez, Gert Storm, Wim E. Hennink, Bruno De Geest, Fabian Kiessling, Hai-jun Yu, Twan Lammers, Yang Shi
Published in: Acta Pharmacologica Sinica, Issue 41/7, 2020, Page(s) 954-958, ISSN 1671-4083
Publisher: Shanghai Institute of Materia Medica
DOI: 10.1038/s41401-020-0448-9

Desmoplastic tumor priming using clinical-stage corticosteroid liposomes

Author(s): Tarun Ojha, Gideon J.L. Schaefer, Rahaf Mihyar, Vertika Pathak, Josef Ehling, Elena Rama, Federica De Lorenzi, Asmaa Said Elshafei, Diana Moeckel, Sara Elsafy, Benjamin Theek, Maike Wagner, Paolo Ceccarini, Lorena Consolino, Marek Weiler, Fabian Peisker, Tim Caspers, Quim Peña, Roman Barmin, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Steffen Meurer, Ralf Weiskirchen, Rafael Kramann
Published in: Cell Biomaterials, Issue 1-16, 2025, Page(s) 100051, ISSN 3050-5623
Publisher: Elsevier BV
DOI: 10.1016/j.celbio.2025.100051

Improving Lyophilization and Long-Term Stability of Gold Nanostars for Photothermal Applications

Author(s): Zhongqian Xi, Rui Zhang, Sven Thoröe-Boveleth, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Published in: ACS Applied Nano Materials, Issue 6, 2023, Page(s) 17336-17346, ISSN 2574-0970
Publisher: ACS
DOI: 10.1021/acsanm.3c03953

Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

Author(s): Jan-Niklas May, Jennifer I. Moss, Florian Mueller, Susanne K. Golombek, Ilaria Biancacci, Larissa Rizzo, Asmaa Said Elshafei, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Svea Becker, Christian Trautwein, Roman D. Bülow, Peter Boor, Ruth Knuechel, Saskia von Stillfried, Gert Storm, Sanyogitta Puri, Simon T. Barry, Volkmar Schulz, Fabian Kiessling, Marianne B. Ashford, Twan Lammers
Published in: Nature Biomedical Engineering, 2024, ISSN 2157-846X
Publisher: Springer-Nature
DOI: 10.1038/s41551-024-01197-4

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Author(s): Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Hans W. Scheeren, Sunil A. David, Fabian Kiessling, Twan Lammers, Bruno G. De Geest, Yang Shi
Published in: Journal of the American Chemical Society, Issue 142/28, 2020, Page(s) 12133-12139, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c01928

Targeting intracellular and extracellular receptors with nano-to-macroscale biomaterials to activate immune cells

Author(s): Bi Wang, Hao Cui, Fabian Kiessling, Twan Lammers, Dirk Baumjohann, Yang Shi
Published in: Journal of Controlled Release, Issue 357, 2024, Page(s) 52-66, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.03.028

A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma

Author(s): Josbert Metselaar, Twan Lammers, Amelie Boquoi, Roland Fenk, Fabio Testaquadra, Mirle Schemionek, Fabian Kiessling, Susanne Isfort, Stefan Wilop, Martina Crysandt
Published in: Drug Delivery and Translational Research, Issue 13, 2023, Page(s) 915-923, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01268-6

Clinical translation of quantum dots

Author(s): Roger M Pallares, Fabian Kiessling, Twan Lammers
Published in: Nanomedicine, Issue 19, 2024, Page(s) 2433-2435, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.1080/17435889.2024.2405458

Lipids in disease pathology, diagnosis & therapy.

Author(s): Twan Lammers; Heidi Noels
Published in: Advanced Drug Delivery Reviews, Issue 1, 2020, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.11.006

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

Author(s): Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Published in: Advanced Drug Delivery Reviews, Issue 189, 2023, Page(s) 114504, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2022.114504

A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system

Author(s): Alexandros Marios Sofias, Francis Combes, Steffen Koschmieder, Gert Storm, Twan Lammers
Published in: Drug Discovery Today, Issue 26/6, 2021, Page(s) 1482-1489, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2021.02.017

Multidrug micelles and sonopermeation for chemotherapy co-delivery to brain tumors

Author(s): Anshuman Dasgupta, Jan-Niklas May, Geir Klinkenberg, Helena C. Besse, Eva Miriam Buhl, Diana Moeckel, Rahaf Mihyar, Quim Peña, Armin Azadkhah Shalmani, Christopher Hark, Anne Rix, Susanne Koletnik, Josbert Metselaar, Yang Shi, Wim E. Hennink, Gert Storm, Dannis van Vuurden, Chrit Moonen, Mario Ries, Ruth Schmid, Fabian Kiessling, Twan Lammers
Published in: Journal of Controlled Release, Issue 380, 2025, Page(s) 818-828, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2025.02.018

Clinical translation of gold nanoparticles

Author(s): Rui Zhang; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Published in: Drug Delivery and Translational Research, Issue 1, 2022, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.18154/rwth-2022-08962

Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles

Author(s): Mengjiao Liu, Anshuman Dasgupta, Patrick Koczera, Sandra Schipper, Dirk Rommel, Yang Shi, Fabian Kiessling, Twan Lammers
Published in: Molecular Pharmaceutics, Issue 17/8, 2020, Page(s) 2840-2848, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00242

Effect of Cellular and Microenvironmental Multidrug Resistance on Tumor-Targeted Drug Delivery in Triple-Negative Breast Cancer

Author(s): Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Published in: Journal of Controlled Release, 2023, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.12.056

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Author(s): Alec Wang, Madeline Walden, Romy Ettlinger, Fabian Kiessling, Jeremiah J. Gassensmith, Twan Lammers, Stefan Wuttke, Quim Peña
Published in: Advanced Functional Materials, 2023, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202308589

Multidrug nanomedicine

Author(s): Alexandros Marios Sofias, Twan Lammers
Published in: Nature Nanotechnology, Issue 18, 2023, Page(s) 104-106, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-022-01265-3

Tunable polymeric micelles for taxane and corticosteroid co-delivery

Author(s): Armin Azadkhah Shalmani, Alec Wang, Zaheer Ahmed, Maryam Sheybanifard, Rahaf Mihyar, Eva Miriam Buhl, Michael Pohl, Wim E. Hennink, Fabian Kiessling, Josbert M. Metselaar, Yang Shi, Twan Lammers, Quim Peña
Published in: Drug Delivery and Translational Research, Issue 14, 2024, Page(s) 2642-2654, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-023-01465-x

Engineering Mesoscopic 3D Tumor Models with a Self‐Organizing Vascularized Matrix

Author(s): Federica De Lorenzi, Nadja Hansen, Benjamin Theek, Rasika Daware, Alessandro Motta, Saskia Breuel, Ramin Nasehi, Julian Baumeister, Jan Schöneberg, Natalija Stojanović, Saskia von Stillfried, Michael Vogt, Gerhard Müller‐Newen, Jochen Maurer, Alexandros Marios Sofias, Twan Lammers, Horst Fischer, Fabian Kiessling
Published in: Advanced Materials, Issue 36, 2024, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202303196

Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance

Author(s): Mirjavad Moosavifar, Roman A. Barmin, Elena Rama, Anne Rix, Rustam A. Gumerov, Thomas Lisson, Céline Bastard, Stephan Rütten, Noah Avraham‐Radermacher, Jens Koehler, Michael Pohl, Vedangi Kulkarni, Jasmin Baier, Susanne Koletnik, Rui Zhang, Anshuman Dasgupta, Alessandro Motta, Marek Weiler, Igor I. Potemkin, Georg Schmitz, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Published in: Advanced Science, Issue 11, 2024, Page(s) 1-13, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202404385

Cancer nanomedicine

Author(s): Sangeeta N. Bhatia, Xiaoyuan Chen, Marina A. Dobrovolskaia, Twan Lammers
Published in: Nature Reviews Cancer, 2022, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-022-00496-9

A translational framework to DELIVER nanomedicines to the clinic

Author(s): Paul Joyce, Christine J. Allen, María José Alonso, Marianne Ashford, Michelle S. Bradbury, Matthieu Germain, Maria Kavallaris, Robert Langer, Twan Lammers, Maria Teresa Peracchia, Amirali Popat, Clive A. Prestidge, Cristianne J. F. Rijcken, Bruno Sarmento, Ruth B. Schmid, Avi Schroeder, Santhni Subramaniam, Chelsea R. Thorn, Kathryn A. Whitehead, Chun-Xia Zhao, Hélder A. Santos
Published in: Nature Nanotechnology, Issue 19, 2024, Page(s) 1597-1611, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-024-01754-7

Intermittent Fasting Primes the Tumor Microenvironment and Improves Nanomedicine Delivery in Hepatocellular Carcinoma

Author(s): Svea Becker, Jeffrey Momoh, Ilaria Biancacci, Diana Möckel, Qingbi Wang, Jan‐Niklas May, Huan Su, Lena Susanna Candels, Marie‐Luise Berres, Fabian Kiessling, Maximilian Hatting, Twan Lammers, Christian Trautwein
Published in: Small, Issue 19, 2024, ISSN 1613-6810
Publisher: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202208042

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

Author(s): Roman A. Barmin; Anshuman Dasgupta; Céline Bastard; Laura De Laporte; Stephan Rütten; Marek Weiler; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Published in: Molecular Pharmaceutics, Issue 1, 2021, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00416

Hydrophobic ion pairing enables co-loading of water-soluble drugs in polymeric micelles

Author(s): Armin Azadkhah Shalmani, Rasika Daware, Asmaa Said Elshafei, Federica De Lorenzi, Diana Moeckel, Eva M. Buhl, Barbara Mara Klinkhammer, Peter Boor, Srinivas Banala, Alina Adams, Fabian Kiessling, Gert Storm, Josbert M. Metselaar, Alexandros Marios Sofias, Yang Shi, Twan Lammers, Quim Peña, Tarun Ojha
Published in: Journal of Controlled Release, Issue 1-13, 2025, Page(s) 113748, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113748

Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis

Author(s): Filip M E Segers, Adele V Ruder, Marijke M Westra, Twan Lammers, Seyed Mohammadali Dadfar, Karolin Roemhild, Tin Sing Lam, Marianne Eline Kooi, Kitty B J M Cleutjens, Fons K Verheyen, Geert W H Schurink, Guido R Haenen, Theo J C van Berkel, Ilze Bot, Bente Halvorsen, Judith C Sluimer, Erik A L Biessen
Published in: Cardiovascular Research, Issue 118, 2024, Page(s) 3346-3359, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvac032

Role of Surface Curvature in Gold Nanostar Properties and Applications

Author(s): Zhongqian Xi, Rui Zhang, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Published in: ACS Biomaterials Science & Engineering, Issue 10, 2024, Page(s) 38-50, ISSN 2373-9878
Publisher: ACS
DOI: 10.1021/acsbiomaterials.3c00249

Improving MPI and hyperthermia performance of superparamagnetic iron oxide nanoparticles through fractional factorial design of experiments

Author(s): Yanchen Li, Rui Zhang, Roman Barmin, Elena Rama, Max Schoenen, Franziska Schrank, Volkmar Schulz, Ioana Slabu, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Published in: Nanoscale Advances, Issue 6, 2024, Page(s) 4352-4359, ISSN 2516-0230
Publisher: RSC
DOI: 10.1039/d4na00378k

Bridging The Gap Between Lab and Clinic for Nanodiagnostics

Author(s): Roger M Pallares, Fabian Kiessling, Twan Lammers
Published in: Nanomedicine, Issue 18, 2024, Page(s) 413-416, ISSN 1743-5889
Publisher: Future Medicine Ltd.
DOI: 10.2217/nnm-2023-0067

Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives

Author(s): Karolin Roemhild, Helena C. Besse, Bi Wang, Quim Peña, Qingxue Sun, Daiki Omata, Burcin Ozbakir, Clemens Bos, Hans W. Scheeren, Gert Storm, Josbert M. Metselaar, Haijun Yu, Ruth Knüchel-Clarke, Fabian Kiessling, Chrit T.W. Moonen, Roel Deckers, Yang Shi, Twan Lammers
Published in: Theranostics, Issue 12, 2022, Page(s) 4791-4801, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/thno.69168

Nanoparticles for Cancer Diagnosis, Radionuclide Therapy and Theranostics.

Author(s): Jordi Llop; Twan Lammers
Published in: ACS Nano, Issue 19360851, 2021, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c09139

The success of nanomedicine

Author(s): Twan Lammers, Mauro Ferrari
Published in: Nano Today, Issue 31, 2020, Page(s) 100853, ISSN 1748-0132
Publisher: Elsevier BV
DOI: 10.1016/j.nantod.2020.100853

Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery

Author(s): Ilaria Biancacci, Daniele De Santis, Elena Rama, Karina Benderski, Jeffrey Momoh, Robert Pohlberger, Diana Moeckel, Leonard Kaps, Cristianne J. F. Rijcken, Jai Prakash, Marielle Thewissen, Fabian Kiessling, Yang Shi, Quim Peña, Alexandros Marios Sofias, Lorena Consolino, Twan Lammers
Published in: Advanced Therapeutics, Issue 6, 2023, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202300098

Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis

Author(s): Ritvik Mathur, Sara Elsafy, Adrian T. Press, Julian Brück, Mathias Hornef, Lukas Martin, Tobias Schürholz, Gernot Marx, Matthias Bartneck, Fabian Kiessling, Josbert Maarten Metselaar, Gert Storm, Twan Lammers, Alexandros Marios Sofias, Patrick Koczera
Published in: ACS Nano, Issue 18, 2024, Page(s) 28866-28880, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.4c09054

Targeting Kidney Fibrosis with Polymeric Nanocarriers

Author(s): Vedangi Kulkarni, Tim Caspers, Diana Moeckel, Susanne Koletnik, Elena Rama, Paraskevi Sotiropoulou, Daniel R. Dietrich, Robert Pola, Lenka Kotrchová, Tomáš Etrych, Yvonne H. W. Derks, Peter Boor, Fabian Kiessling, Felix M. Mottaghy, Barbara M. Klinkhammer, Twan Lammers
Published in: Chemistry of Materials, Issue 36, 2024, Page(s) 9686-9695, ISSN 0897-4756
Publisher: American Chemical Society
DOI: 10.1021/acs.chemmater.4c01788

Unraveling the Seedless Growth of Gold Nanostars through Fractional Factorial Design

Author(s): Rui Zhang; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Published in: Journal of Physical Chemistry C, Issue 3, 2023, ISSN 1932-7447
Publisher: American Chemical Society
DOI: 10.1021/acs.jpcc.2c06396

Analysis of multi-drug cancer nanomedicine

Author(s): Karina Benderski, Twan Lammers, Alexandros Marios Sofias
Published in: Nature Nanotechnology, 2025, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-025-01932-1

Controlled Covalent Self‐Assembly of a Homopolymer for Multiscale Materials Engineering

Author(s): Xiangyang Bai; Qingxue Sun; Hao Cui; Luis P. B. Guerzoni; Stefan Wuttke; Fabian Kiessling; Laura De Laporte; Twan Lammers; Yang Shi
Published in: Advanced Materials, Issue 1, 2022, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202109701

Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles

Author(s): Ilaria Biancacci; Federica De Lorenzi; Benjamin Theek; Xiangyang Bai; Jan‐Niklas May; Lorena Consolino; Maike Baues; Diana Moeckel; Felix Gremse; Saskia Stillfried; Asmaa El Shafei; Karina Benderski; Armin Azadkhah Shalmani; Alec Wang; Jeffrey Momoh; Quim Peña; Eva Miriam Buhl; Johannes Buyel; Wim Hennink; Fabian Kiessling; Josbert Metselaar; Yang Shi; Twan Lammers
Published in: "Advanced science 2103745 (2022). doi:10.1002/advs.202103745 special issue: ""This article also appears in: Hot Topic: Tumors and Cancer""", Issue 21983844, 2022, ISSN 2198-3844
Publisher: Wiley
DOI: 10.18154/rwth-2022-00963

Non-invasive molecular imaging of kidney diseases

Author(s): Barbara M. Klinkhammer, Twan Lammers, Felix M. Mottaghy, Fabian Kiessling, Jürgen Floege, Peter Boor
Published in: Nature Reviews Nephrology, Issue 17/10, 2021, Page(s) 688-703, ISSN 1759-5061
Publisher: Nature Publishing Group
DOI: 10.1038/s41581-021-00440-4

Polymeric antibubbles with strong ultrasound imaging capabilities

Author(s): Roman A. Barmin, Jens Köhler, Michael Pohl, Bea Becker, Fabian Kiessling, Twan Lammers, Albert T. Poortinga, Roger M. Pallares
Published in: Chemical Communications, Issue 60, 2024, Page(s) 13340-13343, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4cc03572k

Transformative Materials for Interfacial Drug Delivery

Author(s): Prachi Desai, Anshuman Dasgupta, Alexandros Marios Sofias, Quim Peña, Robert Göstl, Ioana Slabu, Ulrich Schwaneberg, Thomas Stiehl, Wolfgang Wagner, Stefan Jockenhövel, Julia Stingl, Rafael Kramann, Christian Trautwein, Tim H. Brümmendorf, Fabian Kiessling, Andreas Herrmann, Twan Lammers
Published in: Advanced Healthcare Materials, Issue 12, 2023, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301062

RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier

Author(s): Christopher Hark, Junlin Chen, Julia Blöck, Eva Miriam Buhl, Harald Radermacher, Robert Pola, Michal Pechar, Tomáš Etrych, Quim Peña, Anne Rix, Natascha I. Drude, Fabian Kiessling, Twan Lammers, Jan-Niklas May
Published in: Drug Delivery and Translational Research, Issue 14, 2024, Page(s) 2629-2641, ISSN 2190-393X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01561-6

Metallodrugs in cancer nanomedicine

Author(s): Quim Peña; Alec Wang; Orysia Zaremba; Yang Shi; Hans W. Scheeren; Josbert M. Metselaar; Fabian Kiessling; Roger M. Pallares; Stefan Wuttke; Twan Lammers
Published in: Chemical Society Reviews, Issue 1, 2022, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cs00468a

Roadmap on nanomedicine

Author(s): Paolo Decuzzi, Dan Peer, Daniele Di Mascolo, Anna Lisa Palange, Purnima Naresh Manghnani, S Moein Moghimi, Z Shadi Farhangrazi, Kenneth A Howard, Daniel Rosenblum, Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu, Zhen Gu, Netanel Korin, Didier Letourneur, Cédric Chauvierre, Roy van der Meel, Fabian Kiessling, Twan Lammers
Published in: Nanotechnology, Issue 32/1, 2021, Page(s) 012001, ISSN 0957-4484
Publisher: Institute of Physics Publishing
DOI: 10.1088/1361-6528/abaadb

Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders

Author(s): Alexandros Marios Sofias, Federica De Lorenzi, Quim Peña, Armin Azadkhah Shalmani, Mihael Vucur, Jiong-Wei Wang, Fabian Kiessling, Yang Shi, Lorena Consolino, Gert Storm, Twan Lammers
Published in: Advanced Drug Delivery Reviews, Issue 175, 2021, Page(s) 113831, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2021.113831

Lipids in disease pathology, diagnosis & therapy

Author(s): Twan Lammers, Heidi Noels
Published in: Advanced Drug Delivery Reviews, Issue 159, 2020, Page(s) 1-3, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.11.006

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