Macro-Nanomedicine to Treat Metastatic Cancer

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Nanoparticle Diagnostics and Theranostics in the Clinic

Autori: Roger M. Pallares, Felix M. Mottaghy, Volkmar Schulz, Fabian Kiessling, Twan Lammers
Pubblicato in: Journal of Nuclear Medicine, Numero 63, 2023, Pagina/e 1802-1808, ISSN 0161-5505
Editore: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.263895

CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy

Autori: Diana Möckel, Matthias Bartneck, Patricia Niemietz, Maike Wagner, Josef Ehling, Elena Rama, Marek Weiler, Felix Gremse, Dirk Eulberg, Robert Pola, Michal Pechar, Tomas Etrych, Gert Storm, Fabian Kiessling, Frank Tacke, Twan Lammers
Pubblicato in: Journal of Controlled Release, Numero 365, 2024, Pagina/e 358-368, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2023.11.044

Hybrid ultrasound and photoacoustic contrast agent designs combining metal phthalocyanines and PBCA microbubbles

Autori: Roman A. Barmin, MirJavad Moosavifar, Rui Zhang, Stephan Rütten, Sven Thoröe-Boveleth, Elena Rama, Tarun Ojha, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Pubblicato in: Journal of Materials Chemistry B, Numero 12, 2024, Pagina/e 2511-2522, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/d3tb02950f

Nonspherical ultrasound microbubbles

Autori: Anshuman Dasgupta, Tao Sun, Roberto Palomba, Elena Rama, Yong-Zhi Zhang, Chanikarn Power, Diana Moeckel, Mengjiao Liu, Apoorva Sarode, Marek Weiler, Alessandro Motta, Céline Porte, Zuzanna Magnuska, Asmaa Said ElShafei, Roman Barmin, Adam Graham, Arthur McClelland, Dirk Rommel, Elmar Stickeler, Fabian Kiessling, Roger M. Pallares, Laura De Laporte, Paolo Decuzzi, Nathan McDannold, Samir Mitrago
Pubblicato in: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2218847120

Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles

Autori: Federica De Lorenzi, Larissa Yokota Rizzo, Rasika Daware, Alessandro Motta, Maike Baues, Matthias Bartneck, Michael Vogt, Marc van Zandvoort, Leonard Kaps, Qizhi Hu, Marielle Thewissen, Luca Casettari, Cristianne J. F. Rijcken, Fabian Kiessling, Alexandros Marios Sofias, Twan Lammers
Pubblicato in: Drug Delivery and Translational Research, Numero 13, 2023, Pagina/e 1195-1211, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01204-8

A randomized controlled clinical trial

Autori: Metselaar, Josbert M.; Middelink, Leonie M.; Wortel, Cornelis H.; Bos, Reinhard; van Laar, Jacob M.; Vonkeman, Harald E.; Westhovens, Rene; Lammers, Twan; Yao, Siu Long; Kothekar, Mudgal; Raut, Atul; Bijlsma, Johannes W.J.
Pubblicato in: VOLUME=341;STARTPAGE=548;ENDPAGE=554;ISSN=0168-3659;TITLE=Journal of controlled release, Numero 1, 2023, ISSN 0168-3659
Editore: Elsevier BV

Nanoparticle delivery to tumours: from EPR and ATR mechanisms to clinical impact

Autori: Anshuman Dasgupta, Alexandros Marios Sofias, Fabian Kiessling, Twan Lammers
Pubblicato in: Nature Reviews Bioengineering, Numero 2, 2024, Pagina/e 714-716, ISSN 2731-6092
Editore: Springer-Nature
DOI: 10.1038/s44222-024-00203-3

Iron metabolism: pathophysiology and pharmacology

Autori: Karolin Roemhild, Finn von Maltzahn, Ralf Weiskirchen, Ruth Knüchel, Saskia von Stillfried, Twan Lammers
Pubblicato in: Trends in Pharmacological Sciences, Numero 42/8, 2021, Pagina/e 640-656, ISSN 0165-6147
Editore: Elsevier BV
DOI: 10.1016/j.tips.2021.05.001

Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges

Autori: Tarun Ojha, Qizhi Hu, Claudio Colombo, Jan Wit, Michiel Geijn, Mies J. Steenbergen, Mahsa Bagheri, Hiltrud Königs‐Werner, Eva Miriam Buhl, Ruchi Bansal, Yang Shi, Wim E. Hennink, Gert Storm, Cristianne J. F. Rijcken, Twan Lammers
Pubblicato in: Biotechnology Journal, Numero 16/6, 2021, Pagina/e 2000212, ISSN 1860-6768
Editore: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.202000212

Effect of Radical Polymerization Method on Pharmaceutical Properties of Π Electron-Stabilized HPMA-Based Polymeric Micelles

Autori: Armin Azadkhah Shalmani; Zaheer Ahmed; Maryam Sheybanifard; Alec Wang; Marek Weiler; Eva Miriam Buhl; Geir Klinkenberg; Ruth Schmid; Wim Hennink; Fabian Kiessling; Josbert M. Metselaar; Twan Lammers; Quim Peña; Yang Shi
Pubblicato in: Biomacromolecules, Numero 1, 2023, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c01261

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions

Autori: Thomas Anchordoquy, Natalie Artzi, Irina V. Balyasnikova, Yechezkel Barenholz, Ninh M. La-Beck, Jacob S. Brenner, Warren C. W. Chan, Paolo Decuzzi, Agata A. Exner, Alberto Gabizon, Biana Godin, Samuel K. Lai, Twan Lammers, Michael J. Mitchell, S. Moein Moghimi, Vladimir R. Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J. Serkova, Ravi Singh, Avi Schroeder, Anna A.
Pubblicato in: ACS Nano, Numero 18, 2024, Pagina/e 13983-13999, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.4c00182

Liposome manufacturing under continuous flow conditions: towards a fully integrated set-up with in-line control of critical quality attributes

Autori: Maryam Sheybanifard; Luis P. B. Guerzoni; Abdolrahman Omidinia-Anarkoli; Laura De Laporte; Johannes Buyel; Rut Besseling; Michiel Damen; Ad Gerich; Twan Lammers; Josbert M. Metselaar
Pubblicato in: Lab on a Chip, Numero 1, 2022, ISSN 1473-0197
Editore: Royal Society of Chemistry
DOI: 10.1039/d2lc00463a

Polymeric materials for ultrasound imaging and therapy

Autori: Roman A. Barmin, MirJavad Moosavifar, Anshuman Dasgupta, Andreas Herrmann, Fabian Kiessling, Roger M. Pallares, Twan Lammers
Pubblicato in: Chemical Science, Numero 14, 2024, Pagina/e 11941-11954, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/d3sc04339h

Transferrin Receptor‐Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation

Autori: Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia‐Marie Fletcher, Mirjavad Moosavifar, Roman Barmin, Céline Porte, Eva Miriam Buhl, Céline Bastard, Roger M. Pallares, Fabian Kiessling, Nathan McDannold, Samir Mitragotri, Twan Lammers
Pubblicato in: Advanced Materials, Numero 35, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308150

A randomized controlled clinical trial

Autori: Metselaar, Josbert M.; Middelink, Leonie M.; Wortel, Cornelis H.; Bos, Reinhard; van Laar, Jacob M.; Vonkeman, Harald E.; Westhovens, Rene; Lammers, Twan; Yao, Siu Long; Kothekar, Mudgal; Raut, Atul; Bijlsma, Johannes W.J.
Pubblicato in: Journal of Controlled Release, Numero 1, 2022, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2021.12.007

Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes

Autori: Jeffrey Momoh; Dimitrios Kapsokalyvas; Michael Vogt; Sjoerd Hak; Fabian Kiessling; Marc van Zandvoort; Twan Lammers; Alexandros Marios Sofias
Pubblicato in: Advanced Drug Delivery Reviews, Numero 1, 2022, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2022.114528

Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles

Autori: Mengjiao Liu; Anshuman Dasgupta; Na Qu; Elena Rama; Fabian Kiessling; Twan Lammers
Pubblicato in: ACS Biomaterials Science Engineering, Numero 2, 2022, ISSN 2373-9878
Editore: ACS
DOI: 10.1021/acsbiomaterials.1c01203

Nanomedicine Tumor Targeting

Autori: Twan Lammers
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202312169

Towards bypassing EPR

Autori: Mohamadreza Amin; Twan Lammers; Timo L.M. ten Hagen
Pubblicato in: Advanced Drug Delivery Reviews, Numero 1, 2022, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2022.114503

Dexamethasone nanomedicines for COVID-19

Autori: Twan Lammers, Alexandros Marios Sofias, Roy van der Meel, Raymond Schiffelers, Gert Storm, Frank Tacke, Steffen Koschmieder, Tim H. Brümmendorf, Fabian Kiessling, Josbert M. Metselaar
Pubblicato in: Nature Nanotechnology, Numero 15, 2021, Pagina/e 622-624, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-020-0752-z

Nanoscale engineering of gold nanostars for enhanced photoacoustic imaging

Autori: Rui Zhang, Sven Thoröe-Boveleth, Dmitry N. Chigrin, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Pubblicato in: Journal of Nanobiotechnology, Numero 22, 2024, ISSN 1477-3155
Editore: BioMed Central
DOI: 10.1186/s12951-024-02379-7

Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles

Autori: Ilaria Biancacci, Qingxue Sun, Diana Möckel, Felix Gremse, Stefanie Rosenhain, Fabian Kiessling, Matthias Bartneck, Qizhi Hu, Marielle Thewissen, Gert Storm, Wim E. Hennink, Yang Shi, Cristianne J.F. Rijcken, Twan Lammers, Alexandros Marios Sofias
Pubblicato in: Journal of Controlled Release, Numero 328, 2020, Pagina/e 805-816, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2020.09.046

Clinical translation and landscape of silver nanoparticles

Autori: Manuel Dias, Rui Zhang, Twan Lammers, Roger M. Pallares
Pubblicato in: Drug Delivery and Translational Research, Numero 15, 2025, Pagina/e 789-797, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01716-5

Enhanced Stable Cavitation and Nonlinear Acoustic Properties of Poly(butyl cyanoacrylate) Polymeric Microbubbles after Bioconjugation

Autori: Roman A. Barmin; Anshuman Dasgupta; Anne Rix; Marek Weiler; Lia Appold; Stephan Rütten; Frederic Padilla; Alexander J. C. Kuehne; Andrij Pich; Laura De Laporte; Fabian Kiessling; Roger M. Pallares; Twan Lammers
Pubblicato in: ACS Biomaterials Science Engineering, Numero 1, 2023, ISSN 2373-9878
Editore: ACS
DOI: 10.1021/acsbiomaterials.2c01021

Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

Autori: Chenghua Liang, Xiangyang Bai, Cuiling Qi, Qingxue Sun, Xiaoyan Han, Tianyun Lan, Haibo Zhang, Xiaoming Zheng, Rongpu Liang, Ju Jiao, Zongheng Zheng, Jiafeng Fang, Purun Lei, Yan Wang, Diana Möckel, Josbert M. Metselaar, Gert Storm, Wim E. Hennink, Fabian Kiessling, Hongbo Wei, Twan Lammers, Yang Shi, Bo Wei
Pubblicato in: Biomaterials, Numero 266, 2021, Pagina/e 120432, ISSN 0142-9612
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120432

Cancer nanomedicine meets immunotherapy: opportunities and challenges

Autori: Qingxue Sun, Xiangyang Bai, Alexandros Marios Sofias, Roy van der Meel, Eduardo Ruiz-Hernandez, Gert Storm, Wim E. Hennink, Bruno De Geest, Fabian Kiessling, Hai-jun Yu, Twan Lammers, Yang Shi
Pubblicato in: Acta Pharmacologica Sinica, Numero 41/7, 2020, Pagina/e 954-958, ISSN 1671-4083
Editore: Shanghai Institute of Materia Medica
DOI: 10.1038/s41401-020-0448-9

Desmoplastic tumor priming using clinical-stage corticosteroid liposomes

Autori: Tarun Ojha, Gideon J.L. Schaefer, Rahaf Mihyar, Vertika Pathak, Josef Ehling, Elena Rama, Federica De Lorenzi, Asmaa Said Elshafei, Diana Moeckel, Sara Elsafy, Benjamin Theek, Maike Wagner, Paolo Ceccarini, Lorena Consolino, Marek Weiler, Fabian Peisker, Tim Caspers, Quim Peña, Roman Barmin, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Steffen Meurer, Ralf Weiskirchen, Rafael Kramann
Pubblicato in: Cell Biomaterials, Numero 1-16, 2025, Pagina/e 100051, ISSN 3050-5623
Editore: Elsevier BV
DOI: 10.1016/j.celbio.2025.100051

Improving Lyophilization and Long-Term Stability of Gold Nanostars for Photothermal Applications

Autori: Zhongqian Xi, Rui Zhang, Sven Thoröe-Boveleth, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Pubblicato in: ACS Applied Nano Materials, Numero 6, 2023, Pagina/e 17336-17346, ISSN 2574-0970
Editore: ACS
DOI: 10.1021/acsanm.3c03953

Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

Autori: Jan-Niklas May, Jennifer I. Moss, Florian Mueller, Susanne K. Golombek, Ilaria Biancacci, Larissa Rizzo, Asmaa Said Elshafei, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Svea Becker, Christian Trautwein, Roman D. Bülow, Peter Boor, Ruth Knuechel, Saskia von Stillfried, Gert Storm, Sanyogitta Puri, Simon T. Barry, Volkmar Schulz, Fabian Kiessling, Marianne B. Ashford, Twan Lammers
Pubblicato in: Nature Biomedical Engineering, 2024, ISSN 2157-846X
Editore: Springer-Nature
DOI: 10.1038/s41551-024-01197-4

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Autori: Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Hans W. Scheeren, Sunil A. David, Fabian Kiessling, Twan Lammers, Bruno G. De Geest, Yang Shi
Pubblicato in: Journal of the American Chemical Society, Numero 142/28, 2020, Pagina/e 12133-12139, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.0c01928

Targeting intracellular and extracellular receptors with nano-to-macroscale biomaterials to activate immune cells

Autori: Bi Wang, Hao Cui, Fabian Kiessling, Twan Lammers, Dirk Baumjohann, Yang Shi
Pubblicato in: Journal of Controlled Release, Numero 357, 2024, Pagina/e 52-66, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2023.03.028

A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma

Autori: Josbert Metselaar, Twan Lammers, Amelie Boquoi, Roland Fenk, Fabio Testaquadra, Mirle Schemionek, Fabian Kiessling, Susanne Isfort, Stefan Wilop, Martina Crysandt
Pubblicato in: Drug Delivery and Translational Research, Numero 13, 2023, Pagina/e 915-923, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01268-6

Clinical translation of quantum dots

Autori: Roger M Pallares, Fabian Kiessling, Twan Lammers
Pubblicato in: Nanomedicine, Numero 19, 2024, Pagina/e 2433-2435, ISSN 1743-5889
Editore: Future Medicine Ltd.
DOI: 10.1080/17435889.2024.2405458

Lipids in disease pathology, diagnosis & therapy.

Autori: Twan Lammers; Heidi Noels
Pubblicato in: Advanced Drug Delivery Reviews, Numero 1, 2020, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.11.006

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

Autori: Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Pubblicato in: Advanced Drug Delivery Reviews, Numero 189, 2023, Pagina/e 114504, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2022.114504

A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system

Autori: Alexandros Marios Sofias, Francis Combes, Steffen Koschmieder, Gert Storm, Twan Lammers
Pubblicato in: Drug Discovery Today, Numero 26/6, 2021, Pagina/e 1482-1489, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2021.02.017

Multidrug micelles and sonopermeation for chemotherapy co-delivery to brain tumors

Autori: Anshuman Dasgupta, Jan-Niklas May, Geir Klinkenberg, Helena C. Besse, Eva Miriam Buhl, Diana Moeckel, Rahaf Mihyar, Quim Peña, Armin Azadkhah Shalmani, Christopher Hark, Anne Rix, Susanne Koletnik, Josbert Metselaar, Yang Shi, Wim E. Hennink, Gert Storm, Dannis van Vuurden, Chrit Moonen, Mario Ries, Ruth Schmid, Fabian Kiessling, Twan Lammers
Pubblicato in: Journal of Controlled Release, Numero 380, 2025, Pagina/e 818-828, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2025.02.018

Clinical translation of gold nanoparticles

Autori: Rui Zhang; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Pubblicato in: Drug Delivery and Translational Research, Numero 1, 2022, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.18154/rwth-2022-08962

Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles

Autori: Mengjiao Liu, Anshuman Dasgupta, Patrick Koczera, Sandra Schipper, Dirk Rommel, Yang Shi, Fabian Kiessling, Twan Lammers
Pubblicato in: Molecular Pharmaceutics, Numero 17/8, 2020, Pagina/e 2840-2848, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00242

Effect of Cellular and Microenvironmental Multidrug Resistance on Tumor-Targeted Drug Delivery in Triple-Negative Breast Cancer

Autori: Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Pubblicato in: Journal of Controlled Release, 2023, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2022.12.056

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Autori: Alec Wang, Madeline Walden, Romy Ettlinger, Fabian Kiessling, Jeremiah J. Gassensmith, Twan Lammers, Stefan Wuttke, Quim Peña
Pubblicato in: Advanced Functional Materials, 2023, ISSN 1616-301X
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202308589

Multidrug nanomedicine

Autori: Alexandros Marios Sofias, Twan Lammers
Pubblicato in: Nature Nanotechnology, Numero 18, 2023, Pagina/e 104-106, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-022-01265-3

Tunable polymeric micelles for taxane and corticosteroid co-delivery

Autori: Armin Azadkhah Shalmani, Alec Wang, Zaheer Ahmed, Maryam Sheybanifard, Rahaf Mihyar, Eva Miriam Buhl, Michael Pohl, Wim E. Hennink, Fabian Kiessling, Josbert M. Metselaar, Yang Shi, Twan Lammers, Quim Peña
Pubblicato in: Drug Delivery and Translational Research, Numero 14, 2024, Pagina/e 2642-2654, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-023-01465-x

Engineering Mesoscopic 3D Tumor Models with a Self‐Organizing Vascularized Matrix

Autori: Federica De Lorenzi, Nadja Hansen, Benjamin Theek, Rasika Daware, Alessandro Motta, Saskia Breuel, Ramin Nasehi, Julian Baumeister, Jan Schöneberg, Natalija Stojanović, Saskia von Stillfried, Michael Vogt, Gerhard Müller‐Newen, Jochen Maurer, Alexandros Marios Sofias, Twan Lammers, Horst Fischer, Fabian Kiessling
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202303196

Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance

Autori: Mirjavad Moosavifar, Roman A. Barmin, Elena Rama, Anne Rix, Rustam A. Gumerov, Thomas Lisson, Céline Bastard, Stephan Rütten, Noah Avraham‐Radermacher, Jens Koehler, Michael Pohl, Vedangi Kulkarni, Jasmin Baier, Susanne Koletnik, Rui Zhang, Anshuman Dasgupta, Alessandro Motta, Marek Weiler, Igor I. Potemkin, Georg Schmitz, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Pubblicato in: Advanced Science, Numero 11, 2024, Pagina/e 1-13, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202404385

Cancer nanomedicine

Autori: Sangeeta N. Bhatia, Xiaoyuan Chen, Marina A. Dobrovolskaia, Twan Lammers
Pubblicato in: Nature Reviews Cancer, 2022, ISSN 1474-175X
Editore: Nature Publishing Group
DOI: 10.1038/s41568-022-00496-9

A translational framework to DELIVER nanomedicines to the clinic

Autori: Paul Joyce, Christine J. Allen, María José Alonso, Marianne Ashford, Michelle S. Bradbury, Matthieu Germain, Maria Kavallaris, Robert Langer, Twan Lammers, Maria Teresa Peracchia, Amirali Popat, Clive A. Prestidge, Cristianne J. F. Rijcken, Bruno Sarmento, Ruth B. Schmid, Avi Schroeder, Santhni Subramaniam, Chelsea R. Thorn, Kathryn A. Whitehead, Chun-Xia Zhao, Hélder A. Santos
Pubblicato in: Nature Nanotechnology, Numero 19, 2024, Pagina/e 1597-1611, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-024-01754-7

Intermittent Fasting Primes the Tumor Microenvironment and Improves Nanomedicine Delivery in Hepatocellular Carcinoma

Autori: Svea Becker, Jeffrey Momoh, Ilaria Biancacci, Diana Möckel, Qingbi Wang, Jan‐Niklas May, Huan Su, Lena Susanna Candels, Marie‐Luise Berres, Fabian Kiessling, Maximilian Hatting, Twan Lammers, Christian Trautwein
Pubblicato in: Small, Numero 19, 2024, ISSN 1613-6810
Editore: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202208042

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

Autori: Roman A. Barmin; Anshuman Dasgupta; Céline Bastard; Laura De Laporte; Stephan Rütten; Marek Weiler; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Pubblicato in: Molecular Pharmaceutics, Numero 1, 2021, ISSN 1543-8384
Editore: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00416

Hydrophobic ion pairing enables co-loading of water-soluble drugs in polymeric micelles

Autori: Armin Azadkhah Shalmani, Rasika Daware, Asmaa Said Elshafei, Federica De Lorenzi, Diana Moeckel, Eva M. Buhl, Barbara Mara Klinkhammer, Peter Boor, Srinivas Banala, Alina Adams, Fabian Kiessling, Gert Storm, Josbert M. Metselaar, Alexandros Marios Sofias, Yang Shi, Twan Lammers, Quim Peña, Tarun Ojha
Pubblicato in: Journal of Controlled Release, Numero 1-13, 2025, Pagina/e 113748, ISSN 0168-3659
Editore: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113748

Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis

Autori: Filip M E Segers, Adele V Ruder, Marijke M Westra, Twan Lammers, Seyed Mohammadali Dadfar, Karolin Roemhild, Tin Sing Lam, Marianne Eline Kooi, Kitty B J M Cleutjens, Fons K Verheyen, Geert W H Schurink, Guido R Haenen, Theo J C van Berkel, Ilze Bot, Bente Halvorsen, Judith C Sluimer, Erik A L Biessen
Pubblicato in: Cardiovascular Research, Numero 118, 2024, Pagina/e 3346-3359, ISSN 0008-6363
Editore: Elsevier BV
DOI: 10.1093/cvr/cvac032

Role of Surface Curvature in Gold Nanostar Properties and Applications

Autori: Zhongqian Xi, Rui Zhang, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 10, 2024, Pagina/e 38-50, ISSN 2373-9878
Editore: ACS
DOI: 10.1021/acsbiomaterials.3c00249

Improving MPI and hyperthermia performance of superparamagnetic iron oxide nanoparticles through fractional factorial design of experiments

Autori: Yanchen Li, Rui Zhang, Roman Barmin, Elena Rama, Max Schoenen, Franziska Schrank, Volkmar Schulz, Ioana Slabu, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Pubblicato in: Nanoscale Advances, Numero 6, 2024, Pagina/e 4352-4359, ISSN 2516-0230
Editore: RSC
DOI: 10.1039/d4na00378k

Bridging The Gap Between Lab and Clinic for Nanodiagnostics

Autori: Roger M Pallares, Fabian Kiessling, Twan Lammers
Pubblicato in: Nanomedicine, Numero 18, 2024, Pagina/e 413-416, ISSN 1743-5889
Editore: Future Medicine Ltd.
DOI: 10.2217/nnm-2023-0067

Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives

Autori: Karolin Roemhild, Helena C. Besse, Bi Wang, Quim Peña, Qingxue Sun, Daiki Omata, Burcin Ozbakir, Clemens Bos, Hans W. Scheeren, Gert Storm, Josbert M. Metselaar, Haijun Yu, Ruth Knüchel-Clarke, Fabian Kiessling, Chrit T.W. Moonen, Roel Deckers, Yang Shi, Twan Lammers
Pubblicato in: Theranostics, Numero 12, 2022, Pagina/e 4791-4801, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.69168

Nanoparticles for Cancer Diagnosis, Radionuclide Therapy and Theranostics.

Autori: Jordi Llop; Twan Lammers
Pubblicato in: ACS Nano, Numero 19360851, 2021, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.1c09139

The success of nanomedicine

Autori: Twan Lammers, Mauro Ferrari
Pubblicato in: Nano Today, Numero 31, 2020, Pagina/e 100853, ISSN 1748-0132
Editore: Elsevier BV
DOI: 10.1016/j.nantod.2020.100853

Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery

Autori: Ilaria Biancacci, Daniele De Santis, Elena Rama, Karina Benderski, Jeffrey Momoh, Robert Pohlberger, Diana Moeckel, Leonard Kaps, Cristianne J. F. Rijcken, Jai Prakash, Marielle Thewissen, Fabian Kiessling, Yang Shi, Quim Peña, Alexandros Marios Sofias, Lorena Consolino, Twan Lammers
Pubblicato in: Advanced Therapeutics, Numero 6, 2023, ISSN 2366-3987
Editore: Wiley
DOI: 10.1002/adtp.202300098

Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis

Autori: Ritvik Mathur, Sara Elsafy, Adrian T. Press, Julian Brück, Mathias Hornef, Lukas Martin, Tobias Schürholz, Gernot Marx, Matthias Bartneck, Fabian Kiessling, Josbert Maarten Metselaar, Gert Storm, Twan Lammers, Alexandros Marios Sofias, Patrick Koczera
Pubblicato in: ACS Nano, Numero 18, 2024, Pagina/e 28866-28880, ISSN 1936-0851
Editore: American Chemical Society
DOI: 10.1021/acsnano.4c09054

Targeting Kidney Fibrosis with Polymeric Nanocarriers

Autori: Vedangi Kulkarni, Tim Caspers, Diana Moeckel, Susanne Koletnik, Elena Rama, Paraskevi Sotiropoulou, Daniel R. Dietrich, Robert Pola, Lenka Kotrchová, Tomáš Etrych, Yvonne H. W. Derks, Peter Boor, Fabian Kiessling, Felix M. Mottaghy, Barbara M. Klinkhammer, Twan Lammers
Pubblicato in: Chemistry of Materials, Numero 36, 2024, Pagina/e 9686-9695, ISSN 0897-4756
Editore: American Chemical Society
DOI: 10.1021/acs.chemmater.4c01788

Unraveling the Seedless Growth of Gold Nanostars through Fractional Factorial Design

Autori: Rui Zhang; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Pubblicato in: Journal of Physical Chemistry C, Numero 3, 2023, ISSN 1932-7447
Editore: American Chemical Society
DOI: 10.1021/acs.jpcc.2c06396

Analysis of multi-drug cancer nanomedicine

Autori: Karina Benderski, Twan Lammers, Alexandros Marios Sofias
Pubblicato in: Nature Nanotechnology, 2025, ISSN 1748-3387
Editore: Nature Publishing Group
DOI: 10.1038/s41565-025-01932-1

Controlled Covalent Self‐Assembly of a Homopolymer for Multiscale Materials Engineering

Autori: Xiangyang Bai; Qingxue Sun; Hao Cui; Luis P. B. Guerzoni; Stefan Wuttke; Fabian Kiessling; Laura De Laporte; Twan Lammers; Yang Shi
Pubblicato in: Advanced Materials, Numero 1, 2022, ISSN 1521-4095
Editore: Wiley
DOI: 10.1002/adma.202109701

Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles

Autori: Ilaria Biancacci; Federica De Lorenzi; Benjamin Theek; Xiangyang Bai; Jan‐Niklas May; Lorena Consolino; Maike Baues; Diana Moeckel; Felix Gremse; Saskia Stillfried; Asmaa El Shafei; Karina Benderski; Armin Azadkhah Shalmani; Alec Wang; Jeffrey Momoh; Quim Peña; Eva Miriam Buhl; Johannes Buyel; Wim Hennink; Fabian Kiessling; Josbert Metselaar; Yang Shi; Twan Lammers
Pubblicato in: "Advanced science 2103745 (2022). doi:10.1002/advs.202103745 special issue: ""This article also appears in: Hot Topic: Tumors and Cancer""", Numero 21983844, 2022, ISSN 2198-3844
Editore: Wiley
DOI: 10.18154/rwth-2022-00963

Non-invasive molecular imaging of kidney diseases

Autori: Barbara M. Klinkhammer, Twan Lammers, Felix M. Mottaghy, Fabian Kiessling, Jürgen Floege, Peter Boor
Pubblicato in: Nature Reviews Nephrology, Numero 17/10, 2021, Pagina/e 688-703, ISSN 1759-5061
Editore: Nature Publishing Group
DOI: 10.1038/s41581-021-00440-4

Polymeric antibubbles with strong ultrasound imaging capabilities

Autori: Roman A. Barmin, Jens Köhler, Michael Pohl, Bea Becker, Fabian Kiessling, Twan Lammers, Albert T. Poortinga, Roger M. Pallares
Pubblicato in: Chemical Communications, Numero 60, 2024, Pagina/e 13340-13343, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d4cc03572k

Transformative Materials for Interfacial Drug Delivery

Autori: Prachi Desai, Anshuman Dasgupta, Alexandros Marios Sofias, Quim Peña, Robert Göstl, Ioana Slabu, Ulrich Schwaneberg, Thomas Stiehl, Wolfgang Wagner, Stefan Jockenhövel, Julia Stingl, Rafael Kramann, Christian Trautwein, Tim H. Brümmendorf, Fabian Kiessling, Andreas Herrmann, Twan Lammers
Pubblicato in: Advanced Healthcare Materials, Numero 12, 2023, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301062

RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier

Autori: Christopher Hark, Junlin Chen, Julia Blöck, Eva Miriam Buhl, Harald Radermacher, Robert Pola, Michal Pechar, Tomáš Etrych, Quim Peña, Anne Rix, Natascha I. Drude, Fabian Kiessling, Twan Lammers, Jan-Niklas May
Pubblicato in: Drug Delivery and Translational Research, Numero 14, 2024, Pagina/e 2629-2641, ISSN 2190-393X
Editore: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01561-6

Metallodrugs in cancer nanomedicine

Autori: Quim Peña; Alec Wang; Orysia Zaremba; Yang Shi; Hans W. Scheeren; Josbert M. Metselaar; Fabian Kiessling; Roger M. Pallares; Stefan Wuttke; Twan Lammers
Pubblicato in: Chemical Society Reviews, Numero 1, 2022, ISSN 0306-0012
Editore: Royal Society of Chemistry
DOI: 10.1039/d1cs00468a

Roadmap on nanomedicine

Autori: Paolo Decuzzi, Dan Peer, Daniele Di Mascolo, Anna Lisa Palange, Purnima Naresh Manghnani, S Moein Moghimi, Z Shadi Farhangrazi, Kenneth A Howard, Daniel Rosenblum, Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu, Zhen Gu, Netanel Korin, Didier Letourneur, Cédric Chauvierre, Roy van der Meel, Fabian Kiessling, Twan Lammers
Pubblicato in: Nanotechnology, Numero 32/1, 2021, Pagina/e 012001, ISSN 0957-4484
Editore: Institute of Physics Publishing
DOI: 10.1088/1361-6528/abaadb

Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders

Autori: Alexandros Marios Sofias, Federica De Lorenzi, Quim Peña, Armin Azadkhah Shalmani, Mihael Vucur, Jiong-Wei Wang, Fabian Kiessling, Yang Shi, Lorena Consolino, Gert Storm, Twan Lammers
Pubblicato in: Advanced Drug Delivery Reviews, Numero 175, 2021, Pagina/e 113831, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2021.113831

Lipids in disease pathology, diagnosis & therapy

Autori: Twan Lammers, Heidi Noels
Pubblicato in: Advanced Drug Delivery Reviews, Numero 159, 2020, Pagina/e 1-3, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.11.006

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