Macro-Nanomedicine to Treat Metastatic Cancer

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Nanoparticle Diagnostics and Theranostics in the Clinic

Autores: Roger M. Pallares, Felix M. Mottaghy, Volkmar Schulz, Fabian Kiessling, Twan Lammers
Publicado en: Journal of Nuclear Medicine, Edición 63, 2023, Página(s) 1802-1808, ISSN 0161-5505
Editor: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.122.263895

CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy

Autores: Diana Möckel, Matthias Bartneck, Patricia Niemietz, Maike Wagner, Josef Ehling, Elena Rama, Marek Weiler, Felix Gremse, Dirk Eulberg, Robert Pola, Michal Pechar, Tomas Etrych, Gert Storm, Fabian Kiessling, Frank Tacke, Twan Lammers
Publicado en: Journal of Controlled Release, Edición 365, 2024, Página(s) 358-368, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2023.11.044

Hybrid ultrasound and photoacoustic contrast agent designs combining metal phthalocyanines and PBCA microbubbles

Autores: Roman A. Barmin, MirJavad Moosavifar, Rui Zhang, Stephan Rütten, Sven Thoröe-Boveleth, Elena Rama, Tarun Ojha, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Publicado en: Journal of Materials Chemistry B, Edición 12, 2024, Página(s) 2511-2522, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/d3tb02950f

Nonspherical ultrasound microbubbles

Autores: Anshuman Dasgupta, Tao Sun, Roberto Palomba, Elena Rama, Yong-Zhi Zhang, Chanikarn Power, Diana Moeckel, Mengjiao Liu, Apoorva Sarode, Marek Weiler, Alessandro Motta, Céline Porte, Zuzanna Magnuska, Asmaa Said ElShafei, Roman Barmin, Adam Graham, Arthur McClelland, Dirk Rommel, Elmar Stickeler, Fabian Kiessling, Roger M. Pallares, Laura De Laporte, Paolo Decuzzi, Nathan McDannold, Samir Mitrago
Publicado en: Proceedings of the National Academy of Sciences of the United States of America, 2023, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2218847120

Profiling target engagement and cellular uptake of cRGD-decorated clinical-stage core-crosslinked polymeric micelles

Autores: Federica De Lorenzi, Larissa Yokota Rizzo, Rasika Daware, Alessandro Motta, Maike Baues, Matthias Bartneck, Michael Vogt, Marc van Zandvoort, Leonard Kaps, Qizhi Hu, Marielle Thewissen, Luca Casettari, Cristianne J. F. Rijcken, Fabian Kiessling, Alexandros Marios Sofias, Twan Lammers
Publicado en: Drug Delivery and Translational Research, Edición 13, 2023, Página(s) 1195-1211, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01204-8

A randomized controlled clinical trial

Autores: Metselaar, Josbert M.; Middelink, Leonie M.; Wortel, Cornelis H.; Bos, Reinhard; van Laar, Jacob M.; Vonkeman, Harald E.; Westhovens, Rene; Lammers, Twan; Yao, Siu Long; Kothekar, Mudgal; Raut, Atul; Bijlsma, Johannes W.J.
Publicado en: VOLUME=341;STARTPAGE=548;ENDPAGE=554;ISSN=0168-3659;TITLE=Journal of controlled release, Edición 1, 2023, ISSN 0168-3659
Editor: Elsevier BV

Nanoparticle delivery to tumours: from EPR and ATR mechanisms to clinical impact

Autores: Anshuman Dasgupta, Alexandros Marios Sofias, Fabian Kiessling, Twan Lammers
Publicado en: Nature Reviews Bioengineering, Edición 2, 2024, Página(s) 714-716, ISSN 2731-6092
Editor: Springer-Nature
DOI: 10.1038/s44222-024-00203-3

Iron metabolism: pathophysiology and pharmacology

Autores: Karolin Roemhild, Finn von Maltzahn, Ralf Weiskirchen, Ruth Knüchel, Saskia von Stillfried, Twan Lammers
Publicado en: Trends in Pharmacological Sciences, Edición 42/8, 2021, Página(s) 640-656, ISSN 0165-6147
Editor: Elsevier BV
DOI: 10.1016/j.tips.2021.05.001

Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges

Autores: Tarun Ojha, Qizhi Hu, Claudio Colombo, Jan Wit, Michiel Geijn, Mies J. Steenbergen, Mahsa Bagheri, Hiltrud Königs‐Werner, Eva Miriam Buhl, Ruchi Bansal, Yang Shi, Wim E. Hennink, Gert Storm, Cristianne J. F. Rijcken, Twan Lammers
Publicado en: Biotechnology Journal, Edición 16/6, 2021, Página(s) 2000212, ISSN 1860-6768
Editor: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/biot.202000212

Effect of Radical Polymerization Method on Pharmaceutical Properties of Π Electron-Stabilized HPMA-Based Polymeric Micelles

Autores: Armin Azadkhah Shalmani; Zaheer Ahmed; Maryam Sheybanifard; Alec Wang; Marek Weiler; Eva Miriam Buhl; Geir Klinkenberg; Ruth Schmid; Wim Hennink; Fabian Kiessling; Josbert M. Metselaar; Twan Lammers; Quim Peña; Yang Shi
Publicado en: Biomacromolecules, Edición 1, 2023, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.2c01261

Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions

Autores: Thomas Anchordoquy, Natalie Artzi, Irina V. Balyasnikova, Yechezkel Barenholz, Ninh M. La-Beck, Jacob S. Brenner, Warren C. W. Chan, Paolo Decuzzi, Agata A. Exner, Alberto Gabizon, Biana Godin, Samuel K. Lai, Twan Lammers, Michael J. Mitchell, S. Moein Moghimi, Vladimir R. Muzykantov, Dan Peer, Juliane Nguyen, Rachela Popovtzer, Madison Ricco, Natalie J. Serkova, Ravi Singh, Avi Schroeder, Anna A.
Publicado en: ACS Nano, Edición 18, 2024, Página(s) 13983-13999, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.4c00182

Liposome manufacturing under continuous flow conditions: towards a fully integrated set-up with in-line control of critical quality attributes

Autores: Maryam Sheybanifard; Luis P. B. Guerzoni; Abdolrahman Omidinia-Anarkoli; Laura De Laporte; Johannes Buyel; Rut Besseling; Michiel Damen; Ad Gerich; Twan Lammers; Josbert M. Metselaar
Publicado en: Lab on a Chip, Edición 1, 2022, ISSN 1473-0197
Editor: Royal Society of Chemistry
DOI: 10.1039/d2lc00463a

Polymeric materials for ultrasound imaging and therapy

Autores: Roman A. Barmin, MirJavad Moosavifar, Anshuman Dasgupta, Andreas Herrmann, Fabian Kiessling, Roger M. Pallares, Twan Lammers
Publicado en: Chemical Science, Edición 14, 2024, Página(s) 11941-11954, ISSN 2041-6520
Editor: Royal Society of Chemistry
DOI: 10.1039/d3sc04339h

Transferrin Receptor‐Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation

Autores: Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia‐Marie Fletcher, Mirjavad Moosavifar, Roman Barmin, Céline Porte, Eva Miriam Buhl, Céline Bastard, Roger M. Pallares, Fabian Kiessling, Nathan McDannold, Samir Mitragotri, Twan Lammers
Publicado en: Advanced Materials, Edición 35, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202308150

A randomized controlled clinical trial

Autores: Metselaar, Josbert M.; Middelink, Leonie M.; Wortel, Cornelis H.; Bos, Reinhard; van Laar, Jacob M.; Vonkeman, Harald E.; Westhovens, Rene; Lammers, Twan; Yao, Siu Long; Kothekar, Mudgal; Raut, Atul; Bijlsma, Johannes W.J.
Publicado en: Journal of Controlled Release, Edición 1, 2022, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2021.12.007

Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes

Autores: Jeffrey Momoh; Dimitrios Kapsokalyvas; Michael Vogt; Sjoerd Hak; Fabian Kiessling; Marc van Zandvoort; Twan Lammers; Alexandros Marios Sofias
Publicado en: Advanced Drug Delivery Reviews, Edición 1, 2022, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2022.114528

Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles

Autores: Mengjiao Liu; Anshuman Dasgupta; Na Qu; Elena Rama; Fabian Kiessling; Twan Lammers
Publicado en: ACS Biomaterials Science Engineering, Edición 2, 2022, ISSN 2373-9878
Editor: ACS
DOI: 10.1021/acsbiomaterials.1c01203

Nanomedicine Tumor Targeting

Autores: Twan Lammers
Publicado en: Advanced Materials, Edición 36, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202312169

Towards bypassing EPR

Autores: Mohamadreza Amin; Twan Lammers; Timo L.M. ten Hagen
Publicado en: Advanced Drug Delivery Reviews, Edición 1, 2022, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2022.114503

Dexamethasone nanomedicines for COVID-19

Autores: Twan Lammers, Alexandros Marios Sofias, Roy van der Meel, Raymond Schiffelers, Gert Storm, Frank Tacke, Steffen Koschmieder, Tim H. Brümmendorf, Fabian Kiessling, Josbert M. Metselaar
Publicado en: Nature Nanotechnology, Edición 15, 2021, Página(s) 622-624, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-020-0752-z

Nanoscale engineering of gold nanostars for enhanced photoacoustic imaging

Autores: Rui Zhang, Sven Thoröe-Boveleth, Dmitry N. Chigrin, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Publicado en: Journal of Nanobiotechnology, Edición 22, 2024, ISSN 1477-3155
Editor: BioMed Central
DOI: 10.1186/s12951-024-02379-7

Optical imaging of the whole-body to cellular biodistribution of clinical-stage PEG-b-pHPMA-based core-crosslinked polymeric micelles

Autores: Ilaria Biancacci, Qingxue Sun, Diana Möckel, Felix Gremse, Stefanie Rosenhain, Fabian Kiessling, Matthias Bartneck, Qizhi Hu, Marielle Thewissen, Gert Storm, Wim E. Hennink, Yang Shi, Cristianne J.F. Rijcken, Twan Lammers, Alexandros Marios Sofias
Publicado en: Journal of Controlled Release, Edición 328, 2020, Página(s) 805-816, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2020.09.046

Clinical translation and landscape of silver nanoparticles

Autores: Manuel Dias, Rui Zhang, Twan Lammers, Roger M. Pallares
Publicado en: Drug Delivery and Translational Research, Edición 15, 2025, Página(s) 789-797, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01716-5

Enhanced Stable Cavitation and Nonlinear Acoustic Properties of Poly(butyl cyanoacrylate) Polymeric Microbubbles after Bioconjugation

Autores: Roman A. Barmin; Anshuman Dasgupta; Anne Rix; Marek Weiler; Lia Appold; Stephan Rütten; Frederic Padilla; Alexander J. C. Kuehne; Andrij Pich; Laura De Laporte; Fabian Kiessling; Roger M. Pallares; Twan Lammers
Publicado en: ACS Biomaterials Science Engineering, Edición 1, 2023, ISSN 2373-9878
Editor: ACS
DOI: 10.1021/acsbiomaterials.2c01021

Π electron-stabilized polymeric micelles potentiate docetaxel therapy in advanced-stage gastrointestinal cancer

Autores: Chenghua Liang, Xiangyang Bai, Cuiling Qi, Qingxue Sun, Xiaoyan Han, Tianyun Lan, Haibo Zhang, Xiaoming Zheng, Rongpu Liang, Ju Jiao, Zongheng Zheng, Jiafeng Fang, Purun Lei, Yan Wang, Diana Möckel, Josbert M. Metselaar, Gert Storm, Wim E. Hennink, Fabian Kiessling, Hongbo Wei, Twan Lammers, Yang Shi, Bo Wei
Publicado en: Biomaterials, Edición 266, 2021, Página(s) 120432, ISSN 0142-9612
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2020.120432

Cancer nanomedicine meets immunotherapy: opportunities and challenges

Autores: Qingxue Sun, Xiangyang Bai, Alexandros Marios Sofias, Roy van der Meel, Eduardo Ruiz-Hernandez, Gert Storm, Wim E. Hennink, Bruno De Geest, Fabian Kiessling, Hai-jun Yu, Twan Lammers, Yang Shi
Publicado en: Acta Pharmacologica Sinica, Edición 41/7, 2020, Página(s) 954-958, ISSN 1671-4083
Editor: Shanghai Institute of Materia Medica
DOI: 10.1038/s41401-020-0448-9

Desmoplastic tumor priming using clinical-stage corticosteroid liposomes

Autores: Tarun Ojha, Gideon J.L. Schaefer, Rahaf Mihyar, Vertika Pathak, Josef Ehling, Elena Rama, Federica De Lorenzi, Asmaa Said Elshafei, Diana Moeckel, Sara Elsafy, Benjamin Theek, Maike Wagner, Paolo Ceccarini, Lorena Consolino, Marek Weiler, Fabian Peisker, Tim Caspers, Quim Peña, Roman Barmin, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Steffen Meurer, Ralf Weiskirchen, Rafael Kramann
Publicado en: Cell Biomaterials, Edición 1-16, 2025, Página(s) 100051, ISSN 3050-5623
Editor: Elsevier BV
DOI: 10.1016/j.celbio.2025.100051

Improving Lyophilization and Long-Term Stability of Gold Nanostars for Photothermal Applications

Autores: Zhongqian Xi, Rui Zhang, Sven Thoröe-Boveleth, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Publicado en: ACS Applied Nano Materials, Edición 6, 2023, Página(s) 17336-17346, ISSN 2574-0970
Editor: ACS
DOI: 10.1021/acsanm.3c03953

Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

Autores: Jan-Niklas May, Jennifer I. Moss, Florian Mueller, Susanne K. Golombek, Ilaria Biancacci, Larissa Rizzo, Asmaa Said Elshafei, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Svea Becker, Christian Trautwein, Roman D. Bülow, Peter Boor, Ruth Knuechel, Saskia von Stillfried, Gert Storm, Sanyogitta Puri, Simon T. Barry, Volkmar Schulz, Fabian Kiessling, Marianne B. Ashford, Twan Lammers
Publicado en: Nature Biomedical Engineering, 2024, ISSN 2157-846X
Editor: Springer-Nature
DOI: 10.1038/s41551-024-01197-4

Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles

Autores: Bi Wang, Simon Van Herck, Yong Chen, Xiangyang Bai, Zifu Zhong, Kim Deswarte, Bart N. Lambrecht, Niek N. Sanders, Stefan Lienenklaus, Hans W. Scheeren, Sunil A. David, Fabian Kiessling, Twan Lammers, Bruno G. De Geest, Yang Shi
Publicado en: Journal of the American Chemical Society, Edición 142/28, 2020, Página(s) 12133-12139, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.0c01928

Targeting intracellular and extracellular receptors with nano-to-macroscale biomaterials to activate immune cells

Autores: Bi Wang, Hao Cui, Fabian Kiessling, Twan Lammers, Dirk Baumjohann, Yang Shi
Publicado en: Journal of Controlled Release, Edición 357, 2024, Página(s) 52-66, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2023.03.028

A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma

Autores: Josbert Metselaar, Twan Lammers, Amelie Boquoi, Roland Fenk, Fabio Testaquadra, Mirle Schemionek, Fabian Kiessling, Susanne Isfort, Stefan Wilop, Martina Crysandt
Publicado en: Drug Delivery and Translational Research, Edición 13, 2023, Página(s) 915-923, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01268-6

Clinical translation of quantum dots

Autores: Roger M Pallares, Fabian Kiessling, Twan Lammers
Publicado en: Nanomedicine, Edición 19, 2024, Página(s) 2433-2435, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.1080/17435889.2024.2405458

Lipids in disease pathology, diagnosis & therapy.

Autores: Twan Lammers; Heidi Noels
Publicado en: Advanced Drug Delivery Reviews, Edición 1, 2020, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2020.11.006

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

Autores: Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Publicado en: Advanced Drug Delivery Reviews, Edición 189, 2023, Página(s) 114504, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2022.114504

A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system

Autores: Alexandros Marios Sofias, Francis Combes, Steffen Koschmieder, Gert Storm, Twan Lammers
Publicado en: Drug Discovery Today, Edición 26/6, 2021, Página(s) 1482-1489, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2021.02.017

Multidrug micelles and sonopermeation for chemotherapy co-delivery to brain tumors

Autores: Anshuman Dasgupta, Jan-Niklas May, Geir Klinkenberg, Helena C. Besse, Eva Miriam Buhl, Diana Moeckel, Rahaf Mihyar, Quim Peña, Armin Azadkhah Shalmani, Christopher Hark, Anne Rix, Susanne Koletnik, Josbert Metselaar, Yang Shi, Wim E. Hennink, Gert Storm, Dannis van Vuurden, Chrit Moonen, Mario Ries, Ruth Schmid, Fabian Kiessling, Twan Lammers
Publicado en: Journal of Controlled Release, Edición 380, 2025, Página(s) 818-828, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2025.02.018

Clinical translation of gold nanoparticles

Autores: Rui Zhang; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Publicado en: Drug Delivery and Translational Research, Edición 1, 2022, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.18154/rwth-2022-08962

Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles

Autores: Mengjiao Liu, Anshuman Dasgupta, Patrick Koczera, Sandra Schipper, Dirk Rommel, Yang Shi, Fabian Kiessling, Twan Lammers
Publicado en: Molecular Pharmaceutics, Edición 17/8, 2020, Página(s) 2840-2848, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.0c00242

Effect of Cellular and Microenvironmental Multidrug Resistance on Tumor-Targeted Drug Delivery in Triple-Negative Breast Cancer

Autores: Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Publicado en: Journal of Controlled Release, 2023, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2022.12.056

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Autores: Alec Wang, Madeline Walden, Romy Ettlinger, Fabian Kiessling, Jeremiah J. Gassensmith, Twan Lammers, Stefan Wuttke, Quim Peña
Publicado en: Advanced Functional Materials, 2023, ISSN 1616-301X
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.202308589

Multidrug nanomedicine

Autores: Alexandros Marios Sofias, Twan Lammers
Publicado en: Nature Nanotechnology, Edición 18, 2023, Página(s) 104-106, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-022-01265-3

Tunable polymeric micelles for taxane and corticosteroid co-delivery

Autores: Armin Azadkhah Shalmani, Alec Wang, Zaheer Ahmed, Maryam Sheybanifard, Rahaf Mihyar, Eva Miriam Buhl, Michael Pohl, Wim E. Hennink, Fabian Kiessling, Josbert M. Metselaar, Yang Shi, Twan Lammers, Quim Peña
Publicado en: Drug Delivery and Translational Research, Edición 14, 2024, Página(s) 2642-2654, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-023-01465-x

Engineering Mesoscopic 3D Tumor Models with a Self‐Organizing Vascularized Matrix

Autores: Federica De Lorenzi, Nadja Hansen, Benjamin Theek, Rasika Daware, Alessandro Motta, Saskia Breuel, Ramin Nasehi, Julian Baumeister, Jan Schöneberg, Natalija Stojanović, Saskia von Stillfried, Michael Vogt, Gerhard Müller‐Newen, Jochen Maurer, Alexandros Marios Sofias, Twan Lammers, Horst Fischer, Fabian Kiessling
Publicado en: Advanced Materials, Edición 36, 2024, ISSN 0935-9648
Editor: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202303196

Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance

Autores: Mirjavad Moosavifar, Roman A. Barmin, Elena Rama, Anne Rix, Rustam A. Gumerov, Thomas Lisson, Céline Bastard, Stephan Rütten, Noah Avraham‐Radermacher, Jens Koehler, Michael Pohl, Vedangi Kulkarni, Jasmin Baier, Susanne Koletnik, Rui Zhang, Anshuman Dasgupta, Alessandro Motta, Marek Weiler, Igor I. Potemkin, Georg Schmitz, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Publicado en: Advanced Science, Edición 11, 2024, Página(s) 1-13, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202404385

Cancer nanomedicine

Autores: Sangeeta N. Bhatia, Xiaoyuan Chen, Marina A. Dobrovolskaia, Twan Lammers
Publicado en: Nature Reviews Cancer, 2022, ISSN 1474-175X
Editor: Nature Publishing Group
DOI: 10.1038/s41568-022-00496-9

A translational framework to DELIVER nanomedicines to the clinic

Autores: Paul Joyce, Christine J. Allen, María José Alonso, Marianne Ashford, Michelle S. Bradbury, Matthieu Germain, Maria Kavallaris, Robert Langer, Twan Lammers, Maria Teresa Peracchia, Amirali Popat, Clive A. Prestidge, Cristianne J. F. Rijcken, Bruno Sarmento, Ruth B. Schmid, Avi Schroeder, Santhni Subramaniam, Chelsea R. Thorn, Kathryn A. Whitehead, Chun-Xia Zhao, Hélder A. Santos
Publicado en: Nature Nanotechnology, Edición 19, 2024, Página(s) 1597-1611, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-024-01754-7

Intermittent Fasting Primes the Tumor Microenvironment and Improves Nanomedicine Delivery in Hepatocellular Carcinoma

Autores: Svea Becker, Jeffrey Momoh, Ilaria Biancacci, Diana Möckel, Qingbi Wang, Jan‐Niklas May, Huan Su, Lena Susanna Candels, Marie‐Luise Berres, Fabian Kiessling, Maximilian Hatting, Twan Lammers, Christian Trautwein
Publicado en: Small, Edición 19, 2024, ISSN 1613-6810
Editor: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/smll.202208042

Engineering the Acoustic Response and Drug Loading Capacity of PBCA-Based Polymeric Microbubbles with Surfactants

Autores: Roman A. Barmin; Anshuman Dasgupta; Céline Bastard; Laura De Laporte; Stephan Rütten; Marek Weiler; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Publicado en: Molecular Pharmaceutics, Edición 1, 2021, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.2c00416

Hydrophobic ion pairing enables co-loading of water-soluble drugs in polymeric micelles

Autores: Armin Azadkhah Shalmani, Rasika Daware, Asmaa Said Elshafei, Federica De Lorenzi, Diana Moeckel, Eva M. Buhl, Barbara Mara Klinkhammer, Peter Boor, Srinivas Banala, Alina Adams, Fabian Kiessling, Gert Storm, Josbert M. Metselaar, Alexandros Marios Sofias, Yang Shi, Twan Lammers, Quim Peña, Tarun Ojha
Publicado en: Journal of Controlled Release, Edición 1-13, 2025, Página(s) 113748, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2025.113748

Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis

Autores: Filip M E Segers, Adele V Ruder, Marijke M Westra, Twan Lammers, Seyed Mohammadali Dadfar, Karolin Roemhild, Tin Sing Lam, Marianne Eline Kooi, Kitty B J M Cleutjens, Fons K Verheyen, Geert W H Schurink, Guido R Haenen, Theo J C van Berkel, Ilze Bot, Bente Halvorsen, Judith C Sluimer, Erik A L Biessen
Publicado en: Cardiovascular Research, Edición 118, 2024, Página(s) 3346-3359, ISSN 0008-6363
Editor: Elsevier BV
DOI: 10.1093/cvr/cvac032

Role of Surface Curvature in Gold Nanostar Properties and Applications

Autores: Zhongqian Xi, Rui Zhang, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Publicado en: ACS Biomaterials Science & Engineering, Edición 10, 2024, Página(s) 38-50, ISSN 2373-9878
Editor: ACS
DOI: 10.1021/acsbiomaterials.3c00249

Improving MPI and hyperthermia performance of superparamagnetic iron oxide nanoparticles through fractional factorial design of experiments

Autores: Yanchen Li, Rui Zhang, Roman Barmin, Elena Rama, Max Schoenen, Franziska Schrank, Volkmar Schulz, Ioana Slabu, Fabian Kiessling, Twan Lammers, Roger M. Pallares
Publicado en: Nanoscale Advances, Edición 6, 2024, Página(s) 4352-4359, ISSN 2516-0230
Editor: RSC
DOI: 10.1039/d4na00378k

Bridging The Gap Between Lab and Clinic for Nanodiagnostics

Autores: Roger M Pallares, Fabian Kiessling, Twan Lammers
Publicado en: Nanomedicine, Edición 18, 2024, Página(s) 413-416, ISSN 1743-5889
Editor: Future Medicine Ltd.
DOI: 10.2217/nnm-2023-0067

Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives

Autores: Karolin Roemhild, Helena C. Besse, Bi Wang, Quim Peña, Qingxue Sun, Daiki Omata, Burcin Ozbakir, Clemens Bos, Hans W. Scheeren, Gert Storm, Josbert M. Metselaar, Haijun Yu, Ruth Knüchel-Clarke, Fabian Kiessling, Chrit T.W. Moonen, Roel Deckers, Yang Shi, Twan Lammers
Publicado en: Theranostics, Edición 12, 2022, Página(s) 4791-4801, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/thno.69168

Nanoparticles for Cancer Diagnosis, Radionuclide Therapy and Theranostics.

Autores: Jordi Llop; Twan Lammers
Publicado en: ACS Nano, Edición 19360851, 2021, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.1c09139

The success of nanomedicine

Autores: Twan Lammers, Mauro Ferrari
Publicado en: Nano Today, Edición 31, 2020, Página(s) 100853, ISSN 1748-0132
Editor: Elsevier BV
DOI: 10.1016/j.nantod.2020.100853

Repurposing Tamoxifen for Tumor Microenvironment Priming and Enhanced Tumor‐Targeted Drug Delivery

Autores: Ilaria Biancacci, Daniele De Santis, Elena Rama, Karina Benderski, Jeffrey Momoh, Robert Pohlberger, Diana Moeckel, Leonard Kaps, Cristianne J. F. Rijcken, Jai Prakash, Marielle Thewissen, Fabian Kiessling, Yang Shi, Quim Peña, Alexandros Marios Sofias, Lorena Consolino, Twan Lammers
Publicado en: Advanced Therapeutics, Edición 6, 2023, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202300098

Neutrophil Hitchhiking Enhances Liposomal Dexamethasone Therapy of Sepsis

Autores: Ritvik Mathur, Sara Elsafy, Adrian T. Press, Julian Brück, Mathias Hornef, Lukas Martin, Tobias Schürholz, Gernot Marx, Matthias Bartneck, Fabian Kiessling, Josbert Maarten Metselaar, Gert Storm, Twan Lammers, Alexandros Marios Sofias, Patrick Koczera
Publicado en: ACS Nano, Edición 18, 2024, Página(s) 28866-28880, ISSN 1936-0851
Editor: American Chemical Society
DOI: 10.1021/acsnano.4c09054

Targeting Kidney Fibrosis with Polymeric Nanocarriers

Autores: Vedangi Kulkarni, Tim Caspers, Diana Moeckel, Susanne Koletnik, Elena Rama, Paraskevi Sotiropoulou, Daniel R. Dietrich, Robert Pola, Lenka Kotrchová, Tomáš Etrych, Yvonne H. W. Derks, Peter Boor, Fabian Kiessling, Felix M. Mottaghy, Barbara M. Klinkhammer, Twan Lammers
Publicado en: Chemistry of Materials, Edición 36, 2024, Página(s) 9686-9695, ISSN 0897-4756
Editor: American Chemical Society
DOI: 10.1021/acs.chemmater.4c01788

Unraveling the Seedless Growth of Gold Nanostars through Fractional Factorial Design

Autores: Rui Zhang; Fabian Kiessling; Twan Lammers; Roger M. Pallares
Publicado en: Journal of Physical Chemistry C, Edición 3, 2023, ISSN 1932-7447
Editor: American Chemical Society
DOI: 10.1021/acs.jpcc.2c06396

Analysis of multi-drug cancer nanomedicine

Autores: Karina Benderski, Twan Lammers, Alexandros Marios Sofias
Publicado en: Nature Nanotechnology, 2025, ISSN 1748-3387
Editor: Nature Publishing Group
DOI: 10.1038/s41565-025-01932-1

Controlled Covalent Self‐Assembly of a Homopolymer for Multiscale Materials Engineering

Autores: Xiangyang Bai; Qingxue Sun; Hao Cui; Luis P. B. Guerzoni; Stefan Wuttke; Fabian Kiessling; Laura De Laporte; Twan Lammers; Yang Shi
Publicado en: Advanced Materials, Edición 1, 2022, ISSN 1521-4095
Editor: Wiley
DOI: 10.1002/adma.202109701

Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles

Autores: Ilaria Biancacci; Federica De Lorenzi; Benjamin Theek; Xiangyang Bai; Jan‐Niklas May; Lorena Consolino; Maike Baues; Diana Moeckel; Felix Gremse; Saskia Stillfried; Asmaa El Shafei; Karina Benderski; Armin Azadkhah Shalmani; Alec Wang; Jeffrey Momoh; Quim Peña; Eva Miriam Buhl; Johannes Buyel; Wim Hennink; Fabian Kiessling; Josbert Metselaar; Yang Shi; Twan Lammers
Publicado en: "Advanced science 2103745 (2022). doi:10.1002/advs.202103745 special issue: ""This article also appears in: Hot Topic: Tumors and Cancer""", Edición 21983844, 2022, ISSN 2198-3844
Editor: Wiley
DOI: 10.18154/rwth-2022-00963

Non-invasive molecular imaging of kidney diseases

Autores: Barbara M. Klinkhammer, Twan Lammers, Felix M. Mottaghy, Fabian Kiessling, Jürgen Floege, Peter Boor
Publicado en: Nature Reviews Nephrology, Edición 17/10, 2021, Página(s) 688-703, ISSN 1759-5061
Editor: Nature Publishing Group
DOI: 10.1038/s41581-021-00440-4

Polymeric antibubbles with strong ultrasound imaging capabilities

Autores: Roman A. Barmin, Jens Köhler, Michael Pohl, Bea Becker, Fabian Kiessling, Twan Lammers, Albert T. Poortinga, Roger M. Pallares
Publicado en: Chemical Communications, Edición 60, 2024, Página(s) 13340-13343, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d4cc03572k

Transformative Materials for Interfacial Drug Delivery

Autores: Prachi Desai, Anshuman Dasgupta, Alexandros Marios Sofias, Quim Peña, Robert Göstl, Ioana Slabu, Ulrich Schwaneberg, Thomas Stiehl, Wolfgang Wagner, Stefan Jockenhövel, Julia Stingl, Rafael Kramann, Christian Trautwein, Tim H. Brümmendorf, Fabian Kiessling, Andreas Herrmann, Twan Lammers
Publicado en: Advanced Healthcare Materials, Edición 12, 2023, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202301062

RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier

Autores: Christopher Hark, Junlin Chen, Julia Blöck, Eva Miriam Buhl, Harald Radermacher, Robert Pola, Michal Pechar, Tomáš Etrych, Quim Peña, Anne Rix, Natascha I. Drude, Fabian Kiessling, Twan Lammers, Jan-Niklas May
Publicado en: Drug Delivery and Translational Research, Edición 14, 2024, Página(s) 2629-2641, ISSN 2190-393X
Editor: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01561-6

Metallodrugs in cancer nanomedicine

Autores: Quim Peña; Alec Wang; Orysia Zaremba; Yang Shi; Hans W. Scheeren; Josbert M. Metselaar; Fabian Kiessling; Roger M. Pallares; Stefan Wuttke; Twan Lammers
Publicado en: Chemical Society Reviews, Edición 1, 2022, ISSN 0306-0012
Editor: Royal Society of Chemistry
DOI: 10.1039/d1cs00468a

Roadmap on nanomedicine

Autores: Paolo Decuzzi, Dan Peer, Daniele Di Mascolo, Anna Lisa Palange, Purnima Naresh Manghnani, S Moein Moghimi, Z Shadi Farhangrazi, Kenneth A Howard, Daniel Rosenblum, Tingxizi Liang, Zhaowei Chen, Zejun Wang, Jun-Jie Zhu, Zhen Gu, Netanel Korin, Didier Letourneur, Cédric Chauvierre, Roy van der Meel, Fabian Kiessling, Twan Lammers
Publicado en: Nanotechnology, Edición 32/1, 2021, Página(s) 012001, ISSN 0957-4484
Editor: Institute of Physics Publishing
DOI: 10.1088/1361-6528/abaadb

Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders

Autores: Alexandros Marios Sofias, Federica De Lorenzi, Quim Peña, Armin Azadkhah Shalmani, Mihael Vucur, Jiong-Wei Wang, Fabian Kiessling, Yang Shi, Lorena Consolino, Gert Storm, Twan Lammers
Publicado en: Advanced Drug Delivery Reviews, Edición 175, 2021, Página(s) 113831, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2021.113831

Lipids in disease pathology, diagnosis & therapy

Autores: Twan Lammers, Heidi Noels
Publicado en: Advanced Drug Delivery Reviews, Edición 159, 2020, Página(s) 1-3, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2020.11.006

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