Patient-derived in vitro models of pancreatic cancer
Pancreatic cancer is associated with an extremely poor prognosis, necessitating the development of novel therapies. This requires patient-specific models that mimic the biology of the tumour and the interaction between cancer and cancer-supporting cells. To address this issue, the EU-funded CHIPIN project proposes to develop 3D cancer models using tissue engineering and bioprinting. The built platforms will consist of hydrogels, extracellular matrix molecules and patient-derived cells and will recreate the biomechanical characteristics of the pancreatic tumour microenvironment. This new approach will offer a clinically relevant platform for screening novel therapies.
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