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Three-dimensional dynamic views of proteomes as a novel readout for physiological and pathological alterations

Project description

It may be the quality and not the quantity that counts when it comes to proteins

Proteins are ubiquitous, mediating structural and functional roles in all cells. Their dysfunction is intimately involved in disease and one important way to assess their activity is to screen for their expression (proteomics assays looking at the entire complement of proteins expressed by an organism). However, many disease processes may alter protein function – intricately related to structure – without altering expression. The EU-funded project Proteomes-in-3D is testing a novel methodology to measure altered structures within the entire proteome of an organism and determine whether they are correlated with complex phenotypes. The team is focusing on protein aggregates or superassemblies (SAs), given that SAs are involved in both normal and disease processes. In addition, they will create an atlas of structural proteome dynamics from data generated throughout the project to provide a firm foundation for future studies of the structural proteome.

Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Net EU contribution
€ 2 000 000,00
Address
Raemistrasse 101
8092 Zuerich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
Net EU contribution
€ 2 000 000,00
Address
Raemistrasse 101
8092 Zuerich

See on map

Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00