Project description
It may be the quality and not the quantity that counts when it comes to proteins
Proteins are ubiquitous, mediating structural and functional roles in all cells. Their dysfunction is intimately involved in disease and one important way to assess their activity is to screen for their expression (proteomics assays looking at the entire complement of proteins expressed by an organism). However, many disease processes may alter protein function – intricately related to structure – without altering expression. The EU-funded project Proteomes-in-3D is testing a novel methodology to measure altered structures within the entire proteome of an organism and determine whether they are correlated with complex phenotypes. The team is focusing on protein aggregates or superassemblies (SAs), given that SAs are involved in both normal and disease processes. In addition, they will create an atlas of structural proteome dynamics from data generated throughout the project to provide a firm foundation for future studies of the structural proteome.
Fields of science
Programme(s)
Funding Scheme
ERC-COG - Consolidator GrantHost institution
8092 Zuerich
Switzerland
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Beneficiaries (1)
8092 Zuerich
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