Publications Peer reviewed articles (14) Systematic detection of functional proteoform groups from bottom-up proteomic datasets Author(s): Bludau, Isabell Frank, Max Dörig, Christian Cai, Yujia Heusel, Moritz Rosenberger, George Picotti, Paola Collins, Ben C. Röst, Hannes Aebersold, Ruedi Published in: Nature Communications, 20411723, 2021, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-021-24030-x Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins Author(s): Melnik, Andre Cappelletti, Valentina Vaggi, Federico Piazza, Ilaria Tognetti, Marco Schwarz, Carmen Cereghetti, Gea Ahmed, Mennat A. Soste, Martin Matlack, Kent de Souza, Natalie Csikasz-Nagy, Attila Picotti, Paola Published in: Journal of Proteomics, 18743919, 2020, ISSN 1874-3919 Publisher: Elsevier BV DOI: 10.1016/j.jprot.2020.103862 USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit Author(s): Montellese, Christian van den Heuvel, Jasmin Ashiono, Caroline Dörner, Kerstin Melnik, André Jonas, Stefanie Zemp, Ivo Picotti, Paola Gillet, Ludovic C. Kutay, Ulrike Published in: eLife, 2050084X, 2020, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.54435 Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1). Author(s): Kirsten Jenkins; Teodora Mateeva; István Szabó; Andre Melnik; Paola Picotti; Attila Csikász-Nagy; Attila Csikász-Nagy; Edina Rosta Published in: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1032-1042 (2020), 20010370, 2020, ISSN 2001-0370 Publisher: Elsevier DOI: 10.3929/ethz-b-000465810 Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT) Author(s): Grzmil, Michal Boersema, Paul Sharma, Ashish Blanc, Alain Imobersteg, Stefan Pruschy, Martin Picotti, Paola Schibli, Roger Behe, Martin Published in: Journal of Hematology & Oncology, 17568722, 2022, ISSN 1756-8722 Publisher: BioMed Central DOI: 10.1186/s13045-022-01343-y Combining CRISPRi and metabolomics for functional annotation of compound libraries Author(s): Miquel Anglada-Girotto; Gabriel Handschin; Karin Ortmayr; Adrian I. Campos; Ludovic Gillet; Pablo Manfredi; Claire V. Mulholland; Michael Berney; Urs Jenal; Paola Picotti; Mattia Zampieri Published in: Nature Chemical Biology, 18 (5), 15524469, 2022, ISSN 1552-4469 Publisher: Springer Nature DOI: 10.1038/s41589-022-00970-3 Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ Author(s): Valentina Cappelletti, Thomas Hauser, Ilaria Piazza, Monika Pepelnjak, Liliana Malinovska, Tobias Fuhrer, Yaozong Li, Christian Dörig, Paul Boersema, Ludovic Gillet, Jan Grossbach, Aurelien Dugourd, Julio Saez-Rodriguez, Andreas Beyer, Nicola Zamboni, Amedeo Caflisch, Natalie de Souza, Paola Picotti Published in: Cell, 184/2, 2021, Page(s) 545-559.e22, ISSN 0092-8674 Publisher: Cell Press DOI: 10.1016/j.cell.2020.12.021 Detecting Protein-Small Molecule Interactions Using Limited Proteolysis-Mass Spectrometry (LiP-MS). Author(s): Monika Pepelnjak; Natalie de Souza; Natalie de Souza; Paola Picotti Published in: Trends in Biochemical Sciences, 3, 2020, ISSN 0968-0004 Publisher: Elsevier BV DOI: 10.3929/ethz-b-000441347 A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes Author(s): Ilaria Piazza, Nigel Beaton, Roland Bruderer, Thomas Knobloch, Crystel Barbisan, Lucie Chandat, Alexander Sudau, Isabella Siepe, Oliver Rinner, Natalie de Souza, Paola Picotti, Lukas Reiter Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-020-18071-x Global, in situ analysis of the structural proteome in individuals with Parkinson’s disease to identify a new class of biomarker Author(s): Mackmull, Marie-Therese Nagel, Luise Sesterhenn, Fabian Muntel, Jan Grossbach, Jan Stalder, Patrick Bruderer, Roland Reiter, Lukas van de Berg, Wilma D.J. de Souza, Natalie Beyer, Andreas Picotti, Paola Published in: Nature Structural & Molecular Biology, 14764687, 2022, ISSN 1476-4687 Publisher: Springer Nature DOI: 10.1038/s41594-022-00837-0 Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance Author(s): Kamrad, Stephan Grossbach, Jan Rodríguez-López, Maria Mülleder, Michael Townsend, StJohn Cappelletti, Valentina Stojanovski, Gorjan Correia-Melo, Clara Picotti, Paola Beyer, Andreas Ralser, Markus Bähler, Jürg Published in: Molecular Systems Biology, 17444292, 2020, ISSN 1744-4292 Publisher: Nature Publishing Group DOI: 10.15252/msb.20199270 Deciphering the signaling network of breast cancer improves drug sensitivity prediction. Author(s): Marco Tognetti; Attila Gábor; Attila Gábor; Mi Yang; Mi Yang; Valentina Cappelletti; Jonas Windhager; Oscar M. Rueda; Konstantina Charmpi; Elham Esmaeilishirazifard; Elham Esmaeilishirazifard; Alejandra Bruna; Natalie de Souza; Natalie de Souza; Carlos Caldas; Carlos Caldas; Andreas Beyer; Paola Picotti; Julio Saez-Rodriguez; Julio Saez-Rodriguez; Bernd Bodenmiller Published in: Cell Systems, 12 (5), 24054720, 2021, ISSN 2405-4720 Publisher: CellPress DOI: 10.3929/ethz-b-000485506 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases Author(s): Mehta, Ved Khanppnavar, Basavraj Schuster, Dina Kantarci, Ilayda Vercellino, Irene Kosturanova, Angela Iype, Tarun Stefanic, Sasa Picotti, Paola Korkhov, Volodymyr M. Published in: eLife, 2050084X, 2022, ISSN 2050-084X Publisher: eLife Sciences Publications DOI: 10.7554/elife.77032 Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly Author(s): Gea Cereghetti, Caroline Wilson-Zbinden, Vera M. Kissling, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, Paola Picotti, D. Allan Drummond, Uwe Sauer, Reinhard Dechant, Matthias Peter Published in: Nature Cell Biology, 23/10, 2021, Page(s) 1085-1094, ISSN 1465-7392 Publisher: Nature Publishing Group DOI: 10.1038/s41556-021-00760-4 Monographic books (1) Limited Proteolysis-Mass Spectrometry to Identify Metabolite-Protein Interactions Author(s): Aleš Holfeld, Jan-Philipp Quast, Roland Bruderer, Lukas Reiter, Natalie de Souza & Paola Picotti Published in: Cell-Wide Identification of Metabolite-Protein Interactions, 2022, ISBN 978-1-0716-2624-5 Publisher: Springer Nature Searching for OpenAIRE data... 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