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Three-dimensional dynamic views of proteomes as a novel readout for physiological and pathological alterations

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Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ

Author(s): Valentina Cappelletti, Thomas Hauser, Ilaria Piazza, Monika Pepelnjak, Liliana Malinovska, Tobias Fuhrer, Yaozong Li, Christian Dörig, Paul Boersema, Ludovic Gillet, Jan Grossbach, Aurelien Dugourd, Julio Saez-Rodriguez, Andreas Beyer, Nicola Zamboni, Amedeo Caflisch, Natalie de Souza, Paola Picotti
Published in: Cell, 184/2, 2021, Page(s) 545-559.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.12.021

Detecting Protein-Small Molecule Interactions Using Limited Proteolysis-Mass Spectrometry (LiP-MS).

Author(s): Monika Pepelnjak; Natalie de Souza; Natalie de Souza; Paola Picotti
Published in: Trends in Biochemical Sciences, 3, 2020, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.3929/ethz-b-000441347

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes

Author(s): Ilaria Piazza, Nigel Beaton, Roland Bruderer, Thomas Knobloch, Crystel Barbisan, Lucie Chandat, Alexander Sudau, Isabella Siepe, Oliver Rinner, Natalie de Souza, Paola Picotti, Lukas Reiter
Published in: Nature Communications, 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18071-x

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Author(s): Gea Cereghetti, Caroline Wilson-Zbinden, Vera M. Kissling, Maren Diether, Alexandra Arm, Haneul Yoo, Ilaria Piazza, Shady Saad, Paola Picotti, D. Allan Drummond, Uwe Sauer, Reinhard Dechant, Matthias Peter
Published in: Nature Cell Biology, 23/10, 2021, Page(s) 1085-1094, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00760-4