Polymer Materials for Cryogenic Storage and Distribution of Biologics

Project Information

ICE_PACK

Grant agreement ID: 866056

DOI

10.3030/866056

EC signature date 3 February 2020

Start date 1 September 2020

End date 31 August 2027

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 863,75

EU contribution

€ 1 999 863,75

Coordinated by

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (37)

Post-thaw application of ROCK-inhibitors increases cryopreserved T-cell yield

Author(s): Natalia Gonzalez-Martinez; Matthew I. Gibson
Published in: RSC Medicinal Chemistry, Issue 1, 2024, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3md00378g

Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation

Author(s): Yanan Gao; Akalabya Bissoyi; Nina L. H. Kinney; Thomas F. Whale; Qiongyu Guo; Matthew I. Gibson
Published in: ChemComm, Issue 9, 2023, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3cc02252h

Cryopreservation of assay-ready hepatocyte monolayers by chemically-induced ice nucleation: preservation of hepatic function and hepatotoxicity screening capabilities

Author(s): Ruben M. F. Tomás; Robert Dallman; Thomas R. Congdon; Matthew I. Gibson
Published in: Biomaterials Science, Issue 2, 2023, ISSN 2047-4849
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3bm01046e

Glycan-Based Flow-Through Device for the Detection of SARS-COV-2

Author(s): Alexander N. Baker, Sarah-Jane Richards, Sarojini Pandey, Collette S. Guy, Ashfaq Ahmad, Muhammad Hasan, Caroline I. Biggs, Panagiotis G. Georgiou, Alexander J. Zwetsloot, Anne Straube, Simone Dedola, Robert A. Field, Neil R. Anderson, Marc Walker, Dimitris Grammatopoulos, Matthew I. Gibson
Published in: ACS Sensors, Issue 6/10, 2021, Page(s) 3696-3705, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.1c01470

Cryopreserved Kidney Epithelial (Vero) Cell Monolayers for Rapid Viral Quantification, Enabled by a Combination of Macromolecular Cryoprotectants

Author(s): Agnieszka Nagorska, Ruben M. F. Tomás, Afifah Tasnim, Nicole C. Robb, Matthew I. Gibson
Published in: Biomacromolecules, Issue 25, 2024, Page(s) 5352-5358, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.4c00760

Lateral Flow Glyco-Assays for the Rapid and Low-Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance

Author(s): Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, Matthew I. Gibson
Published in: Advanced Healthcare Materials, Issue 11, 2022, Page(s) 2101784, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/adhm.202101784

The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation

Author(s): Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N. Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, Inge Nelissen
Published in: Nanoscale, Issue 13/24, 2021, Page(s) 10837-10848, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1nr01548f

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding.

Author(s): Ashfaq Ahmad; Panagiotis G. Georgiou; Alessia Pancaro; Muhammad Hasan; Inge Nelissen; Matthew I. Gibson
Published in: Nanoscale, Issue 14, 2022, Page(s) 13261-13273, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr01818g

Synthesis of poly(vinyl alcohol) by blue light bismuth oxide photocatalysed RAFT. Evaluation of the impact of freeze/thaw cycling on ice recrystallisation inhibition

Author(s): Ioanna Kontopoulou; Thomas R. Congdon; Simon Bassett; Ben Mair; Matthew Gibson
Published in: Polymer Chemistry, 2022, ISSN 1759-9962
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2py00852a

Cryopreservation of Liver-Cell Spheroids with Macromolecular Cryoprotectants.

Author(s): Akalabya Bissoyi; Ruben M. F. Tomás; Yanan Gao; Qiongyu Guo; Matthew I. Gibson
Published in: ACS Applied Materials & Interfaces, Issue 15, 2023, Page(s) 2630–2638, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c18288

Minimalistic ice recrystallisation inhibitors based on phenylalanine.

Author(s): Matthew T. Warren; Iain Galpin; Muhammad Hasan; Steven A. Hindmarsh; John D. Padrnos; Charlotte Edwards-Gayle; Robert T. Mathers; Dave J. Adams; Gabriele C. Sosso; Matthew I. Gibson
Published in: Chemical Communications, 2022, ISSN 1364-548X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cc02531k

Ice Recrystallization Inhibition by Amino Acids: The Curious Case of Alpha- and Beta-Alanine

Author(s): Matthew T. Warren; Iain Galpin; Fabienne Bachtiger; Matthew I. Gibson; Gabriele C. Sosso
Published in: The Journal of Physical Chemistry Letters, Issue 13, 2022, Page(s) 2237-2244, ISSN 1948-7185
Publisher: American Chemical Society
DOI: 10.1021/acs.jpclett.1c04080

Proline pre-conditioning of Jurkat cells improves recovery after cryopreservation

Author(s): Alex Murray; Peter Kilbride; Matthew I. Gibson
Published in: RSC Medicinal Chemistry, Issue 6, 2023, ISSN 2632-8682
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3md00274h

Polymer-Mediated Cryopreservation of Bacteriophages.

Author(s): Huba L Marton, Kathryn M Styles, Peter Kilbride, Antonia P. Sagona, Matthew I. Gibson
Published in: Biomacromolecules, Issue 22, 2021, Page(s) 5281-5289, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.1c01187

Chemically Induced Extracellular Ice Nucleation Reduces Intracellular Ice Formation Enabling 2D and 3D Cellular Cryopreservation

Author(s): Yanan Gao, Christopher A. Griffiths, Nina L. H. Kinney, Qiongyu Guo, Matthew I. Gibson, and Thomas F. Whale
Published in: JACS Au, Issue 3, 2023, Page(s) 1314-1320, ISSN 2691-3704
Publisher: American Chemical Society
DOI: 10.1021/jacsau.3c00056

Chemical approaches to cryopreservation

Author(s): Kathryn A. Murray & Matthew I. Gibson
Published in: Nature Reviews Chemistry, 2022, ISSN 2397-3358
Publisher: Spinger-Nature
DOI: 10.1038/s41570-022-00407-4

Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation

Author(s): Toru Ishibe; Natalia Gonzalez-Martinez; Panagiotis G. Georgiou; Kathryn A. Murray; Matthew I. Gibson
Published in: ACS Polymers Au, Issue 2, 2022, Page(s) 449-457, ISSN 2694-2453
Publisher: American Chemical Society
DOI: 10.1021/acspolymersau.2c00028

Data-driven Discovery of Potent Small Molecule Ice Recrystallisation Inhibitors

Author(s): Matthew T. Warren, Caroline I. Biggs, Akalabya Bissoyi, Matthew I. Gibson, Gabriele C. Sosso
Published in: Nature Communications, 2023, Page(s) 8082, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.26434/chemrxiv-2023-gvvk0

Assay-ready Cryopreserved Cell Monolayers Enabled by Macromolecular Cryoprotectants

Author(s): Ruben M. F. Tomás, Akalabya Bissoyi, Thomas R. Congdon, and Matthew I. Gibson
Published in: Biomacromolecules, 2022, ISSN 1526-4602
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c00791

High interspecific variability in ice nucleation activity suggests pollen ice nucleators are incidental

Author(s): Nina L. H. Kinney, Charles A. Hepburn, Matthew I. Gibson, Daniel Ballesteros, Thomas F. Whale
Published in: Biogeosciences, Issue 21, 2024, Page(s) 3201-3214, ISSN 1726-4189
Publisher: Copernicus GmbH
DOI: 10.5194/bg-21-3201-2024

High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding

Author(s): Nicola Judge, Panagiotis G. Georgiou, Akalabya Bissoyi, Ashfaq Ahmad, Andreas Heise, and Matthew I. Gibson
Published in: Biomacromolecules, Issue 24, 2023, Page(s) 2459-2468, ISSN 1526-4602
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01487

End-functionalized poly(vinylpyrrolidone) for ligand display in lateral flow device test lines

Author(s): Alexander N. Baker; Thomas R. Congdon; Sarah-Jane Richards; Panagiotis G. Georgiou; Marc Walker; Simone Dedola; Robert A. Field; Robert A. Field; Matthew I. Gibson
Published in: Polymers Au, Issue 2, 2021, Page(s) 69-79, ISSN 2694-2453
Publisher: American Chemical Society
DOI: 10.1021/acspolymersau.1c00032

Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation

Author(s): Théo Pesenti; Chen Zhu; Natalia Gonzalez-Martinez; Ruben M. F. Tomás; Matthew I. Gibson; Julien Nicolas
Published in: ACS Macroletters, 2022, ISSN 2161-1653
Publisher: American Chemical Society
DOI: 10.1021/acsmacrolett.2c00298

Cryopreservation and Rapid Recovery of Differentiated Intestinal Epithelial Barrier Cells at Complex Transwell Interfaces Is Enabled by Chemically Induced Ice Nucleation

Author(s): Akalabya Bissoyi; Yanan Gao; Ruben M. F. Tomás; Nina L. H. Kinney; Thomas F. Whale; Qiongyu Guo; Matthew I. Gibson
Published in: ACS Applied Materials and Interfaces, Issue 4, 2024, ISSN 1944-8252
Publisher: American Chemical Society
DOI: 10.1021/acsami.4c03931

Pollen derived macromolecules serve as a new class of ice-nucleating cryoprotectants

Author(s): Murray, K.A.; Kinney, N.L.H.; Griffiths, C.A.; Hasan, M.; Gibson, M.I.; Whale, T.F.
Published in: Scientific Reports, Issue 2, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-15545-4

Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers

Author(s): Marta M. P. S. Neves; Sarah-Jane Richards; Alexander N. Baker; Marc Walker; Panagiotis G. Georgiou; Matthew I. Gibson
Published in: Nanoscale Horizons, 2023, ISSN 2055-6764
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nh00470d

Trehalose in cryopreservation. Applications, mechanisms and intracellular delivery opportunities

Author(s): Alex Murray, Peter Kilbride, Matthew I. Gibson
Published in: RSC Medicinal Chemistry, Issue 15, 2024, Page(s) 2980-2995, ISSN 2632-8682
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4md00174e

Induced Extracellular Ice Nucleation Protects Cocultured Spheroid Interior and Exterior during Cryopreservation

Author(s): Yanan Gao, Akalabya Bissoyi, Qiongyu Guo, Matthew I. Gibson
Published in: ACS Biomaterials Science & Engineering, Issue 11, 2025, Page(s) 208-212, ISSN 2373-9878
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.4c00958

Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice

Author(s): Panagiotis G. Georgiou; Nina L. H. Kinney; Ioanna Kontopoulou; Alexander N. Baker; Steven A. Hindmarsh; Akalabya Bissoyi; Thomas R. Congdon; Thomas F. Whale; Matthew I. Gibson
Published in: Biomacromolecules, Issue 23, 2022, Page(s) 5285–5296, ISSN 1526-4602
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.2c01097

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Author(s): Alexander N. Baker; George W. Hawker-Bond; Panagiotis G. Georgiou; Simone Dedola; Robert A. Field; Matthew I. Gibson
Published in: Chemical Society Reviews, Issue 51, 2022, Page(s) 7238-7259, ISSN 1460-4744
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2cs00267a

Mechanical release of homogenous proteins from supramolecular gels

Author(s): Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave J. Adams
Published in: Nature, Issue 631, 2024, Page(s) 544-548, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07580-0

Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods.

Author(s): Panagiotis G. Georgiou; Collette S. Guy; Muhammad Hasan; Ashfaq Ahmad; Sarah-Jane Richards; Alexander N. Baker; Neer V. Thakkar; Marc Walker; Sarojini Pandey; Neil R. Anderson; Dimitris Grammatopoulos; Matthew I. Gibson
Published in: ACS MacroLetters, 2022, ISSN 2161-1653
Publisher: American Chemical Society
DOI: 10.1021/acsmacrolett.1c00716

Anionic Synthetic Polymers Prevent Bacteriophage Infection

Author(s): Huba L. Marton, Peter Kilbride, Ashfaq Ahmad, Antonia P. Sagona, and Matthew I. Gibson
Published in: Journal of the American Chemical Society, Issue 145, 2023, Page(s) 8794-8799, ISSN 1520-5126
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c01874

Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output

Author(s): Julian Micallef; Alexander N. Baker; Sarah-Jane Richards; Douglas E. Soutar; Panagiotis G. Georgiou; Marc Walker; Matthew I. Gibson
Published in: RSC Advances, 2022, ISSN 2046-2069
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ra06265h

Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition

Author(s): Panagiotis G. Georgiou, Huba L. Marton, Alexander N. Baker, Thomas R. Congdon, Thomas F. Whale, Matthew I. Gibson
Published in: Journal of the American Chemical Society, Issue 143/19, 2021, Page(s) 7449-7461, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c01963

Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation

Author(s): Huba L. Marton; Apoorva Bhatt; Antonia P. Sagona; Peter Kilbride; Matthew I. Gibson
Published in: Biomacromolecules, Issue 3, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.3c01042

Red Blood Cell Cryopreservation with Minimal Post-Thaw Lysis Enabled by a Synergistic Combination of a Cryoprotecting Polyampholyte with DMSO/Trehalose

Author(s): Alex Murray, Thomas R. Congdon, Ruben M. F. Tomás, Peter Kilbride, Matthew I. Gibson
Published in: Biomacromolecules, 2021, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.1c00599