Polymer Materials for Cryogenic Storage and Distribution of Biologics

Información del proyecto

ICE_PACK

Identificador del acuerdo de subvención: 866056

DOI

10.3030/866056

Fecha de la firma de la CE 3 Febrero 2020

Fecha de inicio 1 Septiembre 2020

Fecha de finalización 31 Agosto 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 999 863,75

Aportación de la UE

€ 1 999 863,75

Coordinado por

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (37)

Post-thaw application of ROCK-inhibitors increases cryopreserved T-cell yield

Autores: Natalia Gonzalez-Martinez; Matthew I. Gibson
Publicado en: RSC Medicinal Chemistry, Edición 1, 2024, ISSN 2632-8682
Editor: Royal Society of Chemistry
DOI: 10.1039/d3md00378g

Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation

Autores: Yanan Gao; Akalabya Bissoyi; Nina L. H. Kinney; Thomas F. Whale; Qiongyu Guo; Matthew I. Gibson
Publicado en: ChemComm, Edición 9, 2023, ISSN 1359-7345
Editor: Royal Society of Chemistry
DOI: 10.1039/d3cc02252h

Cryopreservation of assay-ready hepatocyte monolayers by chemically-induced ice nucleation: preservation of hepatic function and hepatotoxicity screening capabilities

Autores: Ruben M. F. Tomás; Robert Dallman; Thomas R. Congdon; Matthew I. Gibson
Publicado en: Biomaterials Science, Edición 2, 2023, ISSN 2047-4849
Editor: Royal Society of Chemistry
DOI: 10.1039/d3bm01046e

Glycan-Based Flow-Through Device for the Detection of SARS-COV-2

Autores: Alexander N. Baker, Sarah-Jane Richards, Sarojini Pandey, Collette S. Guy, Ashfaq Ahmad, Muhammad Hasan, Caroline I. Biggs, Panagiotis G. Georgiou, Alexander J. Zwetsloot, Anne Straube, Simone Dedola, Robert A. Field, Neil R. Anderson, Marc Walker, Dimitris Grammatopoulos, Matthew I. Gibson
Publicado en: ACS Sensors, Edición 6/10, 2021, Página(s) 3696-3705, ISSN 2379-3694
Editor: American Chemical Society
DOI: 10.1021/acssensors.1c01470

Cryopreserved Kidney Epithelial (Vero) Cell Monolayers for Rapid Viral Quantification, Enabled by a Combination of Macromolecular Cryoprotectants

Autores: Agnieszka Nagorska, Ruben M. F. Tomás, Afifah Tasnim, Nicole C. Robb, Matthew I. Gibson
Publicado en: Biomacromolecules, Edición 25, 2024, Página(s) 5352-5358, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.4c00760

Lateral Flow Glyco-Assays for the Rapid and Low-Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance

Autores: Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, Matthew I. Gibson
Publicado en: Advanced Healthcare Materials, Edición 11, 2022, Página(s) 2101784, ISSN 2192-2659
Editor: World Scientific
DOI: 10.1002/adhm.202101784

The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation

Autores: Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N. Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, Inge Nelissen
Publicado en: Nanoscale, Edición 13/24, 2021, Página(s) 10837-10848, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/d1nr01548f

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding.

Autores: Ashfaq Ahmad; Panagiotis G. Georgiou; Alessia Pancaro; Muhammad Hasan; Inge Nelissen; Matthew I. Gibson
Publicado en: Nanoscale, Edición 14, 2022, Página(s) 13261-13273, ISSN 2040-3372
Editor: Royal Society of Chemistry
DOI: 10.1039/d2nr01818g

Synthesis of poly(vinyl alcohol) by blue light bismuth oxide photocatalysed RAFT. Evaluation of the impact of freeze/thaw cycling on ice recrystallisation inhibition

Autores: Ioanna Kontopoulou; Thomas R. Congdon; Simon Bassett; Ben Mair; Matthew Gibson
Publicado en: Polymer Chemistry, 2022, ISSN 1759-9962
Editor: Royal Society of Chemistry
DOI: 10.1039/d2py00852a

Cryopreservation of Liver-Cell Spheroids with Macromolecular Cryoprotectants.

Autores: Akalabya Bissoyi; Ruben M. F. Tomás; Yanan Gao; Qiongyu Guo; Matthew I. Gibson
Publicado en: ACS Applied Materials & Interfaces, Edición 15, 2023, Página(s) 2630–2638, ISSN 1944-8252
Editor: American Chemical Society
DOI: 10.1021/acsami.2c18288

Minimalistic ice recrystallisation inhibitors based on phenylalanine.

Autores: Matthew T. Warren; Iain Galpin; Muhammad Hasan; Steven A. Hindmarsh; John D. Padrnos; Charlotte Edwards-Gayle; Robert T. Mathers; Dave J. Adams; Gabriele C. Sosso; Matthew I. Gibson
Publicado en: Chemical Communications, 2022, ISSN 1364-548X
Editor: Royal Society of Chemistry
DOI: 10.1039/d2cc02531k

Ice Recrystallization Inhibition by Amino Acids: The Curious Case of Alpha- and Beta-Alanine

Autores: Matthew T. Warren; Iain Galpin; Fabienne Bachtiger; Matthew I. Gibson; Gabriele C. Sosso
Publicado en: The Journal of Physical Chemistry Letters, Edición 13, 2022, Página(s) 2237-2244, ISSN 1948-7185
Editor: American Chemical Society
DOI: 10.1021/acs.jpclett.1c04080

Proline pre-conditioning of Jurkat cells improves recovery after cryopreservation

Autores: Alex Murray; Peter Kilbride; Matthew I. Gibson
Publicado en: RSC Medicinal Chemistry, Edición 6, 2023, ISSN 2632-8682
Editor: Royal Society of Chemistry
DOI: 10.1039/d3md00274h

Polymer-Mediated Cryopreservation of Bacteriophages.

Autores: Huba L Marton, Kathryn M Styles, Peter Kilbride, Antonia P. Sagona, Matthew I. Gibson
Publicado en: Biomacromolecules, Edición 22, 2021, Página(s) 5281-5289, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.1c01187

Chemically Induced Extracellular Ice Nucleation Reduces Intracellular Ice Formation Enabling 2D and 3D Cellular Cryopreservation

Autores: Yanan Gao, Christopher A. Griffiths, Nina L. H. Kinney, Qiongyu Guo, Matthew I. Gibson, and Thomas F. Whale
Publicado en: JACS Au, Edición 3, 2023, Página(s) 1314-1320, ISSN 2691-3704
Editor: American Chemical Society
DOI: 10.1021/jacsau.3c00056

Chemical approaches to cryopreservation

Autores: Kathryn A. Murray & Matthew I. Gibson
Publicado en: Nature Reviews Chemistry, 2022, ISSN 2397-3358
Editor: Spinger-Nature
DOI: 10.1038/s41570-022-00407-4

Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation

Autores: Toru Ishibe; Natalia Gonzalez-Martinez; Panagiotis G. Georgiou; Kathryn A. Murray; Matthew I. Gibson
Publicado en: ACS Polymers Au, Edición 2, 2022, Página(s) 449-457, ISSN 2694-2453
Editor: American Chemical Society
DOI: 10.1021/acspolymersau.2c00028

Data-driven Discovery of Potent Small Molecule Ice Recrystallisation Inhibitors

Autores: Matthew T. Warren, Caroline I. Biggs, Akalabya Bissoyi, Matthew I. Gibson, Gabriele C. Sosso
Publicado en: Nature Communications, 2023, Página(s) 8082, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.26434/chemrxiv-2023-gvvk0

Assay-ready Cryopreserved Cell Monolayers Enabled by Macromolecular Cryoprotectants

Autores: Ruben M. F. Tomás, Akalabya Bissoyi, Thomas R. Congdon, and Matthew I. Gibson
Publicado en: Biomacromolecules, 2022, ISSN 1526-4602
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.2c00791

High interspecific variability in ice nucleation activity suggests pollen ice nucleators are incidental

Autores: Nina L. H. Kinney, Charles A. Hepburn, Matthew I. Gibson, Daniel Ballesteros, Thomas F. Whale
Publicado en: Biogeosciences, Edición 21, 2024, Página(s) 3201-3214, ISSN 1726-4189
Editor: Copernicus GmbH
DOI: 10.5194/bg-21-3201-2024

High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding

Autores: Nicola Judge, Panagiotis G. Georgiou, Akalabya Bissoyi, Ashfaq Ahmad, Andreas Heise, and Matthew I. Gibson
Publicado en: Biomacromolecules, Edición 24, 2023, Página(s) 2459-2468, ISSN 1526-4602
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.2c01487

End-functionalized poly(vinylpyrrolidone) for ligand display in lateral flow device test lines

Autores: Alexander N. Baker; Thomas R. Congdon; Sarah-Jane Richards; Panagiotis G. Georgiou; Marc Walker; Simone Dedola; Robert A. Field; Robert A. Field; Matthew I. Gibson
Publicado en: Polymers Au, Edición 2, 2021, Página(s) 69-79, ISSN 2694-2453
Editor: American Chemical Society
DOI: 10.1021/acspolymersau.1c00032

Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation

Autores: Théo Pesenti; Chen Zhu; Natalia Gonzalez-Martinez; Ruben M. F. Tomás; Matthew I. Gibson; Julien Nicolas
Publicado en: ACS Macroletters, 2022, ISSN 2161-1653
Editor: American Chemical Society
DOI: 10.1021/acsmacrolett.2c00298

Cryopreservation and Rapid Recovery of Differentiated Intestinal Epithelial Barrier Cells at Complex Transwell Interfaces Is Enabled by Chemically Induced Ice Nucleation

Autores: Akalabya Bissoyi; Yanan Gao; Ruben M. F. Tomás; Nina L. H. Kinney; Thomas F. Whale; Qiongyu Guo; Matthew I. Gibson
Publicado en: ACS Applied Materials and Interfaces, Edición 4, 2024, ISSN 1944-8252
Editor: American Chemical Society
DOI: 10.1021/acsami.4c03931

Pollen derived macromolecules serve as a new class of ice-nucleating cryoprotectants

Autores: Murray, K.A.; Kinney, N.L.H.; Griffiths, C.A.; Hasan, M.; Gibson, M.I.; Whale, T.F.
Publicado en: Scientific Reports, Edición 2, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-15545-4

Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers

Autores: Marta M. P. S. Neves; Sarah-Jane Richards; Alexander N. Baker; Marc Walker; Panagiotis G. Georgiou; Matthew I. Gibson
Publicado en: Nanoscale Horizons, 2023, ISSN 2055-6764
Editor: Royal Society of Chemistry
DOI: 10.1039/d2nh00470d

Trehalose in cryopreservation. Applications, mechanisms and intracellular delivery opportunities

Autores: Alex Murray, Peter Kilbride, Matthew I. Gibson
Publicado en: RSC Medicinal Chemistry, Edición 15, 2024, Página(s) 2980-2995, ISSN 2632-8682
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4md00174e

Induced Extracellular Ice Nucleation Protects Cocultured Spheroid Interior and Exterior during Cryopreservation

Autores: Yanan Gao, Akalabya Bissoyi, Qiongyu Guo, Matthew I. Gibson
Publicado en: ACS Biomaterials Science & Engineering, Edición 11, 2025, Página(s) 208-212, ISSN 2373-9878
Editor: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.4c00958

Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice

Autores: Panagiotis G. Georgiou; Nina L. H. Kinney; Ioanna Kontopoulou; Alexander N. Baker; Steven A. Hindmarsh; Akalabya Bissoyi; Thomas R. Congdon; Thomas F. Whale; Matthew I. Gibson
Publicado en: Biomacromolecules, Edición 23, 2022, Página(s) 5285–5296, ISSN 1526-4602
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.2c01097

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Autores: Alexander N. Baker; George W. Hawker-Bond; Panagiotis G. Georgiou; Simone Dedola; Robert A. Field; Matthew I. Gibson
Publicado en: Chemical Society Reviews, Edición 51, 2022, Página(s) 7238-7259, ISSN 1460-4744
Editor: Royal Society of Chemistry
DOI: 10.1039/d2cs00267a

Mechanical release of homogenous proteins from supramolecular gels

Autores: Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave J. Adams
Publicado en: Nature, Edición 631, 2024, Página(s) 544-548, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-024-07580-0

Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods.

Autores: Panagiotis G. Georgiou; Collette S. Guy; Muhammad Hasan; Ashfaq Ahmad; Sarah-Jane Richards; Alexander N. Baker; Neer V. Thakkar; Marc Walker; Sarojini Pandey; Neil R. Anderson; Dimitris Grammatopoulos; Matthew I. Gibson
Publicado en: ACS MacroLetters, 2022, ISSN 2161-1653
Editor: American Chemical Society
DOI: 10.1021/acsmacrolett.1c00716

Anionic Synthetic Polymers Prevent Bacteriophage Infection

Autores: Huba L. Marton, Peter Kilbride, Ashfaq Ahmad, Antonia P. Sagona, and Matthew I. Gibson
Publicado en: Journal of the American Chemical Society, Edición 145, 2023, Página(s) 8794-8799, ISSN 1520-5126
Editor: American Chemical Society
DOI: 10.1021/jacs.3c01874

Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output

Autores: Julian Micallef; Alexander N. Baker; Sarah-Jane Richards; Douglas E. Soutar; Panagiotis G. Georgiou; Marc Walker; Matthew I. Gibson
Publicado en: RSC Advances, 2022, ISSN 2046-2069
Editor: Royal Society of Chemistry
DOI: 10.1039/d2ra06265h

Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition

Autores: Panagiotis G. Georgiou, Huba L. Marton, Alexander N. Baker, Thomas R. Congdon, Thomas F. Whale, Matthew I. Gibson
Publicado en: Journal of the American Chemical Society, Edición 143/19, 2021, Página(s) 7449-7461, ISSN 0002-7863
Editor: American Chemical Society
DOI: 10.1021/jacs.1c01963

Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation

Autores: Huba L. Marton; Apoorva Bhatt; Antonia P. Sagona; Peter Kilbride; Matthew I. Gibson
Publicado en: Biomacromolecules, Edición 3, 2023, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.3c01042

Red Blood Cell Cryopreservation with Minimal Post-Thaw Lysis Enabled by a Synergistic Combination of a Cryoprotecting Polyampholyte with DMSO/Trehalose

Autores: Alex Murray, Thomas R. Congdon, Ruben M. F. Tomás, Peter Kilbride, Matthew I. Gibson
Publicado en: Biomacromolecules, 2021, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/acs.biomac.1c00599