Polymer Materials for Cryogenic Storage and Distribution of Biologics

Informazioni relative al progetto

ICE_PACK

ID dell’accordo di sovvenzione: 866056

DOI

10.3030/866056

Data della firma CE 3 Febbraio 2020

Data di avvio 1 Settembre 2020

Data di completamento 31 Agosto 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 999 863,75

Contributo UE

€ 1 999 863,75

Coordinato da

THE UNIVERSITY OF MANCHESTER
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (37)

Post-thaw application of ROCK-inhibitors increases cryopreserved T-cell yield

Autori: Natalia Gonzalez-Martinez; Matthew I. Gibson
Pubblicato in: RSC Medicinal Chemistry, Numero 1, 2024, ISSN 2632-8682
Editore: Royal Society of Chemistry
DOI: 10.1039/d3md00378g

Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation

Autori: Yanan Gao; Akalabya Bissoyi; Nina L. H. Kinney; Thomas F. Whale; Qiongyu Guo; Matthew I. Gibson
Pubblicato in: ChemComm, Numero 9, 2023, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/d3cc02252h

Cryopreservation of assay-ready hepatocyte monolayers by chemically-induced ice nucleation: preservation of hepatic function and hepatotoxicity screening capabilities

Autori: Ruben M. F. Tomás; Robert Dallman; Thomas R. Congdon; Matthew I. Gibson
Pubblicato in: Biomaterials Science, Numero 2, 2023, ISSN 2047-4849
Editore: Royal Society of Chemistry
DOI: 10.1039/d3bm01046e

Glycan-Based Flow-Through Device for the Detection of SARS-COV-2

Autori: Alexander N. Baker, Sarah-Jane Richards, Sarojini Pandey, Collette S. Guy, Ashfaq Ahmad, Muhammad Hasan, Caroline I. Biggs, Panagiotis G. Georgiou, Alexander J. Zwetsloot, Anne Straube, Simone Dedola, Robert A. Field, Neil R. Anderson, Marc Walker, Dimitris Grammatopoulos, Matthew I. Gibson
Pubblicato in: ACS Sensors, Numero 6/10, 2021, Pagina/e 3696-3705, ISSN 2379-3694
Editore: American Chemical Society
DOI: 10.1021/acssensors.1c01470

Cryopreserved Kidney Epithelial (Vero) Cell Monolayers for Rapid Viral Quantification, Enabled by a Combination of Macromolecular Cryoprotectants

Autori: Agnieszka Nagorska, Ruben M. F. Tomás, Afifah Tasnim, Nicole C. Robb, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 25, 2024, Pagina/e 5352-5358, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.4c00760

Lateral Flow Glyco-Assays for the Rapid and Low-Cost Detection of Lectins–Polymeric Linkers and Particle Engineering Are Essential for Selectivity and Performance

Autori: Alexander N. Baker, Asier R. Muguruza, Sarah-Jane Richards, Panagiotis G. Georgiou, Stephen Goetz, Marc Walker, Simone Dedola, Robert A. Field, Matthew I. Gibson
Pubblicato in: Advanced Healthcare Materials, Numero 11, 2022, Pagina/e 2101784, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/adhm.202101784

The polymeric glyco-linker controls the signal outputs for plasmonic gold nanorod biosensors due to biocorona formation

Autori: Alessia Pancaro, Michal Szymonik, Panagiotis G. Georgiou, Alexander N. Baker, Marc Walker, Peter Adriaensens, Jelle Hendrix, Matthew I. Gibson, Inge Nelissen
Pubblicato in: Nanoscale, Numero 13/24, 2021, Pagina/e 10837-10848, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/d1nr01548f

Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding.

Autori: Ashfaq Ahmad; Panagiotis G. Georgiou; Alessia Pancaro; Muhammad Hasan; Inge Nelissen; Matthew I. Gibson
Pubblicato in: Nanoscale, Numero 14, 2022, Pagina/e 13261-13273, ISSN 2040-3372
Editore: Royal Society of Chemistry
DOI: 10.1039/d2nr01818g

Synthesis of poly(vinyl alcohol) by blue light bismuth oxide photocatalysed RAFT. Evaluation of the impact of freeze/thaw cycling on ice recrystallisation inhibition

Autori: Ioanna Kontopoulou; Thomas R. Congdon; Simon Bassett; Ben Mair; Matthew Gibson
Pubblicato in: Polymer Chemistry, 2022, ISSN 1759-9962
Editore: Royal Society of Chemistry
DOI: 10.1039/d2py00852a

Cryopreservation of Liver-Cell Spheroids with Macromolecular Cryoprotectants.

Autori: Akalabya Bissoyi; Ruben M. F. Tomás; Yanan Gao; Qiongyu Guo; Matthew I. Gibson
Pubblicato in: ACS Applied Materials & Interfaces, Numero 15, 2023, Pagina/e 2630–2638, ISSN 1944-8252
Editore: American Chemical Society
DOI: 10.1021/acsami.2c18288

Minimalistic ice recrystallisation inhibitors based on phenylalanine.

Autori: Matthew T. Warren; Iain Galpin; Muhammad Hasan; Steven A. Hindmarsh; John D. Padrnos; Charlotte Edwards-Gayle; Robert T. Mathers; Dave J. Adams; Gabriele C. Sosso; Matthew I. Gibson
Pubblicato in: Chemical Communications, 2022, ISSN 1364-548X
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cc02531k

Ice Recrystallization Inhibition by Amino Acids: The Curious Case of Alpha- and Beta-Alanine

Autori: Matthew T. Warren; Iain Galpin; Fabienne Bachtiger; Matthew I. Gibson; Gabriele C. Sosso
Pubblicato in: The Journal of Physical Chemistry Letters, Numero 13, 2022, Pagina/e 2237-2244, ISSN 1948-7185
Editore: American Chemical Society
DOI: 10.1021/acs.jpclett.1c04080

Proline pre-conditioning of Jurkat cells improves recovery after cryopreservation

Autori: Alex Murray; Peter Kilbride; Matthew I. Gibson
Pubblicato in: RSC Medicinal Chemistry, Numero 6, 2023, ISSN 2632-8682
Editore: Royal Society of Chemistry
DOI: 10.1039/d3md00274h

Polymer-Mediated Cryopreservation of Bacteriophages.

Autori: Huba L Marton, Kathryn M Styles, Peter Kilbride, Antonia P. Sagona, Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 22, 2021, Pagina/e 5281-5289, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.1c01187

Chemically Induced Extracellular Ice Nucleation Reduces Intracellular Ice Formation Enabling 2D and 3D Cellular Cryopreservation

Autori: Yanan Gao, Christopher A. Griffiths, Nina L. H. Kinney, Qiongyu Guo, Matthew I. Gibson, and Thomas F. Whale
Pubblicato in: JACS Au, Numero 3, 2023, Pagina/e 1314-1320, ISSN 2691-3704
Editore: American Chemical Society
DOI: 10.1021/jacsau.3c00056

Chemical approaches to cryopreservation

Autori: Kathryn A. Murray & Matthew I. Gibson
Pubblicato in: Nature Reviews Chemistry, 2022, ISSN 2397-3358
Editore: Spinger-Nature
DOI: 10.1038/s41570-022-00407-4

Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation

Autori: Toru Ishibe; Natalia Gonzalez-Martinez; Panagiotis G. Georgiou; Kathryn A. Murray; Matthew I. Gibson
Pubblicato in: ACS Polymers Au, Numero 2, 2022, Pagina/e 449-457, ISSN 2694-2453
Editore: American Chemical Society
DOI: 10.1021/acspolymersau.2c00028

Data-driven Discovery of Potent Small Molecule Ice Recrystallisation Inhibitors

Autori: Matthew T. Warren, Caroline I. Biggs, Akalabya Bissoyi, Matthew I. Gibson, Gabriele C. Sosso
Pubblicato in: Nature Communications, 2023, Pagina/e 8082, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.26434/chemrxiv-2023-gvvk0

Assay-ready Cryopreserved Cell Monolayers Enabled by Macromolecular Cryoprotectants

Autori: Ruben M. F. Tomás, Akalabya Bissoyi, Thomas R. Congdon, and Matthew I. Gibson
Pubblicato in: Biomacromolecules, 2022, ISSN 1526-4602
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c00791

High interspecific variability in ice nucleation activity suggests pollen ice nucleators are incidental

Autori: Nina L. H. Kinney, Charles A. Hepburn, Matthew I. Gibson, Daniel Ballesteros, Thomas F. Whale
Pubblicato in: Biogeosciences, Numero 21, 2024, Pagina/e 3201-3214, ISSN 1726-4189
Editore: Copernicus GmbH
DOI: 10.5194/bg-21-3201-2024

High Molecular Weight Polyproline as a Potential Biosourced Ice Growth Inhibitor: Synthesis, Ice Recrystallization Inhibition, and Specific Ice Face Binding

Autori: Nicola Judge, Panagiotis G. Georgiou, Akalabya Bissoyi, Ashfaq Ahmad, Andreas Heise, and Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 24, 2023, Pagina/e 2459-2468, ISSN 1526-4602
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c01487

End-functionalized poly(vinylpyrrolidone) for ligand display in lateral flow device test lines

Autori: Alexander N. Baker; Thomas R. Congdon; Sarah-Jane Richards; Panagiotis G. Georgiou; Marc Walker; Simone Dedola; Robert A. Field; Robert A. Field; Matthew I. Gibson
Pubblicato in: Polymers Au, Numero 2, 2021, Pagina/e 69-79, ISSN 2694-2453
Editore: American Chemical Society
DOI: 10.1021/acspolymersau.1c00032

Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation

Autori: Théo Pesenti; Chen Zhu; Natalia Gonzalez-Martinez; Ruben M. F. Tomás; Matthew I. Gibson; Julien Nicolas
Pubblicato in: ACS Macroletters, 2022, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.2c00298

Cryopreservation and Rapid Recovery of Differentiated Intestinal Epithelial Barrier Cells at Complex Transwell Interfaces Is Enabled by Chemically Induced Ice Nucleation

Autori: Akalabya Bissoyi; Yanan Gao; Ruben M. F. Tomás; Nina L. H. Kinney; Thomas F. Whale; Qiongyu Guo; Matthew I. Gibson
Pubblicato in: ACS Applied Materials and Interfaces, Numero 4, 2024, ISSN 1944-8252
Editore: American Chemical Society
DOI: 10.1021/acsami.4c03931

Pollen derived macromolecules serve as a new class of ice-nucleating cryoprotectants

Autori: Murray, K.A.; Kinney, N.L.H.; Griffiths, C.A.; Hasan, M.; Gibson, M.I.; Whale, T.F.
Pubblicato in: Scientific Reports, Numero 2, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-15545-4

Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers

Autori: Marta M. P. S. Neves; Sarah-Jane Richards; Alexander N. Baker; Marc Walker; Panagiotis G. Georgiou; Matthew I. Gibson
Pubblicato in: Nanoscale Horizons, 2023, ISSN 2055-6764
Editore: Royal Society of Chemistry
DOI: 10.1039/d2nh00470d

Trehalose in cryopreservation. Applications, mechanisms and intracellular delivery opportunities

Autori: Alex Murray, Peter Kilbride, Matthew I. Gibson
Pubblicato in: RSC Medicinal Chemistry, Numero 15, 2024, Pagina/e 2980-2995, ISSN 2632-8682
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4md00174e

Induced Extracellular Ice Nucleation Protects Cocultured Spheroid Interior and Exterior during Cryopreservation

Autori: Yanan Gao, Akalabya Bissoyi, Qiongyu Guo, Matthew I. Gibson
Pubblicato in: ACS Biomaterials Science & Engineering, Numero 11, 2025, Pagina/e 208-212, ISSN 2373-9878
Editore: American Chemical Society (ACS)
DOI: 10.1021/acsbiomaterials.4c00958

Poly(vinyl alcohol) Molecular Bottlebrushes Nucleate Ice

Autori: Panagiotis G. Georgiou; Nina L. H. Kinney; Ioanna Kontopoulou; Alexander N. Baker; Steven A. Hindmarsh; Akalabya Bissoyi; Thomas R. Congdon; Thomas F. Whale; Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 23, 2022, Pagina/e 5285–5296, ISSN 1526-4602
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.2c01097

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Autori: Alexander N. Baker; George W. Hawker-Bond; Panagiotis G. Georgiou; Simone Dedola; Robert A. Field; Matthew I. Gibson
Pubblicato in: Chemical Society Reviews, Numero 51, 2022, Pagina/e 7238-7259, ISSN 1460-4744
Editore: Royal Society of Chemistry
DOI: 10.1039/d2cs00267a

Mechanical release of homogenous proteins from supramolecular gels

Autori: Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave J. Adams
Pubblicato in: Nature, Numero 631, 2024, Pagina/e 544-548, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07580-0

Plasmonic Detection of SARS-CoV-2 Spike Protein with Polymer-Stabilized Glycosylated Gold Nanorods.

Autori: Panagiotis G. Georgiou; Collette S. Guy; Muhammad Hasan; Ashfaq Ahmad; Sarah-Jane Richards; Alexander N. Baker; Neer V. Thakkar; Marc Walker; Sarojini Pandey; Neil R. Anderson; Dimitris Grammatopoulos; Matthew I. Gibson
Pubblicato in: ACS MacroLetters, 2022, ISSN 2161-1653
Editore: American Chemical Society
DOI: 10.1021/acsmacrolett.1c00716

Anionic Synthetic Polymers Prevent Bacteriophage Infection

Autori: Huba L. Marton, Peter Kilbride, Ashfaq Ahmad, Antonia P. Sagona, and Matthew I. Gibson
Pubblicato in: Journal of the American Chemical Society, Numero 145, 2023, Pagina/e 8794-8799, ISSN 1520-5126
Editore: American Chemical Society
DOI: 10.1021/jacs.3c01874

Polymer-tethered glyconanoparticle colourimetric biosensors for lectin binding: structural and experimental parameters to ensure a robust output

Autori: Julian Micallef; Alexander N. Baker; Sarah-Jane Richards; Douglas E. Soutar; Panagiotis G. Georgiou; Marc Walker; Matthew I. Gibson
Pubblicato in: RSC Advances, 2022, ISSN 2046-2069
Editore: Royal Society of Chemistry
DOI: 10.1039/d2ra06265h

Polymer Self-Assembly Induced Enhancement of Ice Recrystallization Inhibition

Autori: Panagiotis G. Georgiou, Huba L. Marton, Alexander N. Baker, Thomas R. Congdon, Thomas F. Whale, Matthew I. Gibson
Pubblicato in: Journal of the American Chemical Society, Numero 143/19, 2021, Pagina/e 7449-7461, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.1c01963

Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation

Autori: Huba L. Marton; Apoorva Bhatt; Antonia P. Sagona; Peter Kilbride; Matthew I. Gibson
Pubblicato in: Biomacromolecules, Numero 3, 2023, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.3c01042

Red Blood Cell Cryopreservation with Minimal Post-Thaw Lysis Enabled by a Synergistic Combination of a Cryoprotecting Polyampholyte with DMSO/Trehalose

Autori: Alex Murray, Thomas R. Congdon, Ruben M. F. Tomás, Peter Kilbride, Matthew I. Gibson
Pubblicato in: Biomacromolecules, 2021, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/acs.biomac.1c00599