Computational Hematopathology for Improved Diagnostics

Información del proyecto

CompHematoPathology

Identificador del acuerdo de subvención: 866411

DOI

10.3030/866411

Fecha de la firma de la CE 4 Febrero 2020

Fecha de inicio 1 Junio 2020

Fecha de finalización 31 Mayo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 981 213,00

Aportación de la UE

€ 1 981 213,00

Coordinado por

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Book chapters (1)

Sickle Cell Disease Severity Prediction from Percoll Gradient Images Using Graph Convolutional Networks

Autores: Ario Sadafi, Asya Makhro, Leonid Livshits, Nassir Navab, Anna Bogdanova, Shadi Albarqouni, Carsten Marr
Publicado en: Lecture Notes in Computer Science, Domain Adaptation and Representation Transfer, and Affordable Healthcare and AI for Resource Diverse Global Health, 2023, Página(s) 216-225
Editor: Springer International Publishing
DOI: 10.1007/978-3-030-87722-4_20

Peer reviewed articles (16)

Built to last? Reproducibility and Reusability of Deep Learning Algorithms in Computational Pathology

Autores: Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sadafi, Dominik J. E. Waibel, Carsten Marr, Tingying Peng
Publicado en: Modern Pathology, 2024, ISSN 0893-3952
Editor: Nature Publishing Group
DOI: 10.1101/2022.05.15.22275108

Mechanistic models of blood cell fate decisions in the era of single-cell data

Autores: Ingmar Glauche 1 , Carsten Marr 2
Publicado en: Current Opinion in Systems Biology , Edición Monthly, 2021, ISSN 2452-3100
Editor: Elsevier
DOI: 10.1016/j.coisb.2021.100355

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

Autores: Bruno L. Cadilha, Mohamed-Reda Benmebarek, Klara Dorman, Arman Oner, Theo Lorenzini, Hannah Obeck, Mira Vänttinen, Mauro Di Pilato, Jasper N. Pruessmann, Stefan Stoiber, Duc Huynh, Florian Märkl, Matthias Seifert, Katrin Manske, Javier Suarez-Gosalvez, Yi Zeng, Stefanie Lesch, Clara H. Karches, Constanze Heise, Adrian Gottschlich, Moritz Thomas, Carsten Marr, Jin Zhang, Dharmendra Pandey, Tobias
Publicado en: Science Advances, Edición 7, 2024, ISSN 2375-2548
Editor: AAAS
DOI: 10.1126/sciadv.abi5781

Modeling early treatment response in AML from cell-free tumor DNA

Autores: Dantong Wang, Christian Rausch, Simon A. Buerger, Sebastian Tschuri, Maja Rothenberg-Thurley, Melanie Schulz, Jan Hasenauer, Frank Ziemann, Klaus H. Metzeler, Carsten Marr
Publicado en: iScience, Edición 26, 2025, Página(s) 108271, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2023.108271

H4K20 Methylation Is Differently Regulated by Dilution and Demethylation in Proliferating and Cell- Cycle-Arrested Xenopus Embryos

Autores: Lea Schuh 1 , Carolin Loos 2 , Daniil Pokrovsky 3 , Axel Imhof 3 , Ralph A W Rupp 3 , Carsten Marr 4
Publicado en: Cell Systems, Edición Monthly, 2020, ISSN 2405-4712
Editor: Elsevier Inc
DOI: 10.1016/j.cels.2020.11.003

InstantDL - An easy-to-use deep learning pipeline for image segmentation and classification

Autores: Dominik Jens Elias Waibel, Sayedali Shetab Boushehri & Carsten Marr
Publicado en: BMC Bioinformatics, Edición Monthly, 2021, ISSN 1471-2105
Editor: BioMed Central
DOI: 10.1186/s12859-021-04037-3

Spatial proteomics in neurons at single-protein resolution

Autores: Eduard M. Unterauer, Sayedali Shetab Boushehri, Kristina Jevdokimenko, Luciano A. Masullo, Mahipal Ganji, Shama Sograte-Idrissi, Rafal Kowalewski, Sebastian Strauss, Susanne C.M. Reinhardt, Ana Perovic, Carsten Marr, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann
Publicado en: Cell, 2024, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1101/2023.05.17.541210

CHIP & HIPs: Clonal Hematopoiesis is Common in Hip Arthroplasty Patients and Associates with Autoimmune Disease

Autores: Judith S. Hecker, Luise Hartmann, Jennifer Rivière, Michèle C. Buck, Mark van der Garde, Maja Rothenberg-Thurley, Luise Fischer, Susann Winter, Bianka Ksienzyk, Frank Ziemann, Maria Solovey, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Alexander C. Paulus, Jörg Lützner, Andreas Roth, Florian Bassermann, Karsten Spiekermann, Ca
Publicado en: Blood Journal, Edición 8, 2021, ISSN 0006-4971
Editor: American Society of Hematology

Highly accurate differentiation of bone marrow cell morphologies using deep neural networks on a large image data set

Autores: Christian Matek, Sebastian Krappe, Christian Münzenmayer, Torsten Haferlach, Carsten Marr
Publicado en: Blood, Edición 138, 2021, Página(s) 1917-1927, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020010568

Make deep learning algorithms in computational pathology more reproducible and reusable

Autores: Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sadafi, Dominik J. E. Waibel, Carsten Marr, Tingying Peng
Publicado en: Nature Medicine, Edición 28, 2022, Página(s) 1744-1746, ISSN 1078-8956
Editor: Nature Publishing Group
DOI: 10.1038/s41591-022-01905-0

Explainable AI identifies diagnostic cells of genetic AML subtypes

Autores: Matthias Hehr, Ario Sadafi, Christian Matek, Peter Lienemann, Christian Pohlkamp, Torsten Haferlach, Karsten Spiekermann, Carsten Marr
Publicado en: PLOS Digital Health, Edición 2, 2023, Página(s) e0000187, ISSN 2767-3170
Editor: PLOS
DOI: 10.1371/journal.pdig.0000187

Highly accurate differentiation of bone marrow cell morphologies using deep neural networks on a large image dataset

Autores: "Christian Matek, Sebastian Krappe, Christian Münzenmayer, Torsten Haferlach, Carsten Marr"""
Publicado en: Blood Journal, Edición Monthly, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020010568

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Autores: Adrian Gottschlich, Moritz Thomas, Ruth Grünmeier, Stefanie Lesch, Lisa Rohrbacher, Veronika Igl, Daria Briukhovetska, Mohamed-Reda Benmebarek, Binje Vick, Sertac Dede, Katharina Müller, Tao Xu, Dario Dhoqina, Florian Märkl, Sophie Robinson, Andrea Sendelhofert, Heiko Schulz, Öykü Umut, Vladyslav Kavaka, Christina Angeliki Tsiverioti, Emanuele Carlini, Sayantan Nandi, Thaddäus Strzalkowski,
Publicado en: Nature Biotechnology, Edición 41, 2023, Página(s) 1618-1632, ISSN 1087-0156
Editor: Nature Publishing Group
DOI: 10.1038/s41587-023-01684-0

Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies

Autores: Sayedali Shetab Boushehri, Katharina Essig, Nikolaos-Kosmas Chlis, Sylvia Herter, Marina Bacac, Fabian J. Theis, Elke Glasmacher, Carsten Marr, Fabian Schmich
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-43429-2

Tens of images can suffice to train neural networks for malignant leukocyte detection

Autores: Jens P. E. Schouten, Christian Matek, Luuk F. P. Jacobs, Michèle C. Buck, Dragan Bošnački, Carsten Marr
Publicado en: Scientific Reports, Edición 11, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-86995-5

Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS

Autores: Michèle C. Buck, Lisa Bast, Judith S. Hecker, Jennifer Rivière, Maja Rothenberg-Thurley, Luisa Vogel, Dantong Wang, Immanuel Andrä, Fabian J. Theis, Florian Bassermann, Klaus H. Metzeler, Robert A.J. Oostendorp, Carsten Marr, Katharina S. Götze
Publicado en: iScience, Edición 26, 2024, Página(s) 107328, ISSN 2589-0042
Editor: Elsevier
DOI: 10.1016/j.isci.2023.107328

Conference proceedings (2)

CHIP & HIPs: Clonal Hematopoiesis is Common in Hip Arthroplasty Patients and Associates with Autoimmune Disease

Autores: Judith S. Hecker, Luise Hartmann, Jennifer Rivière, Michèle C. Buck, Mark van der Garde, Maja Rothenberg-Thurley, Luise Fischer, Susann Winter, Bianka Ksienzyk, Frank Ziemann, Maria Solovey, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Alexander C. Paulus, Jörg Lützner, Andreas Roth, Florian Bassermann, Karsten Spiekermann, Ca
Publicado en: Blood Journal, Edición Monthly, 2021, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2020010163

Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies

Autores: Lisa Bast 1 2 , Michèle C Buck 3 , Judith S Hecker 3 , Robert A J Oostendorp 3 , Katharina S Götze 3 4 , Carsten Marr 1 2
Publicado en: iScience , Edición Monthly, 2021, ISSN 2589-0042
Editor: Elsevier Inc
DOI: 10.1016/j.isci.2021.102120