Computational Hematopathology for Improved Diagnostics

Informazioni relative al progetto

CompHematoPathology

ID dell’accordo di sovvenzione: 866411

DOI

10.3030/866411

Data della firma CE 4 Febbraio 2020

Data di avvio 1 Giugno 2020

Data di completamento 31 Maggio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 981 213,00

Contributo UE

€ 1 981 213,00

Coordinato da

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Book chapters (1)

Sickle Cell Disease Severity Prediction from Percoll Gradient Images Using Graph Convolutional Networks

Autori: Ario Sadafi, Asya Makhro, Leonid Livshits, Nassir Navab, Anna Bogdanova, Shadi Albarqouni, Carsten Marr
Pubblicato in: Lecture Notes in Computer Science, Domain Adaptation and Representation Transfer, and Affordable Healthcare and AI for Resource Diverse Global Health, 2023, Pagina/e 216-225
Editore: Springer International Publishing
DOI: 10.1007/978-3-030-87722-4_20

Peer reviewed articles (16)

Built to last? Reproducibility and Reusability of Deep Learning Algorithms in Computational Pathology

Autori: Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sadafi, Dominik J. E. Waibel, Carsten Marr, Tingying Peng
Pubblicato in: Modern Pathology, 2024, ISSN 0893-3952
Editore: Nature Publishing Group
DOI: 10.1101/2022.05.15.22275108

Mechanistic models of blood cell fate decisions in the era of single-cell data

Autori: Ingmar Glauche 1 , Carsten Marr 2
Pubblicato in: Current Opinion in Systems Biology , Numero Monthly, 2021, ISSN 2452-3100
Editore: Elsevier
DOI: 10.1016/j.coisb.2021.100355

Combined tumor-directed recruitment and protection from immune suppression enable CAR T cell efficacy in solid tumors

Autori: Bruno L. Cadilha, Mohamed-Reda Benmebarek, Klara Dorman, Arman Oner, Theo Lorenzini, Hannah Obeck, Mira Vänttinen, Mauro Di Pilato, Jasper N. Pruessmann, Stefan Stoiber, Duc Huynh, Florian Märkl, Matthias Seifert, Katrin Manske, Javier Suarez-Gosalvez, Yi Zeng, Stefanie Lesch, Clara H. Karches, Constanze Heise, Adrian Gottschlich, Moritz Thomas, Carsten Marr, Jin Zhang, Dharmendra Pandey, Tobias
Pubblicato in: Science Advances, Numero 7, 2024, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abi5781

Modeling early treatment response in AML from cell-free tumor DNA

Autori: Dantong Wang, Christian Rausch, Simon A. Buerger, Sebastian Tschuri, Maja Rothenberg-Thurley, Melanie Schulz, Jan Hasenauer, Frank Ziemann, Klaus H. Metzeler, Carsten Marr
Pubblicato in: iScience, Numero 26, 2025, Pagina/e 108271, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2023.108271

H4K20 Methylation Is Differently Regulated by Dilution and Demethylation in Proliferating and Cell- Cycle-Arrested Xenopus Embryos

Autori: Lea Schuh 1 , Carolin Loos 2 , Daniil Pokrovsky 3 , Axel Imhof 3 , Ralph A W Rupp 3 , Carsten Marr 4
Pubblicato in: Cell Systems, Numero Monthly, 2020, ISSN 2405-4712
Editore: Elsevier Inc
DOI: 10.1016/j.cels.2020.11.003

InstantDL - An easy-to-use deep learning pipeline for image segmentation and classification

Autori: Dominik Jens Elias Waibel, Sayedali Shetab Boushehri & Carsten Marr
Pubblicato in: BMC Bioinformatics, Numero Monthly, 2021, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-021-04037-3

Spatial proteomics in neurons at single-protein resolution

Autori: Eduard M. Unterauer, Sayedali Shetab Boushehri, Kristina Jevdokimenko, Luciano A. Masullo, Mahipal Ganji, Shama Sograte-Idrissi, Rafal Kowalewski, Sebastian Strauss, Susanne C.M. Reinhardt, Ana Perovic, Carsten Marr, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann
Pubblicato in: Cell, 2024, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1101/2023.05.17.541210

CHIP & HIPs: Clonal Hematopoiesis is Common in Hip Arthroplasty Patients and Associates with Autoimmune Disease

Autori: Judith S. Hecker, Luise Hartmann, Jennifer Rivière, Michèle C. Buck, Mark van der Garde, Maja Rothenberg-Thurley, Luise Fischer, Susann Winter, Bianka Ksienzyk, Frank Ziemann, Maria Solovey, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Alexander C. Paulus, Jörg Lützner, Andreas Roth, Florian Bassermann, Karsten Spiekermann, Ca
Pubblicato in: Blood Journal, Numero 8, 2021, ISSN 0006-4971
Editore: American Society of Hematology

Highly accurate differentiation of bone marrow cell morphologies using deep neural networks on a large image data set

Autori: Christian Matek, Sebastian Krappe, Christian Münzenmayer, Torsten Haferlach, Carsten Marr
Pubblicato in: Blood, Numero 138, 2021, Pagina/e 1917-1927, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020010568

Make deep learning algorithms in computational pathology more reproducible and reusable

Autori: Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sadafi, Dominik J. E. Waibel, Carsten Marr, Tingying Peng
Pubblicato in: Nature Medicine, Numero 28, 2022, Pagina/e 1744-1746, ISSN 1078-8956
Editore: Nature Publishing Group
DOI: 10.1038/s41591-022-01905-0

Explainable AI identifies diagnostic cells of genetic AML subtypes

Autori: Matthias Hehr, Ario Sadafi, Christian Matek, Peter Lienemann, Christian Pohlkamp, Torsten Haferlach, Karsten Spiekermann, Carsten Marr
Pubblicato in: PLOS Digital Health, Numero 2, 2023, Pagina/e e0000187, ISSN 2767-3170
Editore: PLOS
DOI: 10.1371/journal.pdig.0000187

Highly accurate differentiation of bone marrow cell morphologies using deep neural networks on a large image dataset

Autori: "Christian Matek, Sebastian Krappe, Christian Münzenmayer, Torsten Haferlach, Carsten Marr"""
Pubblicato in: Blood Journal, Numero Monthly, 2021, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020010568

Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

Autori: Adrian Gottschlich, Moritz Thomas, Ruth Grünmeier, Stefanie Lesch, Lisa Rohrbacher, Veronika Igl, Daria Briukhovetska, Mohamed-Reda Benmebarek, Binje Vick, Sertac Dede, Katharina Müller, Tao Xu, Dario Dhoqina, Florian Märkl, Sophie Robinson, Andrea Sendelhofert, Heiko Schulz, Öykü Umut, Vladyslav Kavaka, Christina Angeliki Tsiverioti, Emanuele Carlini, Sayantan Nandi, Thaddäus Strzalkowski,
Pubblicato in: Nature Biotechnology, Numero 41, 2023, Pagina/e 1618-1632, ISSN 1087-0156
Editore: Nature Publishing Group
DOI: 10.1038/s41587-023-01684-0

Explainable machine learning for profiling the immunological synapse and functional characterization of therapeutic antibodies

Autori: Sayedali Shetab Boushehri, Katharina Essig, Nikolaos-Kosmas Chlis, Sylvia Herter, Marina Bacac, Fabian J. Theis, Elke Glasmacher, Carsten Marr, Fabian Schmich
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-43429-2

Tens of images can suffice to train neural networks for malignant leukocyte detection

Autori: Jens P. E. Schouten, Christian Matek, Luuk F. P. Jacobs, Michèle C. Buck, Dragan Bošnački, Carsten Marr
Pubblicato in: Scientific Reports, Numero 11, 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-86995-5

Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS

Autori: Michèle C. Buck, Lisa Bast, Judith S. Hecker, Jennifer Rivière, Maja Rothenberg-Thurley, Luisa Vogel, Dantong Wang, Immanuel Andrä, Fabian J. Theis, Florian Bassermann, Klaus H. Metzeler, Robert A.J. Oostendorp, Carsten Marr, Katharina S. Götze
Pubblicato in: iScience, Numero 26, 2024, Pagina/e 107328, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2023.107328

Conference proceedings (2)

CHIP & HIPs: Clonal Hematopoiesis is Common in Hip Arthroplasty Patients and Associates with Autoimmune Disease

Autori: Judith S. Hecker, Luise Hartmann, Jennifer Rivière, Michèle C. Buck, Mark van der Garde, Maja Rothenberg-Thurley, Luise Fischer, Susann Winter, Bianka Ksienzyk, Frank Ziemann, Maria Solovey, Martina Rauner, Elena Tsourdi, Katja Sockel, Marie Schneider, Anne S. Kubasch, Martin Nolde, Dominikus Hausmann, Alexander C. Paulus, Jörg Lützner, Andreas Roth, Florian Bassermann, Karsten Spiekermann, Ca
Pubblicato in: Blood Journal, Numero Monthly, 2021, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2020010163

Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies

Autori: Lisa Bast 1 2 , Michèle C Buck 3 , Judith S Hecker 3 , Robert A J Oostendorp 3 , Katharina S Götze 3 4 , Carsten Marr 1 2
Pubblicato in: iScience , Numero Monthly, 2021, ISSN 2589-0042
Editore: Elsevier Inc
DOI: 10.1016/j.isci.2021.102120