Fluorescence imaging of biological processes in live animals is an excellent non-invasive bioanalytical tool. Due to the intrinsic properties of biological tissues, only red-fluorescing dyes can be used for the imaging. Currently available dyes of this type exhibit important disadvantages including their clear bias towards particular intracellular organelles, for example mitochondria. Therefore, distribution of drug~dye conjugates in live animals is often dominated by the dye, rather than by the drug. The problem is especially prominent if the drug is a low-molecular weight compound. The majority of currently used in clinics drugs are compounds of such type. NoBiasFluors works on solving this problem by developing non-biased red-fluorescing dyes suitable for in vivo imaging of distribution of low molecular weight drugs. If the goal is achieved, it will allow substantial expanding our knowledge on the mode of action of typical drugs.