Descrizione del progetto
La diagnostica su supporto cartaceo potrebbe rimuovere le attuali barriere alla diffusione di test sul campo
Gli acidi nucleici (comprendenti l’acido desossiribonucleico o DNA e l’acido ribonucleico o RNA) sono presenti in tutte le cellule e i virus. Test di amplificazione dell’acido nucleico vengono sempre più utilizzati per agevolare il rilevamento del DNA o dell’RNA associato a batteri, virus o altri agenti patogeni anche se presenti in quantità molto ridotte. Tuttavia, sono ancora relativamente complessi e costosi per l’uso diffuso nei sistemi diagnostici rapidi ambulatoriali (POC). IPANEMA ha formato una vasta rete di competenze multidisciplinari per realizzare rapidamente il potenziale delle piattaforme di microfluidica su supporto cartaceo. Con partner in Europa, negli Stati Uniti e in paesi terzi che comprendono PMI e studiosi, IPANEMA sta lavorando a diverse tecnologie che possono essere integrate con gli smartphone per una diagnostica POC sofisticata, ma economica e di facile utilizzo.
Obiettivo
Twelve-member IPANEMA consortium implements competences of participating academic & industry beneficiaries
and 3rd country partners to 1) create a knowledge/experience-sharing network of scientists, entrepreneurs & endusers
in the multidisciplinary field of biosensors for POCT (point-of care testing); 2) develop innovative bottom-up
approaches for fabrication of low-cost POCT devices & implementation of paper-based nucleic acid testing (NAT);
3) pursue applications in 3 important industry sectors – healthcare, agrifood & environmental monitoring. Research
& Innovation (R&I) activities will be focused on developing low-cost paper-based isothermal NATs, their integration
into microfluidic devices and optimization for use in a) tissue engineering b) agrifood (poultry/plant/fungal) pathogen
detection c) detection of toxigenic freshwater Cyanobacteria causing harmful algal blooms. Secondments & trainings
will enable researchers to acquire both technical & soft skills needed for converting scientific knowledge & ideas
into products & services. Strong involvement of 4 SME partners from Serbia, Israel, France & US contributing their
proprietary knowledge on revolutionary novel materials for microfluidic devices & DNA extraction kits, domain
expertise in agrifood sector, unique portable sensing systems & handheld devices for isoNAT quantification, will help
researchers focus their efforts on development of innovative products for real-life use. Several transducing methods
(colorimetric, fluorescence, SPR, electrochemical, microwave & magnetic) and smartphone-based read-out methods
will be investigated for POCT use. Renowned beneficiaries including academic INRAE, WU, INESC MN, BGU,
UNSPMF & BIOS together with 3rd country academic partners: Columbia University and Xi'an Jiaotong University,
will provide transfer of cutting-edge knowledge and technical expertise in effect yielding good basis for long term
collaboration and joint R&I projects.
Campo scientifico
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- engineering and technologyenvironmental biotechnologybiosensing
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- medical and health sciencesmedical biotechnologytissue engineering
Parole chiave
Programma(i)
Meccanismo di finanziamento
MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)Coordinatore
21000 Novi Sad
Serbia