Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Project Information

InterTAU

Grant agreement ID: 873127

DOI

10.3030/873127

Project closed

EC signature date 27 November 2019

Start date 1 January 2020

End date 30 June 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 1 058 000,00

EU contribution

€ 1 058 000,00

Coordinated by

Masarykova univerzita
Czechia

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website

The website will include information on project objectives and activities, profiles of all labs and PIs, including a brief profile of seconded staff and their secondment reports (experience both in term of research carried out and knowledge acquired). In addition, the website will present all publically open deliverables. Importantly, it will also promote dissemination events, and major outputs of the exploitation plan. The website will be integrated into the coordinators web environment and will be promoted through relevant social networks and/or collaborating institutions (e.g. events promotion).

Other (2)

InterTau Summer School II

"One week Summer School titled ""Integrative structural biology course for tackling Alzheimer's disease"" will be organized by CEITEC-MU in Brno. It is mostly aimed at PhD and master students. Total number of attendees ~40. Due to university examinations it is recommended to organize it in the mid-June 2025."

InterTau Summer School I

One week Summer School titled Drug discovery course will be organized by AXON Neurosciences in Bratislava It is mostly aimed at PhD and master students Total number of attendees 40 Due to university examinations it is recommended to organize it in the second week of June 2023

Publications

Peer reviewed articles (12)

High‐Efficiency Trifluoromethyl‐Methionine Incorporation into Cyclophilin A by Cell‐Free Synthesis for ¹⁹F NMR Studies

Author(s): Wenkai Zhu, Christina M. Monnie, Kristīne Kitoka, Angela M. Gronenborn
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202419709

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Author(s): Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Published in: International Journal of Molecular Sciences, Issue 25, 2025, Page(s) 13049, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313049

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Author(s): Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Published in: International Journal of Biological Macromolecules, Issue 305, 2025, Page(s) 141253, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.141253

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Author(s): Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Published in: International Journal of Biological Macromolecules, Issue 266, 2024, Page(s) 130802, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.130802

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Author(s): Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Published in: Frontiers in Aging Neuroscience, Issue 16, 2024, ISSN 1663-4365
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnagi.2024.1468602

Deciphering opening mechanisms of 14‐3‐3 proteins

Author(s): Exequiel E. Barrera, Rostislav Skrabana, Diego M. Bustos
Published in: Protein Science, Issue 34, 2025, ISSN 0961-8368
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70108

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

Author(s): Eva Syková, Ivan Voříšek, Zenon Starčuk, Jiří Kratochvíla, Iveta Pavlova, Yuki Ichikawa, Jessica C. F. Kwok, Eva Kmoníčková, Svitlana Myronchenko, Tomáš Hromádka, Tomáš Smolek, Martin Avila, Neha Basheer, Norbert Žilka
Published in: The Journal of Neuroscience, Issue 45, 2025, Page(s) e0517242024, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.0517-24.2024

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Author(s): Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202407821

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

Author(s): Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Published in: Acta Neuropathologica Communications, Issue 12, 2024, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-024-01748-5

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Author(s): Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Published in: The FEBS Journal, 2025, ISSN 1742-464X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/febs.17405

NMR Studies of Tau Protein in Tauopathies

Author(s): Kitoka K., Skrabana R., Gašparik N., Hritz J., Jaudzems K.
Published in: Frontiers, 2021, ISSN 2296-889X
Publisher: FRONTIERS IN MOLECULAR BIOSCIENCES
DOI: 10.3389/fmolb.2021.761227

Acidification of phosphate buffered saline

Author(s): Lukáš Veselý, Behera Susrisweta, Radim Štůsek, David Mužík, Dominik Heger
Published in: International Journal of Pharmaceutics, Issue 676, 2025, Page(s) 125593, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125593