Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Informacje na temat projektu

InterTAU

Identyfikator umowy o grant: 873127

DOI

10.3030/873127

Projekt został zamknięty

Data podpisania przez KE 27 Listopada 2019

Data rozpoczęcia 1 Stycznia 2020

Data zakończenia 30 Czerwca 2025

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 1 058 000,00

Wkład UE

€ 1 058 000,00

Koordynowany przez

Masarykova univerzita
Czechia

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Project website

The website will include information on project objectives and activities, profiles of all labs and PIs, including a brief profile of seconded staff and their secondment reports (experience both in term of research carried out and knowledge acquired). In addition, the website will present all publically open deliverables. Importantly, it will also promote dissemination events, and major outputs of the exploitation plan. The website will be integrated into the coordinators web environment and will be promoted through relevant social networks and/or collaborating institutions (e.g. events promotion).

Other (2)

InterTau Summer School II

"One week Summer School titled ""Integrative structural biology course for tackling Alzheimer's disease"" will be organized by CEITEC-MU in Brno. It is mostly aimed at PhD and master students. Total number of attendees ~40. Due to university examinations it is recommended to organize it in the mid-June 2025."

InterTau Summer School I

One week Summer School titled Drug discovery course will be organized by AXON Neurosciences in Bratislava It is mostly aimed at PhD and master students Total number of attendees 40 Due to university examinations it is recommended to organize it in the second week of June 2023

Publikacje

Peer reviewed articles (12)

High‐Efficiency Trifluoromethyl‐Methionine Incorporation into Cyclophilin A by Cell‐Free Synthesis for ¹⁹F NMR Studies

Autorzy: Wenkai Zhu, Christina M. Monnie, Kristīne Kitoka, Angela M. Gronenborn
Opublikowane w: Angewandte Chemie International Edition, Numer 64, 2025, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202419709

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Autorzy: Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2025, Strona(/y) 13049, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313049

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Autorzy: Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Opublikowane w: International Journal of Biological Macromolecules, Numer 305, 2025, Strona(/y) 141253, ISSN 0141-8130
Wydawca: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.141253

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Autorzy: Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Opublikowane w: International Journal of Biological Macromolecules, Numer 266, 2024, Strona(/y) 130802, ISSN 0141-8130
Wydawca: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.130802

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Autorzy: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Opublikowane w: Frontiers in Aging Neuroscience, Numer 16, 2024, ISSN 1663-4365
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnagi.2024.1468602

Deciphering opening mechanisms of 14‐3‐3 proteins

Autorzy: Exequiel E. Barrera, Rostislav Skrabana, Diego M. Bustos
Opublikowane w: Protein Science, Numer 34, 2025, ISSN 0961-8368
Wydawca: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70108

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

Autorzy: Eva Syková, Ivan Voříšek, Zenon Starčuk, Jiří Kratochvíla, Iveta Pavlova, Yuki Ichikawa, Jessica C. F. Kwok, Eva Kmoníčková, Svitlana Myronchenko, Tomáš Hromádka, Tomáš Smolek, Martin Avila, Neha Basheer, Norbert Žilka
Opublikowane w: The Journal of Neuroscience, Numer 45, 2025, Strona(/y) e0517242024, ISSN 0270-6474
Wydawca: Society for Neuroscience
DOI: 10.1523/jneurosci.0517-24.2024

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Autorzy: Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Opublikowane w: Angewandte Chemie International Edition, Numer 63, 2024, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202407821

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

Autorzy: Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Opublikowane w: Acta Neuropathologica Communications, Numer 12, 2024, ISSN 2051-5960
Wydawca: BioMed Central
DOI: 10.1186/s40478-024-01748-5

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Autorzy: Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Opublikowane w: The FEBS Journal, 2025, ISSN 1742-464X
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/febs.17405

NMR Studies of Tau Protein in Tauopathies

Autorzy: Kitoka K., Skrabana R., Gašparik N., Hritz J., Jaudzems K.
Opublikowane w: Frontiers, 2021, ISSN 2296-889X
Wydawca: FRONTIERS IN MOLECULAR BIOSCIENCES
DOI: 10.3389/fmolb.2021.761227

Acidification of phosphate buffered saline

Autorzy: Lukáš Veselý, Behera Susrisweta, Radim Štůsek, David Mužík, Dominik Heger
Opublikowane w: International Journal of Pharmaceutics, Numer 676, 2025, Strona(/y) 125593, ISSN 0378-5173
Wydawca: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125593