Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Informazioni relative al progetto

InterTAU

ID dell’accordo di sovvenzione: 873127

DOI

10.3030/873127

Progetto chiuso

Data della firma CE 27 Novembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 1 058 000,00

Contributo UE

€ 1 058 000,00

Coordinato da

Masarykova univerzita
Czechia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Project website

The website will include information on project objectives and activities, profiles of all labs and PIs, including a brief profile of seconded staff and their secondment reports (experience both in term of research carried out and knowledge acquired). In addition, the website will present all publically open deliverables. Importantly, it will also promote dissemination events, and major outputs of the exploitation plan. The website will be integrated into the coordinators web environment and will be promoted through relevant social networks and/or collaborating institutions (e.g. events promotion).

Other (2)

InterTau Summer School II

"One week Summer School titled ""Integrative structural biology course for tackling Alzheimer's disease"" will be organized by CEITEC-MU in Brno. It is mostly aimed at PhD and master students. Total number of attendees ~40. Due to university examinations it is recommended to organize it in the mid-June 2025."

InterTau Summer School I

One week Summer School titled Drug discovery course will be organized by AXON Neurosciences in Bratislava It is mostly aimed at PhD and master students Total number of attendees 40 Due to university examinations it is recommended to organize it in the second week of June 2023

Pubblicazioni

Peer reviewed articles (12)

High‐Efficiency Trifluoromethyl‐Methionine Incorporation into Cyclophilin A by Cell‐Free Synthesis for ¹⁹F NMR Studies

Autori: Wenkai Zhu, Christina M. Monnie, Kristīne Kitoka, Angela M. Gronenborn
Pubblicato in: Angewandte Chemie International Edition, Numero 64, 2025, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202419709

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Autori: Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2025, Pagina/e 13049, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313049

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Autori: Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Pubblicato in: International Journal of Biological Macromolecules, Numero 305, 2025, Pagina/e 141253, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.141253

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Autori: Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Pubblicato in: International Journal of Biological Macromolecules, Numero 266, 2024, Pagina/e 130802, ISSN 0141-8130
Editore: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.130802

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Autori: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Pubblicato in: Frontiers in Aging Neuroscience, Numero 16, 2024, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2024.1468602

Deciphering opening mechanisms of 14‐3‐3 proteins

Autori: Exequiel E. Barrera, Rostislav Skrabana, Diego M. Bustos
Pubblicato in: Protein Science, Numero 34, 2025, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70108

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

Autori: Eva Syková, Ivan Voříšek, Zenon Starčuk, Jiří Kratochvíla, Iveta Pavlova, Yuki Ichikawa, Jessica C. F. Kwok, Eva Kmoníčková, Svitlana Myronchenko, Tomáš Hromádka, Tomáš Smolek, Martin Avila, Neha Basheer, Norbert Žilka
Pubblicato in: The Journal of Neuroscience, Numero 45, 2025, Pagina/e e0517242024, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/jneurosci.0517-24.2024

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Autori: Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Pubblicato in: Angewandte Chemie International Edition, Numero 63, 2024, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202407821

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

Autori: Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Pubblicato in: Acta Neuropathologica Communications, Numero 12, 2024, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-024-01748-5

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Autori: Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Pubblicato in: The FEBS Journal, 2025, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.17405

NMR Studies of Tau Protein in Tauopathies

Autori: Kitoka K., Skrabana R., Gašparik N., Hritz J., Jaudzems K.
Pubblicato in: Frontiers, 2021, ISSN 2296-889X
Editore: FRONTIERS IN MOLECULAR BIOSCIENCES
DOI: 10.3389/fmolb.2021.761227

Acidification of phosphate buffered saline

Autori: Lukáš Veselý, Behera Susrisweta, Radim Štůsek, David Mužík, Dominik Heger
Pubblicato in: International Journal of Pharmaceutics, Numero 676, 2025, Pagina/e 125593, ISSN 0378-5173
Editore: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125593