Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Información del proyecto

InterTAU

Identificador del acuerdo de subvención: 873127

DOI

10.3030/873127

Proyecto cerrado

Fecha de la firma de la CE 27 Noviembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 30 Junio 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 1 058 000,00

Aportación de la UE

€ 1 058 000,00

Coordinado por

Masarykova univerzita
Czechia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Project website

The website will include information on project objectives and activities, profiles of all labs and PIs, including a brief profile of seconded staff and their secondment reports (experience both in term of research carried out and knowledge acquired). In addition, the website will present all publically open deliverables. Importantly, it will also promote dissemination events, and major outputs of the exploitation plan. The website will be integrated into the coordinators web environment and will be promoted through relevant social networks and/or collaborating institutions (e.g. events promotion).

Other (2)

InterTau Summer School II

"One week Summer School titled ""Integrative structural biology course for tackling Alzheimer's disease"" will be organized by CEITEC-MU in Brno. It is mostly aimed at PhD and master students. Total number of attendees ~40. Due to university examinations it is recommended to organize it in the mid-June 2025."

InterTau Summer School I

One week Summer School titled Drug discovery course will be organized by AXON Neurosciences in Bratislava It is mostly aimed at PhD and master students Total number of attendees 40 Due to university examinations it is recommended to organize it in the second week of June 2023

Publicaciones

Peer reviewed articles (12)

High‐Efficiency Trifluoromethyl‐Methionine Incorporation into Cyclophilin A by Cell‐Free Synthesis for ¹⁹F NMR Studies

Autores: Wenkai Zhu, Christina M. Monnie, Kristīne Kitoka, Angela M. Gronenborn
Publicado en: Angewandte Chemie International Edition, Edición 64, 2025, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202419709

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Autores: Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Publicado en: International Journal of Molecular Sciences, Edición 25, 2025, Página(s) 13049, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313049

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Autores: Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Publicado en: International Journal of Biological Macromolecules, Edición 305, 2025, Página(s) 141253, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.141253

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Autores: Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Publicado en: International Journal of Biological Macromolecules, Edición 266, 2024, Página(s) 130802, ISSN 0141-8130
Editor: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.130802

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Autores: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Publicado en: Frontiers in Aging Neuroscience, Edición 16, 2024, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2024.1468602

Deciphering opening mechanisms of 14‐3‐3 proteins

Autores: Exequiel E. Barrera, Rostislav Skrabana, Diego M. Bustos
Publicado en: Protein Science, Edición 34, 2025, ISSN 0961-8368
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70108

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

Autores: Eva Syková, Ivan Voříšek, Zenon Starčuk, Jiří Kratochvíla, Iveta Pavlova, Yuki Ichikawa, Jessica C. F. Kwok, Eva Kmoníčková, Svitlana Myronchenko, Tomáš Hromádka, Tomáš Smolek, Martin Avila, Neha Basheer, Norbert Žilka
Publicado en: The Journal of Neuroscience, Edición 45, 2025, Página(s) e0517242024, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/jneurosci.0517-24.2024

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Autores: Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Publicado en: Angewandte Chemie International Edition, Edición 63, 2024, ISSN 1433-7851
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202407821

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

Autores: Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Publicado en: Acta Neuropathologica Communications, Edición 12, 2024, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-024-01748-5

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Autores: Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Publicado en: The FEBS Journal, 2025, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.17405

NMR Studies of Tau Protein in Tauopathies

Autores: Kitoka K., Skrabana R., Gašparik N., Hritz J., Jaudzems K.
Publicado en: Frontiers, 2021, ISSN 2296-889X
Editor: FRONTIERS IN MOLECULAR BIOSCIENCES
DOI: 10.3389/fmolb.2021.761227

Acidification of phosphate buffered saline

Autores: Lukáš Veselý, Behera Susrisweta, Radim Štůsek, David Mužík, Dominik Heger
Publicado en: International Journal of Pharmaceutics, Edición 676, 2025, Página(s) 125593, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125593