Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs

Informations projet

InterTAU

N° de convention de subvention: 873127

DOI

10.3030/873127

Projet clôturé

Date de signature de la CE 27 Novembre 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2025

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 1 058 000,00

Contribution de l’UE

€ 1 058 000,00

Coordonné par

Masarykova univerzita
Czechia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project website

The website will include information on project objectives and activities, profiles of all labs and PIs, including a brief profile of seconded staff and their secondment reports (experience both in term of research carried out and knowledge acquired). In addition, the website will present all publically open deliverables. Importantly, it will also promote dissemination events, and major outputs of the exploitation plan. The website will be integrated into the coordinators web environment and will be promoted through relevant social networks and/or collaborating institutions (e.g. events promotion).

Other (2)

InterTau Summer School II

"One week Summer School titled ""Integrative structural biology course for tackling Alzheimer's disease"" will be organized by CEITEC-MU in Brno. It is mostly aimed at PhD and master students. Total number of attendees ~40. Due to university examinations it is recommended to organize it in the mid-June 2025."

InterTau Summer School I

One week Summer School titled Drug discovery course will be organized by AXON Neurosciences in Bratislava It is mostly aimed at PhD and master students Total number of attendees 40 Due to university examinations it is recommended to organize it in the second week of June 2023

Publications

Peer reviewed articles (12)

High‐Efficiency Trifluoromethyl‐Methionine Incorporation into Cyclophilin A by Cell‐Free Synthesis for ¹⁹F NMR Studies

Auteurs: Wenkai Zhu, Christina M. Monnie, Kristīne Kitoka, Angela M. Gronenborn
Publié dans: Angewandte Chemie International Edition, Numéro 64, 2025, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202419709

Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies

Auteurs: Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2025, Page(s) 13049, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms252313049

Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins

Auteurs: Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Publié dans: International Journal of Biological Macromolecules, Numéro 305, 2025, Page(s) 141253, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.141253

Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants

Auteurs: Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Publié dans: International Journal of Biological Macromolecules, Numéro 266, 2024, Page(s) 130802, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.130802

TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model

Auteurs: Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Publié dans: Frontiers in Aging Neuroscience, Numéro 16, 2024, ISSN 1663-4365
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnagi.2024.1468602

Deciphering opening mechanisms of 14‐3‐3 proteins

Auteurs: Exequiel E. Barrera, Rostislav Skrabana, Diego M. Bustos
Publié dans: Protein Science, Numéro 34, 2025, ISSN 0961-8368
Éditeur: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.70108

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

Auteurs: Eva Syková, Ivan Voříšek, Zenon Starčuk, Jiří Kratochvíla, Iveta Pavlova, Yuki Ichikawa, Jessica C. F. Kwok, Eva Kmoníčková, Svitlana Myronchenko, Tomáš Hromádka, Tomáš Smolek, Martin Avila, Neha Basheer, Norbert Žilka
Publié dans: The Journal of Neuroscience, Numéro 45, 2025, Page(s) e0517242024, ISSN 0270-6474
Éditeur: Society for Neuroscience
DOI: 10.1523/jneurosci.0517-24.2024

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments

Auteurs: Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Publié dans: Angewandte Chemie International Edition, Numéro 63, 2024, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202407821

Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models

Auteurs: Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Publié dans: Acta Neuropathologica Communications, Numéro 12, 2024, ISSN 2051-5960
Éditeur: BioMed Central
DOI: 10.1186/s40478-024-01748-5

Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ

Auteurs: Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Publié dans: The FEBS Journal, 2025, ISSN 1742-464X
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/febs.17405

NMR Studies of Tau Protein in Tauopathies

Auteurs: Kitoka K., Skrabana R., Gašparik N., Hritz J., Jaudzems K.
Publié dans: Frontiers, 2021, ISSN 2296-889X
Éditeur: FRONTIERS IN MOLECULAR BIOSCIENCES
DOI: 10.3389/fmolb.2021.761227

Acidification of phosphate buffered saline

Auteurs: Lukáš Veselý, Behera Susrisweta, Radim Štůsek, David Mužík, Dominik Heger
Publié dans: International Journal of Pharmaceutics, Numéro 676, 2025, Page(s) 125593, ISSN 0378-5173
Éditeur: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125593