Evaluation of ratioNally Designed Influenza vaccines

Informations projet

ENDFLU

N° de convention de subvention: 874650

DOI

10.3030/874650

Projet clôturé

Date de signature de la CE 12 Decembre 2019

Date de début 1 Août 2020

Date de fin 31 Juillet 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 14 444 867,50

Contribution de l’UE

€ 8 646 254,25

Coordonné par

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

Composition of the SAB

This deliverable consists of a report listing the names and contact details of the Scientific Advisory Board including their expertise and role

Humoral immunological assay package

This deliverable consists of a report describing the humoral immunological assay package and confirming its availability for implementation and use

Cellular immunological assay package

This deliverable consists of a report describing the cellular immunological assay package and confirming its availability for implementation and use

Other (2)

Harmonized protocols, animal models and virus stocks, including ferret model established in India

This deliverable consists of a report describing and summarising the harmonized protocols, animal models and virus stocks, including ferret model established in India, used in ENDFLU.

ENDFLU website

This deliverable consists of the online publishing of ENDFLU website

Publications

Peer reviewed articles (12)

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.

Auteurs: Nidhi Mittal; Nayanika Sengupta; Sameer Kumar Malladi; Poorvi Reddy; Madhuraj Bhat; R. S. Rajmani; Koen Sedeyn; Xavier Saelens; Somnath Dutta; Raghavan Varadarajan
Publié dans: Viruses, Vol 13, Iss 1710, p 1710 (2021), Numéro 1, 2021, Page(s) 1710, ISSN 1999-4915
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091710

A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases

Auteurs: Zaolan Liang, Xia Lin, Lihong Sun, Kimberly M. Edwards, Wenjun Song, Hailiang Sun, Yanmin Xie, Fangmei Lin, Shiman Ling, Tingting Liang, Biying Xiao, Jiaqi Wang, Min Li, Chin-Yu Leung, Huachen Zhu, Nisha Bhandari, Raghavan Varadarajan, Min Z. Levine, Malik Peiris, Robert Webster, Vijaykrishna Dhanasekaran, Nancy H. L. Leung, Benjamin J. Cowling, Richard J. Webby, Mariette Ducatez, Mark Zanin, Sook
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-49884-9

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Auteurs: Uddipan Kar1† Sara Khaleeq1† Priyanka Garg1 Madhuraj Bhat2 Poorvi Reddy2 Venkada Subramanian Vignesh1 Aditya Upadhyaya2 Mili Das2 Ghadiyaram Chakshusmathi2 Suman Pandey2 Somnath Dutta1 Raghavan Varadarajan1*
Publié dans: Front. Immunol., 2022, ISSN 1664-3224
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.890622

Design and evaluation of a poly-epitope based vaccine for the induction of influenza A virus cross-reactive CD8 + T cell responses

Auteurs: Sharmistha Dam, Alina Tscherne, Leoni Engels, Gerd Sutter, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-025-95479-9

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

Auteurs: Raj, Sneha, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Ritika Khatri, Amit Kumar, Mrityunjay Singh, Surbhi Mishra, Shailendra Asthana, Shubbir Ahmed, and et al.
Publié dans: Vaccines, Numéro 11(4), 2023, Page(s) 780, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040780

Multi-omics characterization of the monkeypox virus infection

Auteurs: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M. Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M. Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I. Schmidt, Michael Way, Roland Rad, Andrew G. Bowie, Ulrike Protzer, Andreas Pichlmair
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-51074-6

Biophysical Correlates of Enhanced Immunogenicity of a Stabilized Variant of the Receptor Binding Domain of SARS-CoV-2

Auteurs: Kawkab Kanjo, Gopinath Chattopadhyay, Sameer Kumar Malladi, Randhir Singh, Sowrabha Jayatheertha, Raghavan Varadarajan
Publié dans: The Journal of Physical Chemistry B, Numéro 127, 2023, Page(s) 1704-1714, ISSN 1520-6106
Éditeur: American Chemical Society
DOI: 10.1021/acs.jpcb.2c07262

Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice

Auteurs: Langenmayer, Martin C., Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, and et al.
Publié dans: Pathogens, Numéro 12(7), 2023, Page(s) 867, ISSN 2078-2489
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12070867

Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge

Auteurs: M. N. Pascha, M. Ballegeer, M. C. Roelofs, L. Meuris, I. C. Albulescu, F. J. M. van Kuppeveld, D. L. Hurdiss, B. J. Bosch, T. Zeev-Ben-Mordehai, X. Saelens, C. A. M. de Haan
Publié dans: npj Vaccines, Numéro 9, 2024, ISSN 2059-0105
Éditeur: Springer
DOI: 10.1038/s41541-024-00891-3

Rethinking IL-1 Antagonism in Respiratory Viral Infections: A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity

Auteurs: Bram Van Den Eeckhout, Marlies Ballegeer, Jozefien De Clercq, Elianne Burg, Xavier Saelens, Linos Vandekerckhove, Sarah Gerlo
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, Page(s) 15770, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242115770

The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus

Auteurs: Pradeep Kumar, Debendra Kumar Sahoo, Deepak Sharma
Publié dans: Metabolic Engineering Communications, Numéro 12, 2024, Page(s) e00160, ISSN 2214-0301
Éditeur: Elsevier BV
DOI: 10.1016/j.mec.2020.e00160

Computational design of vaccine immunogens

Auteurs: Karla M Castro, Andreas Scheck, Shuhao Xiao, Bruno E Correia
Publié dans: Current Opinion in Biotechnology, Numéro 78, 2022, ISSN 0958-1669
Éditeur: Elsevier BV
DOI: 10.1016/j.copbio.2022.102821

Non-peer reviewed articles (3)

Influenza vaccines: successes and continuing challenges

Auteurs: Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan, Albert D M E Osterhaus
Publié dans: The Journal of Infectious Diseases, 2021, ISSN 1537-6613
Éditeur: Oxford Academic
DOI: 10.1093/infdis/jiab269

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

Auteurs: Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Publié dans: mBio, 2021, ISSN 2150-7511
Éditeur: ASM
DOI: 10.1128/mbio.00745-21

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Auteurs: Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Xavier Saelens and Cornelis A. M. de Haan
Publié dans: Frontiers in Immunology, 2021, ISSN 1664-3224
Éditeur: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2021.786617

Book chapters (2)

Vaccine Research and Development in India for COVID-19 and Influenza

Auteurs: Kawkab Kanjo, Ghadiyaram Chakshusmathi, Raghavan Varadarajan
Publié dans: Biotechnology in India - Reworking A Strategy, 2024, Page(s) 147-173
Éditeur: Springer Nature Singapore
DOI: 10.1007/978-981-97-0896-3_6

Chapter 2 - Deep mutational scanning to probe specificity determinants in proteins

Auteurs: Jayantika Bhowmick *, Soumyanetra Chandra *, Raghavan Varadarajan
Publié dans: Structure and Intrinsic Disorder in Enzymology, 2022, ISBN 978-0-323-99533-7
Éditeur: Academic Press
DOI: 10.1016/b978-0-323-99533-7.00005-4

Conference proceedings (1)

Mosaic N1 and N2 neuraminidase nanoparticles induce high antibody titers and potent protection from Influenza A virus H1N1 and H3N2 challenge

Auteurs: Mirte Pascha, Marlies Ballegeer, Irina Albulescu, Berend Jan Bosch, Frank J.M. van Kuppeveld, Xavier Saelens, Cornelis A.M. de Haan
Publié dans: 2022
Éditeur: Zoonosen