Evaluation of ratioNally Designed Influenza vaccines

Risultati finali

This deliverable consists of a report listing the names and contact details of the Scientific Advisory Board including their expertise and role

Humoral immunological assay package

This deliverable consists of a report describing the humoral immunological assay package and confirming its availability for implementation and use

Cellular immunological assay package

This deliverable consists of a report describing the cellular immunological assay package and confirming its availability for implementation and use

ENDFLU website

This deliverable consists of the online publishing of ENDFLU website

Pubblicazioni

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.

Autori: Nidhi Mittal; Nayanika Sengupta; Sameer Kumar Malladi; Poorvi Reddy; Madhuraj Bhat; R. S. Rajmani; Koen Sedeyn; Xavier Saelens; Somnath Dutta; Raghavan Varadarajan
Pubblicato in: Viruses, Vol 13, Iss 1710, p 1710 (2021), Numero 1, 2021, Pagina/e 1710, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091710

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Autori: Uddipan Kar1† Sara Khaleeq1† Priyanka Garg1 Madhuraj Bhat2 Poorvi Reddy2 Venkada Subramanian Vignesh1 Aditya Upadhyaya2 Mili Das2 Ghadiyaram Chakshusmathi2 Suman Pandey2 Somnath Dutta1 Raghavan Varadarajan1*
Pubblicato in: Front. Immunol., 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.890622

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

Autori: Raj, Sneha, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Ritika Khatri, Amit Kumar, Mrityunjay Singh, Surbhi Mishra, Shailendra Asthana, Shubbir Ahmed, and et al.
Pubblicato in: Vaccines, Numero 11(4), 2023, Pagina/e 780, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040780

Biophysical Correlates of Enhanced Immunogenicity of a Stabilized Variant of the Receptor Binding Domain of SARS-CoV-2.

Autori: Kawkab Kanjo, Gopinath Chattopadhyay, Sameer Kumar Malladi, Randhir Singh, Sowrabha Jayatheertha, and Raghavan Varadarajan*
Pubblicato in: J. Phys. Chem. B, 2023, ISSN 1520-5126
Editore: American Chemical Society
DOI: 10.1021/acs.jpcb.2c07262

Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice

Autori: Langenmayer, Martin C., Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, and et al.
Pubblicato in: Pathogens, Numero 12(7), 2023, Pagina/e 867, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12070867

Computational design of vaccine immunogens

Autori: Karla M Castro, Andreas Scheck, Shuhao Xiao, Bruno E Correia
Pubblicato in: Current Opinion in Biotechnology, Numero 78, 2022, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2022.102821

Influenza vaccines: successes and continuing challenges

Autori: Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan, Albert D M E Osterhaus
Pubblicato in: The Journal of Infectious Diseases, 2021, ISSN 1537-6613
Editore: Oxford Academic
DOI: 10.1093/infdis/jiab269

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

Autori: Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Pubblicato in: mBio, 2021, ISSN 2150-7511
Editore: ASM
DOI: 10.1128/mbio.00745-21

The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus

Autori: Pradeep Kumar, Debendra Kumar Sahoo, Deepak Sharma
Pubblicato in: Metabolic Engineering Communications, 2021, ISSN 2214-0301
Editore: Elsevier BV
DOI: 10.1016/j.mec.2020.e00160

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Autori: Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Xavier Saelens and Cornelis A. M. de Haan
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2021.786617

Chapter 2 - Deep mutational scanning to probe specificity determinants in proteins

Autori: Jayantika Bhowmick *, Soumyanetra Chandra *, Raghavan Varadarajan
Pubblicato in: Structure and Intrinsic Disorder in Enzymology, 2022, ISBN 978-0-323-99533-7
Editore: Academic Press
DOI: 10.1016/b978-0-323-99533-7.00005-4

Mosaic N1 and N2 neuraminidase nanoparticles induce high antibody titers and potent protection from Influenza A virus H1N1 and H3N2 challenge

Autori: Mirte Pascha, Marlies Ballegeer, Irina Albulescu, Berend Jan Bosch, Frank J.M. van Kuppeveld, Xavier Saelens, Cornelis A.M. de Haan
Pubblicato in: 2022
Editore: Zoonosen

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