Evaluation of ratioNally Designed Influenza vaccines

Informazioni relative al progetto

ENDFLU

ID dell’accordo di sovvenzione: 874650

DOI

10.3030/874650

Progetto chiuso

Data della firma CE 12 Dicembre 2019

Data di avvio 1 Agosto 2020

Data di completamento 31 Luglio 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 14 444 867,50

Contributo UE

€ 8 646 254,25

Coordinato da

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Composition of the SAB

This deliverable consists of a report listing the names and contact details of the Scientific Advisory Board including their expertise and role

Humoral immunological assay package

This deliverable consists of a report describing the humoral immunological assay package and confirming its availability for implementation and use

Cellular immunological assay package

This deliverable consists of a report describing the cellular immunological assay package and confirming its availability for implementation and use

Other (2)

Harmonized protocols, animal models and virus stocks, including ferret model established in India

This deliverable consists of a report describing and summarising the harmonized protocols, animal models and virus stocks, including ferret model established in India, used in ENDFLU.

ENDFLU website

This deliverable consists of the online publishing of ENDFLU website

Pubblicazioni

Peer reviewed articles (12)

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.

Autori: Nidhi Mittal; Nayanika Sengupta; Sameer Kumar Malladi; Poorvi Reddy; Madhuraj Bhat; R. S. Rajmani; Koen Sedeyn; Xavier Saelens; Somnath Dutta; Raghavan Varadarajan
Pubblicato in: Viruses, Vol 13, Iss 1710, p 1710 (2021), Numero 1, 2021, Pagina/e 1710, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091710

A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases

Autori: Zaolan Liang, Xia Lin, Lihong Sun, Kimberly M. Edwards, Wenjun Song, Hailiang Sun, Yanmin Xie, Fangmei Lin, Shiman Ling, Tingting Liang, Biying Xiao, Jiaqi Wang, Min Li, Chin-Yu Leung, Huachen Zhu, Nisha Bhandari, Raghavan Varadarajan, Min Z. Levine, Malik Peiris, Robert Webster, Vijaykrishna Dhanasekaran, Nancy H. L. Leung, Benjamin J. Cowling, Richard J. Webby, Mariette Ducatez, Mark Zanin, Sook
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-49884-9

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Autori: Uddipan Kar1† Sara Khaleeq1† Priyanka Garg1 Madhuraj Bhat2 Poorvi Reddy2 Venkada Subramanian Vignesh1 Aditya Upadhyaya2 Mili Das2 Ghadiyaram Chakshusmathi2 Suman Pandey2 Somnath Dutta1 Raghavan Varadarajan1*
Pubblicato in: Front. Immunol., 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.890622

Design and evaluation of a poly-epitope based vaccine for the induction of influenza A virus cross-reactive CD8 + T cell responses

Autori: Sharmistha Dam, Alina Tscherne, Leoni Engels, Gerd Sutter, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-95479-9

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

Autori: Raj, Sneha, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Ritika Khatri, Amit Kumar, Mrityunjay Singh, Surbhi Mishra, Shailendra Asthana, Shubbir Ahmed, and et al.
Pubblicato in: Vaccines, Numero 11(4), 2023, Pagina/e 780, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040780

Multi-omics characterization of the monkeypox virus infection

Autori: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M. Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M. Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I. Schmidt, Michael Way, Roland Rad, Andrew G. Bowie, Ulrike Protzer, Andreas Pichlmair
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-51074-6

Biophysical Correlates of Enhanced Immunogenicity of a Stabilized Variant of the Receptor Binding Domain of SARS-CoV-2

Autori: Kawkab Kanjo, Gopinath Chattopadhyay, Sameer Kumar Malladi, Randhir Singh, Sowrabha Jayatheertha, Raghavan Varadarajan
Pubblicato in: The Journal of Physical Chemistry B, Numero 127, 2023, Pagina/e 1704-1714, ISSN 1520-6106
Editore: American Chemical Society
DOI: 10.1021/acs.jpcb.2c07262

Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice

Autori: Langenmayer, Martin C., Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, and et al.
Pubblicato in: Pathogens, Numero 12(7), 2023, Pagina/e 867, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12070867

Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge

Autori: M. N. Pascha, M. Ballegeer, M. C. Roelofs, L. Meuris, I. C. Albulescu, F. J. M. van Kuppeveld, D. L. Hurdiss, B. J. Bosch, T. Zeev-Ben-Mordehai, X. Saelens, C. A. M. de Haan
Pubblicato in: npj Vaccines, Numero 9, 2024, ISSN 2059-0105
Editore: Springer
DOI: 10.1038/s41541-024-00891-3

Rethinking IL-1 Antagonism in Respiratory Viral Infections: A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity

Autori: Bram Van Den Eeckhout, Marlies Ballegeer, Jozefien De Clercq, Elianne Burg, Xavier Saelens, Linos Vandekerckhove, Sarah Gerlo
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, Pagina/e 15770, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242115770

The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus

Autori: Pradeep Kumar, Debendra Kumar Sahoo, Deepak Sharma
Pubblicato in: Metabolic Engineering Communications, Numero 12, 2024, Pagina/e e00160, ISSN 2214-0301
Editore: Elsevier BV
DOI: 10.1016/j.mec.2020.e00160

Computational design of vaccine immunogens

Autori: Karla M Castro, Andreas Scheck, Shuhao Xiao, Bruno E Correia
Pubblicato in: Current Opinion in Biotechnology, Numero 78, 2022, ISSN 0958-1669
Editore: Elsevier BV
DOI: 10.1016/j.copbio.2022.102821

Non-peer reviewed articles (3)

Influenza vaccines: successes and continuing challenges

Autori: Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan, Albert D M E Osterhaus
Pubblicato in: The Journal of Infectious Diseases, 2021, ISSN 1537-6613
Editore: Oxford Academic
DOI: 10.1093/infdis/jiab269

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

Autori: Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Pubblicato in: mBio, 2021, ISSN 2150-7511
Editore: ASM
DOI: 10.1128/mbio.00745-21

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Autori: Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Xavier Saelens and Cornelis A. M. de Haan
Pubblicato in: Frontiers in Immunology, 2021, ISSN 1664-3224
Editore: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2021.786617

Book chapters (2)

Vaccine Research and Development in India for COVID-19 and Influenza

Autori: Kawkab Kanjo, Ghadiyaram Chakshusmathi, Raghavan Varadarajan
Pubblicato in: Biotechnology in India - Reworking A Strategy, 2024, Pagina/e 147-173
Editore: Springer Nature Singapore
DOI: 10.1007/978-981-97-0896-3_6

Chapter 2 - Deep mutational scanning to probe specificity determinants in proteins

Autori: Jayantika Bhowmick *, Soumyanetra Chandra *, Raghavan Varadarajan
Pubblicato in: Structure and Intrinsic Disorder in Enzymology, 2022, ISBN 978-0-323-99533-7
Editore: Academic Press
DOI: 10.1016/b978-0-323-99533-7.00005-4

Conference proceedings (1)

Mosaic N1 and N2 neuraminidase nanoparticles induce high antibody titers and potent protection from Influenza A virus H1N1 and H3N2 challenge

Autori: Mirte Pascha, Marlies Ballegeer, Irina Albulescu, Berend Jan Bosch, Frank J.M. van Kuppeveld, Xavier Saelens, Cornelis A.M. de Haan
Pubblicato in: 2022
Editore: Zoonosen