Evaluation of ratioNally Designed Influenza vaccines

Información del proyecto

ENDFLU

Identificador del acuerdo de subvención: 874650

DOI

10.3030/874650

Proyecto cerrado

Fecha de la firma de la CE 12 Diciembre 2019

Fecha de inicio 1 Agosto 2020

Fecha de finalización 31 Julio 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 14 444 867,50

Aportación de la UE

€ 8 646 254,25

Coordinado por

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Composition of the SAB

This deliverable consists of a report listing the names and contact details of the Scientific Advisory Board including their expertise and role

Humoral immunological assay package

This deliverable consists of a report describing the humoral immunological assay package and confirming its availability for implementation and use

Cellular immunological assay package

This deliverable consists of a report describing the cellular immunological assay package and confirming its availability for implementation and use

Other (2)

Harmonized protocols, animal models and virus stocks, including ferret model established in India

This deliverable consists of a report describing and summarising the harmonized protocols, animal models and virus stocks, including ferret model established in India, used in ENDFLU.

ENDFLU website

This deliverable consists of the online publishing of ENDFLU website

Publicaciones

Peer reviewed articles (12)

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.

Autores: Nidhi Mittal; Nayanika Sengupta; Sameer Kumar Malladi; Poorvi Reddy; Madhuraj Bhat; R. S. Rajmani; Koen Sedeyn; Xavier Saelens; Somnath Dutta; Raghavan Varadarajan
Publicado en: Viruses, Vol 13, Iss 1710, p 1710 (2021), Edición 1, 2021, Página(s) 1710, ISSN 1999-4915
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091710

A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases

Autores: Zaolan Liang, Xia Lin, Lihong Sun, Kimberly M. Edwards, Wenjun Song, Hailiang Sun, Yanmin Xie, Fangmei Lin, Shiman Ling, Tingting Liang, Biying Xiao, Jiaqi Wang, Min Li, Chin-Yu Leung, Huachen Zhu, Nisha Bhandari, Raghavan Varadarajan, Min Z. Levine, Malik Peiris, Robert Webster, Vijaykrishna Dhanasekaran, Nancy H. L. Leung, Benjamin J. Cowling, Richard J. Webby, Mariette Ducatez, Mark Zanin, Sook
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-49884-9

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Autores: Uddipan Kar1† Sara Khaleeq1† Priyanka Garg1 Madhuraj Bhat2 Poorvi Reddy2 Venkada Subramanian Vignesh1 Aditya Upadhyaya2 Mili Das2 Ghadiyaram Chakshusmathi2 Suman Pandey2 Somnath Dutta1 Raghavan Varadarajan1*
Publicado en: Front. Immunol., 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.890622

Design and evaluation of a poly-epitope based vaccine for the induction of influenza A virus cross-reactive CD8 + T cell responses

Autores: Sharmistha Dam, Alina Tscherne, Leoni Engels, Gerd Sutter, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-95479-9

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

Autores: Raj, Sneha, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Ritika Khatri, Amit Kumar, Mrityunjay Singh, Surbhi Mishra, Shailendra Asthana, Shubbir Ahmed, and et al.
Publicado en: Vaccines, Edición 11(4), 2023, Página(s) 780, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040780

Multi-omics characterization of the monkeypox virus infection

Autores: Yiqi Huang, Valter Bergant, Vincent Grass, Quirin Emslander, M. Sabri Hamad, Philipp Hubel, Julia Mergner, Antonio Piras, Karsten Krey, Alexander Henrici, Rupert Öllinger, Yonas M. Tesfamariam, Ilaria Dalla Rosa, Till Bunse, Gerd Sutter, Gregor Ebert, Florian I. Schmidt, Michael Way, Roland Rad, Andrew G. Bowie, Ulrike Protzer, Andreas Pichlmair
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-51074-6

Biophysical Correlates of Enhanced Immunogenicity of a Stabilized Variant of the Receptor Binding Domain of SARS-CoV-2

Autores: Kawkab Kanjo, Gopinath Chattopadhyay, Sameer Kumar Malladi, Randhir Singh, Sowrabha Jayatheertha, Raghavan Varadarajan
Publicado en: The Journal of Physical Chemistry B, Edición 127, 2023, Página(s) 1704-1714, ISSN 1520-6106
Editor: American Chemical Society
DOI: 10.1021/acs.jpcb.2c07262

Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice

Autores: Langenmayer, Martin C., Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, and et al.
Publicado en: Pathogens, Edición 12(7), 2023, Página(s) 867, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12070867

Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge

Autores: M. N. Pascha, M. Ballegeer, M. C. Roelofs, L. Meuris, I. C. Albulescu, F. J. M. van Kuppeveld, D. L. Hurdiss, B. J. Bosch, T. Zeev-Ben-Mordehai, X. Saelens, C. A. M. de Haan
Publicado en: npj Vaccines, Edición 9, 2024, ISSN 2059-0105
Editor: Springer
DOI: 10.1038/s41541-024-00891-3

Rethinking IL-1 Antagonism in Respiratory Viral Infections: A Role for IL-1 Signaling in the Development of Antiviral T Cell Immunity

Autores: Bram Van Den Eeckhout, Marlies Ballegeer, Jozefien De Clercq, Elianne Burg, Xavier Saelens, Linos Vandekerckhove, Sarah Gerlo
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, Página(s) 15770, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242115770

The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus

Autores: Pradeep Kumar, Debendra Kumar Sahoo, Deepak Sharma
Publicado en: Metabolic Engineering Communications, Edición 12, 2024, Página(s) e00160, ISSN 2214-0301
Editor: Elsevier BV
DOI: 10.1016/j.mec.2020.e00160

Computational design of vaccine immunogens

Autores: Karla M Castro, Andreas Scheck, Shuhao Xiao, Bruno E Correia
Publicado en: Current Opinion in Biotechnology, Edición 78, 2022, ISSN 0958-1669
Editor: Elsevier BV
DOI: 10.1016/j.copbio.2022.102821

Non-peer reviewed articles (3)

Influenza vaccines: successes and continuing challenges

Autores: Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan, Albert D M E Osterhaus
Publicado en: The Journal of Infectious Diseases, 2021, ISSN 1537-6613
Editor: Oxford Academic
DOI: 10.1093/infdis/jiab269

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

Autores: Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Publicado en: mBio, 2021, ISSN 2150-7511
Editor: ASM
DOI: 10.1128/mbio.00745-21

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Autores: Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Xavier Saelens and Cornelis A. M. de Haan
Publicado en: Frontiers in Immunology, 2021, ISSN 1664-3224
Editor: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2021.786617

Book chapters (2)

Vaccine Research and Development in India for COVID-19 and Influenza

Autores: Kawkab Kanjo, Ghadiyaram Chakshusmathi, Raghavan Varadarajan
Publicado en: Biotechnology in India - Reworking A Strategy, 2024, Página(s) 147-173
Editor: Springer Nature Singapore
DOI: 10.1007/978-981-97-0896-3_6

Chapter 2 - Deep mutational scanning to probe specificity determinants in proteins

Autores: Jayantika Bhowmick *, Soumyanetra Chandra *, Raghavan Varadarajan
Publicado en: Structure and Intrinsic Disorder in Enzymology, 2022, ISBN 978-0-323-99533-7
Editor: Academic Press
DOI: 10.1016/b978-0-323-99533-7.00005-4

Conference proceedings (1)

Mosaic N1 and N2 neuraminidase nanoparticles induce high antibody titers and potent protection from Influenza A virus H1N1 and H3N2 challenge

Autores: Mirte Pascha, Marlies Ballegeer, Irina Albulescu, Berend Jan Bosch, Frank J.M. van Kuppeveld, Xavier Saelens, Cornelis A.M. de Haan
Publicado en: 2022
Editor: Zoonosen