Evaluation of ratioNally Designed Influenza vaccines

Projektinformationen

ENDFLU

ID Finanzhilfevereinbarung: 874650

DOI 10.3030/874650

EK-Unterschriftsdatum 12 Dezember 2019

Startdatum 1 August 2020

Enddatum 31 Juli 2025

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten € 14 444 867,50

EU-Beitrag € 8 646 254,25

Koordiniert durch

STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany

Leistungen

Documents, reports (3)

Composition of the SAB

This deliverable consists of a report listing the names and contact details of the Scientific Advisory Board including their expertise and role

Humoral immunological assay package

This deliverable consists of a report describing the humoral immunological assay package and confirming its availability for implementation and use

Cellular immunological assay package

This deliverable consists of a report describing the cellular immunological assay package and confirming its availability for implementation and use

Other (1)

ENDFLU website

This deliverable consists of the online publishing of ENDFLU website

Veröffentlichungen

Peer reviewed articles (6)

Protective Efficacy of Recombinant Influenza Hemagglutinin Ectodomain Fusions.

Autoren: Nidhi Mittal; Nayanika Sengupta; Sameer Kumar Malladi; Poorvi Reddy; Madhuraj Bhat; R. S. Rajmani; Koen Sedeyn; Xavier Saelens; Somnath Dutta; Raghavan Varadarajan
Veröffentlicht in: Viruses, Vol 13, Iss 1710, p 1710 (2021), Ausgabe 1, 2021, Seite(n) 1710, ISSN 1999-4915
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13091710

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Autoren: Uddipan Kar1† Sara Khaleeq1† Priyanka Garg1 Madhuraj Bhat2 Poorvi Reddy2 Venkada Subramanian Vignesh1 Aditya Upadhyaya2 Mili Das2 Ghadiyaram Chakshusmathi2 Suman Pandey2 Somnath Dutta1 Raghavan Varadarajan1*
Veröffentlicht in: Front. Immunol., 2022, ISSN 1664-3224
Herausgeber: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.890622

Intradermal Immunization of Soluble Influenza HA Derived from a Lethal Virus Induces High Magnitude and Breadth of Antibody Responses and Provides Complete Protection In Vivo

Autoren: Raj, Sneha, Preeti Vishwakarma, Shikha Saxena, Varun Kumar, Ritika Khatri, Amit Kumar, Mrityunjay Singh, Surbhi Mishra, Shailendra Asthana, Shubbir Ahmed, and et al.
Veröffentlicht in: Vaccines, Ausgabe 11(4), 2023, Seite(n) 780, ISSN 2078-2489
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines11040780

Biophysical Correlates of Enhanced Immunogenicity of a Stabilized Variant of the Receptor Binding Domain of SARS-CoV-2.

Autoren: Kawkab Kanjo, Gopinath Chattopadhyay, Sameer Kumar Malladi, Randhir Singh, Sowrabha Jayatheertha, and Raghavan Varadarajan*
Veröffentlicht in: J. Phys. Chem. B, 2023, ISSN 1520-5126
Herausgeber: American Chemical Society
DOI: 10.1021/acs.jpcb.2c07262

Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice

Autoren: Langenmayer, Martin C., Anna-Theresa Luelf-Averhoff, Lisa Marr, Sylvia Jany, Astrid Freudenstein, Silvia Adam-Neumair, Alina Tscherne, Robert Fux, Juan J. Rojas, Andreas Blutke, and et al.
Veröffentlicht in: Pathogens, Ausgabe 12(7), 2023, Seite(n) 867, ISSN 2078-2489
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pathogens12070867

Computational design of vaccine immunogens

Autoren: Karla M Castro, Andreas Scheck, Shuhao Xiao, Bruno E Correia
Veröffentlicht in: Current Opinion in Biotechnology, Ausgabe 78, 2022, ISSN 0958-1669
Herausgeber: Elsevier BV
DOI: 10.1016/j.copbio.2022.102821

Non-peer reviewed articles (4)

Influenza vaccines: successes and continuing challenges

Autoren: Tanja Becker, Husni Elbahesh, Leslie A Reperant, Guus F Rimmelzwaan, Albert D M E Osterhaus
Veröffentlicht in: The Journal of Infectious Diseases, 2021, ISSN 1537-6613
Herausgeber: Oxford Academic
DOI: 10.1093/infdis/jiab269

In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

Autoren: Silvie Van den Hoecke, Marlies Ballegeer, Bram Vrancken, Lei Deng, Emma R. Job, Kenny Roose, Bert Schepens, Lien Van Hoecke, Philippe Lemey, Xavier Saelens
Veröffentlicht in: mBio, 2021, ISSN 2150-7511
Herausgeber: ASM
DOI: 10.1128/mbio.00745-21

The identification of novel promoters and terminators for protein expression and metabolic engineering applications in Kluyveromyces marxianus

Autoren: Pradeep Kumar, Debendra Kumar Sahoo, Deepak Sharma
Veröffentlicht in: Metabolic Engineering Communications, 2021, ISSN 2214-0301
Herausgeber: Elsevier BV
DOI: 10.1016/j.mec.2020.e00160

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Autoren: Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Xavier Saelens and Cornelis A. M. de Haan
Veröffentlicht in: Frontiers in Immunology, 2021, ISSN 1664-3224
Herausgeber: International Union of Immunological Societies (IUIS)
DOI: 10.3389/fimmu.2021.786617

Book chapters (1)

Chapter 2 - Deep mutational scanning to probe specificity determinants in proteins

Autoren: Jayantika Bhowmick *, Soumyanetra Chandra *, Raghavan Varadarajan
Veröffentlicht in: Structure and Intrinsic Disorder in Enzymology, 2022, ISBN 978-0-323-99533-7
Herausgeber: Academic Press
DOI: 10.1016/b978-0-323-99533-7.00005-4

Conference proceedings (1)

Mosaic N1 and N2 neuraminidase nanoparticles induce high antibody titers and potent protection from Influenza A virus H1N1 and H3N2 challenge

Autoren: Mirte Pascha, Marlies Ballegeer, Irina Albulescu, Berend Jan Bosch, Frank J.M. van Kuppeveld, Xavier Saelens, Cornelis A.M. de Haan
Veröffentlicht in: 2022
Herausgeber: Zoonosen