New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes

Informations projet

VANGUARD

N° de convention de subvention: 874700

DOI

10.3030/874700

Projet clôturé

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 6 844 625,00

Contribution de l’UE

€ 6 844 625,00

Coordonné par

UNIVERSITE DE GENEVE
Switzerland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

VANGUARD Communication Portfolio

ACCEL will create a communication portfolio of updated VANGUARD print visual and media information and documentation including factsheets brochures and posters and visual content will be developed to offer information about the project in a condensed form that can be handed out during various events and downloaded from the project website

VANGUARD Stakeholder Engagement and Dissemination Assessment Reports

To asses the implementation and impact of the stakeholder engagement and dissemination activities, ACCEL will monitor and document (D9.4, M48) the implemented measures to assess the individual activities and adapt any activities where required to facilitate outreach and impact M24 and 48)

ELSA Training Manual

Training of VANGUARD researchers in M6, in particular newly recruited staff, on the ethical implications and safety requirements involved in regenerative medicine in general and the therapy developed during the VANGUARD project. The existing literature will be reviewed, experts in bioethics consulted, and together with partners we will develop a training manual.

Project website

To support aforementioned dissemination and communication activities throughout the duration of the project, ACCEL will set up and maintain the project website, which will notably function as the main source of information and resources related to the project, partners, latest developments, publications and public deliverables for all stakeholders.

Publications

Conference proceedings (4)

Vascularized endocrine pancreas for type 1 diabetes

Auteurs: Bellofatto, Kevin; Lebreton, Fanny; Fonseca, Laura Mar; Hanna, Reine; Bignard, Juliette; Galvan, Victor; Peloso, Andrea; Berney, Thierry; Compagnon, Philippe; VANGUARD Consortium; Berishvili, Ekaterine
Publié dans: Transplantation, Numéro 107, 2023, Page(s) 58
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994052.77218.10

Ethics of Early Clinical Trials of Bio-Artificial Organs

Auteurs: Bunnik, E.M., de Jongh, D. and Massey, E.
Publié dans: Transplant International, Numéro 35, 2022, Page(s) 10621, ISSN 0934-0874
Éditeur: Frontiers Publishing Partnerships
DOI: 10.3389/ti.2022.10621

Generation of Prevascularized Endocrine Constructs to Treat Type 1 Diabetes

Auteurs: Bellofatto K, Lebreton F, Wassmer CH Fonseca L, Hanna R, Berishvili E.
Publié dans: Transplantation, Numéro 9, 2022
Éditeur: Lippincott Williams & Wilkins
DOI: 10.1097/01.tp.0000885936.38573.32

Hydrogel-based, prevascularized, retrievable endocrine construct to treat Type 1 Diabetes

Auteurs: Bellofatto K, Lebreton F, Hanna R, Fonseca L M, Bignard J, Galvan V, Peloso A, Berney TH, Compagnon PH, VANGUARD Consortium, Berishvili E.
Publié dans: Transplantation, Numéro 107, 2023, Page(s) 57
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994048.59940.dd

Peer reviewed articles (28)

Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells

Auteurs: Lebreton F, Hanna R, Wassmer CH, Bellofatto K, Perez L, Othenin-Girard V, de Tejada BM, Cohen M, Berishvili E.
Publié dans: Stem Cell Reviews and Reports, Numéro 18, 2021, Page(s) 346-359, ISSN 1550-8943
Éditeur: Springer Verlag
DOI: 10.1007/s12015-021-10269-w

Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves In Vitro Function and Transplantation Outcome

Auteurs: Honarpisheh M, Lei Y, Zhang Y, Pehl M, Kemter E, Lange A, Wolf E, Wolf-van Buerck L, VANGUARD consortium, Seissler S.
Publié dans: Transplant International, Numéro 35, 2022, ISSN 1432-2277
Éditeur: Frontiers
DOI: 10.3389/ti.2022.10697

Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

Auteurs: Alibashe-Ahmed M., Berney T., Giovannoni L., Berishvili E.
Publié dans: CellR4, Numéro 8, 2020, ISSN 2329-7042
Éditeur: Verduci International
DOI: 10.32113/cellr4_20205_2850

Regulatory Challenges at the Intersection of Cellular and Medical Device Therapies in Europe: The Case of the Bioartificial Pancreas

Auteurs: Cronin AJ, Thom RL.
Publié dans: Law, Technology and Human, Numéro 5(2), 2023, ISSN 2652-4074
Éditeur: QUT
DOI: 10.5204/lthj.3118

Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Auteurs: Charles-Henri Wassmer, Ekaterine Berishvili
Publié dans: Current Diabetes Reports, Numéro 20/8, 2020, Page(s) 31, ISSN 1534-4827
Éditeur: Current Science Inc.
DOI: 10.1007/s11892-020-01316-w

Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

Auteurs: Charles‐Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Domenico Bosco, Thierry Berney, Ekaterine Berishvili
Publié dans: Transplant International, Numéro 33/12, 2020, Page(s) 1577-1588, ISSN 0934-0874
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/tri.13721

Factor VIII, a coagulation cofactor, is a relevant survival factor in bladder cancer cell lines

Auteurs: Gillian E. Walker, Ester Borroni, Rida Haider, Cristina Olgasi, Chiara Borsotti, Antonia Follenzi
Publié dans: Journal of Thrombosis and Haemostasis, 2025, ISSN 1538-7836
Éditeur: Elsevier BV
DOI: 10.1016/j.jtha.2025.03.002

Organoids: a systematic review of ethical issues

Auteurs: Dide de Jongh, Emma K. Massey , the VANGUARD consortium*, Eline M. Bunnik
Publié dans: Stem Cell Research & Therapy, Numéro 13, 2022, Page(s) 337, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-022-02950-9

Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy

Auteurs: Ekaterine Berishvili, Laurent Kaiser, Marie Cohen, Thierry Berney, Hanne Scholz, Yngvar Floisand, Jonas Mattsson
Publié dans: Stem Cell Reviews and Reports, Numéro 17/1, 2021, Page(s) 63-70, ISSN 2629-3277
Éditeur: Springer
DOI: 10.1007/s12015-020-10004-x

Spheroids Composed of Reaggregated Neonatal Porcine Islets and Human Endothelial Cells Accelerate Development of Normoglycemia in Diabetic Mice

Auteurs: Mohsen Honarpisheh, Yutian Lei, Antonia Follenzi, Alessia Cucci, Cristina Olgasi, Ekaterine Berishvili, Fanny Lebreton, Kevin Bellofatto, Lorenzo Piemonti, Antonio Citro, Francesco Campo, Cataldo Pignatelli, Olivier Thaunat, Elisabeth Kemter, Martin Kraetzl, Eckhard Wolf, Jochen Seissler, Lelia Wolf-van Buerck, null null
Publié dans: Cells, Numéro 14, 2025, Page(s) 366, ISSN 2073-4409
Éditeur: MDPI AG
DOI: 10.3390/cells14050366

Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues

Auteurs: de Jongh, D., Massey, E. K., Cronin, A. J., Schermer, M. H. N., Bunnik, E. M. and the VANGUARD Consortium
Publié dans: Transplant International, Numéro 14322277, 2022, ISSN 1432-2277
Éditeur: Frontiers Publishing Partnership
DOI: 10.3389/ti.2022.10751

Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study

Auteurs: Charles-Henri Wassmer, Kevin Bellofatto, Lisa Perez, Vanessa Lavallard, David Cottet-Dumoulin, Sanda Ljubicic, Géraldine Parnaud, Domenico Bosco, Ekaterine Berishvili, Fanny Lebreton
Publié dans: Cell Transplantation, Numéro 29, 2020, Page(s) 096368972093729, ISSN 0963-6897
Éditeur: Cognizant Communication Corp.
DOI: 10.1177/0963689720937292

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device

Auteurs: Olgasi, C., Borsotti, C., Merlin, S., Bergmann, T., Bittorf, P., Adewoye, A. B., Wragg, N., Patterson, K., Calabria, A., Benedicenti, F., Cucci, A., Borchiellini, A., Pollio, B., Montini, E., Mazzuca, D. M., Zierau, M., Stolzing, A., Toleikis, P., Braspenning, J., & Follenzi, A.
Publié dans: Molecular Therapy - Methods & Clinical Development, Numéro 23, 2021, Page(s) 551-566, ISSN 2329-0501
Éditeur: Cell Press
DOI: 10.1016/j.omtm.2021.10.015

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

Auteurs: Sarah Grimus, Victoria Sarangova, Petra B. Welzel, Barbara Ludwig, Jochen Seissler, Elisabeth Kemter, Eckhard Wolf, Asghar Ali
Publié dans: Advanced Science, Numéro 11, 2024, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202401385

Factor VIII promotes angiogenesis and vessel stability regulating extracellular matrix proteins

Auteurs: Cristina Olgasi, Alessia Cucci, Ivan Molineris, Simone Assanelli, Francesca Anselmi, Chiara Borsotti, Chiara Sgromo, Andrea Lauria, Simone Merlin, Gillian E. Walker, Salvatore Oliviero, Antonia Follenzi
Publié dans: Haematologica, Numéro 109, 2024, Page(s) 3391-3397, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2024.285089

The bio-artificial pancreas to treat type 1 diabetes: Perspectives from healthcare professionals in the Netherlands

Auteurs: Dide de Jongh, Eline Bunnik, Behiye Ozcan, Robert Zietse, Emma Massey
Publié dans: Journal of Clinical & Translational Endocrinology, Numéro 38, 2024, Page(s) 100372, ISSN 2214-6237
Éditeur: Elsevier BV
DOI: 10.1016/j.jcte.2024.100372

Legal and Regulatory Challenges for Emerging Regenerative Medicine Solutions for Diabetes

Auteurs: Thom RL, Cronin AJ; VANGUARD Consortium.
Publié dans: Transplantation, Numéro 9, 2023, ISSN 0041-1337
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004797

Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations

Auteurs: de Jongh D, Thom RL, Cronin AJ, Bunnik EM, Massey EK.
Publié dans: Transplant international, 2023, ISSN 1432-2277
Éditeur: Frontiers
DOI: 10.3389/ti.2023.11705

From islet of Langerhans transplantation to the bioartificial pancreas

Auteurs: Thierry Berney; Charles H. Wassmer; Fanny Lebreton; Kevin Bellofatto; Laura Mar Fonseca; Juliette Bignard; Reine Hanna; Andrea Peloso; Ekaterine Berishvili
Publié dans: La Presse Médicale, Numéro 9, 2022, ISSN 0755-4982
Éditeur: Elsevier Masson
DOI: 10.1016/j.lpm.2022.104139

Therapeutic potential of fetal liver cell transplantation in hemophilia A mice

Auteurs: Simone, Merlin; Saicharan, Akula; Alessia, Cottonaro; Tamara, Garcia-Leal; Luis Javier, Serrano; Ester, Borroni; Vakhtang, Kalandadze; Rocio, Galiano; Chiara, Borsotti; Antonio, Liras; María José, Sanchez; Antonia, Follenzi
Publié dans: Haematologica, Numéro 6, 2023, Page(s) 1544-1554, ISSN 1592-8721
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.282001

What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Auteurs: Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, Eckhard Wolf
Publié dans: Transplant International, Numéro 37, 2024, ISSN 1432-2277
Éditeur: Frontiers Media SA
DOI: 10.3389/ti.2024.13681

Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives

Auteurs: Pires, Salomé; Bollini, Sveva; Botelho, Maria Filomena; Lang-Olip, Ingrid; Ponsaerts, Peter; Balbi, Carolina; Lange-Consiglio, Anna; Fénelon, Mathilde; Mojsilović, Slavko; Cremonesi, Fausto; Bugarski, Diana; Berishvili, Ekaterine; Gazouli, Maria; Gellhaus, Alexandra; Kerdjoudj, Halima; Schoeberlein, Andreina
Publié dans: Methods and Protocols, 2023, ISSN 2409-9279
Éditeur: MDPI
DOI: 10.3390/mps6030045

Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells

Auteurs: Pignatelli C, Campo F, Neroni A, Piemonti L and Citro A
Publié dans: Transplant International, Numéro 14322277, 2022, ISSN 1432-2277
Éditeur: Frontiers
DOI: 10.3389/ti.2022.10555

Advances and challenges of endocrine pancreas bioengineering

Auteurs: Hanna, R., & Berishvili, E.
Publié dans: Current Opinion in Endocrine and Metabolic Research, Numéro 23, 100320, 2022, ISSN 2451-9650
Éditeur: Elsevier Ltd.
DOI: 10.1016/j.coemr.2022.100320

Allogeneic Islet Transplantation: Chronicle of a Death Foretold?

Auteurs: Thierry Berney, Olivier Thaunat, Ekaterine Berishvili
Publié dans: Transplant International, Numéro 38, 2025, ISSN 1432-2277
Éditeur: Frontiers Media SA
DOI: 10.3389/ti.2025.14598

I’ve got you under my skin

Auteurs: Thierry Berney, Ekaterine Berishvili
Publié dans: Nature Metabolism, Numéro 2/10, 2020, Page(s) 993-994, ISSN 2522-5812
Éditeur: Nature Research
DOI: 10.1038/s42255-020-0268-8

Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes

Auteurs: Wassmer, C.H., Lebreton, F., Bellofatto, K., Perez, L., Cottet-Dumoulin, D., Andres, A., Bosco, D., Berney, T., Othenin-Girard, V., Martinez De Tejada, B., Cohen, M., Follenzi, A., Berishvili, E., and the VANGUARD Consortium
Publié dans: Transplant International, Numéro 35, 2022, ISSN 1432-2277
Éditeur: Frontiers
DOI: 10.3389/ti.2021.10214

Clinical Translation and Implementation of a Bioartificial Pancreas Therapy: A Qualitative Study Exploring the Perspectives of People With Type 1 Diabetes

Auteurs: Dide de Jongh, Silke Lapré, Behiye Özcan, Robert Zietse, Eline M. Bunnik, Emma K. Massey, null null
Publié dans: Transplantation Direct, Numéro 10, 2025, Page(s) e1711, ISSN 2373-8731
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/txd.0000000000001711

Non-peer reviewed articles (1)

Organoïdes sécréteurs d’insuline

Auteurs: Fanny Lebreton, Charles-Henri Wassmer, Kevin Belofatto, Thierry Berney, Ekaterine Berishvili
Publié dans: médecine/sciences, Numéro 36/10, 2020, Page(s) 879-885, ISSN 0767-0974
Éditeur: Editions E D K
DOI: 10.1051/medsci/2020129