New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes

Risultati finali

ACCEL will create a communication portfolio of updated VANGUARD print visual and media information and documentation including factsheets brochures and posters and visual content will be developed to offer information about the project in a condensed form that can be handed out during various events and downloaded from the project website

VANGUARD Stakeholder Engagement and Dissemination Assessment Reports

To asses the implementation and impact of the stakeholder engagement and dissemination activities, ACCEL will monitor and document (D9.4, M48) the implemented measures to assess the individual activities and adapt any activities where required to facilitate outreach and impact M24 and 48)

ELSA Training Manual

Training of VANGUARD researchers in M6, in particular newly recruited staff, on the ethical implications and safety requirements involved in regenerative medicine in general and the therapy developed during the VANGUARD project. The existing literature will be reviewed, experts in bioethics consulted, and together with partners we will develop a training manual.

Project website

To support aforementioned dissemination and communication activities throughout the duration of the project, ACCEL will set up and maintain the project website, which will notably function as the main source of information and resources related to the project, partners, latest developments, publications and public deliverables for all stakeholders.

Pubblicazioni

Vascularized endocrine pancreas for type 1 diabetes

Autori: Bellofatto, Kevin; Lebreton, Fanny; Fonseca, Laura Mar; Hanna, Reine; Bignard, Juliette; Galvan, Victor; Peloso, Andrea; Berney, Thierry; Compagnon, Philippe; VANGUARD Consortium; Berishvili, Ekaterine
Pubblicato in: Transplantation, Numero 107, 2023, Pagina/e 58
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994052.77218.10

Ethics of Early Clinical Trials of Bio-Artificial Organs

Autori: Bunnik, E.M., de Jongh, D. and Massey, E.
Pubblicato in: Transplant International, Numero 35, 2022, Pagina/e 10621, ISSN 0934-0874
Editore: Frontiers Publishing Partnerships
DOI: 10.3389/ti.2022.10621

Generation of Prevascularized Endocrine Constructs to Treat Type 1 Diabetes

Autori: Bellofatto K, Lebreton F, Wassmer CH Fonseca L, Hanna R, Berishvili E.
Pubblicato in: Transplantation, Numero 9, 2022
Editore: Lippincott Williams & Wilkins
DOI: 10.1097/01.tp.0000885936.38573.32

Hydrogel-based, prevascularized, retrievable endocrine construct to treat Type 1 Diabetes

Autori: Bellofatto K, Lebreton F, Hanna R, Fonseca L M, Bignard J, Galvan V, Peloso A, Berney TH, Compagnon PH, VANGUARD Consortium, Berishvili E.
Pubblicato in: Transplantation, Numero 107, 2023, Pagina/e 57
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/01.tp.0000994048.59940.dd

Mechanisms of Immunomodulation and Cytoprotection Conferred to Pancreatic Islet by Human Amniotic Epithelial Cells

Autori: Lebreton F, Hanna R, Wassmer CH, Bellofatto K, Perez L, Othenin-Girard V, de Tejada BM, Cohen M, Berishvili E.
Pubblicato in: Stem Cell Reviews and Reports, Numero 18, 2021, Pagina/e 346-359, ISSN 1550-8943
Editore: Springer Verlag
DOI: 10.1007/s12015-021-10269-w

Formation of Re-Aggregated Neonatal Porcine Islet Clusters Improves In Vitro Function and Transplantation Outcome

Autori: Honarpisheh M, Lei Y, Zhang Y, Pehl M, Kemter E, Lange A, Wolf E, Wolf-van Buerck L, VANGUARD consortium, Seissler S.
Pubblicato in: Transplant International, Numero 35, 2022, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2022.10697

Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

Autori: Alibashe-Ahmed M., Berney T., Giovannoni L., Berishvili E.
Pubblicato in: CellR4, Numero 8, 2020, ISSN 2329-7042
Editore: Verduci International
DOI: 10.32113/cellr4_20205_2850

Regulatory Challenges at the Intersection of Cellular and Medical Device Therapies in Europe: The Case of the Bioartificial Pancreas

Autori: Cronin AJ, Thom RL.
Pubblicato in: Law, Technology and Human, Numero 5(2), 2023, ISSN 2652-4074
Editore: QUT
DOI: 10.5204/lthj.3118

Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Autori: Charles-Henri Wassmer, Ekaterine Berishvili
Pubblicato in: Current Diabetes Reports, Numero 20/8, 2020, Pagina/e 31, ISSN 1534-4827
Editore: Current Science Inc.
DOI: 10.1007/s11892-020-01316-w

Generation of insulin‐secreting organoids: a step toward engineering and transplanting the bioartificial pancreas

Autori: Charles‐Henri Wassmer, Fanny Lebreton, Kevin Bellofatto, Domenico Bosco, Thierry Berney, Ekaterine Berishvili
Pubblicato in: Transplant International, Numero 33/12, 2020, Pagina/e 1577-1588, ISSN 0934-0874
Editore: Blackwell Publishing Inc.
DOI: 10.1111/tri.13721

Organoids: a systematic review of ethical issues

Autori: Dide de Jongh, Emma K. Massey , the VANGUARD consortium*, Eline M. Bunnik
Pubblicato in: Stem Cell Research & Therapy, Numero 13, 2022, Pagina/e 337, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-022-02950-9

Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy

Autori: Ekaterine Berishvili, Laurent Kaiser, Marie Cohen, Thierry Berney, Hanne Scholz, Yngvar Floisand, Jonas Mattsson
Pubblicato in: Stem Cell Reviews and Reports, Numero 17/1, 2021, Pagina/e 63-70, ISSN 2629-3277
Editore: Springer
DOI: 10.1007/s12015-020-10004-x

Early-Phase Clinical Trials of Bio-Artificial Organ Technology: A Systematic Review of Ethical Issues

Autori: de Jongh, D., Massey, E. K., Cronin, A. J., Schermer, M. H. N., Bunnik, E. M. and the VANGUARD Consortium
Pubblicato in: Transplant International, Numero 14322277, 2022, ISSN 1432-2277
Editore: Frontiers Publishing Partnership
DOI: 10.3389/ti.2022.10751

Engineering of Primary Pancreatic Islet Cell Spheroids for Three-dimensional Culture or Transplantation: A Methodological Comparative Study

Autori: Charles-Henri Wassmer, Kevin Bellofatto, Lisa Perez, Vanessa Lavallard, David Cottet-Dumoulin, Sanda Ljubicic, Géraldine Parnaud, Domenico Bosco, Ekaterine Berishvili, Fanny Lebreton
Pubblicato in: Cell Transplantation, Numero 29, 2020, Pagina/e 096368972093729, ISSN 0963-6897
Editore: Cognizant Communication Corp.
DOI: 10.1177/0963689720937292

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device

Autori: Olgasi, C., Borsotti, C., Merlin, S., Bergmann, T., Bittorf, P., Adewoye, A. B., Wragg, N., Patterson, K., Calabria, A., Benedicenti, F., Cucci, A., Borchiellini, A., Pollio, B., Montini, E., Mazzuca, D. M., Zierau, M., Stolzing, A., Toleikis, P., Braspenning, J., & Follenzi, A.
Pubblicato in: Molecular Therapy - Methods & Clinical Development, Numero 23, 2021, Pagina/e 551-566, ISSN 2329-0501
Editore: Cell Press
DOI: 10.1016/j.omtm.2021.10.015

Legal and Regulatory Challenges for Emerging Regenerative Medicine Solutions for Diabetes

Autori: Thom RL, Cronin AJ; VANGUARD Consortium.
Pubblicato in: Transplantation, Numero 9, 2023, ISSN 0041-1337
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/tp.0000000000004797

Clinical Translation of Bio-Artificial Pancreas Therapies: Ethical, Legal and Psychosocial Interdisciplinary Considerations and Key Recommendations

Autori: de Jongh D, Thom RL, Cronin AJ, Bunnik EM, Massey EK.
Pubblicato in: Transplant international, 2023, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2023.11705

From islet of Langerhans transplantation to the bioartificial pancreas

Autori: Thierry Berney; Charles H. Wassmer; Fanny Lebreton; Kevin Bellofatto; Laura Mar Fonseca; Juliette Bignard; Reine Hanna; Andrea Peloso; Ekaterine Berishvili
Pubblicato in: La Presse Médicale, Numero 9, 2022, ISSN 0755-4982
Editore: Elsevier Masson
DOI: 10.1016/j.lpm.2022.104139

Therapeutic potential of fetal liver cell transplantation in hemophilia A mice

Autori: Simone, Merlin; Saicharan, Akula; Alessia, Cottonaro; Tamara, Garcia-Leal; Luis Javier, Serrano; Ester, Borroni; Vakhtang, Kalandadze; Rocio, Galiano; Chiara, Borsotti; Antonio, Liras; María José, Sanchez; Antonia, Follenzi
Pubblicato in: Haematologica, Numero 6, 2023, Pagina/e 1544-1554, ISSN 1592-8721
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2022.282001

Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives

Autori: Pires, Salomé; Bollini, Sveva; Botelho, Maria Filomena; Lang-Olip, Ingrid; Ponsaerts, Peter; Balbi, Carolina; Lange-Consiglio, Anna; Fénelon, Mathilde; Mojsilović, Slavko; Cremonesi, Fausto; Bugarski, Diana; Berishvili, Ekaterine; Gazouli, Maria; Gellhaus, Alexandra; Kerdjoudj, Halima; Schoeberlein, Andreina
Pubblicato in: Methods and Protocols, 2023, ISSN 2409-9279
Editore: MDPI
DOI: 10.3390/mps6030045

Bioengineering the Vascularized Endocrine Pancreas: A Fine-Tuned Interplay Between Vascularization, Extracellular-Matrix-Based Scaffold Architecture, and Insulin-Producing Cells

Autori: Pignatelli C, Campo F, Neroni A, Piemonti L and Citro A
Pubblicato in: Transplant International, Numero 14322277, 2022, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2022.10555

Advances and challenges of endocrine pancreas bioengineering

Autori: Hanna, R., & Berishvili, E.
Pubblicato in: Current Opinion in Endocrine and Metabolic Research, Numero 23, 100320, 2022, ISSN 2451-9650
Editore: Elsevier Ltd.
DOI: 10.1016/j.coemr.2022.100320

I’ve got you under my skin

Autori: Thierry Berney, Ekaterine Berishvili
Pubblicato in: Nature Metabolism, Numero 2/10, 2020, Pagina/e 993-994, ISSN 2522-5812
Editore: Nature Research
DOI: 10.1038/s42255-020-0268-8

Bio-Engineering of Pre-Vascularized Islet Organoids for the Treatment of Type 1 Diabetes

Autori: Wassmer, C.H., Lebreton, F., Bellofatto, K., Perez, L., Cottet-Dumoulin, D., Andres, A., Bosco, D., Berney, T., Othenin-Girard, V., Martinez De Tejada, B., Cohen, M., Follenzi, A., Berishvili, E., and the VANGUARD Consortium
Pubblicato in: Transplant International, Numero 35, 2022, ISSN 1432-2277
Editore: Frontiers
DOI: 10.3389/ti.2021.10214

Organoïdes sécréteurs d’insuline

Autori: Fanny Lebreton, Charles-Henri Wassmer, Kevin Belofatto, Thierry Berney, Ekaterine Berishvili
Pubblicato in: médecine/sciences, Numero 36/10, 2020, Pagina/e 879-885, ISSN 0767-0974
Editore: Editions E D K
DOI: 10.1051/medsci/2020129

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