Deliverables Documents, reports (14) Protocol for the collection, pre-processing and storage of biological samples in WP6, WP7 Protocols will be developed for the collection, pre-processing and storage of blood, urine, exhaled breath and exhaled breath condensate samples to be incorporated in WP6 and 7 study protocols. Report on the establishment of the EPHOR mega cohort The EPHOR mega cohort will be created including cohorts with data on occupational histories Occupations will be coded including using automated free text mining developed in WP4 crosswalks between different coding systems will be developed and used to harmonize data across different occupational coding systems and versions together with WP4 and the newly developed EuroJEM WP2 will be applied to occupational histories over the lifecourse of included participants A framework for decentralized largescale pooling of data for epidemiological analyses will be implemented with WP4 Inventory of European cohorts with extensive information on occupational exposures Extension and refinement of a searchable web-based database inventory of occupational cohorts based on the ongoing COST Action OMEGA-NET. Protocol for feasibility study Protocol for the feasibility study, that will be conducted in at least two countries with at least 12 participants, to test the exposure protocol including the wearable sensor system in the field. The exposure protocol will ultimately be applied in the case studies. Report on the external exposome protocol development for the case studies Development of a full external exposome protocol for in the case studies that will bring together the protocols on the wearable sensor system and passive sampling A protocol for field implementation informed consent forms data collection QAQC data management and data analysis will be developed with the case studies The protocol will also encompass a digital questionnaire on working time sleep specific chemical and physical exposures diet lifestyle workplace organisation psychosocial factors and jobrecords Report on protocol for including new data in EuroJEM To ensure that the dynamic EuroJEM includes the latest available information of highest quality possible a protocol will be developed for including new data into EuroJEM The protocol will include methods for searching and collecting new data from literature assisted by text mining WP4 exposure databases eg ECHA REACH database reports and Bayesian decision criteria to determine if and how to revise exposure estimates in the JEM This task will also investigate the use of optimized and dynamic coding systems Report on tutorial on the use of hierarchical models in working-life exposome research Hierarchical regression methods will be further developed and applied to the EPHOR mega cohort WP5 to identify new exposuredisease associations in the agnostic analyses and use the outcomes within WP2 to evaluate and improve EuroJEM Report on harmonizing existing JEMs Occupational codes will be harmonized Inconsistencies and gaps between different JEMs will be resolved by expert judgement leaving the possibility to keep betweencountry differences when factually motivated Imputation will be applied to cover missing values occupationscountries resulting in a first version of EuroJEM Report on tutorial for the application of a suite of ‘multiple exposure methods' Methods capable of handling multiple exposures in exposureresponse analyses will be developed This includes the conventional approach of analysing all exposureresponse associations in parallel while adjusting for multiple comparisons and novel methods based on machine learning approaches that account for the correlations between exposures Report on inventory of ETR models relevant for EPHOR An inventory will be compiled of all Compartmental multistate models twostage clonal expansion models and exposure rate models for ETR analyses that have been published to date This inventory will document what the underlying assumptions of these models are what inference they provide and to what extent they overlap Protocol of study on working life exposome and respiratory health A protocol will be developed for new data collection on respiratory health and working life exposome in 12 study centres from 7 European countries (Spain, France, Sweden, Norway, Estonia, Iceland, Denmark) and Australia. Report on collection and defining JEMs For each JEM information will be collected on coding systems of occupation and industry timeperiods covered and time intervals exposure indices and data sources For each exposure definitions of exposednonexposed will be suggested based on an agreed European background level of exposure and the unit of exposure to be used Report on automated job coding Improved methods for automated coding of free text fields in occupational histories into job coding will be developed based on artificial intelligence AI mimicking human experts for coding of occupational histories to be used in WP5 Report on development of new and more specific JEMs New partsdimensions for the EuroJEM will be developed to cover 1 selected exposures which for the same occupational code vary largely by industry eg mechanic maintenance or assembly worker or by gender eg job control physical work load 2 key emerging risks eg threats and violence at work 3 new concepts eg societal status of the work 4 employment conditions eg nonstandard temporarily in another country precarious and 5 key nonoccupational exposures lifestyle socioeconomic conditions will be addressed when countryspecific data are available by occupational code Websites, patent fillings, videos etc. (1) Part 1: Web-based toolbox version 1.0 Webbased toolbox version 10 including an interactive visualization tool several protocols for external and internal exposome assessment searchable databases of JEMs and populations Publications Peer reviewed articles (6) Working life expectancy and working years lost among users of part- and full-time sickness absence in Finland Author(s): Hartikainen, E., Solovieva, S., Viikari-Juntura, E., & Leinonen, T. Published in: Scandinavian Journal of Work, Environment & Health, Issue 2023;49(1):23-32, 2023, Page(s) 23-32, ISSN 0355-3140 Publisher: Nordic Association of Occupational Safety and Health (NOROSH) DOI: 10.5271/sjweh.4054 Applying the exposome concept to working life health Author(s): Pronk, Anjoeka; Loh, Miranda; Kuijpers, Eelco; Albin, Maria; Selander, Jenny; Godderis, Lode; Ghosh, Manosij; Vermeulen, Roel; Peters, Susan; Mehlum, Ingrid Sivesind; Turner, Michelle C.; Schlünssen, Vivi; Goldberg, Marcel; Kogevinas, Manolis; Harding, Barbara N.; Solovieva, Svetlana; Garani-Papadatos, Tina; van Tongeren, Martie; Stierum, Rob Published in: Environmental Epidemiology, Issue 2, 2022, ISSN 2474-7882 Publisher: Wolters Kluwer Health DOI: 10.1097/ee9.0000000000000185 The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome? Author(s): López-Cervantes, J. P., Lønnebotn, M., Jogi, N. O., Calciano, L., Kuiper, I. N., Darby, M. G., Dharmage, S. C., Gómez-Real, F., Hammer, B., Bertelsen, R. J., Johannessen, A., Würtz, A. M. L., Mørkve Knudsen, T., Koplin, J., Pape, K., Skulstad, S. M., Timm, S., Tjalvin, G., Krauss-Etschmann, S., Accordini, S., … Svanes, C. Published in: International Journal of Environmental Research and Public Health, Issue 18 (23), 2021, Page(s) 12684, ISSN 1660-4601 Publisher: MDPI DOI: 10.3390/ijerph182312684 Exposure to a SARS-CoV-2 infection at work: development of an international job exposure matrix (COVID-19-JEM) Author(s): Oude Hengel KM, Burdorf A, Pronk A, Schlünssen V, Stokholm ZA, Kolstad HA, van Veldhoven K, Basinas I, van Tongeren M, Peters S Published in: Scand J Work Environ Health, Issue 48 (1), 2021, Page(s) 61-70, ISSN 0355-3140 Publisher: Nordic Association of Occupational Safety and Health (NOROSH) DOI: 10.5271/sjweh.3998 Development of Harmonized COVID-19 Occupational Questionnaires Author(s): Vivi Schlünssen, Jean Baptist du Prel, Martie van Tongeren, Lode Godderis, Michelle C Turner, and Damien McElvenny, OMEGA-NET COVID-19 Questionnaire Subtask Group Published in: Annals of Work Exposures and Health, Issue 67(1), 2023, Page(s) 4-8, ISSN 2398-7308 Publisher: Oxford University Press DOI: 10.1093/annweh/wxac044 Applying the exposome concept to working life healthThe EU EPHOR project Author(s): Pronk, Anjoeka, Loh, Miranda; Kuijpers, Eelco; Albin, Maria; Selander, Jenny; Godderis, Lode; Ghosh, Manosij; Vermeulen, Roel; Peters, Susan; Mehlum, Ingrid Sivesind; Turner, Michelle C.; Schlünssen, Vivi; Goldberg, Marcel; Kogevinas, Manolis; Harding, Barbara N.; Solovieva, Svetlana, Garani-Papadatos, Tina; van Tongeren, Martie; The EPHOR Consortium; Stierum, Rob Published in: Environmental Epidemiology, Issue volume 6, issue 2, 2022, Page(s) e185, ISSN 2474-7882 Publisher: Woters Kluwen DOI: 10.1097/ee9.0000000000000185 Searching for OpenAIRE data... 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