Exposome project for health and occupational research

Livrables

Protocol for the collection, pre-processing and storage of biological samples in WP6, WP7

Protocols will be developed for the collection, pre-processing and storage of blood, urine, exhaled breath and exhaled breath condensate samples to be incorporated in WP6 and 7 study protocols.

Report on the establishment of the EPHOR mega cohort

The EPHOR mega cohort will be created including cohorts with data on occupational histories Occupations will be coded including using automated free text mining developed in WP4 crosswalks between different coding systems will be developed and used to harmonize data across different occupational coding systems and versions together with WP4 and the newly developed EuroJEM WP2 will be applied to occupational histories over the lifecourse of included participants A framework for decentralized largescale pooling of data for epidemiological analyses will be implemented with WP4

Report on dynamic coding for more meaningful categories for exposure assessment

Improved coding systems will be developed and used in by WP2 for more flexible coding that allows for different coding structures depending on the risk factor.

Inventory of European cohorts with extensive information on occupational exposures

Extension and refinement of a searchable web-based database inventory of occupational cohorts based on the ongoing COST Action OMEGA-NET.

Protocol for feasibility study

Protocol for the feasibility study, that will be conducted in at least two countries with at least 12 participants, to test the exposure protocol including the wearable sensor system in the field. The exposure protocol will ultimately be applied in the case studies.

Report on the external exposome protocol development for the case studies

Development of a full external exposome protocol for in the case studies that will bring together the protocols on the wearable sensor system and passive sampling A protocol for field implementation informed consent forms data collection QAQC data management and data analysis will be developed with the case studies The protocol will also encompass a digital questionnaire on working time sleep specific chemical and physical exposures diet lifestyle workplace organisation psychosocial factors and jobrecords

Report on protocol for including new data in EuroJEM

To ensure that the dynamic EuroJEM includes the latest available information of highest quality possible a protocol will be developed for including new data into EuroJEM The protocol will include methods for searching and collecting new data from literature assisted by text mining WP4 exposure databases eg ECHA REACH database reports and Bayesian decision criteria to determine if and how to revise exposure estimates in the JEM This task will also investigate the use of optimized and dynamic coding systems

Report on tutorial on the use of hierarchical models in working-life exposome research

Hierarchical regression methods will be further developed and applied to the EPHOR mega cohort WP5 to identify new exposuredisease associations in the agnostic analyses and use the outcomes within WP2 to evaluate and improve EuroJEM

Report on harmonizing existing JEMs

Occupational codes will be harmonized Inconsistencies and gaps between different JEMs will be resolved by expert judgement leaving the possibility to keep betweencountry differences when factually motivated Imputation will be applied to cover missing values occupationscountries resulting in a first version of EuroJEM

Report on tutorial for the application of a suite of ‘multiple exposure methods'

Methods capable of handling multiple exposures in exposureresponse analyses will be developed This includes the conventional approach of analysing all exposureresponse associations in parallel while adjusting for multiple comparisons and novel methods based on machine learning approaches that account for the correlations between exposures

Report on inventory of ETR models relevant for EPHOR

An inventory will be compiled of all Compartmental multistate models twostage clonal expansion models and exposure rate models for ETR analyses that have been published to date This inventory will document what the underlying assumptions of these models are what inference they provide and to what extent they overlap

Protocol of study on working life exposome and respiratory health

A protocol will be developed for new data collection on respiratory health and working life exposome in 12 study centres from 7 European countries (Spain, France, Sweden, Norway, Estonia, Iceland, Denmark) and Australia.

Report on collection and defining JEMs

For each JEM information will be collected on coding systems of occupation and industry timeperiods covered and time intervals exposure indices and data sources For each exposure definitions of exposednonexposed will be suggested based on an agreed European background level of exposure and the unit of exposure to be used

Report on automated job coding

Improved methods for automated coding of free text fields in occupational histories into job coding will be developed based on artificial intelligence AI mimicking human experts for coding of occupational histories to be used in WP5

Report on methods and results passive sampling method

Protocol development for applying and analyzing passive sampling wristbands for chemical analyses and passive dust collection for biological analyses. Analyses and reporting on passive samples collected in the case studies.

Report on development of new and more specific JEMs

New partsdimensions for the EuroJEM will be developed to cover 1 selected exposures which for the same occupational code vary largely by industry eg mechanic maintenance or assembly worker or by gender eg job control physical work load 2 key emerging risks eg threats and violence at work 3 new concepts eg societal status of the work 4 employment conditions eg nonstandard temporarily in another country precarious and 5 key nonoccupational exposures lifestyle socioeconomic conditions will be addressed when countryspecific data are available by occupational code

Part 1: Web-based toolbox version 1.0

Webbased toolbox version 10 including an interactive visualization tool several protocols for external and internal exposome assessment searchable databases of JEMs and populations

Publications

Worker perspectives on improving occupational health and safety using wearable sensors: a crosssectional survey

Auteurs: William Mueller, Alice Smith, Eelco Kuijpers, , Anjoeka Pronk, , Miranda Loh
Publié dans: Annals of Work Exposures and Health, Numéro xx, 2024, Page(s) 1-7, ISSN 2398-7308
Éditeur: Oxford Acedemic
DOI: 10.1093/annweh/wxae057

Characterization of the internal working-life exposome using minimally and non-invasive sampling methods - a narrative review

Auteurs: Eline Verscheure a, Rob Stierum b, Vivi Schlünssen c, Anne Mette Lund Würtz c, Dorian Vanneste a, Manolis Kogevinas d, Barbara N. Harding d, Karin Broberg e f, Shan Zienolddiny-Narui g, Johanna Samulin Erdem g, Mrinal K. Das g, Konstantinos C. Makris h, Corina Konstantinou h, Xanthi Andrianou h, Susan Dekkers b, Lorna Morris i 1, Anjoeka Pronk b, Lode Godderis a j 2, Manosij Ghosh a 2, of EPHOR
Publié dans: Enviromental research, Numéro 238; 1, 2023, Page(s) 117001, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2023.117001

A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome

Auteurs: Annika M. Schoene; Ioannis Basinas; Martie van Tongeren; Sophia Ananiadou
Publié dans: International Journal of Environmental Research and Public Health, Numéro 19 (14), 2022, Page(s) 1-14, ISSN 1660-4601
Éditeur: MDPI (Multidisciplinary Digital Publishing Institute)
DOI: 10.3390/ijerph19148544

Mapping dynamic working life patterns and the impact of occupational exposures: a scoping review

Auteurs: Rachel Louise Hasting, Karen Marieke Oude Hengel, Taina Leinonen, Ute Bültmann, Ingrid Sivesind Mehlum, Alex Burdorf, Michelle C Turner, Laura Salonen, Damien M McElvenny, Svetlana Solovieva
Publié dans: BMC Public Health, Numéro 25, 2025, ISSN 1471-2458
Éditeur: BioMed Central
DOI: 10.1186/s12889-025-23487-5

A quantitative solar ultraviolet radiation job-exposure matrix for Europe

Auteurs: Else T Würtz, Kirsten Pugdahl, Morten Fenger-Grøn, Ina A Berglind, Mark P C Cherrie, Anna Dahlman-Höglund, Kasper Grandahl, Jelena Macan, Alberto Modenese, Hilde Notø, Svetlana Solovieva, Kurt Straif, Marc Wittlich, Sven Connemann, Timo Heepenstrick, Peter A Philipsen, Stephan Westerhausen, Calvin B Ge, Johnni Hansen, Cheryl E Peters, Ingrid Sivesind Mehlum, Vivi Schlünssen, Henrik A Kolstad
Publié dans: Annals of Work Exposures and Health, Numéro 69, 2025, Page(s) 415-428, ISSN 2398-7308
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/annweh/wxaf011

Socioeconomic differences in working life expectancy: a scoping review

Auteurs: Svetlana Solovieva, Astrid de Wind, Karina Undem, Christian Dudel, Ingrid S. Mehlum, Swenne G. van den Heuvel, Suzan J. W. Robroek & Taina Leinonen
Publié dans: BMC Public Health, Numéro 24, 2024, Page(s) 735, ISSN 1471-2458
Éditeur: BioMed Central
DOI: 10.1186/s12889-024-18229-y

Natural language processing applied to mental illness detection: a narrative review

Auteurs: Tianlin Zhang, Annika M. Schoene, Shaoxiong Ji, Sophia Ananiadou
Publié dans: npj Digital Medicine, Numéro 5, 2024, ISSN 2398-6352
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41746-022-00589-7

Working life expectancy and working years lost among users of part- and full-time sickness absence in Finland

Auteurs: Hartikainen, E., Solovieva, S., Viikari-Juntura, E., & Leinonen, T.
Publié dans: Scandinavian Journal of Work, Environment & Health, Numéro 2023;49(1):23-32, 2023, Page(s) 23-32, ISSN 0355-3140
Éditeur: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4054

Night shift work and indicators of cardiovascular risk: A systematic review and meta-analysis

Auteurs: Johanna Samulin Erdem, Mrinal K. Das, Evi De Ryck, Øivind Skare, Jenny-Anne S. Lie, Merete Bugge, Barbara Harding, Ingrid L. Jorgensen, Ingrid Sivesind Mehlum, Manolis Kogevinas, Karl-Christian Nordby, Shan Zienolddiny-Narui
Publié dans: Environmental Research, Numéro 276, 2025, Page(s) 121503, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2025.121503

Effects of exposure to environmental factors on obesity-related growth parameters and leptin (LEP) methylation in children.

Auteurs: Evi De Ryck; Manosij Ghosh; Tim S. Nawrot; Brigitte Reimann; Gudrun Koppen; Els Verachtert; Roland Devlieger; Lode Godderis; Sara Pauwels
Publié dans: Environmental Pollution, Numéro 346 (1), 2024, Page(s) 1, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123465

Applying the exposome concept to working life health

Auteurs: Pronk, Anjoeka; Loh, Miranda; Kuijpers, Eelco; Albin, Maria; Selander, Jenny; Godderis, Lode; Ghosh, Manosij; Vermeulen, Roel; Peters, Susan; Mehlum, Ingrid Sivesind; Turner, Michelle C.; Schlünssen, Vivi; Goldberg, Marcel; Kogevinas, Manolis; Harding, Barbara N.; Solovieva, Svetlana; Garani-Papadatos, Tina; van Tongeren, Martie; Stierum, Rob
Publié dans: Environmental Epidemiology, Numéro 2, 2022, ISSN 2474-7882
Éditeur: Wolters Kluwer Health
DOI: 10.1097/ee9.0000000000000185

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

Auteurs: López-Cervantes, J. P., Lønnebotn, M., Jogi, N. O., Calciano, L., Kuiper, I. N., Darby, M. G., Dharmage, S. C., Gómez-Real, F., Hammer, B., Bertelsen, R. J., Johannessen, A., Würtz, A. M. L., Mørkve Knudsen, T., Koplin, J., Pape, K., Skulstad, S. M., Timm, S., Tjalvin, G., Krauss-Etschmann, S., Accordini, S., … Svanes, C.
Publié dans: International Journal of Environmental Research and Public Health, Numéro 18 (23), 2021, Page(s) 12684, ISSN 1660-4601
Éditeur: MDPI
DOI: 10.3390/ijerph182312684

Development of a gender-specific European job exposure matrix (EuroJEM) for physical workload and its validation against musculoskeletal pain

Auteurs: Svetlana Solovieva, Alexis Descatha, Ingrid Sivesind Mehlum, Eira Viikari-Juntura, Karina Undem, Karin Berglund, Fabien Gilbert, Francesca Wuytack, Angelo d’Errico, Kathryn Badarin, Bradley Evanoff, Katarina Kjellberg
Publié dans: Scandinavian Journal of Work, Environment & Health, Numéro 51, 2025, Page(s) 119-129, ISSN 0355-3140
Éditeur: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4203

The 1001 nights-cohort – paving the way for future research on working hours, night work, circadian disruption, sleep, and health

Auteurs: Kirsten Nabe-Nielsen, Anne Emily Saunte Fiehn Arup, Mette Sallerup, Rikke Harmsen, Anna Sofie Ginty, Marie Tolver Nielsen, Anne-Sofie Rosenfeldt Jensen, Anders Aagaard, Vivi Schlünssen, Ann Dyreborg Larsen, Anne Helene Garde
Publié dans: European Journal of Epidemiology, Numéro 40, 2025, Page(s) 371-382, ISSN 0393-2990
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10654-025-01201-4

Narrative review of occupational exposures and noncommunicable diseases

Auteurs: Susan Peters, Karina Undem, Svetlana Solovieva, Jenny Selander, Vivi Schlünssen, Karen M Oude Hengel, Maria Albin, Calvin B Ge, Katarina Kjellberg, Damien M McElvenny, Per Gustavsson, Henrik A Kolstad, Anne Mette L Würtz, Bendik C Brinchmann, Karin Broberg, Stine Fossum, Merete Bugge, Mette Wulf Christensen, Manosij Ghosh, David Høyrup Christiansen, Suzanne L Merkus, Lars-Kristian Lunde, Eira V
Publié dans: Annals of Work Exposures and Health, Numéro 68; 6, 2024, Page(s) 562-580, ISSN 2398-7308
Éditeur: Oxford Academic
DOI: 10.1093/annweh/wxae045

Detailed assessment of night shift work aspects and potential mediators of its health effects: the contribution of field studies

Auteurs: Tara van der Grinten, Daniella van de Langenberg, Linda van Kerkhof, Barbara N. Harding, Anne Helene Garde, Caisa Laurell, Roel Vermeulen, Susan Peters, Jelle Vlaanderen
Publié dans: Frontiers in Public Health, Numéro 13, 2025, ISSN 2296-2565
Éditeur: Frontiers Media SA
DOI: 10.3389/fpubh.2025.1578128

Capturing occupational risk of airborne disease: An international job-exposure matrix based on five exposure factors

Auteurs: Karen M Oude Hengel, Susan Peters, Zara A Stokholm, Alex Burdorf, Anjoeka Pronk, Henrik A Kolstad, Martie van Tongeren, Ioannis Basinas, Vivi Schlünssen
Publié dans: Scandinavian Journal of Work, Environment & Health, 2025, ISSN 0355-3140
Éditeur: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4235

Exposure to a SARS-CoV-2 infection at work: development of an international job exposure matrix (COVID-19-JEM)

Auteurs: Oude Hengel KM, Burdorf A, Pronk A, Schlünssen V, Stokholm ZA, Kolstad HA, van Veldhoven K, Basinas I, van Tongeren M, Peters S
Publié dans: Scand J Work Environ Health, Numéro 48 (1), 2021, Page(s) 61-70, ISSN 0355-3140
Éditeur: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.3998

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Auteurs: Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Publié dans: Breathe, Numéro 19, 2023, Page(s) 23044, ISSN 1810-6838
Éditeur: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

Development of Harmonized COVID-19 Occupational Questionnaires

Auteurs: Vivi Schlünssen, Jean Baptist du Prel, Martie van Tongeren, Lode Godderis, Michelle C Turner, and Damien McElvenny, OMEGA-NET COVID-19 Questionnaire Subtask Group
Publié dans: Annals of Work Exposures and Health, Numéro 67(1), 2023, Page(s) 4-8, ISSN 2398-7308
Éditeur: Oxford University Press
DOI: 10.1093/annweh/wxac044

Automated Coding of Job Descriptions From a General Population Study: Overview of Existing Tools, Their Application and Comparison

Auteurs: Wenxin Wan, Calvin B Ge, Melissa C Friesen, Sarah J Locke, Daniel E Russ, Igor Burstyn, Christopher J O Baker, Anil Adisesh, Qing Lan, Nathaniel Rothman, Anke Huss, Martie van Tongeren, Roel Vermeulen, Susan Peters
Publié dans: Annals of Work Exposures and Health, Numéro 67; 5, 2023, Page(s) 663-672, ISSN 2398-7316
Éditeur: Oxford Academic
DOI: 10.1093/annweh/wxad002

Artificial intelligence exceeds humans in epidemiological job coding

Auteurs: Mathijs A. Langezaal; Egon L. van den Broek; Susan Peters; Marcel Goldberg; Grégoire Rey; Melissa C. Friesen; Sarah J. Locke; Nathaniel Rothman; Qing Lan; Roel C. H. Vermeulen
Publié dans: Communications Medicine, Numéro 3(1), 2023, Page(s) 160, ISSN 2730-664X
Éditeur: Springer Nature
DOI: 10.1038/s43856-023-00397-4

Cohort Profile: The Nor-Work Cohort

Auteurs: Rachel L Hasting, Suzanne L Merkus, Karina Undem, Jorunn Kirkeleit, Rune Hoff, Jon Michael Gran, Karl-Christian Nordby, Ingrid S Mehlum
Publié dans: International Journal of Epidemiology, Numéro 54, 2025, ISSN 1464-3685
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/ije/dyaf019

EPHOR Deliverable D3.1- Protocols for collection, pre-processing and storage of biological samples (WP3)

Auteurs: Verscheure, Eline; Schlünssen, Vivi; Broberg, Karin; Makris, Konstantinos; Charisiadis,Pantelis; Narui, Shan; Samulin Erdem, Johanna; Harding, Barbara; Kogevinas, Manolis; Samuel, Helen; Murch, William; Christie, Francesca; Schaber, Chad; Stierum, Rob; Pronk, Anjoeka; Godderis, Lode; Ghosh, Manosij
Publié dans: 2023
Éditeur: KUL
DOI: 10.48804/9s65kb

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Publications

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