Exposome project for health and occupational research

Leistungen

Protocol for the collection, pre-processing and storage of biological samples in WP6, WP7

Protocols will be developed for the collection, pre-processing and storage of blood, urine, exhaled breath and exhaled breath condensate samples to be incorporated in WP6 and 7 study protocols.

Report on the establishment of the EPHOR mega cohort

The EPHOR mega cohort will be created including cohorts with data on occupational histories Occupations will be coded including using automated free text mining developed in WP4 crosswalks between different coding systems will be developed and used to harmonize data across different occupational coding systems and versions together with WP4 and the newly developed EuroJEM WP2 will be applied to occupational histories over the lifecourse of included participants A framework for decentralized largescale pooling of data for epidemiological analyses will be implemented with WP4

Inventory of European cohorts with extensive information on occupational exposures

Extension and refinement of a searchable web-based database inventory of occupational cohorts based on the ongoing COST Action OMEGA-NET.

Protocol for feasibility study

Protocol for the feasibility study, that will be conducted in at least two countries with at least 12 participants, to test the exposure protocol including the wearable sensor system in the field. The exposure protocol will ultimately be applied in the case studies.

Report on the external exposome protocol development for the case studies

Development of a full external exposome protocol for in the case studies that will bring together the protocols on the wearable sensor system and passive sampling A protocol for field implementation informed consent forms data collection QAQC data management and data analysis will be developed with the case studies The protocol will also encompass a digital questionnaire on working time sleep specific chemical and physical exposures diet lifestyle workplace organisation psychosocial factors and jobrecords

Report on protocol for including new data in EuroJEM

To ensure that the dynamic EuroJEM includes the latest available information of highest quality possible a protocol will be developed for including new data into EuroJEM The protocol will include methods for searching and collecting new data from literature assisted by text mining WP4 exposure databases eg ECHA REACH database reports and Bayesian decision criteria to determine if and how to revise exposure estimates in the JEM This task will also investigate the use of optimized and dynamic coding systems

Report on tutorial on the use of hierarchical models in working-life exposome research

Hierarchical regression methods will be further developed and applied to the EPHOR mega cohort WP5 to identify new exposuredisease associations in the agnostic analyses and use the outcomes within WP2 to evaluate and improve EuroJEM

Report on harmonizing existing JEMs

Occupational codes will be harmonized Inconsistencies and gaps between different JEMs will be resolved by expert judgement leaving the possibility to keep betweencountry differences when factually motivated Imputation will be applied to cover missing values occupationscountries resulting in a first version of EuroJEM

Report on tutorial for the application of a suite of ‘multiple exposure methods'

Methods capable of handling multiple exposures in exposureresponse analyses will be developed This includes the conventional approach of analysing all exposureresponse associations in parallel while adjusting for multiple comparisons and novel methods based on machine learning approaches that account for the correlations between exposures

Report on inventory of ETR models relevant for EPHOR

An inventory will be compiled of all Compartmental multistate models twostage clonal expansion models and exposure rate models for ETR analyses that have been published to date This inventory will document what the underlying assumptions of these models are what inference they provide and to what extent they overlap

Protocol of study on working life exposome and respiratory health

A protocol will be developed for new data collection on respiratory health and working life exposome in 12 study centres from 7 European countries (Spain, France, Sweden, Norway, Estonia, Iceland, Denmark) and Australia.

Report on collection and defining JEMs

For each JEM information will be collected on coding systems of occupation and industry timeperiods covered and time intervals exposure indices and data sources For each exposure definitions of exposednonexposed will be suggested based on an agreed European background level of exposure and the unit of exposure to be used

Report on automated job coding

Improved methods for automated coding of free text fields in occupational histories into job coding will be developed based on artificial intelligence AI mimicking human experts for coding of occupational histories to be used in WP5

Report on development of new and more specific JEMs

New partsdimensions for the EuroJEM will be developed to cover 1 selected exposures which for the same occupational code vary largely by industry eg mechanic maintenance or assembly worker or by gender eg job control physical work load 2 key emerging risks eg threats and violence at work 3 new concepts eg societal status of the work 4 employment conditions eg nonstandard temporarily in another country precarious and 5 key nonoccupational exposures lifestyle socioeconomic conditions will be addressed when countryspecific data are available by occupational code

Part 1: Web-based toolbox version 1.0

Webbased toolbox version 10 including an interactive visualization tool several protocols for external and internal exposome assessment searchable databases of JEMs and populations

Veröffentlichungen

Worker perspectives on improving occupational health and safety using wearable sensors: a crosssectional survey

Autoren: William Mueller, Alice Smith, Eelco Kuijpers, , Anjoeka Pronk, , Miranda Loh
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe xx, 2024, Seite(n) 1-7, ISSN 2398-7308
Herausgeber: Oxford Acedemic
DOI: 10.1093/annweh/wxae057

Characterization of the internal working-life exposome using minimally and non-invasive sampling methods - a narrative review

Autoren: Eline Verscheure a, Rob Stierum b, Vivi Schlünssen c, Anne Mette Lund Würtz c, Dorian Vanneste a, Manolis Kogevinas d, Barbara N. Harding d, Karin Broberg e f, Shan Zienolddiny-Narui g, Johanna Samulin Erdem g, Mrinal K. Das g, Konstantinos C. Makris h, Corina Konstantinou h, Xanthi Andrianou h, Susan Dekkers b, Lorna Morris i 1, Anjoeka Pronk b, Lode Godderis a j 2, Manosij Ghosh a 2, of EPHOR
Veröffentlicht in: Enviromental research, Ausgabe 238; 1, 2023, Seite(n) 117001, ISSN 0013-9351
Herausgeber: Academic Press
DOI: 10.1016/j.envres.2023.117001

A Narrative Literature Review of Natural Language Processing Applied to the Occupational Exposome

Autoren: Annika M. Schoene; Ioannis Basinas; Martie van Tongeren; Sophia Ananiadou
Veröffentlicht in: International Journal of Environmental Research and Public Health, Ausgabe 19 (14), 2022, Seite(n) 1-14, ISSN 1660-4601
Herausgeber: MDPI (Multidisciplinary Digital Publishing Institute)
DOI: 10.3390/ijerph19148544

Socioeconomic differences in working life expectancy: a scoping review

Autoren: Svetlana Solovieva, Astrid de Wind, Karina Undem, Christian Dudel, Ingrid S. Mehlum, Swenne G. van den Heuvel, Suzan J. W. Robroek & Taina Leinonen
Veröffentlicht in: BMC Public Health, Ausgabe 24, 2024, Seite(n) 735, ISSN 1471-2458
Herausgeber: BioMed Central
DOI: 10.1186/s12889-024-18229-y

Working life expectancy and working years lost among users of part- and full-time sickness absence in Finland

Autoren: Hartikainen, E., Solovieva, S., Viikari-Juntura, E., & Leinonen, T.
Veröffentlicht in: Scandinavian Journal of Work, Environment & Health, Ausgabe 2023;49(1):23-32, 2023, Seite(n) 23-32, ISSN 0355-3140
Herausgeber: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4054

Effects of exposure to environmental factors on obesity-related growth parameters and leptin (LEP) methylation in children.

Autoren: Evi De Ryck; Manosij Ghosh; Tim S. Nawrot; Brigitte Reimann; Gudrun Koppen; Els Verachtert; Roland Devlieger; Lode Godderis; Sara Pauwels
Veröffentlicht in: Environmental Pollution, Ausgabe 346 (1), 2024, Seite(n) 1, ISSN 0269-7491
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2024.123465

Applying the exposome concept to working life health

Autoren: Pronk, Anjoeka; Loh, Miranda; Kuijpers, Eelco; Albin, Maria; Selander, Jenny; Godderis, Lode; Ghosh, Manosij; Vermeulen, Roel; Peters, Susan; Mehlum, Ingrid Sivesind; Turner, Michelle C.; Schlünssen, Vivi; Goldberg, Marcel; Kogevinas, Manolis; Harding, Barbara N.; Solovieva, Svetlana; Garani-Papadatos, Tina; van Tongeren, Martie; Stierum, Rob
Veröffentlicht in: Environmental Epidemiology, Ausgabe 2, 2022, ISSN 2474-7882
Herausgeber: Wolters Kluwer Health
DOI: 10.1097/ee9.0000000000000185

The Exposome Approach in Allergies and Lung Diseases: Is It Time to Define a Preconception Exposome?

Autoren: López-Cervantes, J. P., Lønnebotn, M., Jogi, N. O., Calciano, L., Kuiper, I. N., Darby, M. G., Dharmage, S. C., Gómez-Real, F., Hammer, B., Bertelsen, R. J., Johannessen, A., Würtz, A. M. L., Mørkve Knudsen, T., Koplin, J., Pape, K., Skulstad, S. M., Timm, S., Tjalvin, G., Krauss-Etschmann, S., Accordini, S., … Svanes, C.
Veröffentlicht in: International Journal of Environmental Research and Public Health, Ausgabe 18 (23), 2021, Seite(n) 12684, ISSN 1660-4601
Herausgeber: MDPI
DOI: 10.3390/ijerph182312684

Narrative review of occupational exposures and noncommunicable diseases

Autoren: Susan Peters, Karina Undem, Svetlana Solovieva, Jenny Selander, Vivi Schlünssen, Karen M Oude Hengel, Maria Albin, Calvin B Ge, Katarina Kjellberg, Damien M McElvenny, Per Gustavsson, Henrik A Kolstad, Anne Mette L Würtz, Bendik C Brinchmann, Karin Broberg, Stine Fossum, Merete Bugge, Mette Wulf Christensen, Manosij Ghosh, David Høyrup Christiansen, Suzanne L Merkus, Lars-Kristian Lunde, Eira V
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe 68; 6, 2024, Seite(n) 562-580, ISSN 2398-7308
Herausgeber: Oxford Academic
DOI: 10.1093/annweh/wxae045

Exposure to a SARS-CoV-2 infection at work: development of an international job exposure matrix (COVID-19-JEM)

Autoren: Oude Hengel KM, Burdorf A, Pronk A, Schlünssen V, Stokholm ZA, Kolstad HA, van Veldhoven K, Basinas I, van Tongeren M, Peters S
Veröffentlicht in: Scand J Work Environ Health, Ausgabe 48 (1), 2021, Seite(n) 61-70, ISSN 0355-3140
Herausgeber: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.3998

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Autoren: Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Veröffentlicht in: Breathe, Ausgabe 19, 2023, Seite(n) 23044, ISSN 1810-6838
Herausgeber: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

Development of Harmonized COVID-19 Occupational Questionnaires

Autoren: Vivi Schlünssen, Jean Baptist du Prel, Martie van Tongeren, Lode Godderis, Michelle C Turner, and Damien McElvenny, OMEGA-NET COVID-19 Questionnaire Subtask Group
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe 67(1), 2023, Seite(n) 4-8, ISSN 2398-7308
Herausgeber: Oxford University Press
DOI: 10.1093/annweh/wxac044

Automated Coding of Job Descriptions From a General Population Study: Overview of Existing Tools, Their Application and Comparison

Autoren: Wenxin Wan, Calvin B Ge, Melissa C Friesen, Sarah J Locke, Daniel E Russ, Igor Burstyn, Christopher J O Baker, Anil Adisesh, Qing Lan, Nathaniel Rothman, Anke Huss, Martie van Tongeren, Roel Vermeulen, Susan Peters
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe 67; 5, 2023, Seite(n) 663-672, ISSN 2398-7316
Herausgeber: Oxford Academic
DOI: 10.1093/annweh/wxad002

Artificial intelligence exceeds humans in epidemiological job coding

Autoren: Mathijs A. Langezaal; Egon L. van den Broek; Susan Peters; Marcel Goldberg; Grégoire Rey; Melissa C. Friesen; Sarah J. Locke; Nathaniel Rothman; Qing Lan; Roel C. H. Vermeulen
Veröffentlicht in: Communications Medicine, Ausgabe 3(1), 2023, Seite(n) 160, ISSN 2730-664X
Herausgeber: Springer Nature
DOI: 10.1038/s43856-023-00397-4

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