Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

Información del proyecto

EXIMIOUS

Identificador del acuerdo de subvención: 874707

DOI

10.3030/874707

Proyecto cerrado

Fecha de la firma de la CE 6 Diciembre 2019

Fecha de inicio 1 Enero 2020

Fecha de finalización 30 Junio 2025

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 10 878 331,83

Aportación de la UE

€ 10 878 331,25

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Report 7: Updated Dissemination and Communication strategy

Joint dissemination and communication activities for the network

Report 3 Handover document to next coordinating team

Document summarising network activities and ongoing activities to facilitate a smooth transition

Report on mediating immunome factors and gene-environment interactions between exposures and disease

Identification of the genetic factors controlling variation in the immune system described in WP6 Task 6.5

Websites, patent fillings, videos etc. (4)

Exposome tool

A direct and cheap instrument for assessing the initial exposure will be developed to perform measurements of the chemicals in the air and on the skin with a direct result on the potential risk of the mixture to which the individual is exposed WP3 Task 3.3.3

Project Website and online portal

Set up and maintain the project website including dedicated sections for stakeholders, such as scientific community, health practitioners, clinicians, health researchers, and the general public. The website will further feature all suitable dissemination and communication activities and resources, including guidance documents and links to social media channels. This is described in Task 7.3 WP7

EXIMIOUS topical webinars

WP7 Task 7.4 Will set-up and develop topical webinars (3 annually), such as environmental measurements of microplastics in air, innate immunity and exposure, gene-immune-environment interactions starting in the third project open to scientists, environmental and occupational health practitioners, health researchers and epidemiologists as well as policy and decision makers.

Project Newsletter

WP7 Task 7.2 :Develop and distribute bi-annual project newsletters as of the second project year with information on project activities and discussions as well as news updates on relevant events and developments

Publicaciones

Peer reviewed articles (32)

Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review

Autores: Lisa M. F. Janssen; Manosij Ghosh; Frauke Lemaire; K. Michael Pollard; Peter H. M. Hoet
Publicado en: Particle and Fibre Toxicology, Edición 4, 2021, ISSN 1743-8977
Editor: BioMed Central
DOI: 10.1186/s12989-021-00439-6

Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing

Autores: Cristina Pavan, Riccardo Leinardi, Anissa Benhida, Saloua Ibouraadaten, Yousof Yakoub, Sybille van den Brule, Dominique Lison, Francesco Turci, François Huaux
Publicado en: Particle and Fibre Toxicology, Edición 21, 2024, ISSN 1743-8977
Editor: BioMed Central
DOI: 10.1186/s12989-024-00611-8

A cross-sectional study on occupational hygiene in biowaste plants

Autores: Anne Mette Madsen, Pil Uthaug Rasmussen, Mohammad Seeiar Delsuz, Margit W Frederiksen
Publicado en: Annals of Work Exposures and Health, Edición 68, 2024, Página(s) 967-981, ISSN 2398-7308
Editor: Oxford University Press (OUP)
DOI: 10.1093/annweh/wxae074

Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure

Autores: Riccardo Leinardi; Amandine Pochet; Francine Uwambayinema; Yousof Yakoub; Valérie Quesniaux; Bernhard Ryffel; Petr Broz; Cristina Pavan; François Huaux
Publicado en: Archives of toxicology, Edición Vol. 97, no. 4, 2023, Página(s) p. 1001-1015, ISSN 1432-0738
Editor: Springer Nature
DOI: 10.1007/s00204-023-03463-x

Carbon Nanotubes Under Scrutiny: Their Toxicity and Utility in Mesothelioma Research

Autores: Micaela Orsi, Chafik Al Hatem, Riccardo Leinardi, François Huaux
Publicado en: Applied Sciences, Edición 10/13, 2020, Página(s) 4513, ISSN 2076-3417
Editor: Applied Sciences
DOI: 10.3390/app10134513

Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development

Autores: Riccardo Leinardi; Chiara Longo Sanchez-Calero; François Huaux
Publicado en: Frontiers in Toxicology, Edición Vol. 4, no.1, 2022, Página(s) 1, ISSN 2673-3080
Editor: Frontiers
DOI: 10.3389/ftox.2022.887228

ERS International Congress 2022: highlights from the Epidemiology and Environment Assembly

Autores: James G.H. Parkin, Laura Delgado-Ortiz, Rosalie Delvert, Manosij Ghosh, Aliki Korkontzelou, Sarang Patil, Marine Savouré, Mateusz Jankowski, Orianne Dumas
Publicado en: ERJ Open Research, Edición 9, 2023, Página(s) 00574-2022, ISSN 2312-0541
Editor: European Respiratory Society
DOI: 10.1183/23120541.00574-2022

A rapid test for the environmental detection of pigeon antigen

Autores: Silvia Sánchez-Díez, María-Jesús Cruz, Daniel Álvarez-Simón, Tomás Montalvo, Xavier Muñoz, Peter M. Hoet, Jeroen A. Vanoirbeek, Susana Gómez-Ollés
Publicado en: Science of The Total Environment, Edición 788, 2021, Página(s) 147789, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.147789

Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring

Autores: Riccardo Leinardi, Chiara Longo Sanchez-Calero, Saloua Ibouraadaten, Francine Uwambayinema, Yousof Yakoub, Cristina Pavan, Rani Claus, Frauke Lemaire, Steven Ronsmans, Manosij Ghosh, Lénárd Farczádi, Horatiu Moldovan, Jeroen A.J. Vanoirbeek, Francesco Turci, Peter H.M. Hoet, François Huaux
Publicado en: Environment International, Edición 199, 2025, Página(s) 109473, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109473

Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients

Autores: Frédéric Baron; Frédéric Baron; Lorenzo Canti; Kevin K. Ariën; Kevin K. Ariën; Delphine Kemlin; Isabelle Desombere; Margaux Gerbaux; Margaux Gerbaux; Pieter Pannus; Yves Beguin; Yves Beguin; Arnaud Marchant; Stéphanie Humblet-Baron
Publicado en: Frontiers in immunology, Edición Volume 13 - 2022, 2022, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2022.827242

Genetic Algorithm Based Band Relevance Selection in Hyperspectral Imaging for Plastic Waste Material Discrimination

Autores: Carolina Blanch-Perez-del-Notario, Murali Jayapala
Publicado en: Sustainability, Edición 17, 2025, Página(s) 8123, ISSN 2071-1050
Editor: MDPI Open Access Publishing
DOI: 10.3390/su17188123

The EXIMIOUS project—Mapping exposure-induced immune effects: connecting the exposome and the immunome

Autores: Ronsmans, S; Sørig Hougaard, K; Nawrot, TS; Plusquin, M; Huaux, F; Jesús Cruz, M; Moldovan, H; Verpaele, S; Jayapala, Murali; Tunney, M; Humblet-Baron, Stephanie; Dirven, H; Cecilie Nygaard, U; Lindeman, B; Duale, N; Liston, Adrian; Meulengracht Flachs, E; Kastaniegaard, K; Ketzel, M; Goetz, J; Vanoirbeek, Jeroen; Ghosh, M; Hoet, Peter; The EXIMIOUS Consortium§
Publicado en: Environmental Epidemiology, 2022, ISSN 2474-7882
Editor: Wolters Kluwer Health, Inc.
DOI: 10.1097/ee9.0000000000000193

Effects of different amosite preparations on macrophages, lung damages, and autoimmunity

Autores: Alain Lescoat, Riccardo Leinardi, Kévin Pouxvielh, Yousof Yakoub, Marie Lelong, Amandine Pochet, Erwan Dumontet, Nessrine Bellamri, Erwan Le Tallec, Cristina Pavan, Francesco Turci, Christophe Paris, François Huaux, Valérie Lecureur
Publicado en: Journal of Molecular Medicine, Edición 102, 2024, Página(s) 197-211, ISSN 0946-2716
Editor: Springer Verlag
DOI: 10.1007/s00109-023-02401-9

Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages

Autores: Riccardo Leinardi, Jasmine Rita Petriglieri, Amandine Pochet, Yousof Yakoub, Marie Lelong, Alain Lescoat, Francesco Turci, Valérie Lecureur, François Huaux
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015145

External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis

Autores: Lisa MF. Janssen, Frauke Lemaire, Chiara Longo Sanchez-Calero, François Huaux, Steven Ronsmans, Peter HM. Hoet, Manosij Ghosh
Publicado en: Journal of Autoimmunity, Edición 150, 2025, Página(s) 103342, ISSN 0896-8411
Editor: Academic Press
DOI: 10.1016/j.jaut.2024.103342

Differential Pulmonary Toxicity and Autoantibody Formation in Genetically Distinct Mouse Strains Following Combined Exposure to Silica and Diesel Exhaust Particles

Autores: Lisa MF Janssen; Frauke Lemaire; Nora Fopke Marain; Steven Ronsmans; Natasja Heylen; Arno Vanstapel; Greetje Vande Velde; Jeroen AJ Vanoirbeek; Kenneth Michael Pollard; Manosij Ghosh; Peter HM Hoet
Publicado en: Particle and Fibre Toxicology, Edición Vol 21, Iss 1, 2024, Página(s) 1-18, ISSN 1743-8977
Editor: BioMed Central
DOI: 10.1186/s12989-024-00569-7

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Autores: Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Publicado en: Breathe, Edición 19, 2023, Página(s) 230044, ISSN 1810-6838
Editor: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Autores: Nicolas Gemander, Julika Neumann, Rafael Veiga, Isabelle Etienne, Teresa Prezzemolo, Delphine Kemlin, Pieter Pannus, Stéphanie Depickère, Véronique Olislagers, Inès Vu Duc, Alexandra Waegemans, Margaux Gerbaux, Leoni Bücken, Hafid Dahma, Charlotte Martin, Nicolas Dauby, Maria E. Goossens, Isabelle Desombere, Carlos P. Roca, Mathijs Willemsen, Stanislas Goriely, Alain Le Moine, Arnaud Marchant
Publicado en: npj Vaccines, Edición 10, 2025, ISSN 2059-0105
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01182-1

B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles

Autores: Léa Hiéronimus; François Huaux
Publicado en: Frontiers in toxicology, Edición Vol. 5, no.1, 2023, Página(s) 960861, ISSN 2673-3080
Editor: Frontiers
DOI: 10.3389/ftox.2023.960861

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

Autores: Carlos P. Roca, Oliver T. Burton, Václav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stéphanie Humblet-Baron, Adrian Liston
Publicado en: Nature Communications, Edición 12/1, 2021, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-23126-8

Human immune diversity: from evolution to modernity.

Autores: Adrian Liston; Stephanie Humblet-Baron; Darragh Duffy; An Goris
Publicado en: Nature Immunology, 2021, ISSN 1529-2908
Editor: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Air pollution and risk of rheumatoid arthritis – A Danish register-based cohort study

Autores: Regitze Sølling Wils, Helena Breth Nielsen, Esben Meulengracht Flachs, Astrid Juhl Andersen, Lene Wohlfahrt Dreyer, Matthias Ketzel, Jørgen Brandt, Jibran Khan, Ulla Vogel, Camilla Sandal Sejbaek, Karin Sørig Hougaard
Publicado en: Environmental Toxicology and Pharmacology, Edición 120, 2025, Página(s) 104855, ISSN 1382-6689
Editor: Elsevier BV
DOI: 10.1016/j.etap.2025.104855

Fungal and bacterial species on biowaste workers’ hands and inhalation zone, and potential airway deposition

Autores: Madsen, AM, Rasmussen, PU, Frederiksen, MW
Publicado en: Waste Management, Edición Volume 183, 30 June 2024, 2024, Página(s) 290-301, ISSN 0956-053X
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.wasman.2024.05.018

Associations between occupational and environmental exposures and organ involvement in sarcoidosis: a retrospective case-case analysis

Autores: Steven Ronsmans, Jolien De Ridder, Eline Vandebroek, Stephan Keirsbilck, Benoit Nemery, Peter H. M. Hoet, Steven Vanderschueren, Wim A. Wuyts, Jonas Yserbyt 
Publicado en: Respiratory Research, 2021, ISSN 1465-9921
Editor: BioMed Central
DOI: 10.1186/s12931-021-01818-5

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Autores: Riccardo Leinardi, François Huaux
Publicado en: Frontiers in Toxicology, Edición 7, 2025, ISSN 2673-3080
Editor: Frontiers Media SA
DOI: 10.3389/ftox.2025.1625874

Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes

Autores: Micaela Orsi, Mihaly Palmai-Pallag, Yousof Yakoub, Saloua Ibouraadaten, Michèle De Beukelaer, Caroline Bouzin, Bertrand Bearzatto, Jérôme Ambroise, Jean-Luc Gala, Davide Brusa, Dominique Lison, François Huaux
Publicado en: Frontiers in Immunology, Edición 12, 2021, Página(s) 2303, ISSN 1664-3224
Editor: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.666107

Data management and protection in occupational and environmental exposome research - A case study from the EU-funded EXIMIOUS project

Autores: Ghosh, Manosij; Broothaerts, Katrijn; Ronsmans, Steven; Roig, Ingrid Barcena; Scheepers, Jef; Dikmen, Mustafa; Ciscato, Emily Rose; Blanch, Carolina; Plusquin, Michelle; Nygaard, Unni C.; Sejbaek, Camilla Sandal; Hougaard, Karin S.; Hoet, Peter HM.; EXIMIOUS Consortium
Publicado en: Environmental Research, Edición Volume 237, Part 1, 116886, 2023, ISSN 0013-9351
Editor: Academic Press
DOI: 10.1016/j.envres.2023.116886

Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases – a Danish register-based cohort study

Autores: Helena Breth Nielsen, Camilla Sandal Sejbaek, Lene Wohlfahrt Dreyer, Ida EH Madsen, Esben Meulengracht Flachs, Karin Sørig Hougaard
Publicado en: Scandinavian Journal of Work, Environment & Health, Edición 51, 2025, Página(s) 226-236, ISSN 0355-3140
Editor: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4220

Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma

Autores: Mette Møller Dornfeldt, Sandra Søgaard Tøttenborg, Esben Meulengracht Flachs, Luise Mølenberg Begtrup, Ida Elisabeth Huitfeldt Madsen, Karin Sørig Hougaard, Camilla Sandal Sejbaek
Publicado en: International Archives of Occupational and Environmental Health, Edición 98, 2025, Página(s) 13-23, ISSN 0340-0131
Editor: Springer Verlag
DOI: 10.1007/s00420-024-02107-6

Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

Autores: François Huaux
Publicado en: Frontiers in Immunology, Edición Vol. 12, 2021, Página(s) 690375, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2021.690375

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages

Autores: Léa Hiéronimus, Raïssa Demazy, Laura Christiaens, Francine Uwambayinema, Jean-François Geuens, Youssof Yacoub, François Huaux
Publicado en: Archives of Toxicology, Edición 96, 2022, Página(s) 585-599, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-021-03200-2

Comparison of a novel glove connector to chemical tape as a sealing device between gloves and protection suits

Autores: Rani Claus, Wai Kei Chu, Luke D. Savory, Astrid Staelens, Katrien Poels, Mike Draper, Matteo Creta, Jeroen A.J. Vanoirbeek
Publicado en: Journal of Hazardous Materials, Edición 476, 2025, Página(s) 135186, ISSN 0304-3894
Editor: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.135186

Conference proceedings (5)

Compact high-speed snapshot multispectral imagers in the VIS/NIR (460-960 nm) and SWIR range (1.1-1.65 nm) and its potential in a diverse range of applications

Autores: C. Blanch-Perez-del-Notario, B. Geelen, Y. Li, R. Vandebriel, J. Bentell, M. Jayapala and W. Charle
Publicado en: Proceedings of SPIE, Edición 12338, 2023
Editor: SPIE
DOI: 10.1117/12.2664944

Hyperspectral microscopy as a particle exposure assessment tool

Autores: C. Blanch-Perez-del-Notario, P. Bertier, M. Jayapala and A. Lambrechts
Publicado en: SPIE Photonics West 2024 Proceedings, 2024
Editor: SPIE
DOI: 10.1117/12.3002829

O-60 FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project

Autores: Manosij Ghosh; Katrijn Broothaerts; Steven Ronsmans; Ingrid Barcena Roig; Jef Scheepers; Mustafa Dikmen; Emily Rose Ciscato; Carolina Blanch; Michelle Plusquin; Unni C Nygaard; Camilla Sandal Sejbæk; Karin S Hougaard; Peter HM Hoet
Publicado en: FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project, Edición March 2023 - Volume 80 - Suppl 1, 2023
Editor: Indian Association of Occupational Health
DOI: 10.1136/oem-2023-epicoh.203

Microplastic Discrimination with Hyperspectral Microscopy

Autores: Carolina Blanch-Perez-Del-Notario, Aala Azari, Murali Jayapala, Andy Lambrechts
Publicado en: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Página(s) 1-5
Editor: IEEE
DOI: 10.1109/whispers65427.2024.10876553

Multispectral Snapshot Microscopy as an Exposure Assessment Tool

Autores: Carolina Blanch-Perez-del-Notario, Amir Asadollahi, Pieter Bertier, Murali Jayapala
Publicado en: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Página(s) 1-5
Editor: IEEE
DOI: 10.1109/whispers65427.2024.10876513

Other (4)

<b>Study protocol: Physical work demands and risk of rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus. A study protocol from the EU-funded EXIMIOUS project.</b>

Autores: Breth Nielsen, Helena; Gupta, Nidhi; Andersen, Astrid Juhl; Dreyer, Lene W.; Flachs, Esben Meulengracht; Madsen, Ida E. H.; Kolstad, Henrik A.; Kromhout, Hans; Sejbaek, Camilla Sandal; Hougaard, Karin Sørig
Publicado en: Edición 2, 2025
Editor: figshare
DOI: 10.6084/m9.figshare.29136848

<b>Study protocol for analyses of the association between psychosocial work environment exposures and risk of autoimmune rheumatic diseases. A study protocol from the EU-funded EXIMIOUS project</b>

Autores: Breth Nielsen, Helena; Sejbæk, Camilla Sandal; Dreyer, Lene Wohlfahrt; Madsen, Ida E.H.; Flachs, Esben Meulengracht; Hougaard, Karin Sørig
Publicado en: Edición 2, 2023
Editor: Figshare
DOI: 10.6084/m9.figshare.24745563

EXIMIOUS SOP for collection, storage and shipment of biological samples (updated version 3)

Autores: Nygaard, Unni; Ghosh, Manosij; Humblet-Baron, Stephanie; Nawrot, Tim; Sarah Elisabet Josefsson; Plusquin, Michelle; Huaux, François; Vanoirbeek, Jeroen; Dirven, Hubert; Rasmussen, Pil Uthaug; Cruz, María-Jesus; Claus, Rani; Lindeman, Birgitte; Broothaerts, Katrijn; Hoet, Peter
Publicado en: 2022
Editor: KU Leuven RDR
DOI: 10.48804/amzhsd

Study protocol: Analysis of the association between occupational wood dust exposure and risk of rheumatoid arthritis

Autores: Andersen, A.J., Nielsen, H.B., Flachs, E.M., Vogel, U., Madsen, I.E.H., Bonde, J.P., Hoet, P., Ronsmans, S., Ghosh, M., Kromhout, H., Peters, S., Ohlander, J., Kolstad, H.A., Basinas, I., Schlünssen, V., Sejbæk, C.S., Hougaard, K.S
Publicado en: 2025
Editor: figshare
DOI: 10.6084/m9.figshare.29423693.v1

Thesis and dissertations (1)

Characterization of a new intermediate macrophage subpopulation: SDC-1 positive SPM-like macrophages possess immunosuppressive functions in early mesotheliomagenic responses to carbon nanotubes

Autores: Micaela Orsi
Publicado en: 2021
Editor: UCL