Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

Informations projet

EXIMIOUS

N° de convention de subvention: 874707

DOI

10.3030/874707

Projet clôturé

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2025

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 10 878 331,83

Contribution de l’UE

€ 10 878 331,25

Coordonné par

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

Report 7: Updated Dissemination and Communication strategy

Joint dissemination and communication activities for the network

Report 3 Handover document to next coordinating team

Document summarising network activities and ongoing activities to facilitate a smooth transition

Websites, patent fillings, videos etc. (2)

Project Website and online portal

Set up and maintain the project website including dedicated sections for stakeholders, such as scientific community, health practitioners, clinicians, health researchers, and the general public. The website will further feature all suitable dissemination and communication activities and resources, including guidance documents and links to social media channels. This is described in Task 7.3 WP7

Project Newsletter

WP7 Task 7.2 :Develop and distribute bi-annual project newsletters as of the second project year with information on project activities and discussions as well as news updates on relevant events and developments

Publications

Peer reviewed articles (30)

Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review

Auteurs: Lisa M. F. Janssen; Manosij Ghosh; Frauke Lemaire; K. Michael Pollard; Peter H. M. Hoet
Publié dans: Particle and Fibre Toxicology, Numéro 4, 2021, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-021-00439-6

Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing

Auteurs: Cristina Pavan, Riccardo Leinardi, Anissa Benhida, Saloua Ibouraadaten, Yousof Yakoub, Sybille van den Brule, Dominique Lison, Francesco Turci, François Huaux
Publié dans: Particle and Fibre Toxicology, Numéro 21, 2024, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-024-00611-8

A cross-sectional study on occupational hygiene in biowaste plants

Auteurs: Anne Mette Madsen, Pil Uthaug Rasmussen, Mohammad Seeiar Delsuz, Margit W Frederiksen
Publié dans: Annals of Work Exposures and Health, Numéro 68, 2024, Page(s) 967-981, ISSN 2398-7308
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/annweh/wxae074

Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure

Auteurs: Riccardo Leinardi; Amandine Pochet; Francine Uwambayinema; Yousof Yakoub; Valérie Quesniaux; Bernhard Ryffel; Petr Broz; Cristina Pavan; François Huaux
Publié dans: Archives of toxicology, Numéro Vol. 97, no. 4, 2023, Page(s) p. 1001-1015, ISSN 1432-0738
Éditeur: Springer Nature
DOI: 10.1007/s00204-023-03463-x

Carbon Nanotubes Under Scrutiny: Their Toxicity and Utility in Mesothelioma Research

Auteurs: Micaela Orsi, Chafik Al Hatem, Riccardo Leinardi, François Huaux
Publié dans: Applied Sciences, Numéro 10/13, 2020, Page(s) 4513, ISSN 2076-3417
Éditeur: Applied Sciences
DOI: 10.3390/app10134513

Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development

Auteurs: Riccardo Leinardi; Chiara Longo Sanchez-Calero; François Huaux
Publié dans: Frontiers in Toxicology, Numéro Vol. 4, no.1, 2022, Page(s) 1, ISSN 2673-3080
Éditeur: Frontiers
DOI: 10.3389/ftox.2022.887228

ERS International Congress 2022: highlights from the Epidemiology and Environment Assembly

Auteurs: James G.H. Parkin, Laura Delgado-Ortiz, Rosalie Delvert, Manosij Ghosh, Aliki Korkontzelou, Sarang Patil, Marine Savouré, Mateusz Jankowski, Orianne Dumas
Publié dans: ERJ Open Research, Numéro 9, 2023, Page(s) 00574-2022, ISSN 2312-0541
Éditeur: European Respiratory Society
DOI: 10.1183/23120541.00574-2022

A rapid test for the environmental detection of pigeon antigen

Auteurs: Silvia Sánchez-Díez, María-Jesús Cruz, Daniel Álvarez-Simón, Tomás Montalvo, Xavier Muñoz, Peter M. Hoet, Jeroen A. Vanoirbeek, Susana Gómez-Ollés
Publié dans: Science of The Total Environment, Numéro 788, 2021, Page(s) 147789, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.147789

Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring

Auteurs: Riccardo Leinardi, Chiara Longo Sanchez-Calero, Saloua Ibouraadaten, Francine Uwambayinema, Yousof Yakoub, Cristina Pavan, Rani Claus, Frauke Lemaire, Steven Ronsmans, Manosij Ghosh, Lénárd Farczádi, Horatiu Moldovan, Jeroen A.J. Vanoirbeek, Francesco Turci, Peter H.M. Hoet, François Huaux
Publié dans: Environment International, Numéro 199, 2025, Page(s) 109473, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109473

Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients

Auteurs: Frédéric Baron; Frédéric Baron; Lorenzo Canti; Kevin K. Ariën; Kevin K. Ariën; Delphine Kemlin; Isabelle Desombere; Margaux Gerbaux; Margaux Gerbaux; Pieter Pannus; Yves Beguin; Yves Beguin; Arnaud Marchant; Stéphanie Humblet-Baron
Publié dans: Frontiers in immunology, Numéro Volume 13 - 2022, 2022, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2022.827242

The EXIMIOUS project—Mapping exposure-induced immune effects: connecting the exposome and the immunome

Auteurs: Ronsmans, S; Sørig Hougaard, K; Nawrot, TS; Plusquin, M; Huaux, F; Jesús Cruz, M; Moldovan, H; Verpaele, S; Jayapala, Murali; Tunney, M; Humblet-Baron, Stephanie; Dirven, H; Cecilie Nygaard, U; Lindeman, B; Duale, N; Liston, Adrian; Meulengracht Flachs, E; Kastaniegaard, K; Ketzel, M; Goetz, J; Vanoirbeek, Jeroen; Ghosh, M; Hoet, Peter; The EXIMIOUS Consortium§
Publié dans: Environmental Epidemiology, 2022, ISSN 2474-7882
Éditeur: Wolters Kluwer Health, Inc.
DOI: 10.1097/ee9.0000000000000193

Effects of different amosite preparations on macrophages, lung damages, and autoimmunity

Auteurs: Alain Lescoat, Riccardo Leinardi, Kévin Pouxvielh, Yousof Yakoub, Marie Lelong, Amandine Pochet, Erwan Dumontet, Nessrine Bellamri, Erwan Le Tallec, Cristina Pavan, Francesco Turci, Christophe Paris, François Huaux, Valérie Lecureur
Publié dans: Journal of Molecular Medicine, Numéro 102, 2024, Page(s) 197-211, ISSN 0946-2716
Éditeur: Springer Verlag
DOI: 10.1007/s00109-023-02401-9

Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages

Auteurs: Riccardo Leinardi, Jasmine Rita Petriglieri, Amandine Pochet, Yousof Yakoub, Marie Lelong, Alain Lescoat, Francesco Turci, Valérie Lecureur, François Huaux
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015145

External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis

Auteurs: Lisa MF. Janssen, Frauke Lemaire, Chiara Longo Sanchez-Calero, François Huaux, Steven Ronsmans, Peter HM. Hoet, Manosij Ghosh
Publié dans: Journal of Autoimmunity, Numéro 150, 2025, Page(s) 103342, ISSN 0896-8411
Éditeur: Academic Press
DOI: 10.1016/j.jaut.2024.103342

Differential Pulmonary Toxicity and Autoantibody Formation in Genetically Distinct Mouse Strains Following Combined Exposure to Silica and Diesel Exhaust Particles

Auteurs: Lisa MF Janssen; Frauke Lemaire; Nora Fopke Marain; Steven Ronsmans; Natasja Heylen; Arno Vanstapel; Greetje Vande Velde; Jeroen AJ Vanoirbeek; Kenneth Michael Pollard; Manosij Ghosh; Peter HM Hoet
Publié dans: Particle and Fibre Toxicology, Numéro Vol 21, Iss 1, 2024, Page(s) 1-18, ISSN 1743-8977
Éditeur: BioMed Central
DOI: 10.1186/s12989-024-00569-7

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Auteurs: Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Publié dans: Breathe, Numéro 19, 2023, Page(s) 230044, ISSN 1810-6838
Éditeur: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Auteurs: Nicolas Gemander, Julika Neumann, Rafael Veiga, Isabelle Etienne, Teresa Prezzemolo, Delphine Kemlin, Pieter Pannus, Stéphanie Depickère, Véronique Olislagers, Inès Vu Duc, Alexandra Waegemans, Margaux Gerbaux, Leoni Bücken, Hafid Dahma, Charlotte Martin, Nicolas Dauby, Maria E. Goossens, Isabelle Desombere, Carlos P. Roca, Mathijs Willemsen, Stanislas Goriely, Alain Le Moine, Arnaud Marchant
Publié dans: npj Vaccines, Numéro 10, 2025, ISSN 2059-0105
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01182-1

B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles

Auteurs: Léa Hiéronimus; François Huaux
Publié dans: Frontiers in toxicology, Numéro Vol. 5, no.1, 2023, Page(s) 960861, ISSN 2673-3080
Éditeur: Frontiers
DOI: 10.3389/ftox.2023.960861

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

Auteurs: Carlos P. Roca, Oliver T. Burton, Václav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stéphanie Humblet-Baron, Adrian Liston
Publié dans: Nature Communications, Numéro 12/1, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-23126-8

Human immune diversity: from evolution to modernity.

Auteurs: Adrian Liston; Stephanie Humblet-Baron; Darragh Duffy; An Goris
Publié dans: Nature Immunology, 2021, ISSN 1529-2908
Éditeur: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Fungal and bacterial species on biowaste workers’ hands and inhalation zone, and potential airway deposition

Auteurs: Madsen, AM, Rasmussen, PU, Frederiksen, MW
Publié dans: Waste Management, Numéro Volume 183, 30 June 2024, 2024, Page(s) 290-301, ISSN 0956-053X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.wasman.2024.05.018

Associations between occupational and environmental exposures and organ involvement in sarcoidosis: a retrospective case-case analysis

Auteurs: Steven Ronsmans, Jolien De Ridder, Eline Vandebroek, Stephan Keirsbilck, Benoit Nemery, Peter H. M. Hoet, Steven Vanderschueren, Wim A. Wuyts, Jonas Yserbyt 
Publié dans: Respiratory Research, 2021, ISSN 1465-9921
Éditeur: BioMed Central
DOI: 10.1186/s12931-021-01818-5

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Auteurs: Riccardo Leinardi, François Huaux
Publié dans: Frontiers in Toxicology, Numéro 7, 2025, ISSN 2673-3080
Éditeur: Frontiers Media SA
DOI: 10.3389/ftox.2025.1625874

Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes

Auteurs: Micaela Orsi, Mihaly Palmai-Pallag, Yousof Yakoub, Saloua Ibouraadaten, Michèle De Beukelaer, Caroline Bouzin, Bertrand Bearzatto, Jérôme Ambroise, Jean-Luc Gala, Davide Brusa, Dominique Lison, François Huaux
Publié dans: Frontiers in Immunology, Numéro 12, 2021, Page(s) 2303, ISSN 1664-3224
Éditeur: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.666107

Data management and protection in occupational and environmental exposome research - A case study from the EU-funded EXIMIOUS project

Auteurs: Ghosh, Manosij; Broothaerts, Katrijn; Ronsmans, Steven; Roig, Ingrid Barcena; Scheepers, Jef; Dikmen, Mustafa; Ciscato, Emily Rose; Blanch, Carolina; Plusquin, Michelle; Nygaard, Unni C.; Sejbaek, Camilla Sandal; Hougaard, Karin S.; Hoet, Peter HM.; EXIMIOUS Consortium
Publié dans: Environmental Research, Numéro Volume 237, Part 1, 116886, 2023, ISSN 0013-9351
Éditeur: Academic Press
DOI: 10.1016/j.envres.2023.116886

Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases – a Danish register-based cohort study

Auteurs: Helena Breth Nielsen, Camilla Sandal Sejbaek, Lene Wohlfahrt Dreyer, Ida EH Madsen, Esben Meulengracht Flachs, Karin Sørig Hougaard
Publié dans: Scandinavian Journal of Work, Environment & Health, Numéro 51, 2025, Page(s) 226-236, ISSN 0355-3140
Éditeur: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4220

Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma

Auteurs: Mette Møller Dornfeldt, Sandra Søgaard Tøttenborg, Esben Meulengracht Flachs, Luise Mølenberg Begtrup, Ida Elisabeth Huitfeldt Madsen, Karin Sørig Hougaard, Camilla Sandal Sejbaek
Publié dans: International Archives of Occupational and Environmental Health, Numéro 98, 2025, Page(s) 13-23, ISSN 0340-0131
Éditeur: Springer Verlag
DOI: 10.1007/s00420-024-02107-6

Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

Auteurs: François Huaux
Publié dans: Frontiers in Immunology, Numéro Vol. 12, 2021, Page(s) 690375, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2021.690375

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages

Auteurs: Léa Hiéronimus, Raïssa Demazy, Laura Christiaens, Francine Uwambayinema, Jean-François Geuens, Youssof Yacoub, François Huaux
Publié dans: Archives of Toxicology, Numéro 96, 2022, Page(s) 585-599, ISSN 0340-5761
Éditeur: Springer Verlag
DOI: 10.1007/s00204-021-03200-2

Comparison of a novel glove connector to chemical tape as a sealing device between gloves and protection suits

Auteurs: Rani Claus, Wai Kei Chu, Luke D. Savory, Astrid Staelens, Katrien Poels, Mike Draper, Matteo Creta, Jeroen A.J. Vanoirbeek
Publié dans: Journal of Hazardous Materials, Numéro 476, 2025, Page(s) 135186, ISSN 0304-3894
Éditeur: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.135186

Conference proceedings (5)

Compact high-speed snapshot multispectral imagers in the VIS/NIR (460-960 nm) and SWIR range (1.1-1.65 nm) and its potential in a diverse range of applications

Auteurs: C. Blanch-Perez-del-Notario, B. Geelen, Y. Li, R. Vandebriel, J. Bentell, M. Jayapala and W. Charle
Publié dans: Proceedings of SPIE, Numéro 12338, 2023
Éditeur: SPIE
DOI: 10.1117/12.2664944

Hyperspectral microscopy as a particle exposure assessment tool

Auteurs: C. Blanch-Perez-del-Notario, P. Bertier, M. Jayapala and A. Lambrechts
Publié dans: SPIE Photonics West 2024 Proceedings, 2024
Éditeur: SPIE
DOI: 10.1117/12.3002829

O-60 FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project

Auteurs: Manosij Ghosh; Katrijn Broothaerts; Steven Ronsmans; Ingrid Barcena Roig; Jef Scheepers; Mustafa Dikmen; Emily Rose Ciscato; Carolina Blanch; Michelle Plusquin; Unni C Nygaard; Camilla Sandal Sejbæk; Karin S Hougaard; Peter HM Hoet
Publié dans: FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project, Numéro March 2023 - Volume 80 - Suppl 1, 2023
Éditeur: Indian Association of Occupational Health
DOI: 10.1136/oem-2023-epicoh.203

Microplastic Discrimination with Hyperspectral Microscopy

Auteurs: Carolina Blanch-Perez-Del-Notario, Aala Azari, Murali Jayapala, Andy Lambrechts
Publié dans: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Page(s) 1-5
Éditeur: IEEE
DOI: 10.1109/whispers65427.2024.10876553

Multispectral Snapshot Microscopy as an Exposure Assessment Tool

Auteurs: Carolina Blanch-Perez-del-Notario, Amir Asadollahi, Pieter Bertier, Murali Jayapala
Publié dans: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Page(s) 1-5
Éditeur: IEEE
DOI: 10.1109/whispers65427.2024.10876513

Other (4)

<b>Study protocol: Physical work demands and risk of rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus. A study protocol from the EU-funded EXIMIOUS project.</b>

Auteurs: Breth Nielsen, Helena; Gupta, Nidhi; Andersen, Astrid Juhl; Dreyer, Lene W.; Flachs, Esben Meulengracht; Madsen, Ida E. H.; Kolstad, Henrik A.; Kromhout, Hans; Sejbaek, Camilla Sandal; Hougaard, Karin Sørig
Publié dans: Numéro 2, 2025
Éditeur: figshare
DOI: 10.6084/m9.figshare.29136848

<b>Study protocol for analyses of the association between psychosocial work environment exposures and risk of autoimmune rheumatic diseases. A study protocol from the EU-funded EXIMIOUS project</b>

Auteurs: Breth Nielsen, Helena; Sejbæk, Camilla Sandal; Dreyer, Lene Wohlfahrt; Madsen, Ida E.H.; Flachs, Esben Meulengracht; Hougaard, Karin Sørig
Publié dans: Numéro 2, 2023
Éditeur: Figshare
DOI: 10.6084/m9.figshare.24745563

EXIMIOUS SOP for collection, storage and shipment of biological samples (updated version 3)

Auteurs: Nygaard, Unni; Ghosh, Manosij; Humblet-Baron, Stephanie; Nawrot, Tim; Sarah Elisabet Josefsson; Plusquin, Michelle; Huaux, François; Vanoirbeek, Jeroen; Dirven, Hubert; Rasmussen, Pil Uthaug; Cruz, María-Jesus; Claus, Rani; Lindeman, Birgitte; Broothaerts, Katrijn; Hoet, Peter
Publié dans: 2022
Éditeur: KU Leuven RDR
DOI: 10.48804/amzhsd

Study protocol: Analysis of the association between occupational wood dust exposure and risk of rheumatoid arthritis

Auteurs: Andersen, A.J., Nielsen, H.B., Flachs, E.M., Vogel, U., Madsen, I.E.H., Bonde, J.P., Hoet, P., Ronsmans, S., Ghosh, M., Kromhout, H., Peters, S., Ohlander, J., Kolstad, H.A., Basinas, I., Schlünssen, V., Sejbæk, C.S., Hougaard, K.S
Publié dans: 2025
Éditeur: figshare
DOI: 10.6084/m9.figshare.29423693.v1

Thesis and dissertations (1)

Characterization of a new intermediate macrophage subpopulation: SDC-1 positive SPM-like macrophages possess immunosuppressive functions in early mesotheliomagenic responses to carbon nanotubes

Auteurs: Micaela Orsi
Publié dans: 2021
Éditeur: UCL