Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

Informazioni relative al progetto

EXIMIOUS

ID dell’accordo di sovvenzione: 874707

DOI

10.3030/874707

Progetto chiuso

Data della firma CE 6 Dicembre 2019

Data di avvio 1 Gennaio 2020

Data di completamento 30 Giugno 2025

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 10 878 331,83

Contributo UE

€ 10 878 331,25

Coordinato da

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

Report 7: Updated Dissemination and Communication strategy

Joint dissemination and communication activities for the network

Report 3 Handover document to next coordinating team

Document summarising network activities and ongoing activities to facilitate a smooth transition

Websites, patent fillings, videos etc. (2)

Project Website and online portal

Set up and maintain the project website including dedicated sections for stakeholders, such as scientific community, health practitioners, clinicians, health researchers, and the general public. The website will further feature all suitable dissemination and communication activities and resources, including guidance documents and links to social media channels. This is described in Task 7.3 WP7

Project Newsletter

WP7 Task 7.2 :Develop and distribute bi-annual project newsletters as of the second project year with information on project activities and discussions as well as news updates on relevant events and developments

Pubblicazioni

Peer reviewed articles (30)

Exposure to silicates and systemic autoimmune-related outcomes in rodents: a systematic review

Autori: Lisa M. F. Janssen; Manosij Ghosh; Frauke Lemaire; K. Michael Pollard; Peter H. M. Hoet
Pubblicato in: Particle and Fibre Toxicology, Numero 4, 2021, ISSN 1743-8977
Editore: BioMed Central
DOI: 10.1186/s12989-021-00439-6

Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing

Autori: Cristina Pavan, Riccardo Leinardi, Anissa Benhida, Saloua Ibouraadaten, Yousof Yakoub, Sybille van den Brule, Dominique Lison, Francesco Turci, François Huaux
Pubblicato in: Particle and Fibre Toxicology, Numero 21, 2024, ISSN 1743-8977
Editore: BioMed Central
DOI: 10.1186/s12989-024-00611-8

A cross-sectional study on occupational hygiene in biowaste plants

Autori: Anne Mette Madsen, Pil Uthaug Rasmussen, Mohammad Seeiar Delsuz, Margit W Frederiksen
Pubblicato in: Annals of Work Exposures and Health, Numero 68, 2024, Pagina/e 967-981, ISSN 2398-7308
Editore: Oxford University Press (OUP)
DOI: 10.1093/annweh/wxae074

Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure

Autori: Riccardo Leinardi; Amandine Pochet; Francine Uwambayinema; Yousof Yakoub; Valérie Quesniaux; Bernhard Ryffel; Petr Broz; Cristina Pavan; François Huaux
Pubblicato in: Archives of toxicology, Numero Vol. 97, no. 4, 2023, Pagina/e p. 1001-1015, ISSN 1432-0738
Editore: Springer Nature
DOI: 10.1007/s00204-023-03463-x

Carbon Nanotubes Under Scrutiny: Their Toxicity and Utility in Mesothelioma Research

Autori: Micaela Orsi, Chafik Al Hatem, Riccardo Leinardi, François Huaux
Pubblicato in: Applied Sciences, Numero 10/13, 2020, Pagina/e 4513, ISSN 2076-3417
Editore: Applied Sciences
DOI: 10.3390/app10134513

Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development

Autori: Riccardo Leinardi; Chiara Longo Sanchez-Calero; François Huaux
Pubblicato in: Frontiers in Toxicology, Numero Vol. 4, no.1, 2022, Pagina/e 1, ISSN 2673-3080
Editore: Frontiers
DOI: 10.3389/ftox.2022.887228

ERS International Congress 2022: highlights from the Epidemiology and Environment Assembly

Autori: James G.H. Parkin, Laura Delgado-Ortiz, Rosalie Delvert, Manosij Ghosh, Aliki Korkontzelou, Sarang Patil, Marine Savouré, Mateusz Jankowski, Orianne Dumas
Pubblicato in: ERJ Open Research, Numero 9, 2023, Pagina/e 00574-2022, ISSN 2312-0541
Editore: European Respiratory Society
DOI: 10.1183/23120541.00574-2022

A rapid test for the environmental detection of pigeon antigen

Autori: Silvia Sánchez-Díez, María-Jesús Cruz, Daniel Álvarez-Simón, Tomás Montalvo, Xavier Muñoz, Peter M. Hoet, Jeroen A. Vanoirbeek, Susana Gómez-Ollés
Pubblicato in: Science of The Total Environment, Numero 788, 2021, Pagina/e 147789, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/j.scitotenv.2021.147789

Dynamic biodistribution of inhaled silica particles to extrapulmonary sites: Early and late translocation mechanisms with implication for particle biomonitoring

Autori: Riccardo Leinardi, Chiara Longo Sanchez-Calero, Saloua Ibouraadaten, Francine Uwambayinema, Yousof Yakoub, Cristina Pavan, Rani Claus, Frauke Lemaire, Steven Ronsmans, Manosij Ghosh, Lénárd Farczádi, Horatiu Moldovan, Jeroen A.J. Vanoirbeek, Francesco Turci, Peter H.M. Hoet, François Huaux
Pubblicato in: Environment International, Numero 199, 2025, Pagina/e 109473, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2025.109473

Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients

Autori: Frédéric Baron; Frédéric Baron; Lorenzo Canti; Kevin K. Ariën; Kevin K. Ariën; Delphine Kemlin; Isabelle Desombere; Margaux Gerbaux; Margaux Gerbaux; Pieter Pannus; Yves Beguin; Yves Beguin; Arnaud Marchant; Stéphanie Humblet-Baron
Pubblicato in: Frontiers in immunology, Numero Volume 13 - 2022, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.827242

The EXIMIOUS project—Mapping exposure-induced immune effects: connecting the exposome and the immunome

Autori: Ronsmans, S; Sørig Hougaard, K; Nawrot, TS; Plusquin, M; Huaux, F; Jesús Cruz, M; Moldovan, H; Verpaele, S; Jayapala, Murali; Tunney, M; Humblet-Baron, Stephanie; Dirven, H; Cecilie Nygaard, U; Lindeman, B; Duale, N; Liston, Adrian; Meulengracht Flachs, E; Kastaniegaard, K; Ketzel, M; Goetz, J; Vanoirbeek, Jeroen; Ghosh, M; Hoet, Peter; The EXIMIOUS Consortium§
Pubblicato in: Environmental Epidemiology, 2022, ISSN 2474-7882
Editore: Wolters Kluwer Health, Inc.
DOI: 10.1097/ee9.0000000000000193

Effects of different amosite preparations on macrophages, lung damages, and autoimmunity

Autori: Alain Lescoat, Riccardo Leinardi, Kévin Pouxvielh, Yousof Yakoub, Marie Lelong, Amandine Pochet, Erwan Dumontet, Nessrine Bellamri, Erwan Le Tallec, Cristina Pavan, Francesco Turci, Christophe Paris, François Huaux, Valérie Lecureur
Pubblicato in: Journal of Molecular Medicine, Numero 102, 2024, Pagina/e 197-211, ISSN 0946-2716
Editore: Springer Verlag
DOI: 10.1007/s00109-023-02401-9

Distinct Pro-Inflammatory Mechanisms Elicited by Short and Long Amosite Asbestos Fibers in Macrophages

Autori: Riccardo Leinardi, Jasmine Rita Petriglieri, Amandine Pochet, Yousof Yakoub, Marie Lelong, Alain Lescoat, Francesco Turci, Valérie Lecureur, François Huaux
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms242015145

External and internal exposome as triggers of biological signalling in systemic sclerosis – A narrative synthesis

Autori: Lisa MF. Janssen, Frauke Lemaire, Chiara Longo Sanchez-Calero, François Huaux, Steven Ronsmans, Peter HM. Hoet, Manosij Ghosh
Pubblicato in: Journal of Autoimmunity, Numero 150, 2025, Pagina/e 103342, ISSN 0896-8411
Editore: Academic Press
DOI: 10.1016/j.jaut.2024.103342

Differential Pulmonary Toxicity and Autoantibody Formation in Genetically Distinct Mouse Strains Following Combined Exposure to Silica and Diesel Exhaust Particles

Autori: Lisa MF Janssen; Frauke Lemaire; Nora Fopke Marain; Steven Ronsmans; Natasja Heylen; Arno Vanstapel; Greetje Vande Velde; Jeroen AJ Vanoirbeek; Kenneth Michael Pollard; Manosij Ghosh; Peter HM Hoet
Pubblicato in: Particle and Fibre Toxicology, Numero Vol 21, Iss 1, 2024, Pagina/e 1-18, ISSN 1743-8977
Editore: BioMed Central
DOI: 10.1186/s12989-024-00569-7

The exposome concept: how has it changed our understanding of environmental causes of chronic respiratory diseases?

Autori: Alicia Guillien, Manosij Ghosh, Thomas Gille, Orianne Dumas
Pubblicato in: Breathe, Numero 19, 2023, Pagina/e 230044, ISSN 1810-6838
Editore: European Respiratory Society
DOI: 10.1183/20734735.0044-2023

Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients

Autori: Nicolas Gemander, Julika Neumann, Rafael Veiga, Isabelle Etienne, Teresa Prezzemolo, Delphine Kemlin, Pieter Pannus, Stéphanie Depickère, Véronique Olislagers, Inès Vu Duc, Alexandra Waegemans, Margaux Gerbaux, Leoni Bücken, Hafid Dahma, Charlotte Martin, Nicolas Dauby, Maria E. Goossens, Isabelle Desombere, Carlos P. Roca, Mathijs Willemsen, Stanislas Goriely, Alain Le Moine, Arnaud Marchant
Pubblicato in: npj Vaccines, Numero 10, 2025, ISSN 2059-0105
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41541-025-01182-1

B-1 cells in immunotoxicology: Mechanisms underlying their response to chemicals and particles

Autori: Léa Hiéronimus; François Huaux
Pubblicato in: Frontiers in toxicology, Numero Vol. 5, no.1, 2023, Pagina/e 960861, ISSN 2673-3080
Editore: Frontiers
DOI: 10.3389/ftox.2023.960861

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

Autori: Carlos P. Roca, Oliver T. Burton, Václav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stéphanie Humblet-Baron, Adrian Liston
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-23126-8

Human immune diversity: from evolution to modernity.

Autori: Adrian Liston; Stephanie Humblet-Baron; Darragh Duffy; An Goris
Pubblicato in: Nature Immunology, 2021, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-021-01058-1

Fungal and bacterial species on biowaste workers’ hands and inhalation zone, and potential airway deposition

Autori: Madsen, AM, Rasmussen, PU, Frederiksen, MW
Pubblicato in: Waste Management, Numero Volume 183, 30 June 2024, 2024, Pagina/e 290-301, ISSN 0956-053X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.wasman.2024.05.018

Associations between occupational and environmental exposures and organ involvement in sarcoidosis: a retrospective case-case analysis

Autori: Steven Ronsmans, Jolien De Ridder, Eline Vandebroek, Stephan Keirsbilck, Benoit Nemery, Peter H. M. Hoet, Steven Vanderschueren, Wim A. Wuyts, Jonas Yserbyt 
Pubblicato in: Respiratory Research, 2021, ISSN 1465-9921
Editore: BioMed Central
DOI: 10.1186/s12931-021-01818-5

Uncovering exposome-related diseases through the pathologic metallome: a novel approach for clinical populations

Autori: Riccardo Leinardi, François Huaux
Pubblicato in: Frontiers in Toxicology, Numero 7, 2025, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/ftox.2025.1625874

Monocytic Ontogeny of Regenerated Macrophages Characterizes the Mesotheliomagenic Responses to Carbon Nanotubes

Autori: Micaela Orsi, Mihaly Palmai-Pallag, Yousof Yakoub, Saloua Ibouraadaten, Michèle De Beukelaer, Caroline Bouzin, Bertrand Bearzatto, Jérôme Ambroise, Jean-Luc Gala, Davide Brusa, Dominique Lison, François Huaux
Pubblicato in: Frontiers in Immunology, Numero 12, 2021, Pagina/e 2303, ISSN 1664-3224
Editore: Frontiers in Immunology
DOI: 10.3389/fimmu.2021.666107

Data management and protection in occupational and environmental exposome research - A case study from the EU-funded EXIMIOUS project

Autori: Ghosh, Manosij; Broothaerts, Katrijn; Ronsmans, Steven; Roig, Ingrid Barcena; Scheepers, Jef; Dikmen, Mustafa; Ciscato, Emily Rose; Blanch, Carolina; Plusquin, Michelle; Nygaard, Unni C.; Sejbaek, Camilla Sandal; Hougaard, Karin S.; Hoet, Peter HM.; EXIMIOUS Consortium
Pubblicato in: Environmental Research, Numero Volume 237, Part 1, 116886, 2023, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2023.116886

Occupational history of psychosocial work environment exposures and risk of autoimmune rheumatic diseases – a Danish register-based cohort study

Autori: Helena Breth Nielsen, Camilla Sandal Sejbaek, Lene Wohlfahrt Dreyer, Ida EH Madsen, Esben Meulengracht Flachs, Karin Sørig Hougaard
Pubblicato in: Scandinavian Journal of Work, Environment & Health, Numero 51, 2025, Pagina/e 226-236, ISSN 0355-3140
Editore: Nordic Association of Occupational Safety and Health (NOROSH)
DOI: 10.5271/sjweh.4220

Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma

Autori: Mette Møller Dornfeldt, Sandra Søgaard Tøttenborg, Esben Meulengracht Flachs, Luise Mølenberg Begtrup, Ida Elisabeth Huitfeldt Madsen, Karin Sørig Hougaard, Camilla Sandal Sejbaek
Pubblicato in: International Archives of Occupational and Environmental Health, Numero 98, 2025, Pagina/e 13-23, ISSN 0340-0131
Editore: Springer Verlag
DOI: 10.1007/s00420-024-02107-6

Interpreting Immunoregulation in Lung Fibrosis: A New Branch of the Immune Model

Autori: François Huaux
Pubblicato in: Frontiers in Immunology, Numero Vol. 12, 2021, Pagina/e 690375, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2021.690375

Mouse innate-like B-1 lymphocytes promote inhaled particle-induced in vitro granuloma formation and inflammation in conjunction with macrophages

Autori: Léa Hiéronimus, Raïssa Demazy, Laura Christiaens, Francine Uwambayinema, Jean-François Geuens, Youssof Yacoub, François Huaux
Pubblicato in: Archives of Toxicology, Numero 96, 2022, Pagina/e 585-599, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03200-2

Comparison of a novel glove connector to chemical tape as a sealing device between gloves and protection suits

Autori: Rani Claus, Wai Kei Chu, Luke D. Savory, Astrid Staelens, Katrien Poels, Mike Draper, Matteo Creta, Jeroen A.J. Vanoirbeek
Pubblicato in: Journal of Hazardous Materials, Numero 476, 2025, Pagina/e 135186, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/j.jhazmat.2024.135186

Conference proceedings (5)

Compact high-speed snapshot multispectral imagers in the VIS/NIR (460-960 nm) and SWIR range (1.1-1.65 nm) and its potential in a diverse range of applications

Autori: C. Blanch-Perez-del-Notario, B. Geelen, Y. Li, R. Vandebriel, J. Bentell, M. Jayapala and W. Charle
Pubblicato in: Proceedings of SPIE, Numero 12338, 2023
Editore: SPIE
DOI: 10.1117/12.2664944

Hyperspectral microscopy as a particle exposure assessment tool

Autori: C. Blanch-Perez-del-Notario, P. Bertier, M. Jayapala and A. Lambrechts
Pubblicato in: SPIE Photonics West 2024 Proceedings, 2024
Editore: SPIE
DOI: 10.1117/12.3002829

O-60 FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project

Autori: Manosij Ghosh; Katrijn Broothaerts; Steven Ronsmans; Ingrid Barcena Roig; Jef Scheepers; Mustafa Dikmen; Emily Rose Ciscato; Carolina Blanch; Michelle Plusquin; Unni C Nygaard; Camilla Sandal Sejbæk; Karin S Hougaard; Peter HM Hoet
Pubblicato in: FAIR data management in exposome research – a case study from the EU-funded EXIMIOUS project, Numero March 2023 - Volume 80 - Suppl 1, 2023
Editore: Indian Association of Occupational Health
DOI: 10.1136/oem-2023-epicoh.203

Microplastic Discrimination with Hyperspectral Microscopy

Autori: Carolina Blanch-Perez-Del-Notario, Aala Azari, Murali Jayapala, Andy Lambrechts
Pubblicato in: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Pagina/e 1-5
Editore: IEEE
DOI: 10.1109/whispers65427.2024.10876553

Multispectral Snapshot Microscopy as an Exposure Assessment Tool

Autori: Carolina Blanch-Perez-del-Notario, Amir Asadollahi, Pieter Bertier, Murali Jayapala
Pubblicato in: 2024 14th Workshop on Hyperspectral Imaging and Signal Processing: Evolution in Remote Sensing (WHISPERS), 2025, Pagina/e 1-5
Editore: IEEE
DOI: 10.1109/whispers65427.2024.10876513

Other (4)

<b>Study protocol: Physical work demands and risk of rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus. A study protocol from the EU-funded EXIMIOUS project.</b>

Autori: Breth Nielsen, Helena; Gupta, Nidhi; Andersen, Astrid Juhl; Dreyer, Lene W.; Flachs, Esben Meulengracht; Madsen, Ida E. H.; Kolstad, Henrik A.; Kromhout, Hans; Sejbaek, Camilla Sandal; Hougaard, Karin Sørig
Pubblicato in: Numero 2, 2025
Editore: figshare
DOI: 10.6084/m9.figshare.29136848

<b>Study protocol for analyses of the association between psychosocial work environment exposures and risk of autoimmune rheumatic diseases. A study protocol from the EU-funded EXIMIOUS project</b>

Autori: Breth Nielsen, Helena; Sejbæk, Camilla Sandal; Dreyer, Lene Wohlfahrt; Madsen, Ida E.H.; Flachs, Esben Meulengracht; Hougaard, Karin Sørig
Pubblicato in: Numero 2, 2023
Editore: Figshare
DOI: 10.6084/m9.figshare.24745563

EXIMIOUS SOP for collection, storage and shipment of biological samples (updated version 3)

Autori: Nygaard, Unni; Ghosh, Manosij; Humblet-Baron, Stephanie; Nawrot, Tim; Sarah Elisabet Josefsson; Plusquin, Michelle; Huaux, François; Vanoirbeek, Jeroen; Dirven, Hubert; Rasmussen, Pil Uthaug; Cruz, María-Jesus; Claus, Rani; Lindeman, Birgitte; Broothaerts, Katrijn; Hoet, Peter
Pubblicato in: 2022
Editore: KU Leuven RDR
DOI: 10.48804/amzhsd

Study protocol: Analysis of the association between occupational wood dust exposure and risk of rheumatoid arthritis

Autori: Andersen, A.J., Nielsen, H.B., Flachs, E.M., Vogel, U., Madsen, I.E.H., Bonde, J.P., Hoet, P., Ronsmans, S., Ghosh, M., Kromhout, H., Peters, S., Ohlander, J., Kolstad, H.A., Basinas, I., Schlünssen, V., Sejbæk, C.S., Hougaard, K.S
Pubblicato in: 2025
Editore: figshare
DOI: 10.6084/m9.figshare.29423693.v1

Thesis and dissertations (1)

Characterization of a new intermediate macrophage subpopulation: SDC-1 positive SPM-like macrophages possess immunosuppressive functions in early mesotheliomagenic responses to carbon nanotubes

Autori: Micaela Orsi
Pubblicato in: 2021
Editore: UCL