Gene Therapy to restore lymphatic flow lymphedema

Resultado final

Intralymphatic injection of Luciferase expressing lentivector in mice
Design and validate probes for CRISPR ON, CRISPR/CAS9, CRISPR/CAS13

Intralymphatic injection of GFP expressing lentivector in mice

Project website

Data Management Plan

Publicaciones

Functional Crosstalk between Human Adipose Tissue and Lymphatic System

Autores: Zuzana Varaliová
Publicado en: 2022
Editor: Univerzita Karlova

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Autores: Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, and Kari Alitalo
Publicado en: The Journal of Clinical Investigation, Edición 132(15), 2022, Página(s) e155478, ISSN 1558-8238
Editor: ASCI
DOI: 10.1172/jci155478

Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis-generating study in breast cancer survivors

Autores: Michal Koc, Martin Wald, Zuzana Varaliová, Barbora Ondrůjová, Terezie Čížková, Milan Brychta, Jana Kračmerová, Lenka Beranová, Jan Pala, Veronika Šrámková, Michaela Šiklová, Jan Gojda, Lenka Rossmeislová
Publicado en: Scientific Reports, Edición 11/1, 2021, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-021-87494-3

The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases

Autores: Coralie Fontaine, Florent Morfoisse, Florence Tatin, Audrey Zamora, Rana Zahreddine, Daniel Henrion, Jean-François Arnal, Françoise Lenfant, Barbara Garmy-Susini
Publicado en: International Journal of Molecular Sciences, Edición 21/9, 2020, Página(s) 3244, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093244

VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells

Autores: Manon Penco-Campillo, Yannick Comoglio, Álvaro Javier Feliz Morel, Rita Hanna, Jérôme Durivault, Magalie Leloire, Bastien Mejias, Marina Pagnuzzi, Amandine Morot, Fanny Burel-Vandenbos, Matthew Selby, Daniel Williamson, Steven C. Clifford, Audrey Claren, Jérôme Doyen, Vincent Picco, Sonia Martial, Gilles Pagès
Publicado en: Communications Biology, Edición 3/1, 2020, ISSN 2399-3642
Editor: Nature publishing group
DOI: 10.1038/s42003-020-01306-4

Development and aging of the lymphatic vascular system

Autores: Alejandra González-Loyola, Tatiana V. Petrova
Publicado en: Advanced Drug Delivery Reviews, Edición 169, 2021, Página(s) 63-78, ISSN 0169-409X
Editor: Elsevier BV
DOI: 10.1016/j.addr.2020.12.005

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Autores: Taija Mäkinen, Laurence M. Boon, Miikka Vikkula, Kari Alitalo
Publicado en: Circulation Research, Edición 129/1, 2021, Página(s) 136-154, ISSN 0009-7330
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.318142

Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis

Autores: Florent Morfoisse, Fabienne De Toni, Jeremy Nigri, Mohsen Hosseini, Audrey Zamora, Florence Tatin, Françoise Pujol, Jean-Emmanuel Sarry, Dominique Langin, Eric Lacazette, Anne-Catherine Prats, Richard Tomasini, Jean Galitzky, Anne Bouloumié, Barbara Garmy-Susini
Publicado en: Cancers, Edición 13/12, 2021, Página(s) 2851, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13122851

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

Autores: Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Publicado en: Journal of experimental medicine, Edición March 7, 219(3à, 2022, Página(s) e20210565, ISSN 0022-1007
Editor: Rockefeller University Press
DOI: 10.1084/jem.20210565

Sex Hormones in Lymphedema

Autores: Florent Morfoisse, Audrey Zamora, Emmanuelle Marchaud, Manon Nougue, Leila H. Diallo, Florian David, Emilie Roussel, Eric Lacazette, Anne-Catherine Prats, Florence Tatin, Barbara Garmy-Susini
Publicado en: Cancers, Edición 13/3, 2021, Página(s) 530, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030530

Targeting of the ELR+CXCL/CXCR1/2 Pathway Is a Relevant Strategy for the Treatment of Paediatric Medulloblastomas

Autores: Manon Penco-Campillo, Clément Molina, Patricia Piris, Nouha Soufi, Manon Carré, Marina Pagnuzzi-Boncompagni, Vincent Picco, Maeva Dufies, Cyril Ronco, Rachid Benhida, Sonia Martial, and Gilles Pagès
Publicado en: MDPI, Edición Volume 11 Edición 23, 2022, Página(s) 3933, ISSN 2078-2489
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11233933

Characterization of ANGPT2 mutations associated with primary lymphedema

Autores: Veli-Matti Leppänen, Pascal Brouillard, Emilia A. Korhonen, Tuomas Sipilä, Sawan Kumar Jha, Nicole Revencu, Veerle Labarque, Elodie Fastré, Matthieu Schlögel, Marie Ravoet, Amihood Singer, Claudia Luzzatto, Donatella Angelone, Giovanni Crichiutti, Angela D’Elia, Jaakko Kuurne, Harri Elamaa, Gou Young Koh, Pipsa Saharinen, Miikka Vikkula, Kari Alitalo
Publicado en: Science Translational Medicine, Edición 12/560, 2020, Página(s) eaax8013, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8013

Resultado final

Publicaciones

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