Gene Therapy to restore lymphatic flow lymphedema

Risultati finali

Intralymphatic injection of Luciferase expressing lentivector in mice
Design and validate probes for CRISPR ON, CRISPR/CAS9, CRISPR/CAS13

Intralymphatic injection of GFP expressing lentivector in mice

Project website

Data Management Plan

Pubblicazioni

Functional Crosstalk between Human Adipose Tissue and Lymphatic System

Autori: Zuzana Varaliová
Pubblicato in: 2022
Editore: Univerzita Karlova

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression

Autori: Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, and Kari Alitalo
Pubblicato in: The Journal of Clinical Investigation, Numero 132(15), 2022, Pagina/e e155478, ISSN 1558-8238
Editore: ASCI
DOI: 10.1172/jci155478

Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis-generating study in breast cancer survivors

Autori: Michal Koc, Martin Wald, Zuzana Varaliová, Barbora Ondrůjová, Terezie Čížková, Milan Brychta, Jana Kračmerová, Lenka Beranová, Jan Pala, Veronika Šrámková, Michaela Šiklová, Jan Gojda, Lenka Rossmeislová
Pubblicato in: Scientific Reports, Numero 11/1, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-87494-3

The Impact of Estrogen Receptor in Arterial and Lymphatic Vascular Diseases

Autori: Coralie Fontaine, Florent Morfoisse, Florence Tatin, Audrey Zamora, Rana Zahreddine, Daniel Henrion, Jean-François Arnal, Françoise Lenfant, Barbara Garmy-Susini
Pubblicato in: International Journal of Molecular Sciences, Numero 21/9, 2020, Pagina/e 3244, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21093244

VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells

Autori: Manon Penco-Campillo, Yannick Comoglio, Álvaro Javier Feliz Morel, Rita Hanna, Jérôme Durivault, Magalie Leloire, Bastien Mejias, Marina Pagnuzzi, Amandine Morot, Fanny Burel-Vandenbos, Matthew Selby, Daniel Williamson, Steven C. Clifford, Audrey Claren, Jérôme Doyen, Vincent Picco, Sonia Martial, Gilles Pagès
Pubblicato in: Communications Biology, Numero 3/1, 2020, ISSN 2399-3642
Editore: Nature publishing group
DOI: 10.1038/s42003-020-01306-4

Development and aging of the lymphatic vascular system

Autori: Alejandra González-Loyola, Tatiana V. Petrova
Pubblicato in: Advanced Drug Delivery Reviews, Numero 169, 2021, Pagina/e 63-78, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/j.addr.2020.12.005

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies

Autori: Taija Mäkinen, Laurence M. Boon, Miikka Vikkula, Kari Alitalo
Pubblicato in: Circulation Research, Numero 129/1, 2021, Pagina/e 136-154, ISSN 0009-7330
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.121.318142

Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis

Autori: Florent Morfoisse, Fabienne De Toni, Jeremy Nigri, Mohsen Hosseini, Audrey Zamora, Florence Tatin, Françoise Pujol, Jean-Emmanuel Sarry, Dominique Langin, Eric Lacazette, Anne-Catherine Prats, Richard Tomasini, Jean Galitzky, Anne Bouloumié, Barbara Garmy-Susini
Pubblicato in: Cancers, Numero 13/12, 2021, Pagina/e 2851, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13122851

Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance

Autori: Sinem Karaman, Satu Paavonsalo, Krista Heinolainen, Madeleine H. Lackman, Amanda Ranta, Karthik A. Hemanthakumar, Yoshiaki Kubota, Kari Alitalo
Pubblicato in: Journal of experimental medicine, Numero March 7, 219(3à, 2022, Pagina/e e20210565, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/jem.20210565

Sex Hormones in Lymphedema

Autori: Florent Morfoisse, Audrey Zamora, Emmanuelle Marchaud, Manon Nougue, Leila H. Diallo, Florian David, Emilie Roussel, Eric Lacazette, Anne-Catherine Prats, Florence Tatin, Barbara Garmy-Susini
Pubblicato in: Cancers, Numero 13/3, 2021, Pagina/e 530, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13030530

Targeting of the ELR+CXCL/CXCR1/2 Pathway Is a Relevant Strategy for the Treatment of Paediatric Medulloblastomas

Autori: Manon Penco-Campillo, Clément Molina, Patricia Piris, Nouha Soufi, Manon Carré, Marina Pagnuzzi-Boncompagni, Vincent Picco, Maeva Dufies, Cyril Ronco, Rachid Benhida, Sonia Martial, and Gilles Pagès
Pubblicato in: MDPI, Numero Volume 11 Numero 23, 2022, Pagina/e 3933, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cells11233933

Characterization of ANGPT2 mutations associated with primary lymphedema

Autori: Veli-Matti Leppänen, Pascal Brouillard, Emilia A. Korhonen, Tuomas Sipilä, Sawan Kumar Jha, Nicole Revencu, Veerle Labarque, Elodie Fastré, Matthieu Schlögel, Marie Ravoet, Amihood Singer, Claudia Luzzatto, Donatella Angelone, Giovanni Crichiutti, Angela D’Elia, Jaakko Kuurne, Harri Elamaa, Gou Young Koh, Pipsa Saharinen, Miikka Vikkula, Kari Alitalo
Pubblicato in: Science Translational Medicine, Numero 12/560, 2020, Pagina/e eaax8013, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aax8013

Risultati finali

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