Descripción del proyecto
Primera versión del atlas celular humano del páncreas
Entre las enfermedades que afectan al páncreas se incluye el adenocarcinoma pancreático, un tipo de cáncer devastador, y la pancreatitis, un trastorno potencialmente mortal. La diabetes es una afección crónica extremadamente extendida que también afecta al páncreas. El consorcio financiado con fondos europeos ESPACE tiene por objeto crear una primera versión del atlas celular humano (ACH) del páncreas. La investigación integrará perfiles moleculares y datos del transcriptoma y de epigenómica obtenidos a partir de más de un millón de células individuales con datos de proteómica de tejidos para abordar cuestiones fundamentales del fenotipo celular, tanto en adultos sanos como a lo largo del desarrollo embrionario. ESPACE se centrará en la diabetes de tipo 2 en el trabajo del ACH para comprender las enfermedades pancreáticas. Asimismo, la creación de un amplio atlas del páncreas humano, el primero de este tipo, hará avanzar los métodos y los estándares de alta relevancia para el proyecto del ACH de otros órganos.
Objetivo
The human pancreas is a physiologically unique organ involved in the secretion of several hormones, such as insulin, thus regulating blood sugar levels, as well as the secretion of enzymes for the digestive system. Several human diseases are associated with the pancreas: Pancreatic andenocarcinoma is one of the most aggressive cancers in humans and pancreatitis is a common potentially life-threatening disorder related to adverse lifestyle conditions. A very common chronical disease affecting the pancreas is Diabetes mellitus, a metabolic disorder that is characterised by high blood sugar levels due to the lack of insulin produced in the pancreas. Despite its high physiological importance, the high autolytic activity makes the pancreas a challenging tissue to study. The Expression and Spatial analysis Pancreas Atlas Consortium Europe, ESPACE, has formed as merger of three prior Human Cell Atlas (HCA) early pilot studies of the pancreas funded by the Chan Zuckerberg initiative. Based on the there developed methods and standards for sample procurement, single cell profiling, spatial proteomics, and computational pipelines we will here build a first version of the Human Cell Atlas of the Pancreas. We will integrate molecular profiles, including transcriptome and epigenomics data from more than 1 million single cells jointly together with tissue proteomics allowing to address fundamental questions of cell state and phenotype in healthy adults and during foetal development. Thus, we will provide a first version of an open single cell repository of the pancreas built upon the Data Coordination Platform of the HCA. Exploring the benefit of the HCA of the pancreas for tackling pancreatic diseases, ESPACE will reach out into types 2 diabetes. Besides creating a unique and first of its kind comprehensive atlas of the human pancreas the methods and standards developed by ESPACE will be of high relevance for HCA projects in other organs.
Ámbito científico
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
- natural sciencesbiological sciencesgeneticsepigenetics
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2019-Single-Stage-RTD
Régimen de financiación
RIA - Research and Innovation actionCoordinador
10117 Berlin
Alemania