Novel Strategies for Cell-based Neural Reconstruction

Livrables

Report on the generation of novel hPSC lines and virus engineered for cell replacement
To define the cytokine environment post grafting at the transplant site using microdialysis
Complete profiling of optimized grafts using multiplexed molecular and protein-based methods
Report summarising the outcome of workshop on Transplant connectomics: strategies to improve the structural and functional integration of replacement cells in neurodegenerative conditions and trauma

Report summarising the outcome of workshop on Transplant connectomics strategies to improve the structural and functional integration of replacement cells in neurodegenerative conditions and trauma

First report on the effects of host mHtt pathology on grafted MSNs
Report on best available tools for circuitry analysis and a list of priorities for future improvements
Intermediate preclinical validation of optimised hPSC-derived MSNs

Intermediate preclinical validation of optimised hPSCderived MSNs

Report summarising the outcome of workshop on Regulatory and ethical issues related to the development and clinical use of next generation cell therapy products
A comprehensive definition of endogenous human cortical, striatal and midbrain cell-types and their gene expression profiles

A comprehensive definition of endogenous human cortical striatal and midbrain celltypes and their gene expression profiles

Report on graft composition of the current state of the art transplants based on new methodologies developed within the WP
Report on the function of TFs specifically expressed in human cortical, MSN and mDA neurons
Protocols for comprehensive image-based assessment of graft-host connectomes and donor cell function

Protocols for comprehensive imagebased assessment of grafthost connectomes and donor cell function

Intermediate report on the impact of communication, dissemination and training activities

Intermediate report on the impact of communication dissemination and training activities

Report summarising the outcome of workshop on Strategies and goals for the development of next generation cell therapy products for cell replacement in brain disorders
Report summarising the outcome of workshop on Strategies for the development of therapeutic cell products that can evade the host´s immune system, including the development of tools to monitor graft rejection in clinical trials

NSC-Reconstruct dedicated website is online

NSCReconstruct dedicated website is online

Description and Implementation of the Data Management Plan
ORDP: Open Research Data Pilot Defined

ORDP Open Research Data Pilot Defined

Publications

Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices

Auteurs: Giacomoni J, Habekost M, Cepeda-Prado E, Mattsson B, Ottosson DR, Parmar M, Kajtez J
Publié dans: STAR Protoc, Numéro Mar 17;4(1):102041, 2023, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2022.102041

A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons

Auteurs: Nishimura K, Ásgrímsdóttir ES, Yang S, Arenas E
Publié dans: STAR Protocols, Numéro Volume 4, Numéro 3, 15 September 2023, 2023, ISSN 2666-1667
Éditeur: Cell Press Elsevier Inc
DOI: 10.1016/j.xpro.2023.102355

Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation

Auteurs: Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilia Sif Asgrimsdottir, Kasra Nikodei, Wojciech Paslawski, Gnodde Sabine, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arenas
Publié dans: Stem Cell Reports, Numéro Vol. 18 Numéro 1, 2023, Page(s) 337-353, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2022.10.016

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

Auteurs: Libé-Philippot B, Lejeune A, Wierda K, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Nyitrai H, Vennekens KM, Bird TW, Soto D, Dennis MY, Comoletti D, Theys T, de Wit J, Vanderhaeghen P
Publié dans: Cell, Numéro 186(26), 2023, Page(s) 5766-5783.e25, ISSN 1097-4172
Éditeur: Cell Press
DOI: 10.1016/j.cell.2023.11.028

Excessive local host-graft connectivity in aging and amyloid-loaded brain

Auteurs: Thomas J, Martinez-Reza MF, Thorwirth M, Zarb Y, Conzelmann KK, Hauck SM, Grade S, Götz M
Publié dans: Science Advances, Numéro 10;8(23), 2022, Page(s) eabg9287, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9287

Probing cell identity hierarchies by fate titration and collision during direct reprogramming

Auteurs: Bob A Hersbach, David S Fischer, Giacomo Masserdotti, Deeksha, Karolina Mojžišová, Thomas Waltzhöni, Diego Rodriguez-Terrones, Matthias Heinig, Fabian J Theis, Magdalena Götz, Stefan H Stricker
Publié dans: Mol Syst Biol., 2022, Page(s) e11129, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.15252/msb.202211129

Bringing Advanced Therapies for Parkinson’s Disease to the Clinic: The Scientist’s Perspective

Auteurs: Mark Tomishima, Agnete Kirkeby
Publié dans: Journal of Parkinson's Disease, 2021, Page(s) 1-6, ISSN 1877-7171
Éditeur: IOS Press
DOI: 10.3233/jpd-212685

Generation of human cerebral organoids with a structured outer subventricular zone

Auteurs: Walsh RM, Luongo R, Giacomelli E, Ciceri G, Rittenhouse C, Verrillo A, Galimberti M, Bocchi VD, Wu Y, Xu N, Mosole S, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker RA, Cattaneo E, Studer L, Baggiolini A
Publié dans: Cell Reports, Numéro 43(4), 2024, Page(s) 114031, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2024.114031

Stem cell programming – prospects for perinatal medicine

Auteurs: Berg, L.J., Brüstle, O
Publié dans: Journal of Perinatal Medicine, Numéro 2023 Feb 22;51(6), 2023, Page(s) 730-736, ISSN 0300-5577
Éditeur: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/jpm-2022-0575

Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells

Auteurs: Edoardo Sozzi, Fredrik Nilsson, Janko Kajtez, Malin Parmar, Alessandro Fiorenzano
Publié dans: Current protocols., 2022, ISSN 2691-1299
Éditeur: Hoboken, NJ : John Wiley & Sons, [2021]-
DOI: 10.1002/cpz1.555

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

Auteurs: J. Kempf, K. Knelles, B.A. Hersbach, D. Petrik, T. Riedemann, V. Bednarova, A. Janjic, T. Simon-Ebert, W. Enard, P. Smialowski, M. Götz, G. Masserdotti
Publié dans: Cell Reports, Numéro 36/3, 2021, Page(s) 109409, ISSN 2211-1247
Éditeur: Cell Press
DOI: 10.1016/j.celrep.2021.109409

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Auteurs: Swetlana Sirko, Christian Schichor, Patrizia Della Vecchia, Fabian Metzger, Giovanna Sonsalla, Tatiana Simon, Martina Bürkle, Sofia Kalpazidou, Jovica Ninkovic, Giacomo Masserdotti, Jean-Frederic Sauniere, Valentina Iacobelli, Stefano Iacobelli, Claire Delbridge, Stefanie M. Hauck, Jörg-Christian Tonn & Magdalena Götz
Publié dans: Nature Medicine, Numéro 29, 2023, Page(s) 149–3161, ISSN 1546-170X
Éditeur: Nature Publishing Group
DOI: 10.1038/s41591-023-02644-6

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Auteurs: Aldrin-Kirk P, Åkerblom M, Cardoso T, Nolbrant S, Adler AF, Liu X, Heuer A, Davidsson M, Parmar M, Björklund T
Publié dans: Stem Cell Reports, 2022, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2021.11.014

Transcriptomic diversity of cell types across the adult human brain

Auteurs: Kimberly Siletti*, Rebecca Hodge†, Alejandro Mossi Albiach†, Ka Wai Lee, Song-Lin Ding Lijuan Hu, Peter Lönnerberg, Trygve Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, Daniel Hirschstein , Nadiya V Shapovalova, C. Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed S. Lein, Sten Linnarsson
Publié dans: Science, Numéro Vol 382, Numéro 6667, 13 October 2023, 2023, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.add7046

A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons

Auteurs: Maria Cruz-Santos, Lucia Fernandez Cardo, Meng Li
Publié dans: Cells, Numéro 11(5), 853, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11050853

Silk scaffolding drives self-assembly of functional and mature human brain organoids

Auteurs: Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar, Alessandro Fiorenzano
Publié dans: Frontiers in cell and developmental biology, 2022, ISSN 2296-634X
Éditeur: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2022.1023279

A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico

Auteurs: Jianbin Wen, Michael Peitz, Oliver Brüstle
Publié dans: Journal of Neuroscience Methods, Numéro 373, 2022, ISSN 0165-0270
Éditeur: Elsevier BV
DOI: 10.1016/j.jneumeth.2022.109562

Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells

Auteurs: Emilía Sif Ásgrímsdóttir, Ernest Arenas
Publié dans: Frontiers in Cell and Developmental Biology, Numéro 8, 2020, ISSN 2296-634X
Éditeur: Frontier Media SA
DOI: 10.3389/fcell.2020.00463

In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?

Auteurs: Malin Parmar, Anders Björklund, Tomas Björklund
Publié dans: Current Opinion in Genetics & Development, 2021, Page(s) 76-82, ISSN 0959-437X
Éditeur: Elsevier BV
DOI: 10.1016/j.gde.2021.06.002

Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development

Auteurs: Juan Eduardo Rodriguez-Gatica; Vira Iefremova; Liubov Sokhranyaeva; Si Wah Christina Au Yeung; Yannik Breitkreuz; Oliver Brüstle; Martin Karl Schwarz; Ulrich Kubitscheck
Publié dans: Development, Numéro 149, 2022, ISSN 0950-1991
Éditeur: The Company of Biologists Ltd.
DOI: 10.1242/dev.200439

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Auteurs: Riccardo Bocchi, Giacomo Masserdotti, Magdalena Götz
Publié dans: Neuron, Numéro 110(3), 2022, Page(s) 366-393, ISSN 0896-6273
Éditeur: Cell Press
DOI: 10.1016/j.neuron.2021.11.023

ADHD-associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient-derived cell lines

Auteurs: Franzsika Radtke,Viola Stella Palladino,Rhiannon V McNeill, Andreas G Chiocchetti, Denise Haslinger, Matthias Leyh, Danijel Gersic, Markus Frank, Lena Grünewald, Stephan Klebe, Oliver Brüstle, Katharina Günther, Frank Edenhofer, Thorsten M Kranz, Andreas Reif,Sarah Kittel-Schneider
Publié dans: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numéro 189(7-8), 2022, ISSN 1552-4876
Éditeur: Wiley Periodicals LLC.
DOI: 10.1002/ajmg.b.32918

Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model

Auteurs: Maria Cruz Santos, Meng Li
Publié dans: Neuronal Signaling, Numéro 5 (4), 2021, ISSN 2059-6553
Éditeur: Portland Press
DOI: 10.1042/ns20210020

Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids

Auteurs: Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parmar
Publié dans: Nat Commun, 2021, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-021-27464-5

Comprehensive cell atlas of the first-trimester developing human brain

Auteurs: Emelie Braun, Miri Danan-Gotthold, Lars E. Borm, Elin Vinsland, Ka Wai Lee, Peter Lönnerberg, Lijuan Hu, Xiaofei Li, Xiaoling He, Žaneta Andrusivová, Joakim Lundeberg, Roger A. Barker, Ernest Arenas, Erik Sundström, Sten Linnarsson
Publié dans: Science, Numéro Vol 382, Numéro 6667, 13 October 2023, 2023, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.adf1226

Combinatorial ECM arrays identify cooperative roles for matricellular proteins in enhancing the generation of TH+ neurons from human pluripotent cells

Auteurs: Maqsood Ahmed, Matthew J. Owens, Enrique M. Toledo, Ernest Arenas, Mark Bradley, Charles ffrench-Constant
Publié dans: Frontiers in Cell and Developmental Biology, Numéro Volume 9 - 2021, 2021, ISSN 2296-634X
Éditeur: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2021.755406

Studying human neural function in vivo at the cellular level: Chasing chimeras?

Auteurs: Ben Vermaercke, Vincent Bonin, Pierre Vanderhaeghen
Publié dans: Cell, Numéro 185(26), 2022, Page(s) 4869-4872, ISSN 0092-8674
Éditeur: Cell Press
DOI: 10.1016/j.cell.2022.11.020

Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD

Auteurs: Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjálmar Bjartmarz, Novo Nordisk Cell Therapy R&D, Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso , Bengt Mattsson, Anne M. Landau, Andreas N Glud, Jens C. Sørensen, Thea P. Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders
Publié dans: Cell Stem Cell, 2023, ISSN 1934-5909
Éditeur: Cell Press
DOI: 10.1016/j.stem.2023.08.014

Mitochondria metabolism sets the species-specific tempo of neuronal development

Auteurs: Ryohei Iwata, Pierre Casimir, Emir Erkol , Leïla Boubakar , Mélanie Planque , Isabel M Gallego López, Martyna Ditkowska , Vaiva Gaspariunaite, Sofie Beckers, Daan Remans, Katlijn Vints, Anke Vandekeere, Suresh Poovathingal, Matthew Bird, Ine Vlaeminck, Eline Creemers, Keimpe Wierda, Nikky Corthout, Pieter Vermeersch, Sébastien Carpentier, Kristofer Davie, Massimiliano Mazzone, Natalia V Gounko
Publié dans: Science, Numéro Vol. 379, No. 6632, 2023, Page(s) 1-9, ISSN 1422-6944
Éditeur: Birkhauser Verlag
DOI: 10.1126/science.abn4705

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Auteurs: Lea Jessica Flitsch; Kathleen Börner; Christian Stüllein; Simon Ziegler; Vera Sonntag-Buck; Ellen Wiedtke; Vesselina Semkova; Si Wah Christina Au Yeung; Julia Schlee; Mohamad Hajo; Mona Mathews; Beatrice Stefanie Ludwig; Susanne Kossatz; Horst Kessler; Dirk Grimm; Oliver Brüstle
Publié dans: Scientific Report, Numéro 12(1), 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-12404-0

Energy Metabolism Disturbances in Cell Models of PARK2 CNV Carriers with ADHD

Auteurs: Viola Stella Palladino, Andreas G. Chiocchetti, Lukas Frank, Denise Haslinger, Rhiannon McNeill, Franziska Radtke, Andreas Till, Simone Haupt, Oliver Brüstle, Katharina Günther, Frank Edenhofer, Per Hoffmann, Andreas Reif, Sarah Kittel-Schneider
Publié dans: Journal of Clinical Medicine, Numéro 9/12, 2020, Page(s) 4092, ISSN 2077-0383
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9124092

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease

Auteurs: Dario Besusso, Roberta Schellino, Marina Boido, Sara Belloli, Roberta Parolisi, Paola Conforti, Andrea Faedo, Manuel Cernigoj, Ilaria Campus, Angela Laporta, Vittoria Dickinson Bocchi, Valentina Murtaj, Malin Parmar, Paolo Spaiardi, Francesca Talpo, Claudia Maniezzi, Mauro Giuseppe Toselli, Gerardo Biella, Rosa Maria Moresco, Alessandro Vercelli, Annalisa Buffo, Elena Cattaneo
Publié dans: Stem Cell Reports, Numéro 14/5, 2020, Page(s) 876-891, ISSN 2213-6711
Éditeur: Cell Press
DOI: 10.1016/j.stemcr.2020.03.018

A reference induced pluripotent stem cell line for large-scale collaborative studies

Auteurs: Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kanaujiya, Jizhong Zou, David Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, Constance Medura, Christopher Tompkins12, Stephen Hughes, Marianita Santiana, Faraz Faghri, Mike A. Nalls, Daniel Vitale, Yue A. Qi, Daniel M. Ramo
Publié dans: Cell Stem Cell, Numéro Volume 29, Numéro 12, 2022, Page(s) 1685-1702.e22, ISSN 1934-5909
Éditeur: Cell Press
DOI: 10.1016/j.stem.2022.11.004

Predicting Astrocytic Nuclear Morphology with Machine Learning: A Tree Ensemble Classifier Study

Auteurs: Piercesare Grimaldi; Martina Lorenzati; Marta Ribodino; Elena Signorino; Annalisa Buffo; Paola Berchialla
Publié dans: Applied Sciences, Numéro Volume 13; Numéro 7, 2023, Page(s) 4289, ISSN 2076-3417
Éditeur: MDPI
DOI: 10.3390/app13074289

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

Auteurs: Martino Avallone, Joaquín Pardo, Tadiwos F Mergiya, Jana Rájová, Atte Räsänen, Marcus Davidsson, Malin Åkerblom, Luis Quintino, Darshan Kumar, Clive R Bramham, Tomas Björklund
Publié dans: Frontiers in Molecular Neuroscience, 2023, ISSN 1662-5099
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fnmol.2023.1140785

A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2

Auteurs: Dario Besusso, Andrea Cossu, Ayat Mohamed, Manuel Cernigoj, Paolo Codega, Maura Galimberti, Ilaria Campus, Paola Conforti, Elena Cattaneo
Publié dans: Stem Cell Research, Numéro 49, 2020, Page(s) 102016, ISSN 1873-5061
Éditeur: Elsevier
DOI: 10.1016/j.scr.2020.102016

In vitro derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.

Auteurs: Paola Conforti, Vittoria Dickinson Bocchi, Ilaria Campus, Linda Scaramuzza, Maura Galimberti, Tiziana Lischetti, Francesca Talpo, Matteo Pedrazzoli, Alessio Murgia, Ivan Ferrari, Chiara Cordiglieri, Alessandra Fasciani, Ernest Arenas, Dan Felsenfeld, Gerardo Biella, Dario Besusso, Elena Cattaneo
Publié dans: Cell Reports Methods, Numéro Volume 2, Numéro 12, 2022, ISSN 2667-2375
Éditeur: Cell Press
DOI: 10.1016/j.crmeth.2022.100367

Bringing Advanced Therapies for Parkinson’s Disease to the Clinic: The Scientist’s Perspective

Auteurs: Mark Tomishima, Agnete Kirkeby
Publié dans: Journal of Parkinsons Disease, 2021, ISSN 1877-7171
Éditeur: IOS Press
DOI: 10.3233/jpd-212685

The coding and long noncoding single-cell atlas of the developing human fetal striatum

Auteurs: Vittoria Dickinson Bocchi, Paola Conforti, Elena Vezzoli, Dario Besusso, Claudio Cappadona, Tiziana Lischetti, Maura Galimberti, Valeria Ranzani, Raoul J. P. Bonnal, Marco De Simone, Grazisa Rossetti, Xiaoling He, Kenji Kamimoto, Ira Espuny-Camacho, Andrea Faedo, Federica Gervasoni, Romina Vuono, Samantha A. Morris, Jian Chen, Dan Felsenfeld, Giulio Pavesi, Roger A. Barker, Massimiliano Pagani, El
Publié dans: Science, Numéro 372/6542, 2021, Page(s) eabf5759, ISSN 0036-8075
Éditeur: American Association for the Advancement of Science
DOI: 10.1126/science.abf5759

The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease.

Auteurs: Shamma Qarin; Sarah Howlett; Joanne L. Jones; Roger A. Barker
Publié dans: Neuronal Signaling, Numéro 5 (3), 2021, ISSN 2059-6553
Éditeur: Portland Press
DOI: 10.1042/ns20200083

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo

Auteurs: Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Annelie Mollbrink, Petter Storm, Andreas Heuer, Malin Parmar, Tomas Björklund
Publié dans: Mol Ther Methods Clin Dev, 2023, ISSN 2329-0501
Éditeur: Nature Publishing Group
DOI: 10.1016/j.omtm.2023.04.008

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

Auteurs: Amelie Bauer, Matteo Puglisi, Dennis Nagl, Joel A Schick, Thomas Werner, Andreas Klingl, Jihad El Andari, Veit Hornung, Horst Kessler, Magdalena Götz, Dirk Grimm, Ruth Brack-Werner
Publié dans: Advanced Science, Numéro Volume 9, Numéro 16, 2021, ISSN 2198-3844
Éditeur: Wiley-VCH
DOI: 10.1002/advs.202104979

Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells

Auteurs: Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeby
Publié dans: Stem Cell Research and Therapy, 2023, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-023-03580-5

hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.

Auteurs: Pia Rivetti di Val Cervo; Dario Besusso; Paola Conforti; Elena Cattaneo
Publié dans: Nature Reviews. Neurology, Numéro 17, 2021, Page(s) 381–392, ISSN 1759-4758
Éditeur: Nature Publishing Group
DOI: 10.1038/s41582-021-00465-0

hESC-derived striatal progenitors grafted into a Huntington's disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum

Auteurs: Schellino R, Besusso D, Parolisi R, Gómez-González GB, Dallere S, Scaramuzza L, Ribodino M, Campus I, Conforti P, Parmar M, Boido M, Cattaneo E, Buffo A
Publié dans: Stem Cell Res Ther, Numéro Jul 28;14(1), 2023, Page(s) Article number: 189, ISSN 1757-6512
Éditeur: BioMed Central
DOI: 10.1186/s13287-023-03422-4

Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4

Auteurs: Stefanie Ohlig, Solène Clavreul, Manja Thorwirth, Tatiana Simon-Ebert, Riccardo Bocchi, Sabine Ulbricht, Nirmal Kannayian, Moritz Rossner, Swetlana Sirko, Pawel Smialowski, Judith Fischer-Sternjak , Magdalena Götz
Publié dans: EMBO J, Numéro 40(21), 2021, Page(s) e107532, ISSN 1460-2075
Éditeur: EMBO Press
DOI: 10.15252/embj.2020107532

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

Auteurs: Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I. Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M. Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar & Jürgen A. Knoblich
Publié dans: Nature Methods, 2023, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-023-02080-x

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: implications for the STEM-PD clinical trial

Auteurs: Annabel J Curle, Shaline V Fazal, Shamma Qarin, Sarah K Howlett, Xiaoling He, Roger A Barker, Joanne L Jones
Publié dans: biorxiv, 2024, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.01.23.576826

Generation of human cerebral organoids with a structured outer subventricular zone

Auteurs: Ryan Walsh; Elisa Giacomelli; Gabriele Ciceri; Chelsea Rittenhouse; Maura Galimberti; Youjun Wu; James Muller; Elena Vezzoli; Johannes Jungverdorben; Ting Zhou; Roger A Barker; Elena Cattaneo; Lorenz Studer; Arianna Baggiolini
Publié dans: bioRxiv, 2023, ISSN 2692-8205
Éditeur: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.17.528906

Method to combat Parkinson’s disease by astrocyte-to-neuron conversion

Auteurs: Ernest Arenas
Publié dans: Nature, Numéro 582/7813, 2020, Page(s) 489-490, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/d41586-020-01817-4

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