Novel Strategies for Cell-based Neural Reconstruction

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Intermediate assessment of the therapeutic efficacy and potency of stem cell-derived MSNs
Report on the generation of novel hPSC lines and virus engineered for cell replacement
To define the cytokine environment post grafting at the transplant site using microdialysis
Report on the protocols on next-generation DA, MSN and cortical neurons for cell replacement based on human gene function analysis , including concept for scale-up and GMP adaptation of selected protocol(s).

Report on the protocols on next-generation DA, MSN and cortical neurons for cell replacement based on human gene function analysis, including concept for scale-up and GMP adaptation of selected protocol(s).

Complete preclinical validation of optimised hPSC-derived MSNs
Extensive pre-clinical validation of new generation A9 DA neurons
Evaluation of graft enhancements for increased therapeutic effect, including designer grafts to support simple circuit replacement and activity regulation approaches
Definition of optimal graft composition
Complete profiling of optimized grafts using multiplexed molecular and protein-based methods
Report on the effects of host mHtt pathology on grafted MSNs
Report summarising the outcome of workshop on Transplant connectomics: strategies to improve the structural and functional integration of replacement cells in neurodegenerative conditions and trauma

Report summarising the outcome of workshop on Transplant connectomics strategies to improve the structural and functional integration of replacement cells in neurodegenerative conditions and trauma

To define the immunogenicity of new generation hPSC derived dopaminergic, MSN and cortical neurons in vitro and in vivo
Final Deliverable, Final report on the impact of communication, dissemination and training activities
Documentation of functional efficacy and circuitry integration of in situ converted DA neurons
First report on the effects of host mHtt pathology on grafted MSNs
Report on the ability of grafted programmed cells to undergo circuit integration in the adult rodent brain
First protocols for in vivo MSN reprogramming from glia
Report on best available tools for circuitry analysis and a list of priorities for future improvements
Intermediate preclinical validation of optimised hPSC-derived MSNs

Intermediate preclinical validation of optimised hPSCderived MSNs

Evaluation of graft enhancements for increased therapeutic effect, including non-DA dependent aspects
Report summarising the outcome of workshop on Regulatory and ethical issues related to the development and clinical use of next generation cell therapy products
A comprehensive definition of endogenous human cortical, striatal and midbrain cell-types and their gene expression profiles

A comprehensive definition of endogenous human cortical striatal and midbrain celltypes and their gene expression profiles

Report on the protocols and next-generation hPSC-derived or converted DA, MSN, cortical, telencephalic interneurons and basal forebrain cholinergic neurons for cell replacement based on human gene expression profiles
Report on graft composition of the current state of the art transplants based on new methodologies developed within the WP
To make defined MHC knock out hPSC derived neurons and study in animal models of disease
Report on the efficiency and specificity of inducing cortico-striatal projection neurons from local glia in vivo
Report on the function of TFs specifically expressed in human cortical, MSN and mDA neurons
Protocols for comprehensive image-based assessment of graft-host connectomes and donor cell function

Protocols for comprehensive imagebased assessment of grafthost connectomes and donor cell function

Complete assessment of the therapeutic efficacy and potency of stem cell-derived MSNs
Report on the ability of grafted human neurons to integrate and restore visual and motor dysfunction
Intermediate report on the impact of communication, dissemination and training activities

Intermediate report on the impact of communication dissemination and training activities

Report summarising the outcome of workshop on Strategies and goals for the development of next generation cell therapy products for cell replacement in brain disorders
Report summarising the outcome of workshop on Strategies for the development of therapeutic cell products that can evade the host´s immune system, including the development of tools to monitor graft rejection in clinical trials

NSC-Reconstruct dedicated website is online

NSCReconstruct dedicated website is online

Description and Implementation of the Data Management Plan
ORDP: Open Research Data Pilot Defined

ORDP Open Research Data Pilot Defined

Publikacje

Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices

Autorzy: Giacomoni J, Habekost M, Cepeda-Prado E, Mattsson B, Ottosson DR, Parmar M, Kajtez J
Opublikowane w: STAR Protoc, Numer Mar 17;4(1):102041, 2023, ISSN 2666-1667
Wydawca: Cell Press
DOI: 10.1016/j.xpro.2022.102041

A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons

Autorzy: Nishimura K, Ásgrímsdóttir ES, Yang S, Arenas E
Opublikowane w: STAR Protocols, Numer Volume 4, Numer 3, 15 September 2023, 2023, ISSN 2666-1667
Wydawca: Cell Press Elsevier Inc
DOI: 10.1016/j.xpro.2023.102355

Spatial Centrosome Proteomic Profiling of Human iPSC-derived Neural Cells

Autorzy: Fatma Uzbas, Adam O’Neill
Opublikowane w: BIO-PROTOCOL, Numer 13, 2024, ISSN 2331-8325
Wydawca: Bio-protocol LLC
DOI: 10.21769/bioprotoc.4812

Dynamic spatiotemporal activation of a pervasive neurogenic competence in striatal astrocytes supports continuous neurogenesis following injury

Autorzy: Marco Fogli, Giulia Nato, Philip Greulich, Jacopo Pinto, Marta Ribodino, Gregorio Valsania, Paolo Peretto, Annalisa Buffo, Federico Luzzati
Opublikowane w: Stem Cell Reports, Numer 19, 2024, Strona(/y) 1432-1450, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2024.08.006

Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation

Autorzy: Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilia Sif Asgrimsdottir, Kasra Nikodei, Wojciech Paslawski, Gnodde Sabine, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arenas
Opublikowane w: Stem Cell Reports, Numer Vol. 18 Numer 1, 2023, Strona(/y) 337-353, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2022.10.016

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

Autorzy: Libé-Philippot B, Lejeune A, Wierda K, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Nyitrai H, Vennekens KM, Bird TW, Soto D, Dennis MY, Comoletti D, Theys T, de Wit J, Vanderhaeghen P
Opublikowane w: Cell, Numer 186(26), 2023, Strona(/y) 5766-5783.e25, ISSN 1097-4172
Wydawca: Cell Press
DOI: 10.1016/j.cell.2023.11.028

Excessive local host-graft connectivity in aging and amyloid-loaded brain

Autorzy: Thomas J, Martinez-Reza MF, Thorwirth M, Zarb Y, Conzelmann KK, Hauck SM, Grade S, Götz M
Opublikowane w: Science Advances, Numer 10;8(23), 2022, Strona(/y) eabg9287, ISSN 2375-2548
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9287

Probing cell identity hierarchies by fate titration and collision during direct reprogramming

Autorzy: Bob A Hersbach, David S Fischer, Giacomo Masserdotti, Deeksha, Karolina Mojžišová, Thomas Waltzhöni, Diego Rodriguez-Terrones, Matthias Heinig, Fabian J Theis, Magdalena Götz, Stefan H Stricker
Opublikowane w: Mol Syst Biol., 2022, Strona(/y) e11129, ISSN 1744-4292
Wydawca: Nature Publishing Group
DOI: 10.15252/msb.202211129

Generation of human cerebral organoids with a structured outer subventricular zone

Autorzy: Walsh RM, Luongo R, Giacomelli E, Ciceri G, Rittenhouse C, Verrillo A, Galimberti M, Bocchi VD, Wu Y, Xu N, Mosole S, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker RA, Cattaneo E, Studer L, Baggiolini A
Opublikowane w: Cell Reports, Numer 43(4), 2024, Strona(/y) 114031, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2024.114031

Stem cell programming – prospects for perinatal medicine

Autorzy: Berg, L.J., Brüstle, O
Opublikowane w: Journal of Perinatal Medicine, Numer 2023 Feb 22;51(6), 2023, Strona(/y) 730-736, ISSN 0300-5577
Wydawca: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/jpm-2022-0575

Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells

Autorzy: Edoardo Sozzi, Fredrik Nilsson, Janko Kajtez, Malin Parmar, Alessandro Fiorenzano
Opublikowane w: Current protocols., 2022, ISSN 2691-1299
Wydawca: Hoboken, NJ : John Wiley & Sons, [2021]-
DOI: 10.1002/cpz1.555

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

Autorzy: J. Kempf, K. Knelles, B.A. Hersbach, D. Petrik, T. Riedemann, V. Bednarova, A. Janjic, T. Simon-Ebert, W. Enard, P. Smialowski, M. Götz, G. Masserdotti
Opublikowane w: Cell Reports, Numer 36/3, 2021, Strona(/y) 109409, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2021.109409

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Autorzy: Swetlana Sirko, Christian Schichor, Patrizia Della Vecchia, Fabian Metzger, Giovanna Sonsalla, Tatiana Simon, Martina Bürkle, Sofia Kalpazidou, Jovica Ninkovic, Giacomo Masserdotti, Jean-Frederic Sauniere, Valentina Iacobelli, Stefano Iacobelli, Claire Delbridge, Stefanie M. Hauck, Jörg-Christian Tonn & Magdalena Götz
Opublikowane w: Nature Medicine, Numer 29, 2023, Strona(/y) 149–3161, ISSN 1546-170X
Wydawca: Nature Publishing Group
DOI: 10.1038/s41591-023-02644-6

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Autorzy: Aldrin-Kirk P, Åkerblom M, Cardoso T, Nolbrant S, Adler AF, Liu X, Heuer A, Davidsson M, Parmar M, Björklund T
Opublikowane w: Stem Cell Reports, 2022, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2021.11.014

Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson’s disease

Autorzy: Amalie Holm Nygaard, Alrik L Schörling, Zehra Abay-Nørgaard, Erno Hänninen, Yuan Li, Adrian Santonja, Gaurav Singh Rathore, Alison Salvador, Charlotte Rusimbi, Katrine Bech Lauritzen, Yu Zhang, Agnete Kirkeby
Opublikowane w: Stem Cells, 2025, ISSN 1066-5099
Wydawca: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxaf004

Transcriptomic diversity of cell types across the adult human brain

Autorzy: Kimberly Siletti*, Rebecca Hodge†, Alejandro Mossi Albiach†, Ka Wai Lee, Song-Lin Ding Lijuan Hu, Peter Lönnerberg, Trygve Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, Daniel Hirschstein , Nadiya V Shapovalova, C. Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed S. Lein, Sten Linnarsson
Opublikowane w: Science, Numer Vol 382, Numer 6667, 13 October 2023, 2023, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.add7046

A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons

Autorzy: Maria Cruz-Santos, Lucia Fernandez Cardo, Meng Li
Opublikowane w: Cells, Numer 11(5), 853, 2022, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells11050853

Silk scaffolding drives self-assembly of functional and mature human brain organoids

Autorzy: Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar, Alessandro Fiorenzano
Opublikowane w: Frontiers in cell and developmental biology, 2022, ISSN 2296-634X
Wydawca: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2022.1023279

A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico

Autorzy: Jianbin Wen, Michael Peitz, Oliver Brüstle
Opublikowane w: Journal of Neuroscience Methods, Numer 373, 2022, ISSN 0165-0270
Wydawca: Elsevier BV
DOI: 10.1016/j.jneumeth.2022.109562

Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells

Autorzy: Emilía Sif Ásgrímsdóttir, Ernest Arenas
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer 8, 2020, ISSN 2296-634X
Wydawca: Frontier Media SA
DOI: 10.3389/fcell.2020.00463

In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?

Autorzy: Malin Parmar, Anders Björklund, Tomas Björklund
Opublikowane w: Current Opinion in Genetics & Development, 2021, Strona(/y) 76-82, ISSN 0959-437X
Wydawca: Elsevier BV
DOI: 10.1016/j.gde.2021.06.002

Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex

Autorzy: Poornemaa Natarajan, Christina Koupourtidou, Thibault de Resseguier, Manja Thorwirth, Riccardo Bocchi, Judith Fischer‐Sternjak, Sarah Gleiss, Diana Rodrigues, Michael H. Myoga, Jovica Ninkovic, Giacomo Masserdotti, Magdalena Götz
Opublikowane w: Glia, 2024, ISSN 0894-1491
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/glia.24645

Brain injury environment critically influences the connectivity of transplanted neurons

Autorzy: Sofia Grade, Judith Thomas, Yvette Zarb, Manja Thorwirth, Karl-Klaus Conzelmann, Stefanie M. Hauck, Magdalena Götz
Opublikowane w: Science Advances, Numer 8, 2024, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.abg9445

Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development

Autorzy: Juan Eduardo Rodriguez-Gatica; Vira Iefremova; Liubov Sokhranyaeva; Si Wah Christina Au Yeung; Yannik Breitkreuz; Oliver Brüstle; Martin Karl Schwarz; Ulrich Kubitscheck
Opublikowane w: Development, Numer 149, 2022, ISSN 0950-1991
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dev.200439

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Autorzy: Riccardo Bocchi, Giacomo Masserdotti, Magdalena Götz
Opublikowane w: Neuron, Numer 110(3), 2022, Strona(/y) 366-393, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2021.11.023

ADHD-associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient-derived cell lines

Autorzy: Franzsika Radtke,Viola Stella Palladino,Rhiannon V McNeill, Andreas G Chiocchetti, Denise Haslinger, Matthias Leyh, Danijel Gersic, Markus Frank, Lena Grünewald, Stephan Klebe, Oliver Brüstle, Katharina Günther, Frank Edenhofer, Thorsten M Kranz, Andreas Reif,Sarah Kittel-Schneider
Opublikowane w: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numer 189(7-8), 2022, ISSN 1552-4876
Wydawca: Wiley Periodicals LLC.
DOI: 10.1002/ajmg.b.32918

Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model

Autorzy: Maria Cruz Santos, Meng Li
Opublikowane w: Neuronal Signaling, Numer 5 (4), 2021, ISSN 2059-6553
Wydawca: Portland Press
DOI: 10.1042/ns20210020

Clinical translation of pluripotent stem cell-based therapies: successes and challenges

Autorzy: Josefine Rågård Christiansen, Agnete Kirkeby
Opublikowane w: Development, Numer 151, 2024, ISSN 0950-1991
Wydawca: The Company of Biologists Ltd.
DOI: 10.1242/dev.202067

SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo

Autorzy: Ben Vermaercke, Ryohei Iwata, Keimpe Wierda, Leïla Boubakar, Paula Rodriguez, Martyna Ditkowska, Vincent Bonin, Pierre Vanderhaeghen
Opublikowane w: Neuron, Numer 112, 2024, Strona(/y) 3058-3068.e8, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2024.07.007

Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids

Autorzy: Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parmar
Opublikowane w: Nat Commun, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-27464-5

Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types

Autorzy: Emilía Sif Ásgrímsdóttir, Ernest Arenas
Opublikowane w: Stem Cell Research, Numer 81, 2025, Strona(/y) 103523, ISSN 1873-5061
Wydawca: Elsevier
DOI: 10.1016/j.scr.2024.103523

Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle

Autorzy: Giovanna Sonsalla, Ana Belen Malpartida, Therese Riedemann, Mirjana Gusic, Ejona Rusha, Giorgia Bulli, Sonia Najas, Aleks Janjic, Bob A. Hersbach, Pawel Smialowski, Micha Drukker, Wolfgang Enard, Jochen H.M. Prehn, Holger Prokisch, Magdalena Götz, Giacomo Masserdotti
Opublikowane w: Neuron, Numer 112, 2024, Strona(/y) 1117-1132.e9, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2023.12.020

Comprehensive cell atlas of the first-trimester developing human brain

Autorzy: Emelie Braun, Miri Danan-Gotthold, Lars E. Borm, Elin Vinsland, Ka Wai Lee, Peter Lönnerberg, Lijuan Hu, Xiaofei Li, Xiaoling He, Žaneta Andrusivová, Joakim Lundeberg, Roger A. Barker, Ernest Arenas, Erik Sundström, Sten Linnarsson
Opublikowane w: Science, Numer Vol 382, Numer 6667, 13 October 2023, 2023, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.adf1226

Combinatorial ECM arrays identify cooperative roles for matricellular proteins in enhancing the generation of TH+ neurons from human pluripotent cells

Autorzy: Maqsood Ahmed, Matthew J. Owens, Enrique M. Toledo, Ernest Arenas, Mark Bradley, Charles ffrench-Constant
Opublikowane w: Frontiers in Cell and Developmental Biology, Numer Volume 9 - 2021, 2021, ISSN 2296-634X
Wydawca: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2021.755406

Comparing Viral Vectors and Fate Mapping Approaches for Astrocyte-to-Neuron Reprogramming in the Injured Mouse Cerebral Cortex

Autorzy: Matteo Puglisi, Chu Lan Lao, Gulzar Wani, Giacomo Masserdotti, Riccardo Bocchi, Magdalena Götz
Opublikowane w: Cells, Numer 13, 2024, Strona(/y) 1408, ISSN 2073-4409
Wydawca: MDPI
DOI: 10.3390/cells13171408

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

Autorzy: Baptiste Libé-Philippot, Ryohei Iwata, Aleksandra J. Recupero, Keimpe Wierda, Sergio Bernal Garcia, Luke Hammond, Anja van Benthem, Ridha Limame, Martyna Ditkowska, Sofie Beckers, Vaiva Gaspariunaite, Eugénie Peze-Heidsieck, Daan Remans, Cécile Charrier, Tom Theys, Franck Polleux, Pierre Vanderhaeghen
Opublikowane w: Neuron, Numer 112, 2024, Strona(/y) 3602-3617.e9, ISSN 0896-6273
Wydawca: Cell Press
DOI: 10.1016/j.neuron.2024.08.021

Lineage tracing of stem cell–derived dopamine grafts in a Parkinson’s model reveals shared origin of all graft-derived cells

Autorzy: Petter Storm, Yu Zhang, Fredrik Nilsson, Alessandro Fiorenzano, Niklas Krausse, Malin Åkerblom, Marcus Davidsson, Joan Yuan, Agnete Kirkeby, Tomas Björklund, Malin Parmar
Opublikowane w: Science Advances, Numer 10, 2024, ISSN 2375-2548
Wydawca: AAAS
DOI: 10.1126/sciadv.adn3057

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter

Autorzy: Riccardo Bocchi, Manja Thorwirth, Tatiana Simon-Ebert, Christina Koupourtidou, Solène Clavreul, Keegan Kolf, Patrizia Della Vecchia, Sara Bottes, Sebastian Jessberger, Jiafeng Zhou, Gulzar Wani, Gregor-Alexander Pilz, Jovica Ninkovic, Annalisa Buffo, Swetlana Sirko, Magdalena Götz, Judith Fischer-Sternjak
Opublikowane w: Nature Neuroscience, 2025, ISSN 1097-6256
Wydawca: Nature Publishing Group
DOI: 10.1038/s41593-025-01878-6

Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD

Autorzy: Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjálmar Bjartmarz, Novo Nordisk Cell Therapy R&D, Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso , Bengt Mattsson, Anne M. Landau, Andreas N Glud, Jens C. Sørensen, Thea P. Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders
Opublikowane w: Cell Stem Cell, 2023, ISSN 1934-5909
Wydawca: Cell Press
DOI: 10.1016/j.stem.2023.08.014

Forced LMX1A expression induces dorsal neural fates and disrupts patterning of human embryonic stem cells into ventral midbrain dopaminergic neurons

Autorzy: Pedro Rifes, Janko Kajtez, Josefine Rågård Christiansen, Alrik Schörling, Gaurav Singh Rathore, Daniel A. Wolf, Andreas Heuer, Agnete Kirkeby
Opublikowane w: Stem Cell Reports, Numer Volume 19, Numer 6, 2024, Strona(/y) 830-838, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2024.04.010

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Autorzy: Lea Jessica Flitsch; Kathleen Börner; Christian Stüllein; Simon Ziegler; Vera Sonntag-Buck; Ellen Wiedtke; Vesselina Semkova; Si Wah Christina Au Yeung; Julia Schlee; Mohamad Hajo; Mona Mathews; Beatrice Stefanie Ludwig; Susanne Kossatz; Horst Kessler; Dirk Grimm; Oliver Brüstle
Opublikowane w: Scientific Report, Numer 12(1), 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-12404-0

Energy Metabolism Disturbances in Cell Models of PARK2 CNV Carriers with ADHD

Autorzy: Viola Stella Palladino, Andreas G. Chiocchetti, Lukas Frank, Denise Haslinger, Rhiannon McNeill, Franziska Radtke, Andreas Till, Simone Haupt, Oliver Brüstle, Katharina Günther, Frank Edenhofer, Per Hoffmann, Andreas Reif, Sarah Kittel-Schneider
Opublikowane w: Journal of Clinical Medicine, Numer 9/12, 2020, Strona(/y) 4092, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9124092

TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity

Autorzy: Alessandro Fiorenzano, Petter Storm, Edoardo Sozzi, Andreas Bruzelius, Sara Corsi, Janko Kajtez, Janitha Mudannayake, Jenny Nelander, Bengt Mattsson, Malin Åkerblom, Tomas Björklund, Anders Björklund, Malin Parmar
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 121, 2024, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2410331121

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease

Autorzy: Dario Besusso, Roberta Schellino, Marina Boido, Sara Belloli, Roberta Parolisi, Paola Conforti, Andrea Faedo, Manuel Cernigoj, Ilaria Campus, Angela Laporta, Vittoria Dickinson Bocchi, Valentina Murtaj, Malin Parmar, Paolo Spaiardi, Francesca Talpo, Claudia Maniezzi, Mauro Giuseppe Toselli, Gerardo Biella, Rosa Maria Moresco, Alessandro Vercelli, Annalisa Buffo, Elena Cattaneo
Opublikowane w: Stem Cell Reports, Numer 14/5, 2020, Strona(/y) 876-891, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2020.03.018

Predicting Astrocytic Nuclear Morphology with Machine Learning: A Tree Ensemble Classifier Study

Autorzy: Piercesare Grimaldi; Martina Lorenzati; Marta Ribodino; Elena Signorino; Annalisa Buffo; Paola Berchialla
Opublikowane w: Applied Sciences, Numer Volume 13; Numer 7, 2023, Strona(/y) 4289, ISSN 2076-3417
Wydawca: MDPI
DOI: 10.3390/app13074289

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

Autorzy: Martino Avallone, Joaquín Pardo, Tadiwos F Mergiya, Jana Rájová, Atte Räsänen, Marcus Davidsson, Malin Åkerblom, Luis Quintino, Darshan Kumar, Clive R Bramham, Tomas Björklund
Opublikowane w: Frontiers in Molecular Neuroscience, 2023, ISSN 1662-5099
Wydawca: Frontiers Research Foundation
DOI: 10.3389/fnmol.2023.1140785

A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2

Autorzy: Dario Besusso, Andrea Cossu, Ayat Mohamed, Manuel Cernigoj, Paolo Codega, Maura Galimberti, Ilaria Campus, Paola Conforti, Elena Cattaneo
Opublikowane w: Stem Cell Research, Numer 49, 2020, Strona(/y) 102016, ISSN 1873-5061
Wydawca: Elsevier
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Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson’s Disease Patients with GBA1 Mutations

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