Novel Strategies for Cell-based Neural Reconstruction

Risultati finali

Report on the generation of novel hPSC lines and virus engineered for cell replacement
To define the cytokine environment post grafting at the transplant site using microdialysis
Complete profiling of optimized grafts using multiplexed molecular and protein-based methods
Report summarising the outcome of workshop on Transplant connectomics: strategies to improve the structural and functional integration of replacement cells in neurodegenerative conditions and trauma

Report summarising the outcome of workshop on Transplant connectomics strategies to improve the structural and functional integration of replacement cells in neurodegenerative conditions and trauma

First report on the effects of host mHtt pathology on grafted MSNs
Report on best available tools for circuitry analysis and a list of priorities for future improvements
Intermediate preclinical validation of optimised hPSC-derived MSNs

Intermediate preclinical validation of optimised hPSCderived MSNs

Report summarising the outcome of workshop on Regulatory and ethical issues related to the development and clinical use of next generation cell therapy products
A comprehensive definition of endogenous human cortical, striatal and midbrain cell-types and their gene expression profiles

A comprehensive definition of endogenous human cortical striatal and midbrain celltypes and their gene expression profiles

Report on graft composition of the current state of the art transplants based on new methodologies developed within the WP
Report on the function of TFs specifically expressed in human cortical, MSN and mDA neurons
Protocols for comprehensive image-based assessment of graft-host connectomes and donor cell function

Protocols for comprehensive imagebased assessment of grafthost connectomes and donor cell function

Intermediate report on the impact of communication, dissemination and training activities

Intermediate report on the impact of communication dissemination and training activities

Report summarising the outcome of workshop on Strategies and goals for the development of next generation cell therapy products for cell replacement in brain disorders
Report summarising the outcome of workshop on Strategies for the development of therapeutic cell products that can evade the host´s immune system, including the development of tools to monitor graft rejection in clinical trials

NSC-Reconstruct dedicated website is online

NSCReconstruct dedicated website is online

Description and Implementation of the Data Management Plan
ORDP: Open Research Data Pilot Defined

ORDP Open Research Data Pilot Defined

Pubblicazioni

Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices

Autori: Giacomoni J, Habekost M, Cepeda-Prado E, Mattsson B, Ottosson DR, Parmar M, Kajtez J
Pubblicato in: STAR Protoc, Numero Mar 17;4(1):102041, 2023, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2022.102041

A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons

Autori: Nishimura K, Ásgrímsdóttir ES, Yang S, Arenas E
Pubblicato in: STAR Protocols, Numero Volume 4, Numero 3, 15 September 2023, 2023, ISSN 2666-1667
Editore: Cell Press Elsevier Inc
DOI: 10.1016/j.xpro.2023.102355

Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation

Autori: Kaneyasu Nishimura, Shanzheng Yang, Ka Wai Lee, Emilia Sif Asgrimsdottir, Kasra Nikodei, Wojciech Paslawski, Gnodde Sabine, Guochang Lyu, Lijuan Hu, Carmen Saltó, Per Svenningsson, Jens Hjerling-Leffler, Sten Linnarsson, Ernest Arenas
Pubblicato in: Stem Cell Reports, Numero Vol. 18 Numero 1, 2023, Pagina/e 337-353, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2022.10.016

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons

Autori: Libé-Philippot B, Lejeune A, Wierda K, Vlaeminck I, Beckers S, Gaspariunaite V, Bilheu A, Nyitrai H, Vennekens KM, Bird TW, Soto D, Dennis MY, Comoletti D, Theys T, de Wit J, Vanderhaeghen P
Pubblicato in: Cell, Numero 186(26), 2023, Pagina/e 5766-5783.e25, ISSN 1097-4172
Editore: Cell Press
DOI: 10.1016/j.cell.2023.11.028

Excessive local host-graft connectivity in aging and amyloid-loaded brain

Autori: Thomas J, Martinez-Reza MF, Thorwirth M, Zarb Y, Conzelmann KK, Hauck SM, Grade S, Götz M
Pubblicato in: Science Advances, Numero 10;8(23), 2022, Pagina/e eabg9287, ISSN 2375-2548
Editore: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abg9287

Probing cell identity hierarchies by fate titration and collision during direct reprogramming

Autori: Bob A Hersbach, David S Fischer, Giacomo Masserdotti, Deeksha, Karolina Mojžišová, Thomas Waltzhöni, Diego Rodriguez-Terrones, Matthias Heinig, Fabian J Theis, Magdalena Götz, Stefan H Stricker
Pubblicato in: Mol Syst Biol., 2022, Pagina/e e11129, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.202211129

Generation of human cerebral organoids with a structured outer subventricular zone

Autori: Walsh RM, Luongo R, Giacomelli E, Ciceri G, Rittenhouse C, Verrillo A, Galimberti M, Bocchi VD, Wu Y, Xu N, Mosole S, Muller J, Vezzoli E, Jungverdorben J, Zhou T, Barker RA, Cattaneo E, Studer L, Baggiolini A
Pubblicato in: Cell Reports, Numero 43(4), 2024, Pagina/e 114031, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2024.114031

Stem cell programming – prospects for perinatal medicine

Autori: Berg, L.J., Brüstle, O
Pubblicato in: Journal of Perinatal Medicine, Numero 2023 Feb 22;51(6), 2023, Pagina/e 730-736, ISSN 0300-5577
Editore: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/jpm-2022-0575

Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells

Autori: Edoardo Sozzi, Fredrik Nilsson, Janko Kajtez, Malin Parmar, Alessandro Fiorenzano
Pubblicato in: Current protocols., 2022, ISSN 2691-1299
Editore: Hoboken, NJ : John Wiley & Sons, [2021]-
DOI: 10.1002/cpz1.555

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

Autori: J. Kempf, K. Knelles, B.A. Hersbach, D. Petrik, T. Riedemann, V. Bednarova, A. Janjic, T. Simon-Ebert, W. Enard, P. Smialowski, M. Götz, G. Masserdotti
Pubblicato in: Cell Reports, Numero 36/3, 2021, Pagina/e 109409, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109409

Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

Autori: Swetlana Sirko, Christian Schichor, Patrizia Della Vecchia, Fabian Metzger, Giovanna Sonsalla, Tatiana Simon, Martina Bürkle, Sofia Kalpazidou, Jovica Ninkovic, Giacomo Masserdotti, Jean-Frederic Sauniere, Valentina Iacobelli, Stefano Iacobelli, Claire Delbridge, Stefanie M. Hauck, Jörg-Christian Tonn & Magdalena Götz
Pubblicato in: Nature Medicine, Numero 29, 2023, Pagina/e 149–3161, ISSN 1546-170X
Editore: Nature Publishing Group
DOI: 10.1038/s41591-023-02644-6

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Autori: Aldrin-Kirk P, Åkerblom M, Cardoso T, Nolbrant S, Adler AF, Liu X, Heuer A, Davidsson M, Parmar M, Björklund T
Pubblicato in: Stem Cell Reports, 2022, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2021.11.014

Transcriptomic diversity of cell types across the adult human brain

Autori: Kimberly Siletti*, Rebecca Hodge†, Alejandro Mossi Albiach†, Ka Wai Lee, Song-Lin Ding Lijuan Hu, Peter Lönnerberg, Trygve Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, Daniel Hirschstein , Nadiya V Shapovalova, C. Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed S. Lein, Sten Linnarsson
Pubblicato in: Science, Numero Vol 382, Numero 6667, 13 October 2023, 2023, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.add7046

A Novel LHX6 Reporter Cell Line for Tracking Human iPSC-Derived Cortical Interneurons

Autori: Maria Cruz-Santos, Lucia Fernandez Cardo, Meng Li
Pubblicato in: Cells, Numero 11(5), 853, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11050853

Silk scaffolding drives self-assembly of functional and mature human brain organoids

Autori: Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar, Alessandro Fiorenzano
Pubblicato in: Frontiers in cell and developmental biology, 2022, ISSN 2296-634X
Editore: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2022.1023279

A defined human-specific platform for modeling neuronal network stimulation in vitro and in silico

Autori: Jianbin Wen, Michael Peitz, Oliver Brüstle
Pubblicato in: Journal of Neuroscience Methods, Numero 373, 2022, ISSN 0165-0270
Editore: Elsevier BV
DOI: 10.1016/j.jneumeth.2022.109562

Midbrain Dopaminergic Neuron Development at the Single Cell Level: In vivo and in Stem Cells

Autori: Emilía Sif Ásgrímsdóttir, Ernest Arenas
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 8, 2020, ISSN 2296-634X
Editore: Frontier Media SA
DOI: 10.3389/fcell.2020.00463

In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?

Autori: Malin Parmar, Anders Björklund, Tomas Björklund
Pubblicato in: Current Opinion in Genetics & Development, 2021, Pagina/e 76-82, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2021.06.002

Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development

Autori: Juan Eduardo Rodriguez-Gatica; Vira Iefremova; Liubov Sokhranyaeva; Si Wah Christina Au Yeung; Yannik Breitkreuz; Oliver Brüstle; Martin Karl Schwarz; Ulrich Kubitscheck
Pubblicato in: Development, Numero 149, 2022, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.200439

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Autori: Riccardo Bocchi, Giacomo Masserdotti, Magdalena Götz
Pubblicato in: Neuron, Numero 110(3), 2022, Pagina/e 366-393, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2021.11.023

ADHD-associated PARK2 copy number variants: A pilot study on gene expression and effects of supplementary deprivation in patient-derived cell lines

Autori: Franzsika Radtke,Viola Stella Palladino,Rhiannon V McNeill, Andreas G Chiocchetti, Denise Haslinger, Matthias Leyh, Danijel Gersic, Markus Frank, Lena Grünewald, Stephan Klebe, Oliver Brüstle, Katharina Günther, Frank Edenhofer, Thorsten M Kranz, Andreas Reif,Sarah Kittel-Schneider
Pubblicato in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Numero 189(7-8), 2022, ISSN 1552-4876
Editore: Wiley Periodicals LLC.
DOI: 10.1002/ajmg.b.32918

Identification of TGFβ signaling as a regulator of interneuron neurogenesis in a human pluripotent stem cell model

Autori: Maria Cruz Santos, Meng Li
Pubblicato in: Neuronal Signaling, Numero 5 (4), 2021, ISSN 2059-6553
Editore: Portland Press
DOI: 10.1042/ns20210020

Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids

Autori: Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parmar
Pubblicato in: Nat Commun, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-27464-5

Comprehensive cell atlas of the first-trimester developing human brain

Autori: Emelie Braun, Miri Danan-Gotthold, Lars E. Borm, Elin Vinsland, Ka Wai Lee, Peter Lönnerberg, Lijuan Hu, Xiaofei Li, Xiaoling He, Žaneta Andrusivová, Joakim Lundeberg, Roger A. Barker, Ernest Arenas, Erik Sundström, Sten Linnarsson
Pubblicato in: Science, Numero Vol 382, Numero 6667, 13 October 2023, 2023, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adf1226

Combinatorial ECM arrays identify cooperative roles for matricellular proteins in enhancing the generation of TH+ neurons from human pluripotent cells

Autori: Maqsood Ahmed, Matthew J. Owens, Enrique M. Toledo, Ernest Arenas, Mark Bradley, Charles ffrench-Constant
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero Volume 9 - 2021, 2021, ISSN 2296-634X
Editore: Lausanne : Frontiers Media S.A., [2013]-
DOI: 10.3389/fcell.2021.755406

Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD

Autori: Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjálmar Bjartmarz, Novo Nordisk Cell Therapy R&D, Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso , Bengt Mattsson, Anne M. Landau, Andreas N Glud, Jens C. Sørensen, Thea P. Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders
Pubblicato in: Cell Stem Cell, 2023, ISSN 1934-5909
Editore: Cell Press
DOI: 10.1016/j.stem.2023.08.014

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Autori: Lea Jessica Flitsch; Kathleen Börner; Christian Stüllein; Simon Ziegler; Vera Sonntag-Buck; Ellen Wiedtke; Vesselina Semkova; Si Wah Christina Au Yeung; Julia Schlee; Mohamad Hajo; Mona Mathews; Beatrice Stefanie Ludwig; Susanne Kossatz; Horst Kessler; Dirk Grimm; Oliver Brüstle
Pubblicato in: Scientific Report, Numero 12(1), 2022, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-022-12404-0

Energy Metabolism Disturbances in Cell Models of PARK2 CNV Carriers with ADHD

Autori: Viola Stella Palladino, Andreas G. Chiocchetti, Lukas Frank, Denise Haslinger, Rhiannon McNeill, Franziska Radtke, Andreas Till, Simone Haupt, Oliver Brüstle, Katharina Günther, Frank Edenhofer, Per Hoffmann, Andreas Reif, Sarah Kittel-Schneider
Pubblicato in: Journal of Clinical Medicine, Numero 9/12, 2020, Pagina/e 4092, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm9124092

Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease

Autori: Dario Besusso, Roberta Schellino, Marina Boido, Sara Belloli, Roberta Parolisi, Paola Conforti, Andrea Faedo, Manuel Cernigoj, Ilaria Campus, Angela Laporta, Vittoria Dickinson Bocchi, Valentina Murtaj, Malin Parmar, Paolo Spaiardi, Francesca Talpo, Claudia Maniezzi, Mauro Giuseppe Toselli, Gerardo Biella, Rosa Maria Moresco, Alessandro Vercelli, Annalisa Buffo, Elena Cattaneo
Pubblicato in: Stem Cell Reports, Numero 14/5, 2020, Pagina/e 876-891, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2020.03.018

Predicting Astrocytic Nuclear Morphology with Machine Learning: A Tree Ensemble Classifier Study

Autori: Piercesare Grimaldi; Martina Lorenzati; Marta Ribodino; Elena Signorino; Annalisa Buffo; Paola Berchialla
Pubblicato in: Applied Sciences, Numero Volume 13; Numero 7, 2023, Pagina/e 4289, ISSN 2076-3417
Editore: MDPI
DOI: 10.3390/app13074289

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

Autori: Martino Avallone, Joaquín Pardo, Tadiwos F Mergiya, Jana Rájová, Atte Räsänen, Marcus Davidsson, Malin Åkerblom, Luis Quintino, Darshan Kumar, Clive R Bramham, Tomas Björklund
Pubblicato in: Frontiers in Molecular Neuroscience, 2023, ISSN 1662-5099
Editore: Frontiers Research Foundation
DOI: 10.3389/fnmol.2023.1140785

A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2

Autori: Dario Besusso, Andrea Cossu, Ayat Mohamed, Manuel Cernigoj, Paolo Codega, Maura Galimberti, Ilaria Campus, Paola Conforti, Elena Cattaneo
Pubblicato in: Stem Cell Research, Numero 49, 2020, Pagina/e 102016, ISSN 1873-5061
Editore: Elsevier
DOI: 10.1016/j.scr.2020.102016

In vitro derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution.

Autori: Paola Conforti, Vittoria Dickinson Bocchi, Ilaria Campus, Linda Scaramuzza, Maura Galimberti, Tiziana Lischetti, Francesca Talpo, Matteo Pedrazzoli, Alessio Murgia, Ivan Ferrari, Chiara Cordiglieri, Alessandra Fasciani, Ernest Arenas, Dan Felsenfeld, Gerardo Biella, Dario Besusso, Elena Cattaneo
Pubblicato in: Cell Reports Methods, Numero Volume 2, Numero 12, 2022, ISSN 2667-2375
Editore: Cell Press
DOI: 10.1016/j.crmeth.2022.100367

Bringing Advanced Therapies for Parkinson’s Disease to the Clinic: The Scientist’s Perspective

Autori: Mark Tomishima, Agnete Kirkeby
Pubblicato in: Journal of Parkinsons Disease, 2021, ISSN 1877-7171
Editore: IOS Press
DOI: 10.3233/jpd-212685

The coding and long noncoding single-cell atlas of the developing human fetal striatum

Autori: Vittoria Dickinson Bocchi, Paola Conforti, Elena Vezzoli, Dario Besusso, Claudio Cappadona, Tiziana Lischetti, Maura Galimberti, Valeria Ranzani, Raoul J. P. Bonnal, Marco De Simone, Grazisa Rossetti, Xiaoling He, Kenji Kamimoto, Ira Espuny-Camacho, Andrea Faedo, Federica Gervasoni, Romina Vuono, Samantha A. Morris, Jian Chen, Dan Felsenfeld, Giulio Pavesi, Roger A. Barker, Massimiliano Pagani, El
Pubblicato in: Science, Numero 372/6542, 2021, Pagina/e eabf5759, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.abf5759

The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson's disease.

Autori: Shamma Qarin; Sarah Howlett; Joanne L. Jones; Roger A. Barker
Pubblicato in: Neuronal Signaling, Numero 5 (3), 2021, ISSN 2059-6553
Editore: Portland Press
DOI: 10.1042/ns20200083

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo

Autori: Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Annelie Mollbrink, Petter Storm, Andreas Heuer, Malin Parmar, Tomas Björklund
Pubblicato in: Mol Ther Methods Clin Dev, 2023, ISSN 2329-0501
Editore: Nature Publishing Group
DOI: 10.1016/j.omtm.2023.04.008

Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1

Autori: Amelie Bauer, Matteo Puglisi, Dennis Nagl, Joel A Schick, Thomas Werner, Andreas Klingl, Jihad El Andari, Veit Hornung, Horst Kessler, Magdalena Götz, Dirk Grimm, Ruth Brack-Werner
Pubblicato in: Advanced Science, Numero Volume 9, Numero 16, 2021, ISSN 2198-3844
Editore: Wiley-VCH
DOI: 10.1002/advs.202104979

Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells

Autori: Pedro Rifes, Marc Isaksson, Charlotte Rusimbi, Adrián Ramón Santonja, Jenny Nelander, Thomas Laurell, Agnete Kirkeby
Pubblicato in: Stem Cell Research and Therapy, 2023, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-023-03580-5

hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.

Autori: Pia Rivetti di Val Cervo; Dario Besusso; Paola Conforti; Elena Cattaneo
Pubblicato in: Nature Reviews. Neurology, Numero 17, 2021, Pagina/e 381–392, ISSN 1759-4758
Editore: Nature Publishing Group
DOI: 10.1038/s41582-021-00465-0

hESC-derived striatal progenitors grafted into a Huntington's disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum

Autori: Schellino R, Besusso D, Parolisi R, Gómez-González GB, Dallere S, Scaramuzza L, Ribodino M, Campus I, Conforti P, Parmar M, Boido M, Cattaneo E, Buffo A
Pubblicato in: Stem Cell Res Ther, Numero Jul 28;14(1), 2023, Pagina/e Article number: 189, ISSN 1757-6512
Editore: BioMed Central
DOI: 10.1186/s13287-023-03422-4

Molecular diversity of diencephalic astrocytes reveals adult astrogenesis regulated by Smad4

Autori: Stefanie Ohlig, Solène Clavreul, Manja Thorwirth, Tatiana Simon-Ebert, Riccardo Bocchi, Sabine Ulbricht, Nirmal Kannayian, Moritz Rossner, Swetlana Sirko, Pawel Smialowski, Judith Fischer-Sternjak , Magdalena Götz
Pubblicato in: EMBO J, Numero 40(21), 2021, Pagina/e e107532, ISSN 1460-2075
Editore: EMBO Press
DOI: 10.15252/embj.2020107532

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

Autori: Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I. Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M. Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar & Jürgen A. Knoblich
Pubblicato in: Nature Methods, 2023, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-023-02080-x

The immunological profile of RC17 hESC-derived dopaminergic neural progenitor cells in vitro: implications for the STEM-PD clinical trial

Autori: Annabel J Curle, Shaline V Fazal, Shamma Qarin, Sarah K Howlett, Xiaoling He, Roger A Barker, Joanne L Jones
Pubblicato in: biorxiv, 2024, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.01.23.576826

Generation of human cerebral organoids with a structured outer subventricular zone

Autori: Ryan Walsh; Elisa Giacomelli; Gabriele Ciceri; Chelsea Rittenhouse; Maura Galimberti; Youjun Wu; James Muller; Elena Vezzoli; Johannes Jungverdorben; Ting Zhou; Roger A Barker; Elena Cattaneo; Lorenz Studer; Arianna Baggiolini
Pubblicato in: bioRxiv, 2023, ISSN 2692-8205
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.02.17.528906

Method to combat Parkinson’s disease by astrocyte-to-neuron conversion

Autori: Ernest Arenas
Pubblicato in: Nature, Numero 582/7813, 2020, Pagina/e 489-490, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/d41586-020-01817-4

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