Project description
Chemically modified RNAs and 3D printing in bone regenerative therapy
The ultimate goal of this EU-funded cmRNAbone project is to develop reliable bone regenerative technology to treat widespread bone traumatic injuries and osteoporosis-induced bone fragile fractures. Researchers aim to create a novel bone regenerative therapeutic approach using a combination of chemically modified RNAs and 3D printing technologies. Chemically modified RNAs of the growth factors targeting neurogenesis, vasculogenesis and osteogenesis will be synthesised together with vectors based on lipids and polysaccharide nanocapsules for the RNAs' delivery. Delivery of the vectors will be achieved with a 3D bioprinting process using hyaluronan-calcium phosphate biomaterial ink that can be loaded with vectors and able to be released later. This bio-ink will provide osteoinductivity and laminin-derived peptides for guiding sensory neurons and endothelial cells' ingrowth. The project aims to achieve preclinical proof of concept for selected drug candidates and prepare a first-in-human clinical trial.
Fields of science
Programme(s)
Funding Scheme
RIA - Research and Innovation action
Coordinator
7270 Davos Platz
Switzerland
See on map
Participants (13)
4051 Basel
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
4031 Basel
See on map
82152 Planegg
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
66386 St Ingbert
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20014 San Sebastian
See on map
3723 MB Bilthoven
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
13288 Marseille
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
33203 Gijon
See on map
9020 Klagenfurt
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6200 MD Maastricht
See on map
33000 Bordeaux
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
75654 Paris
See on map
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
33402 Talence
See on map