Periodic Reporting for period 2 - cmRNAbone (3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients)
Periodo di rendicontazione: 2021-07-01 al 2022-12-31
The cmRNAbone project aims to develop new materials and treatments to improve bone regeneration in osteoporotic patients. To enable the materials to be more patient specific, we aim to 3D print the implant using a novel 3D printer that will be developed by the team. We are also developing a new ceramic ink that will deliver the therapeutic and will work perfectly with the new printer. The way bones heal is dependent both on the mechanical environment and on the underlying biology. Therefore, the bioink developed will be mechanically able to support the loads applied across a fracture gap, and we will attempt to enhance the biology using a new technology. After the coronavirus pandemic, many people are more aware of the potential for messenger RNA (mRNA) molecules to produce proteins in the body, as this forms the basis of some of the new coronavirus vaccines. The mRNA message carries the recipe for proteins, allowing cell to make the protein of interest. After some days, the mRNA has done its job and will be broken down by the body, leaving no permanent changes. Within the cmRNAbone project, we aim to use mRNA to produce proteins that will enhance the healing response that is naturally occurring within the patient.
Therefore, this project aims to 3D print patient specific implants, that can deliver messages on how to make additional proteins to boost the bodies own healing response.