Advancing Innovative Stem Cell-based Therapy for Diabetes in Europe

Project Information

ISLET

Grant agreement ID: 874839

DOI

10.3030/874839

EC signature date 12 December 2019

Start date 1 March 2020

End date 28 February 2026

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 7 999 998,75

EU contribution

€ 7 999 998,75

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (4)

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 3

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 1

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Project website development and launch, ongoing news feed and update about the project, internal project communication of project documents in members area 1

Project website development and launch ongoing news feed and update about the project internal project communication of project documents in members area

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 2

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Other (2)

Building capacity for public engagement at partner institutions: Resources created for digital and face-to-face engagement, initial gap analysis, and to support engagement activities by ISLET 1

Building capacity for public engagement at partner institutions Resources created for digital and facetoface engagement initial gap analysis and to support engagement activities by ISLET

Report on active participation in European outreach and engagement events 1

Report on active participation in European outreach and engagement events: network of partner science engagement champions and partner public engagement professionals, ongoing dissemination of local opportunities for engagement and mentoring, contribution to World Diabetes Day (14 November), European City of Science Festival 2022 Leiden, and Long Night of the Sciences across Germany

Publications

Peer reviewed articles (9)

A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation

Author(s): Adrian Villalba, Yorick Gitton, Megumi Inoue, Virginie Aiello, Raphaël Blain, Maryne Toupin, Séverine Mazaud-Guittot, Latif Rachdi, Henrik Semb, Alain Chédotal, Raphaël Scharfmann
Published in: Diabetologia, Issue 12 issues a year, 2024, Page(s) 1066–1078, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-024-06143-2

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

Author(s): Pallavi U. Mahaddalkar, Katharina Scheibner, Sandra Pfluger, Ansarullah, Michael Sterr, Julia Beckenbauer, Martin Irmler, Johannes Beckers, Sebastian Knöbel, Heiko Lickert
Published in: Nature Biotechnology, Issue 38/9, 2020, Page(s) 1061-1072, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-020-0492-5

Synchro-PASEF Allows Precursor-Specific Fragment Ion Extraction and Interference Removal in Data-Independent Acquisition

Author(s): Patricia Skowronek, Florian Krohs, [...], and Matthias Mann
Published in: Molecular & Cellular Proteomics, 2023, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100489

Making single-cell proteomics biologically relevant

Author(s): Rosenberger FA, Thielert M, Mann M.
Published in: Nature Methods, 2023, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-01771-9

Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

Author(s): Rosenberger FA, Thielert M, Strauss MT, Schweizer L, Ammar C, Mädler SC, Metousis A, Skowronek P, Wahle M, Madden K, Gote-Schniering J, Semenova A, Schiller HB, Rodriguez E, Nordmann TM, Mund A, Mann M.
Published in: Nature Methods, 2023, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-02007-6

Engineering islets from stem cells for advanced therapies of diabetes

Author(s): Johanna Siehler, Anna Karolina Blöchinger, Matthias Meier, Heiko Lickert
Published in: Nature Reviews Drug Discovery, 2021, ISSN 1474-1776
Publisher: Nature Publishing Group
DOI: 10.1038/s41573-021-00262-w

A transcriptional cross species map of pancreatic islet cells

Author(s): Sophie Tritschler, Moritz Thomas, Anika Böttcher, Barbara Ludwig, Janine Schmid, Undine Schubert, Elisabeth Kemter, Eckhard Wolf, Heiko Lickert, Fabian J. Theis,
Published in: Molecular Metabolism,, 2022, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101595

IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma

Author(s): Wahle M, Thielert M, Zwiebel M, Skowronek P, Zeng WF, Mann M.
Published in: Mol Cell Proteomics, 2024, ISSN 1535-9476
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100689

Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel

Author(s): Thielert M, Itang EC, Ammar C, Rosenberger FA, Bludau I, Schweizer L, Nordmann TM, Skowronek P, Wahle M, Zeng WF, Zhou XX, Brunner AD, Richter S, Levesque MP, Theis FJ, Steger M, Mann M.
Published in: Mol Syst Biol, 2023, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202211503

Other (1)

Awaking sleeping islets for a cure of diabetes

Author(s): Katharina Scheibner, Heiko Lickert
Published in: 2022
Publisher: Cell Press
DOI: 10.1016/j.medj.2022.04.004