Advancing Innovative Stem Cell-based Therapy for Diabetes in Europe

Informations projet

ISLET

N° de convention de subvention: 874839

DOI

10.3030/874839

Date de signature de la CE 12 Decembre 2019

Date de début 1 Mars 2020

Date de fin 28 Février 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 7 999 998,75

Contribution de l’UE

€ 7 999 998,75

Coordonné par

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (4)

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 3

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 1

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Project website development and launch, ongoing news feed and update about the project, internal project communication of project documents in members area 1

Project website development and launch ongoing news feed and update about the project internal project communication of project documents in members area

Dissemination of non-confidential summaries of the project and exploitation plans at prominent biotech conferences, forums and meetings including BioEurope, BioFIT and BIO to promote and establish partnerships relevant to ISLET 2

Dissemination of nonconfidential summaries of the project and exploitation plans at prominent biotech conferences forums and meetings including BioEurope BioFIT and BIO to promote and establish partnerships relevant to ISLET

Other (2)

Building capacity for public engagement at partner institutions: Resources created for digital and face-to-face engagement, initial gap analysis, and to support engagement activities by ISLET 1

Building capacity for public engagement at partner institutions Resources created for digital and facetoface engagement initial gap analysis and to support engagement activities by ISLET

Report on active participation in European outreach and engagement events 1

Report on active participation in European outreach and engagement events: network of partner science engagement champions and partner public engagement professionals, ongoing dissemination of local opportunities for engagement and mentoring, contribution to World Diabetes Day (14 November), European City of Science Festival 2022 Leiden, and Long Night of the Sciences across Germany

Publications

Peer reviewed articles (11)

A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation

Auteurs: Adrian Villalba, Yorick Gitton, Megumi Inoue, Virginie Aiello, Raphaël Blain, Maryne Toupin, Séverine Mazaud-Guittot, Latif Rachdi, Henrik Semb, Alain Chédotal, Raphaël Scharfmann
Publié dans: Diabetologia, Numéro 12 issues a year, 2024, Page(s) 1066–1078, ISSN 0012-186X
Éditeur: Springer Verlag
DOI: 10.1007/s00125-024-06143-2

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

Auteurs: Pallavi U. Mahaddalkar, Katharina Scheibner, Sandra Pfluger, Ansarullah, Michael Sterr, Julia Beckenbauer, Martin Irmler, Johannes Beckers, Sebastian Knöbel, Heiko Lickert
Publié dans: Nature Biotechnology, Numéro 38/9, 2020, Page(s) 1061-1072, ISSN 1087-0156
Éditeur: Nature Publishing Group
DOI: 10.1038/s41587-020-0492-5

Synchro-PASEF Allows Precursor-Specific Fragment Ion Extraction and Interference Removal in Data-Independent Acquisition

Auteurs: Patricia Skowronek, Florian Krohs, [...], and Matthias Mann
Publié dans: Molecular & Cellular Proteomics, 2023, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100489

Making single-cell proteomics biologically relevant

Auteurs: Rosenberger FA, Thielert M, Mann M.
Publié dans: Nature Methods, 2023, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-023-01771-9

Stem cell islet replacement in type 1 diabetes: From “shelf” to “self”

Auteurs: Eelco J.P. de Koning, Françoise Carlotti
Publié dans: Cell Stem Cell, Numéro 31, 2024, Page(s) 1727-1729, ISSN 1934-5909
Éditeur: Cell Press
DOI: 10.1016/j.stem.2024.11.011

A Novel Hybrid High-Speed Mass Spectrometer Allows Rapid Translation From Biomarker Candidates to Targeted Clinical Tests Using 15N-Labeled Proteins

Auteurs: Maria Wahle, Philip M. Remes, Vincent Albrecht, Michael Baggio Lorenz, Johannes Mueller-Reif, Sophia Steigerwald, Tim Heymann, Lili Niu, Philip Lössl, Stevan Horning, Cristina C. Jacob, Matthias Mann
Publié dans: Molecular & Cellular Proteomics, Numéro 24, 2025, Page(s) 101050, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2025.101050

Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome

Auteurs: Rosenberger FA, Thielert M, Strauss MT, Schweizer L, Ammar C, Mädler SC, Metousis A, Skowronek P, Wahle M, Madden K, Gote-Schniering J, Semenova A, Schiller HB, Rodriguez E, Nordmann TM, Mund A, Mann M.
Publié dans: Nature Methods, 2023, ISSN 1548-7091
Éditeur: Nature Publishing Group
DOI: 10.1038/s41592-023-02007-6

Engineering islets from stem cells for advanced therapies of diabetes

Auteurs: Johanna Siehler, Anna Karolina Blöchinger, Matthias Meier, Heiko Lickert
Publié dans: Nature Reviews Drug Discovery, 2021, ISSN 1474-1776
Éditeur: Nature Publishing Group
DOI: 10.1038/s41573-021-00262-w

A transcriptional cross species map of pancreatic islet cells

Auteurs: Sophie Tritschler, Moritz Thomas, Anika Böttcher, Barbara Ludwig, Janine Schmid, Undine Schubert, Elisabeth Kemter, Eckhard Wolf, Heiko Lickert, Fabian J. Theis,
Publié dans: Molecular Metabolism,, 2022, ISSN 2212-8778
Éditeur: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101595

IMBAS-MS Discovers Organ-Specific HLA Peptide Patterns in Plasma

Auteurs: Wahle M, Thielert M, Zwiebel M, Skowronek P, Zeng WF, Mann M.
Publié dans: Mol Cell Proteomics, 2024, ISSN 1535-9476
Éditeur: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2023.100689

Robust dimethyl-based multiplex-DIA doubles single-cell proteome depth via a reference channel

Auteurs: Thielert M, Itang EC, Ammar C, Rosenberger FA, Bludau I, Schweizer L, Nordmann TM, Skowronek P, Wahle M, Zeng WF, Zhou XX, Brunner AD, Richter S, Levesque MP, Theis FJ, Steger M, Mann M.
Publié dans: Mol Syst Biol, 2023, ISSN 1744-4292
Éditeur: Nature Publishing Group
DOI: 10.15252/msb.202211503

Other (1)

Awaking sleeping islets for a cure of diabetes

Auteurs: Katharina Scheibner, Heiko Lickert
Publié dans: 2022
Éditeur: Cell Press
DOI: 10.1016/j.medj.2022.04.004